Gene Gene information from NCBI Gene database.
Entrez ID 5655
Gene name Kallikrein related peptidase 10
Gene symbol KLK10
Synonyms (NCBI Gene)
NES1PRSSL1
Chromosome 19
Chromosome location 19q13.41
Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one
miRNA miRNA information provided by mirtarbase database.
188
miRTarBase ID miRNA Experiments Reference
MIRT000455 hsa-let-7f-5p qRT-PCRLuciferase reporter assay 20354523
MIRT000454 hsa-miR-224-5p qRT-PCRLuciferase reporter assay 20354523
MIRT000455 hsa-let-7f-5p ELISALuciferase reporter assayqRT-PCR 18627289
MIRT019672 hsa-miR-375 Microarray 20215506
MIRT569877 hsa-miR-2392 PAR-CLIP 20371350
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
MBD2 Unknown 21693597
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
GO ID Ontology Definition Evidence Reference
GO:0004252 Function Serine-type endopeptidase activity IBA
GO:0004252 Function Serine-type endopeptidase activity IEA
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS 8764136
GO:0005615 Component Extracellular space IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602673 6358 ENSG00000129451
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O43240
Protein name Kallikrein-10 (EC 3.4.21.-) (Normal epithelial cell-specific 1) (Protease serine-like 1)
Protein function Has a tumor-suppressor role for NES1 in breast and prostate cancer.
PDB 5LPE , 5LPF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00089 Trypsin 47 269 Trypsin Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in breast, ovary and prostate.
Sequence
Sequence length 276
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OVARIAN NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
STOMACH NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
ACTH-Secreting Pituitary Adenoma Pituitary adenoma BEFREE 25517869
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 18854834
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 18854834, 29621546
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 10675891, 10810385, 11461080, 11691827, 11705853, 12087468, 12633763, 16254462, 16800732, 17937626, 19150938, 25503118, 26616394, 27825132
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma CTD_human_DG 16800735
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 11461080, 12087468, 14710225, 16103744, 16254462 Inhibit
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Neoplasms Breast neoplasm Pubtator 17656355, 18485221, 18515984, 19150938, 20086175, 27825132 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Carcinoma in Situ Carcinoma in situ Pubtator 11461080 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Pancreatic ductal carcinoma Pubtator 18854834, 34957503 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Pancreatic ductal carcinoma Pubtator 36610378 Stimulate
★☆☆☆☆
Found in Text Mining only