Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	56252
Gene name	YLP motif containing 1
Gene symbol	YLPM1
Synonyms (NCBI Gene)	C14orf170PPP1R169ZAP113ZAP3
Chromosome	14
Chromosome location	14q24.3

135

Show/Hide all (135)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052085	hsa-let-7b-5p	CLASH	23622248
MIRT046757	hsa-miR-222-3p	CLASH	23622248
MIRT1499080	hsa-miR-1245b-5p	CLIP-seq
MIRT1499081	hsa-miR-1272	CLIP-seq
MIRT1499082	hsa-miR-146a	CLIP-seq
MIRT1499083	hsa-miR-146b-5p	CLIP-seq
MIRT1499084	hsa-miR-2110	CLIP-seq
MIRT1499085	hsa-miR-216a	CLIP-seq
MIRT1499086	hsa-miR-2681	CLIP-seq
MIRT1499087	hsa-miR-3125	CLIP-seq
MIRT1499088	hsa-miR-3142	CLIP-seq
MIRT1499089	hsa-miR-3144-5p	CLIP-seq
MIRT1499090	hsa-miR-3150a-3p	CLIP-seq
MIRT1499091	hsa-miR-3191	CLIP-seq
MIRT1499092	hsa-miR-330-3p	CLIP-seq
MIRT1499093	hsa-miR-3613-3p	CLIP-seq
MIRT1499094	hsa-miR-3651	CLIP-seq
MIRT1499095	hsa-miR-3682-3p	CLIP-seq
MIRT1499096	hsa-miR-3908	CLIP-seq
MIRT1499097	hsa-miR-3916	CLIP-seq
MIRT1499098	hsa-miR-3976	CLIP-seq
MIRT1499099	hsa-miR-4282	CLIP-seq
MIRT1499100	hsa-miR-4434	CLIP-seq
MIRT1499101	hsa-miR-4504	CLIP-seq
MIRT1499102	hsa-miR-4516	CLIP-seq
MIRT1499103	hsa-miR-4531	CLIP-seq
MIRT1499104	hsa-miR-4641	CLIP-seq
MIRT1499105	hsa-miR-4652-5p	CLIP-seq
MIRT1499106	hsa-miR-4666-5p	CLIP-seq
MIRT1499107	hsa-miR-4677-3p	CLIP-seq
MIRT1499108	hsa-miR-4679	CLIP-seq
MIRT1499109	hsa-miR-4691-3p	CLIP-seq
MIRT1499110	hsa-miR-4718	CLIP-seq
MIRT1499111	hsa-miR-542-3p	CLIP-seq
MIRT1499112	hsa-miR-548m	CLIP-seq
MIRT1499113	hsa-miR-561	CLIP-seq
MIRT1499114	hsa-miR-635	CLIP-seq
MIRT1499115	hsa-miR-759	CLIP-seq
MIRT1499116	hsa-miR-877	CLIP-seq
MIRT1499080	hsa-miR-1245b-5p	CLIP-seq
MIRT2150275	hsa-miR-1470	CLIP-seq
MIRT2150276	hsa-miR-204	CLIP-seq
MIRT2150277	hsa-miR-211	CLIP-seq
MIRT2150278	hsa-miR-2114	CLIP-seq
MIRT2150279	hsa-miR-214	CLIP-seq
MIRT1499087	hsa-miR-3125	CLIP-seq
MIRT1499088	hsa-miR-3142	CLIP-seq
MIRT2150280	hsa-miR-3163	CLIP-seq
MIRT1499092	hsa-miR-330-3p	CLIP-seq
MIRT2150281	hsa-miR-338-3p	CLIP-seq
MIRT2150282	hsa-miR-34c-3p	CLIP-seq
MIRT2150283	hsa-miR-3619-5p	CLIP-seq
MIRT2150284	hsa-miR-3673	CLIP-seq
MIRT1499097	hsa-miR-3916	CLIP-seq
MIRT1499098	hsa-miR-3976	CLIP-seq
MIRT2150285	hsa-miR-4291	CLIP-seq
MIRT2150286	hsa-miR-4469	CLIP-seq
MIRT2150287	hsa-miR-4530	CLIP-seq
MIRT2150288	hsa-miR-4652-3p	CLIP-seq
MIRT2150289	hsa-miR-4667-3p	CLIP-seq
MIRT2150290	hsa-miR-4691-5p	CLIP-seq
MIRT2150291	hsa-miR-483-3p	CLIP-seq
MIRT2150292	hsa-miR-642b	CLIP-seq
MIRT2150293	hsa-miR-761	CLIP-seq
MIRT2150294	hsa-miR-765	CLIP-seq
MIRT2150295	hsa-miR-766	CLIP-seq
MIRT1499116	hsa-miR-877	CLIP-seq
MIRT2150296	hsa-miR-922	CLIP-seq
