PPAN (peter pan homolog)

Gene

• Entrez ID: 56342
• Gene name: Peter pan homolog
• Gene symbol: PPAN
• Synonyms (NCBI Gene): BXDC3, SSF, SSF-1, SSF1, SSF2
• Chromosome: 19
• Chromosome location: 19p13.2
• Summary: The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022241	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT027452	hsa-miR-98-5p	Microarray	19088304
MIRT031381	hsa-miR-16-5p	Proteomics	18668040
MIRT050514	hsa-miR-20a-5p	CLASH	23622248
MIRT049693	hsa-miR-92a-3p	CLASH	23622248
MIRT048912	hsa-miR-93-5p	CLASH	23622248
MIRT042614	hsa-miR-423-3p	CLASH	23622248
MIRT052786	hsa-miR-3176	CLASH	23622248
MIRT1251168	hsa-miR-122	CLIP-seq
MIRT1251169	hsa-miR-1243	CLIP-seq
MIRT1251170	hsa-miR-3144-5p	CLIP-seq
MIRT1251171	hsa-miR-3190	CLIP-seq
MIRT1251172	hsa-miR-3191	CLIP-seq
MIRT1251173	hsa-miR-3202	CLIP-seq
MIRT1251174	hsa-miR-3654	CLIP-seq
MIRT1251175	hsa-miR-4446-3p	CLIP-seq
MIRT1251176	hsa-miR-4492	CLIP-seq
MIRT1251177	hsa-miR-4496	CLIP-seq
MIRT1251178	hsa-miR-4498	CLIP-seq
MIRT1251179	hsa-miR-4505	CLIP-seq
MIRT1251180	hsa-miR-4533	CLIP-seq
MIRT1251181	hsa-miR-4652-5p	CLIP-seq
MIRT1251182	hsa-miR-4667-5p	CLIP-seq
MIRT1251183	hsa-miR-4700-5p	CLIP-seq
MIRT1251184	hsa-miR-4731-5p	CLIP-seq
MIRT1251185	hsa-miR-488	CLIP-seq
MIRT1251186	hsa-miR-762	CLIP-seq
MIRT1251168	hsa-miR-122	CLIP-seq
MIRT1251170	hsa-miR-3144-5p	CLIP-seq
MIRT1251171	hsa-miR-3190	CLIP-seq
MIRT1251172	hsa-miR-3191	CLIP-seq
MIRT1251173	hsa-miR-3202	CLIP-seq
MIRT1251175	hsa-miR-4446-3p	CLIP-seq
MIRT1251176	hsa-miR-4492	CLIP-seq
MIRT1251178	hsa-miR-4498	CLIP-seq
MIRT1251179	hsa-miR-4505	CLIP-seq
MIRT1251180	hsa-miR-4533	CLIP-seq
MIRT1251181	hsa-miR-4652-5p	CLIP-seq
MIRT1251182	hsa-miR-4667-5p	CLIP-seq
MIRT1251183	hsa-miR-4700-5p	CLIP-seq
MIRT1251184	hsa-miR-4731-5p	CLIP-seq
MIRT1251186	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005634	Component	Nucleus	IDA	15302935
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0019843	Function	RRNA binding	IBA
GO:0019843	Function	RRNA binding	IEA
GO:0030687	Component	Preribosome, large subunit precursor	IBA

Other IDs

• MIM: 607793
• HGNC: 9227
• e!Ensembl: ENSG00000130810

Interactions View interactions

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Cataplexy and narcolepsy	association	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
NARCOLEPSY-CATAPLEXY SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations