Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	56262
Gene name	Leucine rich repeat containing 8 VRAC subunit A
Gene symbol	LRRC8A
Synonyms (NCBI Gene)	AGM5HsLRRC8ALRRC8SWELL1
Chromosome	9
Chromosome location	9q34.11
Summary	This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative fou

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001358	hsa-miR-1-3p	pSILAC	18668040
MIRT001358	hsa-miR-1-3p	Microarray	15685193
MIRT016581	hsa-miR-193b-3p	Microarray	20304954
MIRT018758	hsa-miR-335-5p	Microarray	18185580
MIRT001358	hsa-miR-1-3p	Microarray	15685193
MIRT001358	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT001358	hsa-miR-1-3p	Proteomics	18668040
MIRT028222	hsa-miR-33a-5p	Sequencing	20371350
MIRT032470	hsa-let-7b-5p	Proteomics	18668040
MIRT051458	hsa-let-7e-5p	CLASH	23622248
MIRT045587	hsa-miR-149-5p	CLASH	23622248
MIRT054164	hsa-miR-191-5p	ImmunoprecipitationIn situ hybridizationLuciferase assayMicroarrayNorthern blotQRTPCRWestern blot	23505378
MIRT569276	hsa-miR-4694-3p	PAR-CLIP	20371350
MIRT569275	hsa-miR-4719	PAR-CLIP	20371350
MIRT569274	hsa-miR-184	PAR-CLIP	20371350
MIRT569273	hsa-miR-4804-5p	PAR-CLIP	20371350
MIRT536217	hsa-miR-208a-5p	PAR-CLIP	22012620
MIRT536216	hsa-miR-208b-5p	PAR-CLIP	22012620
MIRT536215	hsa-miR-6715a-3p	PAR-CLIP	22012620
MIRT536214	hsa-miR-330-3p	PAR-CLIP	22012620
MIRT536213	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT536212	hsa-miR-607	PAR-CLIP	22012620
MIRT536211	hsa-miR-1305	PAR-CLIP	22012620
MIRT569276	hsa-miR-4694-3p	PAR-CLIP	20371350
MIRT569275	hsa-miR-4719	PAR-CLIP	20371350
MIRT569274	hsa-miR-184	PAR-CLIP	20371350
MIRT569273	hsa-miR-4804-5p	PAR-CLIP	20371350
MIRT536217	hsa-miR-208a-5p	PAR-CLIP	22012620
MIRT536216	hsa-miR-208b-5p	PAR-CLIP	22012620
MIRT536215	hsa-miR-6715a-3p	PAR-CLIP	22012620
MIRT536214	hsa-miR-330-3p	PAR-CLIP	22012620
MIRT536213	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT536212	hsa-miR-607	PAR-CLIP	22012620
MIRT536211	hsa-miR-1305	PAR-CLIP	22012620
MIRT1120476	hsa-miR-1185	CLIP-seq
MIRT1120477	hsa-miR-1224-3p	CLIP-seq
MIRT1120478	hsa-miR-125a-5p	CLIP-seq
MIRT1120479	hsa-miR-125b	CLIP-seq
MIRT1120480	hsa-miR-1290	CLIP-seq
MIRT1120481	hsa-miR-129-5p	CLIP-seq
MIRT1120482	hsa-miR-191	CLIP-seq
MIRT1120483	hsa-miR-3159	CLIP-seq
MIRT1120484	hsa-miR-323b-5p	CLIP-seq
MIRT1120485	hsa-miR-331-3p	CLIP-seq
MIRT1120486	hsa-miR-3605-5p	CLIP-seq