MIRT2370576	hsa-miR-101	CLIP-seq
MIRT1499080	hsa-miR-1245b-5p	CLIP-seq
MIRT2370577	hsa-miR-144	CLIP-seq
MIRT2150275	hsa-miR-1470	CLIP-seq
MIRT2370578	hsa-miR-224	CLIP-seq
MIRT2370579	hsa-miR-298	CLIP-seq
MIRT2370580	hsa-miR-3120-5p	CLIP-seq
MIRT2370581	hsa-miR-3127-5p	CLIP-seq
MIRT1499088	hsa-miR-3142	CLIP-seq
MIRT1499092	hsa-miR-330-3p	CLIP-seq
MIRT2150282	hsa-miR-34c-3p	CLIP-seq
MIRT2370582	hsa-miR-3614-5p	CLIP-seq
MIRT2370583	hsa-miR-3618	CLIP-seq
MIRT2370584	hsa-miR-382	CLIP-seq
MIRT2370585	hsa-miR-3942-3p	CLIP-seq
MIRT2370586	hsa-miR-4270	CLIP-seq
MIRT2370587	hsa-miR-4277	CLIP-seq
MIRT2370588	hsa-miR-4441	CLIP-seq
MIRT2150286	hsa-miR-4469	CLIP-seq
MIRT2150289	hsa-miR-4667-3p	CLIP-seq
MIRT2370589	hsa-miR-4720-3p	CLIP-seq
MIRT2370590	hsa-miR-4804-3p	CLIP-seq
MIRT2150291	hsa-miR-483-3p	CLIP-seq
MIRT2370591	hsa-miR-548c-3p	CLIP-seq
MIRT2370592	hsa-miR-548k	CLIP-seq
MIRT2370593	hsa-miR-548n	CLIP-seq
MIRT2370594	hsa-miR-548t	CLIP-seq
MIRT2370595	hsa-miR-577	CLIP-seq
MIRT2150292	hsa-miR-642b	CLIP-seq
MIRT2370596	hsa-miR-934	CLIP-seq
MIRT2370597	hsa-miR-935	CLIP-seq
MIRT1499080	hsa-miR-1245b-5p	CLIP-seq
MIRT1499088	hsa-miR-3142	CLIP-seq
MIRT1499092	hsa-miR-330-3p	CLIP-seq
MIRT2150292	hsa-miR-642b	CLIP-seq
MIRT2463688	hsa-miR-31	CLIP-seq
MIRT2463689	hsa-miR-3660	CLIP-seq
MIRT2463690	hsa-miR-4438	CLIP-seq
MIRT2463691	hsa-miR-4511	CLIP-seq
MIRT2463692	hsa-miR-4526	CLIP-seq
MIRT2463693	hsa-miR-570	CLIP-seq
MIRT1499080	hsa-miR-1245b-5p	CLIP-seq
MIRT2664273	hsa-miR-1267	CLIP-seq
MIRT2150279	hsa-miR-214	CLIP-seq
MIRT1499087	hsa-miR-3125	CLIP-seq
MIRT1499088	hsa-miR-3142	CLIP-seq
MIRT1499092	hsa-miR-330-3p	CLIP-seq
MIRT2150281	hsa-miR-338-3p	CLIP-seq
MIRT2150283	hsa-miR-3619-5p	CLIP-seq
MIRT2150284	hsa-miR-3673	CLIP-seq
MIRT1499097	hsa-miR-3916	CLIP-seq
MIRT2150285	hsa-miR-4291	CLIP-seq
MIRT2150287	hsa-miR-4530	CLIP-seq
MIRT2150290	hsa-miR-4691-5p	CLIP-seq
MIRT2150292	hsa-miR-642b	CLIP-seq
MIRT2150293	hsa-miR-761	CLIP-seq
MIRT2150294	hsa-miR-765	CLIP-seq
MIRT2150295	hsa-miR-766	CLIP-seq
MIRT1499116	hsa-miR-877	CLIP-seq
MIRT2150296	hsa-miR-922	CLIP-seq
MIRT1499080	hsa-miR-1245b-5p	CLIP-seq
MIRT1499087	hsa-miR-3125	CLIP-seq
MIRT1499088	hsa-miR-3142	CLIP-seq
MIRT1499092	hsa-miR-330-3p	CLIP-seq
MIRT1499097	hsa-miR-3916	CLIP-seq
MIRT2150292	hsa-miR-642b	CLIP-seq
MIRT1499116	hsa-miR-877	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	21078624, 22321011, 28330616, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	17890166
GO:0005634	Component	Nucleus	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0016607	Component	Nuclear speck	IEA
GO:0032204	Process	Regulation of telomere maintenance	IBA

MIM	HGNC	e!Ensembl
619766	17798	ENSG00000119596

P49750

Protein name

YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113)

Protein function

Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13671	AAA_33	1836 → 1996		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in neuronal, neuroblastoma and embryonic kidney cell lines (at protein level). {ECO:0000269|PubMed:17890166}.

Sequence

MYPNWGRYGGSSHYPPPPVPPPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQ
LQQLQQMHQKQMQCVLQPHHLPPPPLPPPPVMPGGGYGDWQPPPPPMPPPPGPALSYQKQ
QQYKHQMLHHQRDGPPGLVPMELESPPESPPVPPGSYMPPSQSYMPPPQPPPSYYPPTSS
QPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYLSHSQSYLPSSQASPSRPSQGHS
KSQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSTEQQQAAPEPDPSTMTPQEQQQYWYRQ
HLLSLQQRTKVHLPGHKKGPVVAKDTPEPVKEEVTVPATSQVPESPSSEEPPLPPPNEEV
PPPLPPEEPQSEDPEEDARLKQLQAAAAHWQQHQQHRVGFQYQGIMQKHTQLQQILQQYQ
QIIQPPPHIQTMSVDMQLRHYEMQQQQFQHLYQEWEREFQLWEEQLHSYPHKDQLQEYEK
QWKTWQGHMKATQSYLQEKVNSFQNMKNQYMGNMSMPPPFVPYSQMPPPLPTMPPPVLPP
SLPPPVMPPALPATVPPPGMPPPVMPPSLPTSVPPPGMPPSLSSAGPPPVLPPPSLSSAG
PPPVLPPPSLSSTAPPPVMPLPPLSSATPPPGIPPPGVPQGIPPQLTAAPVPPASSSQSS
QVPEKPRPALLPTPVSFGSAPPTTYHPPLQSAGPSEQVNSKAPLSKSALPYSSFSSDQGL
GESSAAPSQPITAVKDMPVRSGGLLPDPPRSSYLESPRGPRFDGPRRFEDLGSRCEGPRP
KGPRFEGNRPDGPRPRYEGHPAEGTKSKWGMIPRGPASQFYITPSTSLSPRQSGPQWKGP
KPAFGQQHQQQPKSQAEPLSGNKEPLADTSSNQQKNFKMQSAAFSIAADVKDVKAAQSNE
NLSDSQQEPPKSEVSEGPVEPSNWDQNVQSMETQIDKAQAVTQPVPLANKPVPAQSTFPS
KTGGMEGGTAVATSSLTADNDFKPVGIGLPHSENNQDKGLPRPDNRDNRLEGNRGNSSSY
RGPGQSRMEDTRDKGLVNRGRGQAISRGPGLVKQEDFRDKMMGRREDSREKMNRGEGSRD
RGLVRPGSSREKVPGGLQGSQDRGAAGSRERGPPRRAGSQERGPLRRAGSRERIPPRRAG
SRERGPPRGPGSRERGLGRSDFGRDRGPFRPEPGDGGEKMYPYHRDEPPRAPWNHGEERG
HEEFPLDGRNAPMERERLDDWDRERYWRECERDYQDDTLELYNREDRFSAPPSRSHDGDR
RGPWWDDWERDQDMDEDYNREMERDMDRDVDRISRPMDMYDRSLDNEWDRDYGRPLDEQE
SQFRERDIPSLPPLPPLPPLPPLDRYRDDRWREERNREHGYDRDFRDRGELRIREYPERG
DTWREKRDYVPDRMDWERERLSDRWYPSDVDRHSPMAEHMPSSHHSSEMMGSDASLDSDQ
GLGGVMVLSQRQHEIILKAAQELKMLREQKEQLQKMKDFGSEPQMADHLPPQESRLQNTS
SRPGMYPPPGSYRPPPPMGKPPGSIVRPSAPPARSSVPVTRPPVPIPPPPPPPPLPPPPP
VIKPQTSAVEQERWDEDSFYGLWDTNDEQGLNSEFKSETAAIPSAPVLPPPPVHSSIPPP
GPVPMGMPPMSKPPPVQQTVDYGHGRDISTNKVEQIPYGERITLRPDPLPERSTFETEHA
GQRDRYDRERDREPYFDRQSNVIADHRDFKRDRETHRDRDRDRGVIDYDRDRFDRERRPR
DDRAQSYRDKKDHSSSRRGGFDRPSYDRKSDRPVYEGPSMFGGERRTYPEERMPLPAPSL
SHQPPPAPRVEKKPESKNVDDILKPPGRESRPERIVVIMRGLPGSGKTHVAKLIRDKEVE
FGGPAPRVLSLDDYFITEVEKEEKDPDSGKKVKKKVMEYEYEAEMEETYRTSMFKTFKKT
LDDGFFPFIILDAINDRVRHFDQFWSAAKTKGFEVYLAEMSADNQTCGKRNIHGRKLKEI
NKMADHWETAPRHMMRLDIRSLLQDAAIEEVEMEDFDANIEEQKEEKKDAEEEESELGYI
PKSKWEMDTSEAKLDKLDGLRTGTKRKRDWEAIASRMEDYLQLPDDYDTRASEPGKKRVR
WADLEEKKDADRKRAIGFVVGQTDWEKITDESGHLAEKALNRTKYI

Sequence length

2146

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Adrenocortical carcinoma, hereditary	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANXIETY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IRRITABLE BOWEL SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOOD DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myoepithelial tumor	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Congestive heart failure	Congestive Heart Failure	BEFREE	30936989	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	30936989	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959	★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	29662059, 29942085	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mood Disorders	Mood Disorder	GWASCAT_DG	29942085	★★★★★ ★☆☆☆☆ Found in Text Mining only

YLPM1 (YLP motif containing 1)