LGALS14 (galectin 14)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 56891
Gene name Galectin 14
Gene symbol LGALS14
Synonyms (NCBI Gene)
CLC2PPL13
Chromosome 19
Chromosome location 19q13.2
Summary This gene is predominantly expressed in placenta. The encoded protein belongs to the galectin (galaptin/S-lectin) family. The members of galectin family contain one or two carbohydrate recognition domains, which can bind beta-galactoside. Two alternativel
miRNA miRNA information provided by mirtarbase database.
4
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (4)
miRTarBase ID miRNA Experiments Reference
MIRT2029915 hsa-miR-3150b-3p CLIP-seq
MIRT2029916 hsa-miR-4294 CLIP-seq
MIRT2029917 hsa-miR-4689 CLIP-seq
MIRT2029918 hsa-miR-4784 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
6
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (6)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 31515488, 32296183, 32814053
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IDA
GO:0006915 Process Apoptotic process IEA
GO:0030246 Function Carbohydrate binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
607260 30054 ENSG00000006659
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TCE9
Protein name Placental protein 13-like (Charcot-Leyden crystal protein 2) (CLC2) (Galectin-14) (Gal-14)
Protein function Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis.
PDB 6K2Y , 6K2Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00337 Gal-bind_lectin 5 → 137 Galactoside-binding lectin Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in placenta. {ECO:0000269|PubMed:11997112, ECO:0000269|PubMed:19497882}.
Sequence
Sequence length 139
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (1)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AUTISM SPECTRUM DISORDER — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (23)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Arteriosclerosis Arteriosclerosis BEFREE 31206525
★★★★★
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 31206525
★★★★★
★☆☆☆☆
Found in Text Mining only
Choroideremia Choroideremia Pubtator 31658584 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Colitis Colitis BEFREE 24030525
★★★★★
★☆☆☆☆
Found in Text Mining only
Complete hydatidiform mole Complete Hydatidiform Mole BEFREE 31658584
★★★★★
★☆☆☆☆
Found in Text Mining only
Conn Syndrome Conn Syndrome BEFREE 31615979
★★★★★
★☆☆☆☆
Found in Text Mining only
Cystic Fibrosis Cystic Fibrosis BEFREE 11401826, 15507145
★★★★★
★☆☆☆☆
Found in Text Mining only
Epilepsy, Generalized Epilepsy BEFREE 15252188
★★★★★
★☆☆☆☆
Found in Text Mining only
Glaucoma, Primary Open Angle Glaucoma BEFREE 23934342
★★★★★
★☆☆☆☆
Found in Text Mining only
Glioma Glioma BEFREE 12843258
★★★★★
★☆☆☆☆
Found in Text Mining only