Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	56271
Gene name	Brain expressed X-linked 4
Gene symbol	BEX4
Synonyms (NCBI Gene)	BEXL1
Chromosome	X
Chromosome location	Xq22.1
Summary	This gene is a member of the brain expressed X-linked gene family. The proteins encoded by some of the other members of this family act as transcription elongation factors which allow RNA polymerase II to escape pausing during elongation. Multiple alterna

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Show/Hide all (251)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016667	hsa-miR-425-5p	Sequencing	20371350
MIRT040055	hsa-miR-615-3p	CLASH	23622248
MIRT645681	hsa-miR-8485	HITS-CLIP	23824327
MIRT645680	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT645679	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT645678	hsa-miR-603	HITS-CLIP	23824327
MIRT108306	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT645677	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT108307	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT645676	hsa-miR-3941	HITS-CLIP	23824327
MIRT662964	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT645675	hsa-miR-3924	HITS-CLIP	23824327
MIRT645681	hsa-miR-8485	HITS-CLIP	23824327
MIRT645680	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT645679	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT645678	hsa-miR-603	HITS-CLIP	23824327
MIRT108306	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT645677	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT645676	hsa-miR-3941	HITS-CLIP	23824327
MIRT645675	hsa-miR-3924	HITS-CLIP	23824327
MIRT645681	hsa-miR-8485	HITS-CLIP	23824327
MIRT645680	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT645679	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT645678	hsa-miR-603	HITS-CLIP	23824327
MIRT108306	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT645677	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT108307	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT645676	hsa-miR-3941	HITS-CLIP	23824327
MIRT662964	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT645675	hsa-miR-3924	HITS-CLIP	23824327
MIRT645681	hsa-miR-8485	HITS-CLIP	23824327
MIRT645680	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT645679	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT645678	hsa-miR-603	HITS-CLIP	23824327
MIRT108306	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT645677	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT645676	hsa-miR-3941	HITS-CLIP	23824327
MIRT645675	hsa-miR-3924	HITS-CLIP	23824327
MIRT1942682	hsa-miR-1279	CLIP-seq
MIRT1942683	hsa-miR-3140-3p	CLIP-seq
MIRT1942684	hsa-miR-3545-3p	CLIP-seq
MIRT1942685	hsa-miR-491-3p	CLIP-seq
MIRT1942686	hsa-miR-586	CLIP-seq
MIRT1942687	hsa-miR-656	CLIP-seq
MIRT2181478	hsa-miR-181a	CLIP-seq
MIRT2181479	hsa-miR-181b	CLIP-seq
MIRT2181480	hsa-miR-181c	CLIP-seq
MIRT2181481	hsa-miR-181d	CLIP-seq
MIRT2181482	hsa-miR-4262	CLIP-seq
MIRT2181483	hsa-miR-4643	CLIP-seq
MIRT2181484	hsa-miR-466	CLIP-seq
MIRT2484808	hsa-miR-1	CLIP-seq
MIRT2484809	hsa-miR-1225-3p	CLIP-seq
MIRT2484810	hsa-miR-1263	CLIP-seq
MIRT2484811	hsa-miR-1270	CLIP-seq
MIRT1942682	hsa-miR-1279	CLIP-seq
MIRT2484812	hsa-miR-129-5p	CLIP-seq
MIRT2484813	hsa-miR-1299	CLIP-seq
MIRT2484814	hsa-miR-133a	CLIP-seq
MIRT2484815	hsa-miR-133b	CLIP-seq
MIRT2181478	hsa-miR-181a	CLIP-seq
MIRT2181479	hsa-miR-181b	CLIP-seq
MIRT2181480	hsa-miR-181c	CLIP-seq
MIRT2181481	hsa-miR-181d	CLIP-seq
MIRT2484816	hsa-miR-183	CLIP-seq
MIRT2484817	hsa-miR-200b	CLIP-seq
MIRT2484818	hsa-miR-200c	CLIP-seq
MIRT2484819	hsa-miR-2053	CLIP-seq
MIRT2484820	hsa-miR-206	CLIP-seq
MIRT2484821	hsa-miR-219-2-3p	CLIP-seq
MIRT2484822	hsa-miR-2964a-3p	CLIP-seq
MIRT2484823	hsa-miR-30a	CLIP-seq
MIRT2484824	hsa-miR-30b	CLIP-seq
MIRT2484825	hsa-miR-30c	CLIP-seq
MIRT2484826	hsa-miR-30d	CLIP-seq
MIRT2484827	hsa-miR-30e	CLIP-seq
MIRT2484828	hsa-miR-3134	CLIP-seq
MIRT1942683	hsa-miR-3140-3p	CLIP-seq
MIRT2484829	hsa-miR-3169	CLIP-seq
MIRT2484830	hsa-miR-329	CLIP-seq
MIRT2484831	hsa-miR-338-5p	CLIP-seq
MIRT1942684	hsa-miR-3545-3p	CLIP-seq
MIRT2484832	hsa-miR-365	CLIP-seq
MIRT2484833	hsa-miR-3664-5p	CLIP-seq
MIRT2484834	hsa-miR-3673	CLIP-seq
MIRT2484835	hsa-miR-3685	CLIP-seq
MIRT2484836	hsa-miR-378	CLIP-seq
MIRT2484837	hsa-miR-378b	CLIP-seq
MIRT2484838	hsa-miR-378c	CLIP-seq
MIRT2484839	hsa-miR-378d	CLIP-seq
MIRT2484840	hsa-miR-378e	CLIP-seq
MIRT2484841	hsa-miR-378f	CLIP-seq
MIRT2484842	hsa-miR-378h	CLIP-seq
MIRT2484843	hsa-miR-378i	CLIP-seq
MIRT2484844	hsa-miR-384	CLIP-seq
MIRT2484845	hsa-miR-422a	CLIP-seq
MIRT2181482	hsa-miR-4262	CLIP-seq
MIRT2484846	hsa-miR-4270	CLIP-seq
MIRT2484847	hsa-miR-4272	CLIP-seq
MIRT2484848	hsa-miR-4275	CLIP-seq
MIRT2484849	hsa-miR-4286	CLIP-seq
MIRT2484850	hsa-miR-429	CLIP-seq
MIRT2484851	hsa-miR-4314	CLIP-seq
MIRT2484852	hsa-miR-4323	CLIP-seq
MIRT2484853	hsa-miR-4441	CLIP-seq
MIRT2484854	hsa-miR-4452	CLIP-seq
MIRT2484855	hsa-miR-4490	CLIP-seq
MIRT2484856	hsa-miR-4494	CLIP-seq
MIRT2484857	hsa-miR-4515	CLIP-seq
MIRT2484858	hsa-miR-4534	CLIP-seq
MIRT2484859	hsa-miR-4638-3p	CLIP-seq
MIRT2484860	hsa-miR-4639-3p	CLIP-seq
MIRT2181483	hsa-miR-4643	CLIP-seq
MIRT2181484	hsa-miR-466	CLIP-seq
MIRT2484861	hsa-miR-4677-3p	CLIP-seq
MIRT2484862	hsa-miR-4679	CLIP-seq
MIRT2484863	hsa-miR-4683	CLIP-seq
MIRT2484864	hsa-miR-4694-3p	CLIP-seq
MIRT2484865	hsa-miR-4704-5p	CLIP-seq
MIRT2484866	hsa-miR-4714-5p	CLIP-seq
MIRT2484867	hsa-miR-4735-5p	CLIP-seq
MIRT2484868	hsa-miR-4738-3p	CLIP-seq
MIRT2484869	hsa-miR-4749-3p	CLIP-seq
MIRT2484870	hsa-miR-4758-3p	CLIP-seq
MIRT2484871	hsa-miR-4766-5p	CLIP-seq
MIRT2484872	hsa-miR-4773	CLIP-seq
MIRT2484873	hsa-miR-4782-5p	CLIP-seq
MIRT1942685	hsa-miR-491-3p	CLIP-seq
MIRT2484874	hsa-miR-496	CLIP-seq
MIRT2484875	hsa-miR-516b	CLIP-seq
MIRT2484876	hsa-miR-520d-5p	CLIP-seq
MIRT2484877	hsa-miR-524-5p	CLIP-seq
MIRT2484878	hsa-miR-548a-3p	CLIP-seq
MIRT2484879	hsa-miR-548a-5p	CLIP-seq
MIRT2484880	hsa-miR-548ab	CLIP-seq
MIRT2484881	hsa-miR-548ae	CLIP-seq
MIRT2484882	hsa-miR-548aj	CLIP-seq
MIRT2484883	hsa-miR-548ak	CLIP-seq
MIRT2484884	hsa-miR-548am	CLIP-seq
MIRT2484885	hsa-miR-548b-5p	CLIP-seq
MIRT2484886	hsa-miR-548c-3p	CLIP-seq
MIRT2484887	hsa-miR-548c-5p	CLIP-seq
MIRT2484888	hsa-miR-548d-5p	CLIP-seq
MIRT2484889	hsa-miR-548e	CLIP-seq
MIRT2484890	hsa-miR-548f	CLIP-seq
MIRT2484891	hsa-miR-548g	CLIP-seq
MIRT2484892	hsa-miR-548h	CLIP-seq
MIRT2484893	hsa-miR-548i	CLIP-seq
MIRT2484894	hsa-miR-548j	CLIP-seq
MIRT2484895	hsa-miR-548n	CLIP-seq
MIRT2484896	hsa-miR-548w	CLIP-seq
MIRT2484897	hsa-miR-548x	CLIP-seq
MIRT2484898	hsa-miR-548y	CLIP-seq
MIRT2484899	hsa-miR-549	CLIP-seq
MIRT2484900	hsa-miR-559	CLIP-seq
MIRT2484901	hsa-miR-576-5p	CLIP-seq
MIRT2484902	hsa-miR-582-3p	CLIP-seq
MIRT1942686	hsa-miR-586	CLIP-seq
MIRT2484903	hsa-miR-587	CLIP-seq
MIRT2484904	hsa-miR-595	CLIP-seq
MIRT2484905	hsa-miR-600	CLIP-seq
MIRT2484906	hsa-miR-613	CLIP-seq
MIRT2484907	hsa-miR-620	CLIP-seq
MIRT2484908	hsa-miR-627	CLIP-seq
MIRT1942687	hsa-miR-656	CLIP-seq
MIRT2484909	hsa-miR-765	CLIP-seq
MIRT2484910	hsa-miR-885-5p	CLIP-seq
MIRT2484911	hsa-miR-924	CLIP-seq
MIRT2484808	hsa-miR-1	CLIP-seq
MIRT2484809	hsa-miR-1225-3p	CLIP-seq
MIRT2484810	hsa-miR-1263	CLIP-seq