MIRT1120487	hsa-miR-3679-5p	CLIP-seq
MIRT1120488	hsa-miR-3975	CLIP-seq
MIRT1120489	hsa-miR-3977	CLIP-seq
MIRT1120490	hsa-miR-4257	CLIP-seq
MIRT1120491	hsa-miR-4292	CLIP-seq
MIRT1120492	hsa-miR-4303	CLIP-seq
MIRT1120493	hsa-miR-4319	CLIP-seq
MIRT1120494	hsa-miR-4446-5p	CLIP-seq
MIRT1120495	hsa-miR-4480	CLIP-seq
MIRT1120496	hsa-miR-4487	CLIP-seq
MIRT1120497	hsa-miR-4643	CLIP-seq
MIRT1120498	hsa-miR-4649-3p	CLIP-seq
MIRT1120499	hsa-miR-4690-3p	CLIP-seq
MIRT1120500	hsa-miR-4717-3p	CLIP-seq
MIRT1120501	hsa-miR-4722-3p	CLIP-seq
MIRT1120502	hsa-miR-4732-3p	CLIP-seq
MIRT1120503	hsa-miR-4755-5p	CLIP-seq
MIRT1120504	hsa-miR-4762-3p	CLIP-seq
MIRT1120505	hsa-miR-4763-5p	CLIP-seq
MIRT1120506	hsa-miR-4802-3p	CLIP-seq
MIRT1120507	hsa-miR-486-3p	CLIP-seq
MIRT1120508	hsa-miR-515-3p	CLIP-seq
MIRT1120509	hsa-miR-519e	CLIP-seq
MIRT1120510	hsa-miR-550a	CLIP-seq
MIRT1120511	hsa-miR-642b	CLIP-seq
MIRT1120512	hsa-miR-648	CLIP-seq
MIRT1120513	hsa-miR-670	CLIP-seq
MIRT1120476	hsa-miR-1185	CLIP-seq
MIRT1120480	hsa-miR-1290	CLIP-seq
MIRT1120481	hsa-miR-129-5p	CLIP-seq
MIRT1120482	hsa-miR-191	CLIP-seq
MIRT1120483	hsa-miR-3159	CLIP-seq
MIRT1120484	hsa-miR-323b-5p	CLIP-seq
MIRT1120486	hsa-miR-3605-5p	CLIP-seq
MIRT1120487	hsa-miR-3679-5p	CLIP-seq
MIRT1120514	hsa-miR-374c	CLIP-seq
MIRT1120488	hsa-miR-3975	CLIP-seq
MIRT1120489	hsa-miR-3977	CLIP-seq
MIRT1120515	hsa-miR-425	CLIP-seq
MIRT1120490	hsa-miR-4257	CLIP-seq
MIRT1120492	hsa-miR-4303	CLIP-seq
MIRT1120516	hsa-miR-4462	CLIP-seq
MIRT1120495	hsa-miR-4480	CLIP-seq
MIRT1120497	hsa-miR-4643	CLIP-seq
MIRT1120498	hsa-miR-4649-3p	CLIP-seq
MIRT1120500	hsa-miR-4717-3p	CLIP-seq
MIRT1120501	hsa-miR-4722-3p	CLIP-seq
MIRT1120504	hsa-miR-4762-3p	CLIP-seq
MIRT1120505	hsa-miR-4763-5p	CLIP-seq
MIRT1120506	hsa-miR-4802-3p	CLIP-seq
MIRT1120508	hsa-miR-515-3p	CLIP-seq
MIRT1120509	hsa-miR-519e	CLIP-seq
MIRT1120510	hsa-miR-550a	CLIP-seq
MIRT1120511	hsa-miR-642b	CLIP-seq
MIRT1120512	hsa-miR-648	CLIP-seq
MIRT1120517	hsa-miR-655	CLIP-seq
MIRT1120478	hsa-miR-125a-5p	CLIP-seq
MIRT1120479	hsa-miR-125b	CLIP-seq
MIRT1120518	hsa-miR-1283	CLIP-seq
MIRT1120519	hsa-miR-146b-3p	CLIP-seq
MIRT1120520	hsa-miR-1539	CLIP-seq
MIRT1120482	hsa-miR-191	CLIP-seq
MIRT1120521	hsa-miR-1915	CLIP-seq
MIRT1120522	hsa-miR-193a-3p	CLIP-seq
MIRT1120523	hsa-miR-193b	CLIP-seq
MIRT1120524	hsa-miR-200b	CLIP-seq
