Gene Gene information from NCBI Gene database.
Entrez ID 56829
Gene name Zinc finger CCCH-type containing, antiviral 1
Gene symbol ZC3HAV1
Synonyms (NCBI Gene)
ARTD13FLB6421PARP13ZAPZC3H2ZC3HDC2
Chromosome 7
Chromosome location 7q34
Summary This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral inf
miRNA miRNA information provided by mirtarbase database.
710
miRTarBase ID miRNA Experiments Reference
MIRT019853 hsa-miR-375 Microarray 20215506
MIRT052130 hsa-let-7b-5p CLASH 23622248
MIRT049602 hsa-miR-92a-3p CLASH 23622248
MIRT039904 hsa-miR-615-3p CLASH 23622248
MIRT541748 hsa-miR-3609 PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IEA
GO:0003950 Function NAD+ poly-ADP-ribosyltransferase activity IMP 25635049
GO:0005515 Function Protein binding IPI 21102435, 21204022, 21876179, 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607312 23721 ENSG00000105939
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q7Z2W4
Protein name Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP)
Protein function Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-sp
PDB 2X5Y , 4X52 , 6UEI , 6UEJ , 7KZH , 7TGQ , 9BGL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18606 HTH_53 5 66 Zap helix turn helix N-terminal domain Domain
PF18633 zf-CCCH_8 143 170 Zinc-finger antiviral protein (ZAP) zinc finger domain 3 Domain
PF02825 WWE 607 682 WWE domain Family
PF00644 PARP 737 895 Poly(ADP-ribose) polymerase catalytic domain Family
Sequence
MADPEVCCFITKILCAHGGRMALDALLQEIALSEPQLCEVLQVAGPDRFVVLETGGEAGI
TRSVVA
TTRARVCRRKYCQRPCDNLHLCKLNLLGRCNYSQSERNLCKYSHEVLSEENFKV
LKNHELSGLNKEELAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRG
NCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRRN
MAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRKFTYL
GSQDRARPPSGSSKATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWK
SLTSWTNDQGARRKTVFSPTLPAARSSLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGTQ
DIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATGRIAD
DADPRVALVNDSLSDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHLPYRWQM
LIGKTWTDFEHMETIEKGYCNPGIHLCSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPAN
SVFTTKWIWYWKNESGTWIQYGEEKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYE
LSFQGMIQTNIASKTQKDVIRR
PTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDF
CFLSSKKYKLSEIHHLHPEYVRVSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKE
EGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCPYDAKNVVM
FVAQVLVGKFTEGNITYTSPPPQFDSCVDTRSNPSVFVIFQKDQVYPQYVIEYTE
DKACV
IS
Sequence length 902
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Herpes simplex virus 1 infection   Signaling by BRAF and RAF fusions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BILIARY LIVER CIRRHOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PRIMARY BILIARY CIRRHOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Carcinoma Breast Carcinoma BEFREE 24278212
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 30196292 Associate
★☆☆☆☆
Found in Text Mining only
Choroideremia Choroideremia BEFREE 1969148
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 36164444 Associate
★☆☆☆☆
Found in Text Mining only
Encephalitis Encephalitis Pubtator 21061152 Associate
★☆☆☆☆
Found in Text Mining only
Gastroesophageal reflux disease Gastroesophageal Reflux Disease BEFREE 31453726
★☆☆☆☆
Found in Text Mining only
Hepatitis B Hepatitis b Pubtator 30196292 Associate
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 28445966, 30196292
★☆☆☆☆
Found in Text Mining only
Liver Cirrhosis Biliary Liver cirrhosis Pubtator 33371893 Associate
★☆☆☆☆
Found in Text Mining only
Multiple Sclerosis Multiple Sclerosis BEFREE 22319148
★★☆☆☆
Found in Text Mining + Unknown/Other Associations