MIRT2484811	hsa-miR-1270	CLIP-seq
MIRT1942682	hsa-miR-1279	CLIP-seq
MIRT2484812	hsa-miR-129-5p	CLIP-seq
MIRT2484813	hsa-miR-1299	CLIP-seq
MIRT2484814	hsa-miR-133a	CLIP-seq
MIRT2484815	hsa-miR-133b	CLIP-seq
MIRT2181478	hsa-miR-181a	CLIP-seq
MIRT2181479	hsa-miR-181b	CLIP-seq
MIRT2181480	hsa-miR-181c	CLIP-seq
MIRT2181481	hsa-miR-181d	CLIP-seq
MIRT2484816	hsa-miR-183	CLIP-seq
MIRT2484819	hsa-miR-2053	CLIP-seq
MIRT2484820	hsa-miR-206	CLIP-seq
MIRT2484823	hsa-miR-30a	CLIP-seq
MIRT2484824	hsa-miR-30b	CLIP-seq
MIRT2484825	hsa-miR-30c	CLIP-seq
MIRT2484826	hsa-miR-30d	CLIP-seq
MIRT2484827	hsa-miR-30e	CLIP-seq
MIRT2484828	hsa-miR-3134	CLIP-seq
MIRT1942683	hsa-miR-3140-3p	CLIP-seq
MIRT2484829	hsa-miR-3169	CLIP-seq
MIRT2484830	hsa-miR-329	CLIP-seq
MIRT2484831	hsa-miR-338-5p	CLIP-seq
MIRT1942684	hsa-miR-3545-3p	CLIP-seq
MIRT2484834	hsa-miR-3673	CLIP-seq
MIRT2484835	hsa-miR-3685	CLIP-seq
MIRT2484844	hsa-miR-384	CLIP-seq
MIRT2181482	hsa-miR-4262	CLIP-seq
MIRT2484846	hsa-miR-4270	CLIP-seq
MIRT2484847	hsa-miR-4272	CLIP-seq
MIRT2484848	hsa-miR-4275	CLIP-seq
MIRT2484849	hsa-miR-4286	CLIP-seq
MIRT2484851	hsa-miR-4314	CLIP-seq
MIRT2484852	hsa-miR-4323	CLIP-seq
MIRT2484853	hsa-miR-4441	CLIP-seq
MIRT2484854	hsa-miR-4452	CLIP-seq
MIRT2484855	hsa-miR-4490	CLIP-seq
MIRT2484856	hsa-miR-4494	CLIP-seq
MIRT2484857	hsa-miR-4515	CLIP-seq
MIRT2484858	hsa-miR-4534	CLIP-seq
MIRT2484860	hsa-miR-4639-3p	CLIP-seq
MIRT2181483	hsa-miR-4643	CLIP-seq
MIRT2181484	hsa-miR-466	CLIP-seq
MIRT2484863	hsa-miR-4683	CLIP-seq
MIRT2484864	hsa-miR-4694-3p	CLIP-seq
MIRT2484865	hsa-miR-4704-5p	CLIP-seq
MIRT2484866	hsa-miR-4714-5p	CLIP-seq
MIRT2484867	hsa-miR-4735-5p	CLIP-seq
MIRT2484868	hsa-miR-4738-3p	CLIP-seq
MIRT2484870	hsa-miR-4758-3p	CLIP-seq
MIRT2484871	hsa-miR-4766-5p	CLIP-seq
MIRT2484872	hsa-miR-4773	CLIP-seq
MIRT2484873	hsa-miR-4782-5p	CLIP-seq
MIRT1942685	hsa-miR-491-3p	CLIP-seq
MIRT2484874	hsa-miR-496	CLIP-seq
MIRT2484875	hsa-miR-516b	CLIP-seq
MIRT2484876	hsa-miR-520d-5p	CLIP-seq
MIRT2484877	hsa-miR-524-5p	CLIP-seq
MIRT2484878	hsa-miR-548a-3p	CLIP-seq
MIRT2484881	hsa-miR-548ae	CLIP-seq
MIRT2484882	hsa-miR-548aj	CLIP-seq
MIRT2484884	hsa-miR-548am	CLIP-seq
MIRT2484886	hsa-miR-548c-3p	CLIP-seq
MIRT2484889	hsa-miR-548e	CLIP-seq
MIRT2484890	hsa-miR-548f	CLIP-seq
MIRT2484891	hsa-miR-548g	CLIP-seq
MIRT2484897	hsa-miR-548x	CLIP-seq
MIRT2484899	hsa-miR-549	CLIP-seq
MIRT2484901	hsa-miR-576-5p	CLIP-seq
MIRT2484902	hsa-miR-582-3p	CLIP-seq
MIRT1942686	hsa-miR-586	CLIP-seq
MIRT2484903	hsa-miR-587	CLIP-seq
MIRT2484904	hsa-miR-595	CLIP-seq
MIRT2484905	hsa-miR-600	CLIP-seq
MIRT2484906	hsa-miR-613	CLIP-seq
MIRT2484907	hsa-miR-620	CLIP-seq
MIRT2484908	hsa-miR-627	CLIP-seq
MIRT1942687	hsa-miR-656	CLIP-seq
MIRT2484909	hsa-miR-765	CLIP-seq
MIRT2484910	hsa-miR-885-5p	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IDA	27512957
GO:0000922	Component	Spindle pole	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	27512957
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	27512957
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IDA	27512957
GO:0007059	Process	Chromosome segregation	IMP	27512957
GO:0030334	Process	Regulation of cell migration	IMP	27512957
GO:0031397	Process	Negative regulation of protein ubiquitination	ISS
GO:0042127	Process	Regulation of cell population proliferation	IMP	27512957
GO:0042826	Function	Histone deacetylase binding	IPI	27512957
GO:0043014	Function	Alpha-tubulin binding	IDA	27512957
GO:0046872	Function	Metal ion binding	IEA
GO:0140678	Function	Molecular function inhibitor activity	ISS
GO:1904428	Process	Negative regulation of tubulin deacetylation	IMP	27512957

MIM	HGNC	e!Ensembl
300692	25475	ENSG00000102409

Q9NWD9

Protein name

Protein BEX4 (BEX1-like protein 1) (Brain-expressed X-linked protein 4) (Nerve growth factor receptor-associated protein 3)

Protein function

May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability (PubMed:27512957). In absence of red

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04538	BEX	14 → 116	Brain expressed X-linked like family	Family

Tissue specificity

TISSUE SPECIFICITY: Very high expression in heart, skeletal muscle, liver, and kidney. The levels of expression are uniform throughout the brain. {ECO:0000269|PubMed:15958283}.

Sequence

MESKEELAANNLNGENAQQENEGGEQAPTQNEEESRHLGGGEGQKPGGNIRRGRVRRLVP
NFRWAIPNRHIEHNEARDDVERFVGQMMEIKRKTREQQMRHYMRFQTPEPDNHYDFCLIP

Sequence length

120

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHOLESTASIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	29660335, 31612060		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aneuploidy	Aneuploidy	Pubtator	39735979	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	15870691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholestasis	Cholestasis	CTD_human_DG	27989131		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31796117	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lip and Oral Cavity Carcinoma	Lip and Oral Cavity Carcinoma	BEFREE	27297407		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of mouth	Malignant neoplasm of mouth	BEFREE	27297407		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	15870691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28145533, 30367032		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27297407		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	28145533		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	15870691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	27297407		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	33217815	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

BEX4 (brain expressed X-linked 4)