MIRT1120525	hsa-miR-200c	CLIP-seq
MIRT1120526	hsa-miR-3130-3p	CLIP-seq
MIRT1120527	hsa-miR-3145-5p	CLIP-seq
MIRT1120528	hsa-miR-3153	CLIP-seq
MIRT1120529	hsa-miR-3173-5p	CLIP-seq
MIRT1120484	hsa-miR-323b-5p	CLIP-seq
MIRT1120530	hsa-miR-3591-5p	CLIP-seq
MIRT1120531	hsa-miR-3618	CLIP-seq
MIRT1120532	hsa-miR-3620	CLIP-seq
MIRT1120533	hsa-miR-3672	CLIP-seq
MIRT1120534	hsa-miR-3680	CLIP-seq
MIRT1120514	hsa-miR-374c	CLIP-seq
MIRT1120488	hsa-miR-3975	CLIP-seq
MIRT1120489	hsa-miR-3977	CLIP-seq
MIRT1120490	hsa-miR-4257	CLIP-seq
MIRT1120535	hsa-miR-4261	CLIP-seq
MIRT1120536	hsa-miR-429	CLIP-seq
MIRT1120537	hsa-miR-4318	CLIP-seq
MIRT1120493	hsa-miR-4319	CLIP-seq
MIRT1120538	hsa-miR-4324	CLIP-seq
MIRT1120539	hsa-miR-4329	CLIP-seq
MIRT1120540	hsa-miR-4496	CLIP-seq
MIRT1120541	hsa-miR-4681	CLIP-seq
MIRT1120542	hsa-miR-4693-5p	CLIP-seq
MIRT1120543	hsa-miR-4709-3p	CLIP-seq
MIRT1120544	hsa-miR-4711-3p	CLIP-seq
MIRT1120545	hsa-miR-4715-3p	CLIP-seq
MIRT1120546	hsa-miR-4724-5p	CLIP-seq
MIRT1120547	hsa-miR-511	CLIP-seq
MIRT1120512	hsa-miR-648	CLIP-seq
MIRT1120517	hsa-miR-655	CLIP-seq
MIRT1120548	hsa-miR-7	CLIP-seq
MIRT1120549	hsa-miR-874	CLIP-seq
MIRT1120550	hsa-miR-892a	CLIP-seq
MIRT1120551	hsa-miR-95	CLIP-seq
MIRT1120476	hsa-miR-1185	CLIP-seq
MIRT1120483	hsa-miR-3159	CLIP-seq
MIRT1120484	hsa-miR-323b-5p	CLIP-seq
MIRT1120486	hsa-miR-3605-5p	CLIP-seq
MIRT1120487	hsa-miR-3679-5p	CLIP-seq
MIRT1120488	hsa-miR-3975	CLIP-seq
MIRT1120490	hsa-miR-4257	CLIP-seq
MIRT1120492	hsa-miR-4303	CLIP-seq
MIRT1120498	hsa-miR-4649-3p	CLIP-seq
MIRT1120504	hsa-miR-4762-3p	CLIP-seq
MIRT1120512	hsa-miR-648	CLIP-seq
MIRT2034130	hsa-miR-4457	CLIP-seq
MIRT1120501	hsa-miR-4722-3p	CLIP-seq
MIRT2034131	hsa-miR-513b	CLIP-seq
MIRT2034132	hsa-miR-671-5p	CLIP-seq
MIRT1120478	hsa-miR-125a-5p	CLIP-seq
MIRT1120479	hsa-miR-125b	CLIP-seq
MIRT1120524	hsa-miR-200b	CLIP-seq
MIRT1120525	hsa-miR-200c	CLIP-seq
MIRT1120536	hsa-miR-429	CLIP-seq
MIRT1120493	hsa-miR-4319	CLIP-seq
MIRT2264478	hsa-miR-4521	CLIP-seq
MIRT1120518	hsa-miR-1283	CLIP-seq
MIRT1120531	hsa-miR-3618	CLIP-seq
MIRT1120516	hsa-miR-4462	CLIP-seq
MIRT2430853	hsa-miR-570	CLIP-seq
MIRT1120478	hsa-miR-125a-5p	CLIP-seq
MIRT1120479	hsa-miR-125b	CLIP-seq
MIRT1120519	hsa-miR-146b-3p	CLIP-seq
MIRT1120522	hsa-miR-193a-3p	CLIP-seq
MIRT1120523	hsa-miR-193b	CLIP-seq
MIRT1120527	hsa-miR-3145-5p	CLIP-seq
MIRT1120529	hsa-miR-3173-5p	CLIP-seq
MIRT1120530	hsa-miR-3591-5p	CLIP-seq
MIRT1120532	hsa-miR-3620	CLIP-seq
MIRT1120533	hsa-miR-3672	CLIP-seq
MIRT1120534	hsa-miR-3680	CLIP-seq
MIRT1120493	hsa-miR-4319	CLIP-seq
MIRT1120538	hsa-miR-4324	CLIP-seq
MIRT1120539	hsa-miR-4329	CLIP-seq
MIRT1120544	hsa-miR-4711-3p	CLIP-seq
MIRT1120545	hsa-miR-4715-3p	CLIP-seq
MIRT1120547	hsa-miR-511	CLIP-seq
MIRT1120549	hsa-miR-874	CLIP-seq
MIRT2453394	hsa-miR-1252	CLIP-seq
MIRT2453395	hsa-miR-1255a	CLIP-seq
MIRT2453396	hsa-miR-1255b	CLIP-seq
MIRT2453397	hsa-miR-3126-3p	CLIP-seq
MIRT2453398	hsa-miR-3173-3p	CLIP-seq
MIRT2453399	hsa-miR-3689d	CLIP-seq
MIRT2453400	hsa-miR-4782-5p	CLIP-seq
MIRT2264478	hsa-miR-4521	CLIP-seq
MIRT2563451	hsa-miR-1228	CLIP-seq
MIRT2563452	hsa-miR-1245	CLIP-seq
MIRT1120478	hsa-miR-125a-5p	CLIP-seq
MIRT1120479	hsa-miR-125b	CLIP-seq
MIRT2563453	hsa-miR-1285	CLIP-seq
MIRT1120519	hsa-miR-146b-3p	CLIP-seq
MIRT2563454	hsa-miR-1470	CLIP-seq
MIRT2563455	hsa-miR-18a	CLIP-seq
MIRT2563456	hsa-miR-18b	CLIP-seq
MIRT2563457	hsa-miR-1908	CLIP-seq
MIRT1120522	hsa-miR-193a-3p	CLIP-seq
MIRT1120523	hsa-miR-193b	CLIP-seq
MIRT2563458	hsa-miR-208a	CLIP-seq
MIRT2563459	hsa-miR-208b	CLIP-seq
MIRT2563460	hsa-miR-2115	CLIP-seq
MIRT2563461	hsa-miR-2355-5p	CLIP-seq
MIRT2563462	hsa-miR-3121-3p	CLIP-seq
MIRT1120526	hsa-miR-3130-3p	CLIP-seq
MIRT2563463	hsa-miR-3144-5p	CLIP-seq
MIRT1120527	hsa-miR-3145-5p	CLIP-seq
MIRT2563464	hsa-miR-3150b-3p	CLIP-seq
MIRT1120529	hsa-miR-3173-5p	CLIP-seq
MIRT2563465	hsa-miR-3187-5p	CLIP-seq
MIRT2563466	hsa-miR-3191	CLIP-seq
MIRT2563467	hsa-miR-3192	CLIP-seq
MIRT1120530	hsa-miR-3591-5p	CLIP-seq
MIRT2563468	hsa-miR-3613-3p	CLIP-seq
MIRT2563469	hsa-miR-3617	CLIP-seq
MIRT2563470	hsa-miR-3619-3p	CLIP-seq
MIRT1120532	hsa-miR-3620	CLIP-seq
MIRT1120533	hsa-miR-3672	CLIP-seq
MIRT1120534	hsa-miR-3680	CLIP-seq
MIRT2563471	hsa-miR-3690	CLIP-seq
MIRT2563472	hsa-miR-378g	CLIP-seq
MIRT2563473	hsa-miR-3940-3p	CLIP-seq
MIRT2563474	hsa-miR-3974	CLIP-seq
MIRT2563475	hsa-miR-4254	CLIP-seq
MIRT2563476	hsa-miR-4263	CLIP-seq
MIRT2563477	hsa-miR-4314	CLIP-seq
MIRT1120493	hsa-miR-4319	CLIP-seq
MIRT1120538	hsa-miR-4324	CLIP-seq
MIRT1120539	hsa-miR-4329	CLIP-seq
MIRT2563478	hsa-miR-4422	CLIP-seq
MIRT2563479	hsa-miR-4434	CLIP-seq
MIRT1120516	hsa-miR-4462	CLIP-seq
MIRT2563480	hsa-miR-4469	CLIP-seq
MIRT1120495	hsa-miR-4480	CLIP-seq
MIRT2563481	hsa-miR-4497	CLIP-seq
