LGMN (legumain)

Gene

• Entrez ID: 5641
• Gene name: Legumain
• Gene symbol: LGMN
• Synonyms (NCBI Gene): AEP, LGMN1, PRSC1
• Chromosome: 14
• Chromosome location: 14q32.12
• Summary: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal s

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024860	hsa-miR-215-5p	Microarray	19074876
MIRT026385	hsa-miR-192-5p	Microarray	19074876
MIRT029310	hsa-miR-26b-5p	Microarray	19088304
MIRT039572	hsa-miR-642a-5p	CLASH	23622248
MIRT1108479	hsa-miR-1276	CLIP-seq
MIRT1108480	hsa-miR-3671	CLIP-seq
MIRT1108481	hsa-miR-4311	CLIP-seq
MIRT1108482	hsa-miR-583	CLIP-seq
MIRT1108483	hsa-miR-607	CLIP-seq
MIRT1108484	hsa-miR-3074-5p	CLIP-seq
MIRT1108485	hsa-miR-370	CLIP-seq
MIRT1108486	hsa-miR-3943	CLIP-seq
MIRT1108487	hsa-miR-4268	CLIP-seq
MIRT1108488	hsa-miR-4448	CLIP-seq
MIRT1108489	hsa-miR-516a-3p	CLIP-seq
MIRT1108490	hsa-miR-556-5p	CLIP-seq
MIRT2029965	hsa-miR-3065-3p	CLIP-seq
MIRT2029966	hsa-miR-383	CLIP-seq
MIRT2029967	hsa-miR-3921	CLIP-seq
MIRT2029968	hsa-miR-3925-3p	CLIP-seq
MIRT2029969	hsa-miR-4653-5p	CLIP-seq
MIRT2029970	hsa-miR-4772-5p	CLIP-seq
MIRT2029971	hsa-miR-548u	CLIP-seq
MIRT1108490	hsa-miR-556-5p	CLIP-seq
MIRT2029972	hsa-miR-593	CLIP-seq
MIRT2029965	hsa-miR-3065-3p	CLIP-seq
MIRT2029966	hsa-miR-383	CLIP-seq
MIRT2029967	hsa-miR-3921	CLIP-seq
MIRT2029968	hsa-miR-3925-3p	CLIP-seq
MIRT2029969	hsa-miR-4653-5p	CLIP-seq
MIRT2029970	hsa-miR-4772-5p	CLIP-seq
MIRT2029972	hsa-miR-593	CLIP-seq
MIRT2260872	hsa-miR-766	CLIP-seq
MIRT2560890	hsa-miR-1224-3p	CLIP-seq
MIRT2560891	hsa-miR-1233	CLIP-seq
MIRT2560892	hsa-miR-1260	CLIP-seq
MIRT2560893	hsa-miR-1260b	CLIP-seq
MIRT2560894	hsa-miR-1280	CLIP-seq
MIRT2560895	hsa-miR-1827	CLIP-seq
MIRT2560896	hsa-miR-188-3p	CLIP-seq
MIRT2560897	hsa-miR-194	CLIP-seq
MIRT2560898	hsa-miR-2110	CLIP-seq
MIRT2560899	hsa-miR-2115	CLIP-seq
MIRT2560900	hsa-miR-2355-5p	CLIP-seq
MIRT2560901	hsa-miR-3148	CLIP-seq
MIRT2560902	hsa-miR-3156-3p	CLIP-seq
MIRT2560903	hsa-miR-3185	CLIP-seq
MIRT2560904	hsa-miR-3611	CLIP-seq
MIRT2560905	hsa-miR-3612	CLIP-seq
MIRT2560906	hsa-miR-3614-5p	CLIP-seq
MIRT2560907	hsa-miR-3674	CLIP-seq
MIRT2560908	hsa-miR-3690	CLIP-seq
MIRT2560909	hsa-miR-3942-3p	CLIP-seq
MIRT2560910	hsa-miR-4254	CLIP-seq
MIRT2560911	hsa-miR-4271	CLIP-seq
MIRT2560912	hsa-miR-4283	CLIP-seq
MIRT2560913	hsa-miR-4308	CLIP-seq
MIRT2560914	hsa-miR-4446-5p	CLIP-seq
MIRT2560915	hsa-miR-4459	CLIP-seq
MIRT2560916	hsa-miR-4463	CLIP-seq
MIRT2560917	hsa-miR-4660	CLIP-seq
MIRT2560918	hsa-miR-4667-5p	CLIP-seq
MIRT2560919	hsa-miR-4695-5p	CLIP-seq
MIRT2560920	hsa-miR-4700-5p	CLIP-seq
MIRT2560921	hsa-miR-4703-3p	CLIP-seq
MIRT2560922	hsa-miR-4725-3p	CLIP-seq
MIRT2560923	hsa-miR-4725-5p	CLIP-seq
MIRT2560924	hsa-miR-4735-5p	CLIP-seq
MIRT2560925	hsa-miR-4779	CLIP-seq
MIRT2560926	hsa-miR-4781-5p	CLIP-seq
MIRT2560927	hsa-miR-4797-5p	CLIP-seq
MIRT2560928	hsa-miR-493	CLIP-seq
MIRT2560929	hsa-miR-504	CLIP-seq
MIRT2560930	hsa-miR-513c	CLIP-seq
MIRT2560931	hsa-miR-514b-5p	CLIP-seq
MIRT2029971	hsa-miR-548u	CLIP-seq
MIRT2560932	hsa-miR-581	CLIP-seq
MIRT2560933	hsa-miR-650	CLIP-seq
MIRT2560934	hsa-miR-665	CLIP-seq
MIRT2560935	hsa-miR-890	CLIP-seq
MIRT2560890	hsa-miR-1224-3p	CLIP-seq
MIRT2560891	hsa-miR-1233	CLIP-seq
MIRT2560892	hsa-miR-1260	CLIP-seq
MIRT2560893	hsa-miR-1260b	CLIP-seq
MIRT2560894	hsa-miR-1280	CLIP-seq
MIRT2560895	hsa-miR-1827	CLIP-seq
MIRT2560896	hsa-miR-188-3p	CLIP-seq
MIRT2560897	hsa-miR-194	CLIP-seq
MIRT2560898	hsa-miR-2110	CLIP-seq
MIRT2560899	hsa-miR-2115	CLIP-seq
MIRT2560900	hsa-miR-2355-5p	CLIP-seq
MIRT2560901	hsa-miR-3148	CLIP-seq
MIRT2560902	hsa-miR-3156-3p	CLIP-seq
MIRT2560903	hsa-miR-3185	CLIP-seq
MIRT2560904	hsa-miR-3611	CLIP-seq
MIRT2560905	hsa-miR-3612	CLIP-seq
MIRT2560906	hsa-miR-3614-5p	CLIP-seq
MIRT2560907	hsa-miR-3674	CLIP-seq
MIRT2560908	hsa-miR-3690	CLIP-seq
MIRT2560909	hsa-miR-3942-3p	CLIP-seq
MIRT2560910	hsa-miR-4254	CLIP-seq
MIRT2560911	hsa-miR-4271	CLIP-seq
MIRT2560912	hsa-miR-4283	CLIP-seq
MIRT2560913	hsa-miR-4308	CLIP-seq
MIRT2560914	hsa-miR-4446-5p	CLIP-seq
MIRT2560915	hsa-miR-4459	CLIP-seq
MIRT2560916	hsa-miR-4463	CLIP-seq
MIRT2560917	hsa-miR-4660	CLIP-seq
MIRT2560918	hsa-miR-4667-5p	CLIP-seq
MIRT2560919	hsa-miR-4695-5p	CLIP-seq
MIRT2560920	hsa-miR-4700-5p	CLIP-seq
MIRT2560921	hsa-miR-4703-3p	CLIP-seq
MIRT2560922	hsa-miR-4725-3p	CLIP-seq
MIRT2560923	hsa-miR-4725-5p	CLIP-seq
MIRT2560924	hsa-miR-4735-5p	CLIP-seq
MIRT2560925	hsa-miR-4779	CLIP-seq
MIRT2560926	hsa-miR-4781-5p	CLIP-seq
MIRT2560927	hsa-miR-4797-5p	CLIP-seq
MIRT2560928	hsa-miR-493	CLIP-seq
MIRT2560929	hsa-miR-504	CLIP-seq
MIRT2560930	hsa-miR-513c	CLIP-seq
MIRT2560931	hsa-miR-514b-5p	CLIP-seq
MIRT2029971	hsa-miR-548u	CLIP-seq
MIRT2560932	hsa-miR-581	CLIP-seq
MIRT2560933	hsa-miR-650	CLIP-seq
MIRT2560934	hsa-miR-665	CLIP-seq
MIRT2560935	hsa-miR-890	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002479	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	IDA	9716645
GO:0003014	Process	Renal system process	IEA
GO:0003014	Process	Renal system process	ISS
GO:0004197	Function	Cysteine-type endopeptidase activity	IBA
GO:0004197	Function	Cysteine-type endopeptidase activity	IDA	9821970, 9872320, 18374643, 22718532, 25326800
GO:0004197	Function	Cysteine-type endopeptidase activity	IEA
GO:0004197	Function	Cysteine-type endopeptidase activity	IMP	9065484
GO:0004197	Function	Cysteine-type endopeptidase activity	ISS	9065484, 18374643
GO:0004197	Function	Cysteine-type endopeptidase activity	TAS	18377911
GO:0005515	Function	Protein binding	IPI	25630877
GO:0005576	Component	Extracellular region	IDA	18377911
GO:0005737	Component	Cytoplasm	IDA	18377911
GO:0005764	Component	Lysosome	IEA
GO:0005764	Component	Lysosome	ISS
GO:0005764	Component	Lysosome	TAS	18377911
GO:0005770	Component	Late endosome	IEA
GO:0005770	Component	Late endosome	TAS	18377911
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	ISS	9065484
GO:0006624	Process	Vacuolar protein processing	IBA
GO:0007613	Process	Memory	IEA
GO:0007613	Process	Memory	ISS	25326800
GO:0008233	Function	Peptidase activity	IDA	136644
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	21237226
GO:0008306	Process	Associative learning	IEA
GO:0008306	Process	Associative learning	ISS	25326800
GO:0010447	Process	Response to acidic pH	IDA	18374643
GO:0010447	Process	Response to acidic pH	IEA
GO:0010447	Process	Response to acidic pH	ISS	9065484, 25326800
GO:0010629	Process	Negative regulation of gene expression	IMP	21237226
GO:0016787	Function	Hydrolase activity	IEA
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA	9872320
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
GO:0032801	Process	Receptor catabolic process	IEA
GO:0032801	Process	Receptor catabolic process	ISS
GO:0035729	Process	Cellular response to hepatocyte growth factor stimulus	IDA	21237226
GO:0036021	Component	Endolysosome lumen	TAS
GO:0040015	Process	Negative regulation of multicellular organism growth	IEA
GO:0042359	Process	Vitamin D metabolic process	TAS
GO:0042590	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I	ISS	37347855
GO:0043202	Component	Lysosomal lumen	IDA	9872320
GO:0043202	Component	Lysosomal lumen	TAS
GO:0043524	Process	Negative regulation of neuron apoptotic process	IGI	18374643
GO:0045177	Component	Apical part of cell	IEA
GO:0045931	Process	Positive regulation of mitotic cell cycle	IMP	21237226
GO:0048156	Function	Tau protein binding	NAS	28386764
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	21237226
GO:0051603	Process	Proteolysis involved in protein catabolic process	IBA
GO:0051603	Process	Proteolysis involved in protein catabolic process	IEA
GO:0051603	Process	Proteolysis involved in protein catabolic process	ISS
GO:0051603	Process	Proteolysis involved in protein catabolic process	TAS	18377911
GO:0051604	Process	Protein maturation	IEA
GO:0051604	Process	Protein maturation	ISS	37347855
GO:0061133	Function	Endopeptidase activator activity	IDA	18374643
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0071277	Process	Cellular response to calcium ion	IDA	21237226
GO:0090026	Process	Positive regulation of monocyte chemotaxis	IDA	18377911
GO:0097061	Process	Dendritic spine organization	IEA
GO:0097061	Process	Dendritic spine organization	ISS	25326800
GO:1900273	Process	Positive regulation of long-term synaptic potentiation	IEA
GO:1900273	Process	Positive regulation of long-term synaptic potentiation	ISS	25326800
GO:1901185	Process	Negative regulation of ERBB signaling pathway	IEA
GO:1901185	Process	Negative regulation of ERBB signaling pathway	ISS
GO:1904646	Process	Cellular response to amyloid-beta	IDA	25326800
GO:2001028	Process	Positive regulation of endothelial cell chemotaxis	IDA	18377911

