TMX4 (thioredoxin related transmembrane protein 4)

Gene

• Entrez ID: 56255
• Gene name: Thioredoxin related transmembrane protein 4
• Gene symbol: TMX4
• Synonyms (NCBI Gene): DJ971N18.2, PDIA14, TXNDC13
• Chromosome: 20
• Chromosome location: 20p12.3
• Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically ac

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029647	hsa-miR-26b-5p	Microarray	19088304
MIRT030889	hsa-miR-21-5p	Microarray	18591254
MIRT050532	hsa-miR-20a-5p	CLASH	23622248
MIRT048092	hsa-miR-197-3p	CLASH	23622248
MIRT042945	hsa-miR-324-3p	CLASH	23622248
MIRT665708	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT665707	hsa-miR-924	HITS-CLIP	23824327
MIRT665706	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT665705	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT665704	hsa-miR-627-5p	HITS-CLIP	23824327
MIRT665703	hsa-miR-8081	HITS-CLIP	23824327
MIRT665702	hsa-miR-8055	HITS-CLIP	23824327
MIRT650323	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT650322	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT650321	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT650320	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT650319	hsa-miR-4469	HITS-CLIP	23824327
MIRT650317	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT650318	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT650316	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT650315	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT650314	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT650313	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT650312	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT442603	hsa-miR-190a-3p	PAR-CLIP	22100165
MIRT665708	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT665707	hsa-miR-924	HITS-CLIP	23824327
MIRT665706	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT665705	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT665704	hsa-miR-627-5p	HITS-CLIP	23824327
MIRT665703	hsa-miR-8081	HITS-CLIP	23824327
MIRT665702	hsa-miR-8055	HITS-CLIP	23824327
MIRT650323	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT650322	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT650321	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT650320	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT650319	hsa-miR-4469	HITS-CLIP	23824327