MIRT2563482	hsa-miR-4509	CLIP-seq
MIRT2563483	hsa-miR-4516	CLIP-seq
MIRT2264478	hsa-miR-4521	CLIP-seq
MIRT1120497	hsa-miR-4643	CLIP-seq
MIRT2563484	hsa-miR-4646-5p	CLIP-seq
MIRT2563485	hsa-miR-4652-5p	CLIP-seq
MIRT2563486	hsa-miR-4667-3p	CLIP-seq
MIRT2563487	hsa-miR-4691-3p	CLIP-seq
MIRT2563488	hsa-miR-4706	CLIP-seq
MIRT1120544	hsa-miR-4711-3p	CLIP-seq
MIRT1120545	hsa-miR-4715-3p	CLIP-seq
MIRT1120500	hsa-miR-4717-3p	CLIP-seq
MIRT2563489	hsa-miR-4733-3p	CLIP-seq
MIRT2563490	hsa-miR-4735-3p	CLIP-seq
MIRT2563491	hsa-miR-4744	CLIP-seq
MIRT2563492	hsa-miR-4749-5p	CLIP-seq
MIRT2563493	hsa-miR-4765	CLIP-seq
MIRT2563494	hsa-miR-4776-5p	CLIP-seq
MIRT2563495	hsa-miR-4784	CLIP-seq
MIRT1120506	hsa-miR-4802-3p	CLIP-seq
MIRT2563496	hsa-miR-4802-5p	CLIP-seq
MIRT2563497	hsa-miR-491-5p	CLIP-seq
MIRT2563498	hsa-miR-495	CLIP-seq
MIRT2563499	hsa-miR-499-5p	CLIP-seq
MIRT1120547	hsa-miR-511	CLIP-seq
MIRT2563500	hsa-miR-524-3p	CLIP-seq
MIRT2563501	hsa-miR-525-3p	CLIP-seq
MIRT2563502	hsa-miR-548ac	CLIP-seq
MIRT2563503	hsa-miR-548ad	CLIP-seq
MIRT2563504	hsa-miR-548d-3p	CLIP-seq
MIRT2563505	hsa-miR-548z	CLIP-seq
MIRT2430853	hsa-miR-570	CLIP-seq
MIRT2563506	hsa-miR-612	CLIP-seq
MIRT2563507	hsa-miR-641	CLIP-seq
MIRT1120511	hsa-miR-642b	CLIP-seq
MIRT2563508	hsa-miR-663	CLIP-seq
MIRT1120548	hsa-miR-7	CLIP-seq
MIRT2563509	hsa-miR-764	CLIP-seq
MIRT2563510	hsa-miR-765	CLIP-seq
MIRT2563511	hsa-miR-873	CLIP-seq
MIRT1120549	hsa-miR-874	CLIP-seq
MIRT2264478	hsa-miR-4521	CLIP-seq
MIRT1120476	hsa-miR-1185	CLIP-seq
MIRT2563451	hsa-miR-1228	CLIP-seq
MIRT2563452	hsa-miR-1245	CLIP-seq
MIRT1120478	hsa-miR-125a-5p	CLIP-seq
MIRT1120479	hsa-miR-125b	CLIP-seq
MIRT1120519	hsa-miR-146b-3p	CLIP-seq
MIRT2563454	hsa-miR-1470	CLIP-seq
MIRT2563455	hsa-miR-18a	CLIP-seq
MIRT2563456	hsa-miR-18b	CLIP-seq
MIRT2563457	hsa-miR-1908	CLIP-seq
MIRT1120522	hsa-miR-193a-3p	CLIP-seq
MIRT1120523	hsa-miR-193b	CLIP-seq
MIRT2684220	hsa-miR-1976	CLIP-seq
MIRT2563458	hsa-miR-208a	CLIP-seq
MIRT2563459	hsa-miR-208b	CLIP-seq
MIRT2563460	hsa-miR-2115	CLIP-seq
MIRT2563461	hsa-miR-2355-5p	CLIP-seq
MIRT2563462	hsa-miR-3121-3p	CLIP-seq
MIRT2563463	hsa-miR-3144-5p	CLIP-seq
MIRT1120527	hsa-miR-3145-5p	CLIP-seq
MIRT2563464	hsa-miR-3150b-3p	CLIP-seq
MIRT2684221	hsa-miR-3155	CLIP-seq
MIRT2684222	hsa-miR-3155b	CLIP-seq
MIRT1120483	hsa-miR-3159	CLIP-seq
MIRT1120529	hsa-miR-3173-5p	CLIP-seq
MIRT2563466	hsa-miR-3191	CLIP-seq
MIRT1120530	hsa-miR-3591-5p	CLIP-seq
MIRT1120486	hsa-miR-3605-5p	CLIP-seq
MIRT2563468	hsa-miR-3613-3p	CLIP-seq
MIRT2563469	hsa-miR-3617	CLIP-seq
MIRT2563470	hsa-miR-3619-3p	CLIP-seq
MIRT1120532	hsa-miR-3620	CLIP-seq
MIRT1120533	hsa-miR-3672	CLIP-seq
MIRT1120487	hsa-miR-3679-5p	CLIP-seq
MIRT1120534	hsa-miR-3680	CLIP-seq
MIRT2563471	hsa-miR-3690	CLIP-seq
MIRT2563472	hsa-miR-378g	CLIP-seq
MIRT2563474	hsa-miR-3974	CLIP-seq
MIRT2563475	hsa-miR-4254	CLIP-seq
MIRT2563476	hsa-miR-4263	CLIP-seq
MIRT1120492	hsa-miR-4303	CLIP-seq
MIRT1120493	hsa-miR-4319	CLIP-seq
MIRT1120538	hsa-miR-4324	CLIP-seq
MIRT1120539	hsa-miR-4329	CLIP-seq
MIRT2563478	hsa-miR-4422	CLIP-seq
MIRT2034130	hsa-miR-4457	CLIP-seq
MIRT1120516	hsa-miR-4462	CLIP-seq
MIRT2563480	hsa-miR-4469	CLIP-seq
MIRT1120495	hsa-miR-4480	CLIP-seq
MIRT2563482	hsa-miR-4509	CLIP-seq
MIRT2264478	hsa-miR-4521	CLIP-seq
MIRT1120497	hsa-miR-4643	CLIP-seq
MIRT1120498	hsa-miR-4649-3p	CLIP-seq
MIRT2563485	hsa-miR-4652-5p	CLIP-seq
MIRT2563486	hsa-miR-4667-3p	CLIP-seq
MIRT2563487	hsa-miR-4691-3p	CLIP-seq
MIRT2563488	hsa-miR-4706	CLIP-seq
MIRT1120544	hsa-miR-4711-3p	CLIP-seq
MIRT1120545	hsa-miR-4715-3p	CLIP-seq
MIRT1120500	hsa-miR-4717-3p	CLIP-seq
MIRT1120501	hsa-miR-4722-3p	CLIP-seq
MIRT2563489	hsa-miR-4733-3p	CLIP-seq
MIRT2563490	hsa-miR-4735-3p	CLIP-seq
MIRT2563491	hsa-miR-4744	CLIP-seq
MIRT2563492	hsa-miR-4749-5p	CLIP-seq
MIRT1120504	hsa-miR-4762-3p	CLIP-seq
MIRT2563493	hsa-miR-4765	CLIP-seq
MIRT2563494	hsa-miR-4776-5p	CLIP-seq
MIRT2563495	hsa-miR-4784	CLIP-seq
MIRT1120506	hsa-miR-4802-3p	CLIP-seq
MIRT2563496	hsa-miR-4802-5p	CLIP-seq
MIRT2684223	hsa-miR-484	CLIP-seq
MIRT2684224	hsa-miR-485-5p	CLIP-seq
MIRT2563497	hsa-miR-491-5p	CLIP-seq
MIRT2563498	hsa-miR-495	CLIP-seq
MIRT2563499	hsa-miR-499-5p	CLIP-seq
MIRT1120547	hsa-miR-511	CLIP-seq
MIRT2034131	hsa-miR-513b	CLIP-seq
MIRT2563500	hsa-miR-524-3p	CLIP-seq
MIRT2563501	hsa-miR-525-3p	CLIP-seq
MIRT2563502	hsa-miR-548ac	CLIP-seq
MIRT2563503	hsa-miR-548ad	CLIP-seq
MIRT2563504	hsa-miR-548d-3p	CLIP-seq
MIRT2563505	hsa-miR-548z	CLIP-seq
MIRT2430853	hsa-miR-570	CLIP-seq
MIRT2563507	hsa-miR-641	CLIP-seq
MIRT1120511	hsa-miR-642b	CLIP-seq
MIRT2563508	hsa-miR-663	CLIP-seq
MIRT1120548	hsa-miR-7	CLIP-seq
MIRT2563510	hsa-miR-765	CLIP-seq
MIRT2563511	hsa-miR-873	CLIP-seq
MIRT1120549	hsa-miR-874	CLIP-seq

Show/Hide all (61)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001678	Process	Intracellular glucose homeostasis	IEA
GO:0001678	Process	Intracellular glucose homeostasis	ISS
GO:0002329	Process	Pre-B cell differentiation	IEA
GO:0002329	Process	Pre-B cell differentiation	ISS
GO:0005225	Function	Volume-sensitive anion channel activity	IBA
GO:0005225	Function	Volume-sensitive anion channel activity	IDA	30095067, 33139539
GO:0005225	Function	Volume-sensitive anion channel activity	IEA
GO:0005225	Function	Volume-sensitive anion channel activity	IMP	26824658, 29769723
GO:0005225	Function	Volume-sensitive anion channel activity	ISS
GO:0005253	Function	Monoatomic anion channel activity	IMP	24725410, 24790029
GO:0005515	Function	Protein binding	IPI	24790029, 28514442, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	33139539
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	24725410, 24790029, 33139539
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006820	Process	Monoatomic anion transport	IMP	24725410, 24790029
GO:0006884	Process	Cell volume homeostasis	IDA	33139539
GO:0006884	Process	Cell volume homeostasis	IMP	24725410, 24790029
GO:0006970	Process	Response to osmotic stress	IEA
GO:0006970	Process	Response to osmotic stress	IMP	24725410, 24790029
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0009986	Component	Cell surface	IDA	14660746
GO:0015711	Process	Organic anion transport	IEA
GO:0015734	Process	Taurine transmembrane transport	IEA
GO:0015810	Process	Aspartate transmembrane transport	IBA
GO:0015810	Process	Aspartate transmembrane transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IDA	30095067
GO:0016020	Component	Membrane	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0032024	Process	Positive regulation of insulin secretion	IEA
GO:0032024	Process	Positive regulation of insulin secretion	ISS
GO:0034214	Process	Protein hexamerization	IDA	30095067
GO:0034214	Process	Protein hexamerization	IEA
GO:0034214	Process	Protein hexamerization	ISS
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IBA
GO:0034702	Component	Monoatomic ion channel complex	IDA	24790029
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	24790029, 30095067, 30127360
GO:0045663	Process	Positive regulation of myoblast differentiation	IEA
GO:0045663	Process	Positive regulation of myoblast differentiation	ISS
GO:0098656	Process	Monoatomic anion transmembrane transport	IBA
GO:0098656	Process	Monoatomic anion transmembrane transport	IDA	30095067
GO:0098656	Process	Monoatomic anion transmembrane transport	IEA
GO:0098656	Process	Monoatomic anion transmembrane transport	IMP	29769723
GO:0098656	Process	Monoatomic anion transmembrane transport	ISS
GO:0140360	Function	Cyclic-GMP-AMP transmembrane transporter activity	IDA	33171122
GO:0140360	Function	Cyclic-GMP-AMP transmembrane transporter activity	IEA
GO:0140361	Process	Cyclic-GMP-AMP transmembrane import across plasma membrane	IBA
GO:0140361	Process	Cyclic-GMP-AMP transmembrane import across plasma membrane	IDA	33171122
GO:0140361	Process	Cyclic-GMP-AMP transmembrane import across plasma membrane	IEA
GO:1902476	Process	Chloride transmembrane transport	IDA	30095067