Other IDs

• MIM: 602620
• HGNC: 9472
• e!Ensembl: ENSG00000100600

Protein

• UniProt ID: Q99538
• Protein name: Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (AEP) (Protease, cysteine 1)
• Protein function: Has a strict specificity for hydrolysis of asparaginyl bonds (PubMed:23776206). Can also cleave aspartyl bonds slowly, especially under acidic conditions (PubMed:23776206). Involved in the processing of proteins for MHC class II antigen presenta
• PDB: 4AW9, 4AWA, 4AWB, 4FGU, 4N6N, 4N6O, 5LU8, 5LU9, 5LUA, 5LUB, 7FQH, 7FQI, 7FQJ, 7FQK, 7FQL, 7O50, 8AE4, 8AE5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01650	Peptidase_C13	29 → 286	Peptidase C13 family	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Particularly abundant in kidney, heart and placenta. {ECO:0000269|PubMed:8893817}.
• Sequence:

  MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNG
  IPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGD
  AEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYR
  KMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMED
  SDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVT
  HLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASE
  AEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHR
  IKLSMDHVCLGHY

• Sequence length: 433

Pathways

KEGG:

Lysosome
Antigen processing and presentation

Reactome:

Trafficking and processing of endosomal TLR
Vitamin D (calciferol) metabolism
MHC class II antigen presentation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
High myopia	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adult Diffuse Large B-Cell Lymphoma	B-cell Lymphoma	BEFREE	27464733		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	40187686	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	29568945		★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm Abdominal	Aortic aneurysm	Pubtator	36551281	Stimulate	★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	18377911, 27940038, 29414692, 31060209, 31181234, 31521890		★☆☆☆☆ Found in Text Mining only
Arthritis Psoriatic	Psoriatic arthritis	Pubtator	39662827	Associate	★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	18377911, 27940038, 29414692, 31060209, 31181234, 31521890		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	23740003, 24742492, 27660925, 28554249, 30906206		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	24742492, 25605174, 30429518, 30906206	Associate	★☆☆☆☆ Found in Text Mining only
Bronchopulmonary Dysplasia	Bronchopulmonary dysplasia	Pubtator	37478211	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	21237226, 24023813, 30906206	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	29568945		★☆☆☆☆ Found in Text Mining only
Carcinoma Ductal Breast	Ductal carcinoma of breast	Pubtator	30429518	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	21237226	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma Intraductal Noninfiltrating	Intraductal noninfiltrating carcinoma	Pubtator	30429518	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	22441772, 28278071		★☆☆☆☆ Found in Text Mining only
Carotid Artery Diseases	Carotid artery disease	Pubtator	31870625	Associate	★☆☆☆☆ Found in Text Mining only
Carotid Atherosclerosis	Carotid Atherosclerosis	BEFREE	27940038, 31060209		★☆☆☆☆ Found in Text Mining only
Carotid Stenosis	Carotid artery stenosis	BEFREE	27940038		★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	26802645		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	26802645		★☆☆☆☆ Found in Text Mining only
CNS disorder	CNS Disorder	BEFREE	21606482		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	23326369, 23740003		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	LHGDN	15788679		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36609651	Associate	★☆☆☆☆ Found in Text Mining only
Comedone	Comedone	BEFREE	30429518		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	31735728		★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	27464733		★☆☆☆☆ Found in Text Mining only
Eosinophilia	Eosinophilia	BEFREE	29369189		★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	28278071		★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	27697099, 29399177		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	27697099, 29399177		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	27697099	Associate	★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	25380136, 30507245		★☆☆☆☆ Found in Text Mining only
Ganglioneuroblastoma	Ganglioneuroblastoma	BEFREE	28994241		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	28557433, 31002346, 31400201		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	34582975	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	28557433, 31002346, 31400201		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	31610656		★☆☆☆☆ Found in Text Mining only
Hypercalcemia	Hypercalcemia	BEFREE	10488118		★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	35053409	Associate	★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	31509774		★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	32218783	Inhibit	★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver cirrhosis	Pubtator	30507245	Associate	★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	40027200	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	25605174	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	23740003, 24742492, 27660925, 28554249, 30906206		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	27697099, 29399177		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	22441772		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	23124822, 23629651, 27590439, 28417919		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	23740003, 24023813, 27102302, 28223821		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22441772, 23124822, 23326369, 23629651, 28820254, 31181234, 31509774		★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	26802645		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	27660925		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	20074384, 28630039	Associate	★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	28630039		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	35053409	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12782603, 23124822, 23691974, 23740003, 24023813, 24742492, 24810641, 25619622, 27464733, 27590439, 27660925, 27993111, 28315495, 29903055, 30027744, 30121849, 30556550, 30662566, 30906206, 31096007, 31400201		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	28994241		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	30135302, 31181234, 31509774		★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	31181234		★☆☆☆☆ Found in Text Mining only
Osteoporosis, Postmenopausal	Osteoporosis	BEFREE	28162997		★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	22441772		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	29568945		★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	29568945		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	29769405		★☆☆☆☆ Found in Text Mining only
Porphyria, Erythropoietic	Congenital erythropoietic porphyria	BEFREE	29369189		★☆☆☆☆ Found in Text Mining only
Precursor B-cell lymphoblastic leukemia	Lymphoblastic Leukemia	BEFREE	21606482		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	23124822, 23629651, 27590439, 28417919		★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	40027200	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Eosinophilia	Pulmonary Eosinophilia	BEFREE	29369189		★☆☆☆☆ Found in Text Mining only
Respiratory Tract Diseases	Respiratory system infectious disease	Pubtator	40027188	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	23740003, 24023813, 27102302, 27793040, 27894812, 28223821		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	24023813	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	29138420	Stimulate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	26802645	Associate	★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal Melanoma	BEFREE	26846877		★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	26846877	Associate	★☆☆☆☆ Found in Text Mining only