Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	56920
Gene name	Semaphorin 3G
Gene symbol	SEMA3G
Synonyms (NCBI Gene)	sem2
Chromosome	3
Chromosome location	3p21.1
Summary	The transcription of this gene is activated by PPAR-gamma, and the resulting protein product plays a role in endothelial cell migration. Expression of this gene also inhibits tumor cell migration and invasion. [provided by RefSeq, Jul 2016]

Show/Hide all (75)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027781	hsa-miR-98-5p	Microarray	19088304
MIRT650650	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT650648	hsa-miR-4287	HITS-CLIP	23824327
MIRT650649	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT650647	hsa-miR-581	HITS-CLIP	23824327
MIRT650646	hsa-miR-4268	HITS-CLIP	23824327
MIRT650645	hsa-miR-4448	HITS-CLIP	23824327
MIRT650644	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT650643	hsa-miR-218-5p	HITS-CLIP	23824327
MIRT650650	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT650648	hsa-miR-4287	HITS-CLIP	23824327
MIRT650649	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT650647	hsa-miR-581	HITS-CLIP	23824327
MIRT650646	hsa-miR-4268	HITS-CLIP	23824327
MIRT650645	hsa-miR-4448	HITS-CLIP	23824327
MIRT650644	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT650643	hsa-miR-218-5p	HITS-CLIP	23824327
MIRT755328	hsa-miR-146b-5p	Luciferase reporter assayWestern blottingqRT-PCR	36882799
MIRT1335002	hsa-miR-101	CLIP-seq
MIRT1335003	hsa-miR-1207-3p	CLIP-seq
MIRT1335004	hsa-miR-1207-5p	CLIP-seq
MIRT1335005	hsa-miR-1273g	CLIP-seq
MIRT1335006	hsa-miR-144	CLIP-seq
MIRT1335007	hsa-miR-149	CLIP-seq
MIRT1335008	hsa-miR-193a-5p	CLIP-seq
MIRT1335009	hsa-miR-3132	CLIP-seq
MIRT1335010	hsa-miR-3137	CLIP-seq
MIRT1335011	hsa-miR-3153	CLIP-seq
MIRT1335012	hsa-miR-3154	CLIP-seq
MIRT1335013	hsa-miR-3187-3p	CLIP-seq
MIRT1335014	hsa-miR-3686	CLIP-seq
MIRT1335015	hsa-miR-3919	CLIP-seq
MIRT1335016	hsa-miR-3929	CLIP-seq
MIRT1335017	hsa-miR-4267	CLIP-seq
MIRT1335018	hsa-miR-4273	CLIP-seq
MIRT1335019	hsa-miR-4419b	CLIP-seq
MIRT1335020	hsa-miR-4436b-3p	CLIP-seq
MIRT1335021	hsa-miR-4438	CLIP-seq
MIRT1335022	hsa-miR-4455	CLIP-seq
MIRT1335023	hsa-miR-4475	CLIP-seq
MIRT1335024	hsa-miR-4478	CLIP-seq
MIRT1335025	hsa-miR-4529-5p	CLIP-seq
MIRT1335026	hsa-miR-4677-5p	CLIP-seq
MIRT1335027	hsa-miR-4755-3p	CLIP-seq
MIRT1335028	hsa-miR-4763-3p	CLIP-seq
MIRT1335029	hsa-miR-4777-5p	CLIP-seq
MIRT1335030	hsa-miR-518d-5p	CLIP-seq
MIRT1335031	hsa-miR-519b-5p	CLIP-seq
MIRT1335032	hsa-miR-519c-5p	CLIP-seq
MIRT1335033	hsa-miR-520c-5p	CLIP-seq
MIRT1335034	hsa-miR-526a	CLIP-seq
MIRT1335035	hsa-miR-555	CLIP-seq
MIRT1335036	hsa-miR-577	CLIP-seq
MIRT1335037	hsa-miR-766	CLIP-seq
MIRT2099055	hsa-miR-1251	CLIP-seq
MIRT2099056	hsa-miR-147	CLIP-seq
MIRT2099057	hsa-miR-2113	CLIP-seq
MIRT1335017	hsa-miR-4267	CLIP-seq
MIRT2099058	hsa-miR-4328	CLIP-seq
MIRT2099059	hsa-miR-4676-5p	CLIP-seq
MIRT2099060	hsa-miR-554	CLIP-seq
MIRT2099061	hsa-miR-575	CLIP-seq
MIRT2099062	hsa-miR-592	CLIP-seq
MIRT2099063	hsa-miR-597	CLIP-seq
MIRT2099064	hsa-miR-599	CLIP-seq
MIRT2323833	hsa-miR-1205	CLIP-seq
MIRT2323834	hsa-miR-1266	CLIP-seq
MIRT2323835	hsa-miR-1324	CLIP-seq
MIRT2323836	hsa-miR-3166	CLIP-seq
MIRT2323837	hsa-miR-4518	CLIP-seq
MIRT2323838	hsa-miR-4530	CLIP-seq
MIRT2323839	hsa-miR-4688	CLIP-seq
MIRT2323840	hsa-miR-486-3p	CLIP-seq
MIRT2323841	hsa-miR-922	CLIP-seq
MIRT2394201	hsa-miR-218	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001755	Process	Neural crest cell migration	IBA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005102	Function	Signaling receptor binding	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0007411	Process	Axon guidance	IBA
GO:0030215	Function	Semaphorin receptor binding	IBA
GO:0030215	Function	Semaphorin receptor binding	IEA
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0030517	Process	Negative regulation of axon extension	IEA
GO:0030517	Process	Negative regulation of axon extension	ISS
GO:0030900	Process	Forebrain development	IEA
GO:0038191	Function	Neuropilin binding	IBA
GO:0045499	Function	Chemorepellent activity	IBA
GO:0050919	Process	Negative chemotaxis	IBA
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA

MIM	HGNC	e!Ensembl
620997	30400	ENSG00000010319

Q9NS98

Protein name

Semaphorin-3G (Semaphorin sem2)

Protein function

Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01403	Sema	60 → 501	Sema domain	Family
PF00047	ig	586 → 668	Immunoglobulin domain	Domain

Sequence

MAPSAWAICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQA
MYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFV
RVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFAS
TFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAARIPENSDQDN
DKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPG
GAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHR
DGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRP
RHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEV
VLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYC
AWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTF
LECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEH
GFSQTVVRLALVVIVASQLDNLFPPEPKPEEPPARGGLASTPPKAWYKDILQLIGFANLP
RVDEYCERVWCRGTTECSGCFRSRSRGKQARGKSWAGLELGKKMKSRVHAEHNRTPREVE
AT

Sequence length

782

Interactions

View interactions

	KEGG
	Axon guidance

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Lung cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEMA3G-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	23317273	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	31821170, 36059531, 37919459, 38070142	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	LHGDN	18781179		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	BEFREE	27180624		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22562223		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	26449484	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	31648186		★★★★★ ★☆☆☆☆ Found in Text Mining only

SEMA3G (semaphorin 3G)