MIM	HGNC	e!Ensembl
608360	19027	ENSG00000136802

Q8IWT6

Protein name

Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1)

Protein function

Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubMed:24790

PDB

5ZSU , 6DJB , 7XZH , 8DXN , 8DXO , 8DXP , 8DXQ , 8DXR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12534	Pannexin_like	1 → 340	Pannexin-like TM region of LRRC8	Family
PF13855	LRR_8	591 → 651	Leucine rich repeat	Repeat
PF13855	LRR_8	659 → 706	Leucine rich repeat	Repeat
PF13855	LRR_8	708 → 766	Leucine rich repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain, kidney, ovary, lung, liver, heart, and fetal brain and liver. Found at high levels in bone marrow; lower levels are detected in peripheral blood cells. Expressed on T-cells as well as on B-lineage cells. {ECO:000026

Sequence

MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV
TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW
FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE
SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA
KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIE
SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES
SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL
TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA
AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL
RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR
CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN
LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI
ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK
RSGLVVEEDLFNTLPPEVKERLWRADKEQA

Sequence length

810

Interactions

View interactions

	Reactome
			Miscellaneous transport and binding events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AGAMMAGLOBULINEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Agammaglobulinemia 5, autosomal dominant	Uncertain significance; Benign; Likely benign; Conflicting classifications of pathogenicity	ClinVar GWAS catalog	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
AUTOSOMAL AGAMMAGLOBULINEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOSOMAL NON-SYNDROMIC AGAMMAGLOBULINEMIA	—	Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LRRC8A-related disorder	Likely benign; Benign; Uncertain significance; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (47)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Agammaglobulinemia	Agammaglobulinemia	BEFREE	14660746, 28192143		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Agammaglobulinemia	Agammaglobulinemia	Pubtator	14660746	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Agammaglobulinemia	Agammaglobulinemia	HPO_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Agammaglobulinemia	Agammaglobulinemia	CTD_human_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Agammaglobulinemia	Agammaglobulinemia	GENOMICS_ENGLAND_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AGAMMAGLOBULINEMIA 5, AUTOSOMAL DOMINANT	Agammaglobulinemia	GENOMICS_ENGLAND_DG			★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Agammaglobulinemia, non-Bruton type	Agammaglobulinemia	ORPHANET_DG	14660746		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	33932953	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autosomal agammaglobulinemia	Agammaglobulinemia	Orphanet			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bronchiectasis	Bronchiectasis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Bruton type agammaglobulinemia	Bruton type agammaglobulinemia	Pubtator	14660738, 15094057	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Byzanthine arch palate	High palate	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	36632452	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31597595	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	30982627, 31127489		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic otitis media	Otitis media	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	30015914		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital Epicanthus	Congenital Epicanthus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Conjunctivitis	Conjunctivitis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Eosinophilic Esophagitis	Eosinophilia	Pubtator	37439560	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	37410995	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	30015914		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	31323188	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	BEFREE	30931966		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	Pubtator	30931966	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	29868469		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	29868469		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	30426452		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypogammaglobulinemia	Hypogammaglobulinemia	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	GWASCAT_DG	30595370		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	30982627		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31597595		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malabsorption Syndrome	Malabsorption Syndrome	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	30015914		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30015914, 31181821		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	30015914		★★★★★ ★☆☆☆☆ Found in Text Mining only
MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS	Megalencephalic Leukoencephalopathy With Subcortical Cysts	BEFREE	30076890		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31323188		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	28436964, 28873008, 31112068		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteomyelitis	Osteomyelitis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	Pubtator	33932953	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sinusitis	Sinusitis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	31323188		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	36632452	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

LRRC8A (leucine rich repeat containing 8 VRAC subunit A)