Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	56660
Gene name	Potassium two pore domain channel subfamily K member 12
Gene symbol	KCNK12
Synonyms (NCBI Gene)	K2p12.1THIK-2THIK2
Chromosome	2
Chromosome location	2p16.3
Summary	This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins fo

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miRTarBase ID	miRNA	Experiments	Reference
MIRT517515	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT517514	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT517513	hsa-miR-1322	HITS-CLIP	21572407
MIRT517512	hsa-miR-586	HITS-CLIP	21572407
MIRT517511	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT707404	hsa-miR-7978	HITS-CLIP	21572407
MIRT517510	hsa-miR-6076	HITS-CLIP	21572407
MIRT517509	hsa-miR-6797-3p	HITS-CLIP	21572407
MIRT707403	hsa-miR-138-5p	HITS-CLIP	21572407
MIRT707402	hsa-miR-3650	HITS-CLIP	21572407
MIRT517508	hsa-miR-567	HITS-CLIP	21572407
MIRT517507	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT517505	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT517506	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT517504	hsa-miR-297	HITS-CLIP	21572407
MIRT517503	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT517502	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT626301	hsa-miR-1470	HITS-CLIP	23824327
MIRT626300	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT626299	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT626298	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT626297	hsa-miR-4469	HITS-CLIP	23824327
MIRT626296	hsa-miR-4290	HITS-CLIP	23824327
MIRT626295	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT517515	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT517514	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT517513	hsa-miR-1322	PAR-CLIP	23446348
MIRT517512	hsa-miR-586	PAR-CLIP	23446348
MIRT517511	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT517510	hsa-miR-6076	PAR-CLIP	23446348
MIRT517509	hsa-miR-6797-3p	PAR-CLIP	23446348
MIRT517508	hsa-miR-567	PAR-CLIP	23446348
MIRT517507	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT517505	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT517506	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT517504	hsa-miR-297	PAR-CLIP	23446348
MIRT517503	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT517502	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT517515	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT517514	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT517513	hsa-miR-1322	HITS-CLIP	21572407
MIRT517512	hsa-miR-586	HITS-CLIP	21572407
MIRT517511	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT707404	hsa-miR-7978	HITS-CLIP	21572407
MIRT517510	hsa-miR-6076	HITS-CLIP	21572407
MIRT517509	hsa-miR-6797-3p	HITS-CLIP	21572407
MIRT707403	hsa-miR-138-5p	HITS-CLIP	21572407
MIRT707402	hsa-miR-3650	HITS-CLIP	21572407
MIRT517508	hsa-miR-567	HITS-CLIP	21572407
MIRT517507	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT517505	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT517506	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT517504	hsa-miR-297	HITS-CLIP	21572407
MIRT517503	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT517502	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT626301	hsa-miR-1470	HITS-CLIP	23824327
MIRT626300	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT626299	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT626298	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT626297	hsa-miR-4469	HITS-CLIP	23824327
MIRT626296	hsa-miR-4290	HITS-CLIP	23824327
MIRT626295	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT517515	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT517514	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT517513	hsa-miR-1322	PAR-CLIP	23446348
MIRT517512	hsa-miR-586	PAR-CLIP	23446348
MIRT517511	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT517510	hsa-miR-6076	PAR-CLIP	23446348
MIRT517509	hsa-miR-6797-3p	PAR-CLIP	23446348
MIRT517508	hsa-miR-567	PAR-CLIP	23446348
MIRT517507	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT517505	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT517506	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT517504	hsa-miR-297	PAR-CLIP	23446348
MIRT517503	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT517502	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT1081719	hsa-miR-134	CLIP-seq
MIRT1081720	hsa-miR-3118	CLIP-seq
MIRT1081721	hsa-miR-3136-5p	CLIP-seq
MIRT1081722	hsa-miR-3653	CLIP-seq
MIRT1081723	hsa-miR-3658	CLIP-seq
MIRT1081724	hsa-miR-4439	CLIP-seq
MIRT1081725	hsa-miR-4513	CLIP-seq
MIRT1081726	hsa-miR-4519	CLIP-seq
MIRT1081727	hsa-miR-4530	CLIP-seq
MIRT1081728	hsa-miR-518a-3p	CLIP-seq
MIRT1081729	hsa-miR-518b	CLIP-seq
MIRT1081730	hsa-miR-518c	CLIP-seq
MIRT1081731	hsa-miR-518d-3p	CLIP-seq
MIRT1081732	hsa-miR-518f	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005267	Function	Potassium channel activity	IDA	25148687
GO:0005267	Function	Potassium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	25148687
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	24163367
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	25148687
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	IEA
GO:0015271	Function	Outward rectifier potassium channel activity	IBA
GO:0016020	Component	Membrane	IEA
GO:0022841	Function	Potassium ion leak channel activity	IBA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0042802	Function	Identical protein binding	IDA	25148687
GO:0046872	Function	Metal ion binding	IEA
GO:0046982	Function	Protein heterodimerization activity	IDA	25148687
GO:0071805	Process	Potassium ion transmembrane transport	IBA
GO:0071805	Process	Potassium ion transmembrane transport	IEA

MIM	HGNC	e!Ensembl
607366	6274	ENSG00000184261

Q9HB15

Protein name

Potassium channel subfamily K member 12 (Tandem pore domain halothane-inhibited potassium channel 2) (THIK-2)

Protein function

K(+) channel subunit that may homo- and heterodimerize to form functional channels with distinct regulatory and gating properties. Can heterodimerize with KCNK13 subunit to conduct K(+) outward rectifying currents at the plasma membrane. The hom

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07885	Ion_trans_2	94 → 170	Ion channel	Family
PF07885	Ion_trans_2	217 → 304	Ion channel	Family

Sequence

MSSRSPRPPPRRSRRRLPRPSCCCCCCRRSHLNEDTGRFVLLAALIGLYLVAGATVFSAL
ESPGEAEARARWGATLRNFSAAHGVAEPELRAFLRHYEAALAAGVRADALRPRWDFPGAF
YFVGTVVSTIGFGMTTPATVGGKAFLIAYGLFGCAGTILFFNLFLERIISLLAFIMRACR
ERQLRRSGLLPATFRRGSALSEADSLAGWKPSVYHVLLILGLFAVLLSCCASAMYTSVEG
WDYVDSLYFCFVTFSTIGFGDLVSSQHAAYRNQGLYRLGNFLFILLGVCCIYSLFNVISI
LIKQVLNWMLRKLSCRCCARCCPAPGAPLARRNAITPGSRLRRRLAALGADPAARDSDAE
GRRLSGELISMRDLTASNKVSLALLQKQLSETANGYPRSVCVNTRQNGFSGGVGALGIMN
NRLAETSASR

Sequence length

430

Interactions

View interactions

	Reactome
			Phase 4 - resting membrane potential

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 1	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Carcinoma	Colorectal Cancer	BEFREE	21438024		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma Follicular	Lymphoma	Pubtator	20220060	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	26023084, 34530906	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

KCNK12 (potassium two pore domain channel subfamily K member 12)