PRL (prolactin)

Gene Gene information from NCBI Gene database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 5617
Gene name Prolactin
Gene symbol PRL
Synonyms (NCBI Gene)
GHA1
Chromosome 6
Chromosome location 6p22.3
Summary This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lact
Transcription factors Transcription factors information provided by TRRUST V2 database.
20
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (20)
Transcription factor Regulation Reference
CEBPA Unknown 17187171
CEBPB Unknown 10455153
CEBPD Unknown 10455153
CREB1 Unknown 17187171
ERF Repression 9822660
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (25)
GO ID Ontology Definition Evidence Reference
GO:0001937 Process Negative regulation of endothelial cell proliferation IDA 23619365
GO:0005148 Function Prolactin receptor binding IBA
GO:0005148 Function Prolactin receptor binding TAS 10854700
GO:0005179 Function Hormone activity IBA
GO:0005179 Function Hormone activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
176760 9445 ENSG00000172179
Protein Protein information from UniProt database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P01236
Protein name Prolactin (PRL)
Protein function Prolactin acts primarily on the mammary gland by promoting lactation.
PDB 1RW5 , 2Q98 , 3D48 , 3EW3 , 3MZG , 3N06 , 3N0P , 3NCB , 3NCC , 3NCE , 3NCF , 3NPZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00103 Hormone_1 15 → 227 Somatotropin hormone family Domain
Sequence
Sequence length 227
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
Neuroactive ligand-receptor interaction
Hormone signaling
PI3K-Akt signaling pathway
JAK-STAT signaling pathway
Prolactin signaling pathway 		  Prolactin receptor signaling
Amyloid fiber formation
Growth hormone receptor signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (28)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AMENORRHEA — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANEMIA — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BASAL GANGLIA DISEASES — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (424)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
22q11 Deletion Syndrome 22q11 deletion syndrome Pubtator 17653112 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
6-pyruvoyl-tetrahydropterin synthase deficiency 6-pyruvoyl-tetrahydropterin synthase deficiency BEFREE 17590551
★★★★★
★☆☆☆☆
Found in Text Mining only
Abetalipoproteinemia Abetalipoproteinemia BEFREE 6959145
★★★★★
★☆☆☆☆
Found in Text Mining only
Acquired clubfoot Acquired Clubfoot BEFREE 28704852
★★★★★
★☆☆☆☆
Found in Text Mining only
Acromegaly Acromegaly BEFREE 12744370, 17893251, 19890024, 2568165, 31721135
★★★★★
★☆☆☆☆
Found in Text Mining only
Acromegaly Acromegaly Pubtator 38003353 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Addison Disease Addison`s Disease BEFREE 16984240, 28784879
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 29363543
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma CTD_human_DG 6280079
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of large intestine Colorectal Cancer BEFREE 11805572
★★★★★
★☆☆☆☆
Found in Text Mining only