MIRT650317	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT650318	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT650316	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT650315	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT650314	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT650313	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT650312	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT442603	hsa-miR-190a-3p	PAR-CLIP	22100165
MIRT1441984	hsa-miR-101	CLIP-seq
MIRT1441985	hsa-miR-1225-5p	CLIP-seq
MIRT1441986	hsa-miR-1228	CLIP-seq
MIRT1441987	hsa-miR-1243	CLIP-seq
MIRT1441988	hsa-miR-1271	CLIP-seq
MIRT1441989	hsa-miR-1284	CLIP-seq
MIRT1441990	hsa-miR-144	CLIP-seq
MIRT1441991	hsa-miR-182	CLIP-seq
MIRT1441992	hsa-miR-219-5p	CLIP-seq
MIRT1441993	hsa-miR-3117-3p	CLIP-seq
MIRT1441994	hsa-miR-3127-5p	CLIP-seq
MIRT1441995	hsa-miR-3160-3p	CLIP-seq
MIRT1441996	hsa-miR-3169	CLIP-seq
MIRT1441997	hsa-miR-34a	CLIP-seq
MIRT1441998	hsa-miR-34c-5p	CLIP-seq
MIRT1441999	hsa-miR-3646	CLIP-seq
MIRT1442000	hsa-miR-3654	CLIP-seq
MIRT1442001	hsa-miR-3663-5p	CLIP-seq
MIRT1442002	hsa-miR-3920	CLIP-seq
MIRT1442003	hsa-miR-3921	CLIP-seq
MIRT1442004	hsa-miR-3922-5p	CLIP-seq
MIRT1442005	hsa-miR-409-5p	CLIP-seq
MIRT1442006	hsa-miR-4256	CLIP-seq
MIRT1442007	hsa-miR-4257	CLIP-seq
MIRT1442008	hsa-miR-4292	CLIP-seq
MIRT1442009	hsa-miR-4303	CLIP-seq
MIRT1442010	hsa-miR-4308	CLIP-seq
MIRT1442011	hsa-miR-4432	CLIP-seq
MIRT1442012	hsa-miR-4445	CLIP-seq
MIRT1442013	hsa-miR-4446-3p	CLIP-seq
MIRT1442014	hsa-miR-4487	CLIP-seq
MIRT1442015	hsa-miR-4492	CLIP-seq
MIRT1442016	hsa-miR-4498	CLIP-seq
MIRT1442017	hsa-miR-449a	CLIP-seq
MIRT1442018	hsa-miR-449b	CLIP-seq
MIRT1442019	hsa-miR-4505	CLIP-seq
MIRT1442020	hsa-miR-4515	CLIP-seq
MIRT1442021	hsa-miR-4646-5p	CLIP-seq
MIRT1442022	hsa-miR-4653-3p	CLIP-seq
MIRT1442023	hsa-miR-4653-5p	CLIP-seq
MIRT1442024	hsa-miR-4704-3p	CLIP-seq
MIRT1442025	hsa-miR-4721	CLIP-seq
MIRT1442026	hsa-miR-4757-5p	CLIP-seq
MIRT1442027	hsa-miR-4759	CLIP-seq
MIRT1442028	hsa-miR-4768-3p	CLIP-seq
MIRT1442029	hsa-miR-4782-3p	CLIP-seq
MIRT1442030	hsa-miR-496	CLIP-seq
MIRT1442031	hsa-miR-508-3p	CLIP-seq
MIRT1442032	hsa-miR-558	CLIP-seq
MIRT1442033	hsa-miR-582-5p	CLIP-seq
MIRT1442034	hsa-miR-584	CLIP-seq
MIRT1442035	hsa-miR-600	CLIP-seq
MIRT1442036	hsa-miR-617	CLIP-seq
MIRT1442037	hsa-miR-619	CLIP-seq
MIRT1442038	hsa-miR-7	CLIP-seq
MIRT1442039	hsa-miR-762	CLIP-seq
MIRT1442040	hsa-miR-936	CLIP-seq
MIRT1442041	hsa-miR-96	CLIP-seq
MIRT2132307	hsa-miR-1184	CLIP-seq
MIRT1441988	hsa-miR-1271	CLIP-seq
MIRT2132308	hsa-miR-1273f	CLIP-seq
MIRT2132309	hsa-miR-143	CLIP-seq
MIRT1441990	hsa-miR-144	CLIP-seq
MIRT1441991	hsa-miR-182	CLIP-seq
MIRT1441997	hsa-miR-34a	CLIP-seq
MIRT1441998	hsa-miR-34c-5p	CLIP-seq
MIRT1442006	hsa-miR-4256	CLIP-seq
MIRT1442007	hsa-miR-4257	CLIP-seq
MIRT2132310	hsa-miR-4272	CLIP-seq
MIRT1442013	hsa-miR-4446-3p	CLIP-seq
MIRT1442015	hsa-miR-4492	CLIP-seq
MIRT1442016	hsa-miR-4498	CLIP-seq
MIRT1442017	hsa-miR-449a	CLIP-seq
MIRT1442018	hsa-miR-449b	CLIP-seq
MIRT1442019	hsa-miR-4505	CLIP-seq
MIRT1442024	hsa-miR-4704-3p	CLIP-seq
MIRT2132311	hsa-miR-4708-5p	CLIP-seq
MIRT1442025	hsa-miR-4721	CLIP-seq
MIRT2132312	hsa-miR-4770	CLIP-seq
MIRT2132313	hsa-miR-570	CLIP-seq
MIRT2132314	hsa-miR-579	CLIP-seq
MIRT1442036	hsa-miR-617	CLIP-seq
MIRT1442039	hsa-miR-762	CLIP-seq
MIRT1442041	hsa-miR-96	CLIP-seq
MIRT2353335	hsa-miR-1244	CLIP-seq
MIRT2353336	hsa-miR-149	CLIP-seq
MIRT2353337	hsa-miR-3064-5p	CLIP-seq
MIRT1442003	hsa-miR-3921	CLIP-seq
MIRT2353338	hsa-miR-4477a	CLIP-seq
MIRT2353339	hsa-miR-4502	CLIP-seq
MIRT1442023	hsa-miR-4653-5p	CLIP-seq
MIRT2353340	hsa-miR-4701-5p	CLIP-seq
MIRT2353341	hsa-miR-4794	CLIP-seq
MIRT2353342	hsa-miR-4795-3p	CLIP-seq
MIRT2353343	hsa-miR-548a-5p	CLIP-seq
MIRT2353344	hsa-miR-548ab	CLIP-seq
MIRT2353345	hsa-miR-548ak	CLIP-seq
MIRT2353346	hsa-miR-548b-5p	CLIP-seq
MIRT2353347	hsa-miR-548c-5p	CLIP-seq
MIRT2353348	hsa-miR-548d-5p	CLIP-seq
MIRT2353349	hsa-miR-548h	CLIP-seq
MIRT2353350	hsa-miR-548i	CLIP-seq
MIRT2353351	hsa-miR-548j	CLIP-seq
MIRT2353352	hsa-miR-548k	CLIP-seq
MIRT2353353	hsa-miR-548l	CLIP-seq
MIRT2353354	hsa-miR-548w	CLIP-seq
MIRT2353355	hsa-miR-548y	CLIP-seq
MIRT2353356	hsa-miR-559	CLIP-seq
MIRT2353357	hsa-miR-588	CLIP-seq
MIRT2353358	hsa-miR-593	CLIP-seq
MIRT2353359	hsa-miR-627	CLIP-seq
MIRT1442007	hsa-miR-4257	CLIP-seq
MIRT1442013	hsa-miR-4446-3p	CLIP-seq
MIRT1442015	hsa-miR-4492	CLIP-seq
MIRT1442016	hsa-miR-4498	CLIP-seq
MIRT1442019	hsa-miR-4505	CLIP-seq
MIRT1442025	hsa-miR-4721	CLIP-seq
MIRT1442036	hsa-miR-617	CLIP-seq
MIRT1442039	hsa-miR-762	CLIP-seq
MIRT2647185	hsa-miR-1178	CLIP-seq
MIRT2647186	hsa-miR-1205	CLIP-seq
MIRT1441986	hsa-miR-1228	CLIP-seq
MIRT2647187	hsa-miR-1263	CLIP-seq
MIRT2647188	hsa-miR-1279	CLIP-seq
MIRT2647189	hsa-miR-137	CLIP-seq
MIRT2353336	hsa-miR-149	CLIP-seq
MIRT2647190	hsa-miR-1972	CLIP-seq
MIRT2647191	hsa-miR-2052	CLIP-seq
MIRT1441992	hsa-miR-219-5p	CLIP-seq
MIRT2647192	hsa-miR-2467-5p	CLIP-seq
MIRT2353337	hsa-miR-3064-5p	CLIP-seq
MIRT2647193	hsa-miR-3065-5p	CLIP-seq
MIRT2647194	hsa-miR-31	CLIP-seq
MIRT2647195	hsa-miR-3120-5p	CLIP-seq
MIRT2647196	hsa-miR-3125	CLIP-seq
MIRT2647197	hsa-miR-3148	CLIP-seq
MIRT2647198	hsa-miR-3188	CLIP-seq
MIRT1441999	hsa-miR-3646	CLIP-seq
MIRT2647199	hsa-miR-3650	CLIP-seq
MIRT2647200	hsa-miR-3658	CLIP-seq
MIRT2647201	hsa-miR-3916	CLIP-seq
MIRT2647202	hsa-miR-3926	CLIP-seq
MIRT2647203	hsa-miR-3975	CLIP-seq
MIRT2647204	hsa-miR-431	CLIP-seq
MIRT2647205	hsa-miR-4418	CLIP-seq
MIRT1442011	hsa-miR-4432	CLIP-seq
MIRT1442012	hsa-miR-4445	CLIP-seq
MIRT2647206	hsa-miR-4477b	CLIP-seq
MIRT2647207	hsa-miR-4520a-3p	CLIP-seq
MIRT2647208	hsa-miR-4520b-3p	CLIP-seq
MIRT2647209	hsa-miR-4529-3p	CLIP-seq
MIRT2647210	hsa-miR-4635	CLIP-seq
MIRT2647211	hsa-miR-4659a-5p	CLIP-seq
MIRT2647212	hsa-miR-4659b-5p	CLIP-seq
MIRT2647213	hsa-miR-4668-3p	CLIP-seq
MIRT2647214	hsa-miR-4696	CLIP-seq
MIRT2647215	hsa-miR-4733-5p	CLIP-seq
MIRT2647216	hsa-miR-4769-3p	CLIP-seq
MIRT1442029	hsa-miR-4782-3p	CLIP-seq
MIRT2647217	hsa-miR-4786-5p	CLIP-seq
MIRT2353341	hsa-miR-4794	CLIP-seq
MIRT2647218	hsa-miR-485-5p	CLIP-seq
MIRT1442031	hsa-miR-508-3p	CLIP-seq
MIRT2647219	hsa-miR-509-3-5p	CLIP-seq
MIRT2647220	hsa-miR-509-5p	CLIP-seq
MIRT2647221	hsa-miR-515-5p	CLIP-seq
MIRT2647222	hsa-miR-526b	CLIP-seq
MIRT2647223	hsa-miR-548c-3p	CLIP-seq
MIRT2132313	hsa-miR-570	CLIP-seq
MIRT1442037	hsa-miR-619	CLIP-seq
MIRT2647224	hsa-miR-630	CLIP-seq
MIRT2647225	hsa-miR-643	CLIP-seq
MIRT1442038	hsa-miR-7	CLIP-seq
MIRT2647226	hsa-miR-769-5p	CLIP-seq
MIRT2647227	hsa-miR-873	CLIP-seq
MIRT2647228	hsa-miR-877	CLIP-seq
MIRT2647185	hsa-miR-1178	CLIP-seq
MIRT2647186	hsa-miR-1205	CLIP-seq
MIRT2693626	hsa-miR-1206	CLIP-seq
MIRT1441986	hsa-miR-1228	CLIP-seq
MIRT2647187	hsa-miR-1263	CLIP-seq
MIRT2647188	hsa-miR-1279	CLIP-seq
MIRT2693627	hsa-miR-1289	CLIP-seq
MIRT2647189	hsa-miR-137	CLIP-seq
MIRT2353336	hsa-miR-149	CLIP-seq
MIRT2647190	hsa-miR-1972	CLIP-seq
MIRT2647191	hsa-miR-2052	CLIP-seq
MIRT2647192	hsa-miR-2467-5p	CLIP-seq
MIRT2353337	hsa-miR-3064-5p	CLIP-seq
MIRT2647193	hsa-miR-3065-5p	CLIP-seq
MIRT2693628	hsa-miR-30a	CLIP-seq
MIRT2693629	hsa-miR-30b	CLIP-seq
MIRT2693630	hsa-miR-30c	CLIP-seq
MIRT2693631	hsa-miR-30d	CLIP-seq
MIRT2693632	hsa-miR-30e	CLIP-seq
MIRT2647194	hsa-miR-31	CLIP-seq
MIRT2647195	hsa-miR-3120-5p	CLIP-seq
MIRT2647196	hsa-miR-3125	CLIP-seq
MIRT2647197	hsa-miR-3148	CLIP-seq
MIRT2647198	hsa-miR-3188	CLIP-seq
MIRT2693633	hsa-miR-3198	CLIP-seq
MIRT1441999	hsa-miR-3646	CLIP-seq
MIRT2647199	hsa-miR-3650	CLIP-seq
MIRT2647200	hsa-miR-3658	CLIP-seq
MIRT2693634	hsa-miR-3909	CLIP-seq
MIRT2693635	hsa-miR-3912	CLIP-seq
MIRT2647201	hsa-miR-3916	CLIP-seq
MIRT2647202	hsa-miR-3926	CLIP-seq
MIRT2647203	hsa-miR-3975	CLIP-seq
MIRT1442006	hsa-miR-4256	CLIP-seq
MIRT2693636	hsa-miR-4294	CLIP-seq
MIRT2693637	hsa-miR-4309	CLIP-seq
MIRT2647204	hsa-miR-431	CLIP-seq
MIRT2647205	hsa-miR-4418	CLIP-seq
MIRT1442011	hsa-miR-4432	CLIP-seq
MIRT2647206	hsa-miR-4477b	CLIP-seq
MIRT2693638	hsa-miR-4495	CLIP-seq
MIRT2647207	hsa-miR-4520a-3p	CLIP-seq
MIRT2647208	hsa-miR-4520b-3p	CLIP-seq
MIRT2647209	hsa-miR-4529-3p	CLIP-seq
MIRT2647210	hsa-miR-4635	CLIP-seq
MIRT2647211	hsa-miR-4659a-5p	CLIP-seq
MIRT2647212	hsa-miR-4659b-5p	CLIP-seq
MIRT2647213	hsa-miR-4668-3p	CLIP-seq
MIRT2693639	hsa-miR-4687-3p	CLIP-seq
MIRT2647214	hsa-miR-4696	CLIP-seq
MIRT2647215	hsa-miR-4733-5p	CLIP-seq
MIRT2647216	hsa-miR-4769-3p	CLIP-seq
MIRT2647217	hsa-miR-4786-5p	CLIP-seq
MIRT2353341	hsa-miR-4794	CLIP-seq
MIRT2647218	hsa-miR-485-5p	CLIP-seq
MIRT2693640	hsa-miR-490-3p	CLIP-seq
MIRT2693641	hsa-miR-500a	CLIP-seq
MIRT2647219	hsa-miR-509-3-5p	CLIP-seq
MIRT2647220	hsa-miR-509-5p	CLIP-seq
MIRT2647221	hsa-miR-515-5p	CLIP-seq
MIRT2647222	hsa-miR-526b	CLIP-seq
MIRT2647223	hsa-miR-548c-3p	CLIP-seq
MIRT2132313	hsa-miR-570	CLIP-seq
MIRT1442037	hsa-miR-619	CLIP-seq
MIRT2647224	hsa-miR-630	CLIP-seq
MIRT2693642	hsa-miR-633	CLIP-seq
MIRT2647225	hsa-miR-643	CLIP-seq
MIRT1442038	hsa-miR-7	CLIP-seq
MIRT2647226	hsa-miR-769-5p	CLIP-seq
MIRT2647227	hsa-miR-873	CLIP-seq
MIRT2647228	hsa-miR-877	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IEA
GO:0005637	Component	Nuclear inner membrane	IEA
GO:0005637	Component	Nuclear inner membrane	ISS
GO:0005783	Component	Endoplasmic reticulum	IDA	22045338
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0012505	Component	Endomembrane system	IBA
GO:0015036	Function	Disulfide oxidoreductase activity	IBA
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 616766
• HGNC: 25237
• e!Ensembl: ENSG00000125827

Protein

• UniProt ID: Q9H1E5
• Protein name: Thioredoxin-related transmembrane protein 4 (Thioredoxin domain-containing protein 13)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00085	Thioredoxin	38 → 137	Thioredoxin	Domain

• Sequence:

  MAGGRCGPQLTALLAAWIAAVAATAGPEEAALPPEQSRVQPMTASNWTLVMEGEWMLKFY
  APWCPSCQQTDSEWEAFAKNGEILQISVGKVDVIQEPGLSGRFFVTTLPAFFHAKDGIFR
  RYRGPGIFEDLQNYILEKKWQSVEPLTGWKSPASLTMSGMAGLFSISGKIWHLHNYFTVT
  LGIPAWCSYVFFVIATLVFGLFMGLVLVVISECFYVPLPRHLSERSEQNRRSEEAHRAEQ
  LQDAEEEKDDSNEEENKDSLVDDEEEKEDLGDEDEAEEEEEEDNLAAGVDEERSEANDQG
  PPGEDGVTREEVEPEEAEEGISEQPCPADTEVVEDSLRQRKSQHADKGL

• Sequence length: 349

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations