Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	56897
Gene name	WRN helicase interacting protein 1
Gene symbol	WRNIP1
Synonyms (NCBI Gene)	CFAP93FAP93WHIPbA420G6.2
Chromosome	6
Chromosome location	6p25.2
Summary	Werner`s syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-te

133

Show/Hide all (133)

miRTarBase ID	miRNA	Experiments	Reference
MIRT168334	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT168347	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT168333	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT1494110	hsa-miR-22	CLIP-seq
MIRT1494111	hsa-miR-25	CLIP-seq
MIRT1494112	hsa-miR-3128	CLIP-seq
MIRT1494113	hsa-miR-32	CLIP-seq
MIRT1494114	hsa-miR-320a	CLIP-seq
MIRT1494115	hsa-miR-320b	CLIP-seq
MIRT1494116	hsa-miR-320c	CLIP-seq
MIRT1494117	hsa-miR-320d	CLIP-seq
MIRT1494118	hsa-miR-363	CLIP-seq
MIRT1494119	hsa-miR-367	CLIP-seq
MIRT1494120	hsa-miR-409-3p	CLIP-seq
MIRT1494121	hsa-miR-4317	CLIP-seq
MIRT1494122	hsa-miR-4429	CLIP-seq
MIRT1494123	hsa-miR-4527	CLIP-seq
MIRT1494124	hsa-miR-4698	CLIP-seq
MIRT1494125	hsa-miR-4720-5p	CLIP-seq
MIRT1494126	hsa-miR-4755-3p	CLIP-seq
MIRT1494127	hsa-miR-4760-3p	CLIP-seq
MIRT1494128	hsa-miR-4781-3p	CLIP-seq
MIRT1494129	hsa-miR-4799-3p	CLIP-seq
MIRT1494130	hsa-miR-513a-3p	CLIP-seq
MIRT1494131	hsa-miR-664	CLIP-seq
MIRT1494132	hsa-miR-92a	CLIP-seq
MIRT1494133	hsa-miR-92b	CLIP-seq
MIRT1494134	hsa-miR-130a	CLIP-seq
MIRT1494135	hsa-miR-130b	CLIP-seq
MIRT1494136	hsa-miR-19a	CLIP-seq
MIRT1494137	hsa-miR-19b	CLIP-seq
MIRT1494110	hsa-miR-22	CLIP-seq
MIRT1494111	hsa-miR-25	CLIP-seq
MIRT1494138	hsa-miR-301a	CLIP-seq
MIRT1494139	hsa-miR-301b	CLIP-seq
MIRT1494140	hsa-miR-3121-3p	CLIP-seq
MIRT1494112	hsa-miR-3128	CLIP-seq
MIRT1494141	hsa-miR-3130-3p	CLIP-seq
MIRT1494142	hsa-miR-3143	CLIP-seq
MIRT1494113	hsa-miR-32	CLIP-seq
MIRT1494114	hsa-miR-320a	CLIP-seq
MIRT1494115	hsa-miR-320b	CLIP-seq
MIRT1494116	hsa-miR-320c	CLIP-seq
MIRT1494117	hsa-miR-320d	CLIP-seq
MIRT1494118	hsa-miR-363	CLIP-seq
MIRT1494143	hsa-miR-3646	CLIP-seq
MIRT1494144	hsa-miR-3666	CLIP-seq
MIRT1494119	hsa-miR-367	CLIP-seq
MIRT1494145	hsa-miR-3941	CLIP-seq
MIRT1494146	hsa-miR-3973	CLIP-seq
MIRT1494120	hsa-miR-409-3p	CLIP-seq
MIRT1494147	hsa-miR-425	CLIP-seq
MIRT1494148	hsa-miR-4275	CLIP-seq
MIRT1494149	hsa-miR-4295	CLIP-seq
MIRT1494121	hsa-miR-4317	CLIP-seq
MIRT1494122	hsa-miR-4429	CLIP-seq
MIRT1494123	hsa-miR-4527	CLIP-seq
MIRT1494150	hsa-miR-454	CLIP-seq
MIRT1494151	hsa-miR-4643	CLIP-seq
MIRT1494152	hsa-miR-466	CLIP-seq
MIRT1494153	hsa-miR-4672	CLIP-seq
MIRT1494154	hsa-miR-4678	CLIP-seq
MIRT1494124	hsa-miR-4698	CLIP-seq
MIRT1494125	hsa-miR-4720-5p	CLIP-seq
MIRT1494126	hsa-miR-4755-3p	CLIP-seq
MIRT1494127	hsa-miR-4760-3p	CLIP-seq
MIRT1494128	hsa-miR-4781-3p	CLIP-seq
MIRT1494155	hsa-miR-4789-3p	CLIP-seq
MIRT1494129	hsa-miR-4799-3p	CLIP-seq
MIRT1494156	hsa-miR-520g	CLIP-seq
MIRT1494157	hsa-miR-520h	CLIP-seq
MIRT1494158	hsa-miR-543	CLIP-seq
MIRT1494159	hsa-miR-577	CLIP-seq
MIRT1494160	hsa-miR-607	CLIP-seq
MIRT1494131	hsa-miR-664	CLIP-seq
MIRT1494132	hsa-miR-92a	CLIP-seq
MIRT1494133	hsa-miR-92b	CLIP-seq
MIRT2369237	hsa-miR-1912	CLIP-seq
MIRT1494110	hsa-miR-22	CLIP-seq
MIRT1494111	hsa-miR-25	CLIP-seq
MIRT2369238	hsa-miR-3130-5p	CLIP-seq
MIRT1494113	hsa-miR-32	CLIP-seq
MIRT1494114	hsa-miR-320a	CLIP-seq
MIRT1494115	hsa-miR-320b	CLIP-seq
MIRT1494116	hsa-miR-320c	CLIP-seq
MIRT1494117	hsa-miR-320d	CLIP-seq
MIRT1494118	hsa-miR-363	CLIP-seq
MIRT1494119	hsa-miR-367	CLIP-seq
MIRT1494147	hsa-miR-425	CLIP-seq
MIRT1494121	hsa-miR-4317	CLIP-seq
MIRT1494122	hsa-miR-4429	CLIP-seq
MIRT2369239	hsa-miR-4482	CLIP-seq
MIRT1494127	hsa-miR-4760-3p	CLIP-seq
MIRT2369240	hsa-miR-548a-3p	CLIP-seq
MIRT2369241	hsa-miR-548e	CLIP-seq
MIRT2369242	hsa-miR-548f	CLIP-seq
MIRT1494131	hsa-miR-664	CLIP-seq
MIRT1494132	hsa-miR-92a	CLIP-seq
MIRT1494133	hsa-miR-92b	CLIP-seq
MIRT2662968	hsa-miR-1291	CLIP-seq
MIRT2662969	hsa-miR-3176	CLIP-seq
MIRT2662970	hsa-miR-328	CLIP-seq
MIRT2662971	hsa-miR-3922-3p	CLIP-seq
MIRT1494120	hsa-miR-409-3p	CLIP-seq
MIRT2662972	hsa-miR-4287	CLIP-seq
MIRT2662973	hsa-miR-4290	CLIP-seq
MIRT2662974	hsa-miR-450b-5p	CLIP-seq
MIRT1494123	hsa-miR-4527	CLIP-seq
MIRT2662975	hsa-miR-4637	CLIP-seq
MIRT2662976	hsa-miR-4645-5p	CLIP-seq
MIRT2662977	hsa-miR-4673	CLIP-seq
MIRT2662978	hsa-miR-4685-3p	CLIP-seq
MIRT1494124	hsa-miR-4698	CLIP-seq
MIRT2662979	hsa-miR-4733-3p	CLIP-seq
MIRT2662980	hsa-miR-4742-5p	CLIP-seq
MIRT1494128	hsa-miR-4781-3p	CLIP-seq
MIRT2662968	hsa-miR-1291	CLIP-seq
MIRT2662969	hsa-miR-3176	CLIP-seq
MIRT2662970	hsa-miR-328	CLIP-seq
MIRT2662971	hsa-miR-3922-3p	CLIP-seq
MIRT1494120	hsa-miR-409-3p	CLIP-seq
MIRT2662972	hsa-miR-4287	CLIP-seq
MIRT2662973	hsa-miR-4290	CLIP-seq
MIRT2662974	hsa-miR-450b-5p	CLIP-seq
MIRT1494123	hsa-miR-4527	CLIP-seq
MIRT2662975	hsa-miR-4637	CLIP-seq
MIRT2662976	hsa-miR-4645-5p	CLIP-seq
MIRT2662977	hsa-miR-4673	CLIP-seq
MIRT2662978	hsa-miR-4685-3p	CLIP-seq
MIRT1494124	hsa-miR-4698	CLIP-seq
MIRT2662979	hsa-miR-4733-3p	CLIP-seq
MIRT2662980	hsa-miR-4742-5p	CLIP-seq
MIRT1494128	hsa-miR-4781-3p	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000731	Process	DNA synthesis involved in DNA repair	IBA
GO:0000731	Process	DNA synthesis involved in DNA repair	IDA	15670210
GO:0000781	Component	Chromosome, telomeric region	IDA	24270157
GO:0002376	Process	Immune system process	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	15670210, 17888034, 21903422, 36179048
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	17888034
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0006260	Process	DNA replication	IEA
GO:0006261	Process	DNA-templated DNA replication	IBA
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0008047	Function	Enzyme activator activity	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IMP	15670210
GO:0017116	Function	Single-stranded DNA helicase activity	IBA
GO:0030174	Process	Regulation of DNA-templated DNA replication initiation	IDA	15670210
GO:0042802	Function	Identical protein binding	IPI	15670210
GO:0045087	Process	Innate immune response	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	17888034

MIM	HGNC	e!Ensembl
608196	20876	ENSG00000124535

Q96S55

Protein name

ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1)

Protein function

Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate im

PDB

3VHS , 3VHT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18279	zf-WRNIP1_ubi	16 → 36	Werner helicase-interacting protein 1 ubiquitin-binding domain	Domain
PF00004	AAA	264 → 379	ATPase family associated with various cellular activities (AAA)	Domain
PF16193	AAA_assoc_2	418 → 511	AAA C-terminal domain	Family
PF12002	MgsA_C	512 → 664	MgsA AAA+ ATPase C terminal	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:11301316}.

Sequence

MEVSGPEDDPFLSQLHQVQCPVCQQMMPAAHINSHLDRCLLLHPAGHAEPAAGSHRAGER
AKGPSPPGAKRRRLSESSALKQPATPTAAESSEGEGEEGDDGGETESRESYDAPPTPSGA
RLIPDFPVARSSSPGRKGSGKRPAAAAAAGSASPRSWDEAEAQEEEEAVGDGDGDGDADA
DGEDDPGHWDADAAEAATAFGASGGGRPHPRALAAEEIRQMLQGKPLADTMRPDTLQDYF
GQSKAVGQDTLLRSLLETNEIPSLILWGPPGCGKTTLAHIIASNSKKHSIRFVTLSATNA
KTNDVRDVIKQAQNEKSFFKRKTILFIDEIHRFNKSQQDTFLPHVECGTITLIGATTENP
SFQVNAALLSRCRVIVLEKLPVEAMVTILMRAINSLGIHVLDSSRPTDPLSHSSNSSSEP
AMFIEDKAVDTLAYLSDGDARAGLNGLQLAVLARLSSRKMFCKKSGQSYSPSRVLITEND
VKEGLQRSHILYDRAGEEHYNCISALHKSMRGSDQNASLYWLARMLEGGEDPLYVARRLV
RFASEDIGLADPSALTQAVAAYQGCHFIGMPECEVLLAQCVVYFARAPKSIEVYSAYNNV
KACLRNHQGPLPPVPLHLRNAPTRLMKDLGYGKGYKYNPMYSEPVDQEYLPEELRGVDFF
KQRRC

Sequence length

665

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTROCYTOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WRNIP1-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Leukemia Promyelocytic Acute	Promyelocytic leukemia	Pubtator	18842586	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	17888034	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Premature aging syndrome	Premature aging	BEFREE	28118071		★★★★★ ★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	31190355	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Werner Syndrome	Werner syndrome	Pubtator	11301316, 21804224, 31061318	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Werner Syndrome	Werner Syndrome	BEFREE	28118071, 31061318		★★★★★ ★☆☆☆☆ Found in Text Mining only

WRNIP1 (WRN helicase interacting protein 1)