Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID	56165
Gene name	Tudor domain containing 1
Gene symbol	TDRD1
Synonyms (NCBI Gene)	CT41.1
Chromosome	10
Chromosome location	10q25.3
Summary	This gene encodes a protein containing a tudor domain that is thought to function in the suppression of transposable elements during spermatogenesis. The related protein in mouse forms a complex with piRNAs and Piwi proteins to promote methylation and sil

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Show/Hide all (159)

miRTarBase ID	miRNA	Experiments	Reference
MIRT664981	hsa-miR-154-3p	HITS-CLIP	23824327
MIRT664980	hsa-miR-487a-3p	HITS-CLIP	23824327
MIRT664979	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT664978	hsa-miR-5693	HITS-CLIP	23824327
MIRT664977	hsa-miR-103b	HITS-CLIP	23824327
MIRT664976	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT664975	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT664974	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT664973	hsa-miR-3135b	HITS-CLIP	23824327
MIRT664972	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT664970	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT664971	hsa-miR-3652	HITS-CLIP	23824327
MIRT664969	hsa-miR-4430	HITS-CLIP	23824327
MIRT664968	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT664967	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT664966	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT664965	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT664964	hsa-miR-5698	HITS-CLIP	23824327
MIRT739204	hsa-miR-4796-3p	HITS-CLIP	33718276
MIRT739206	hsa-miR-4797-5p	HITS-CLIP	33718276
MIRT664981	hsa-miR-154-3p	HITS-CLIP	23824327
MIRT664980	hsa-miR-487a-3p	HITS-CLIP	23824327
MIRT664979	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT664978	hsa-miR-5693	HITS-CLIP	23824327
MIRT664977	hsa-miR-103b	HITS-CLIP	23824327
MIRT664976	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT664975	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT664974	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT664973	hsa-miR-3135b	HITS-CLIP	23824327
MIRT664972	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT664970	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT664971	hsa-miR-3652	HITS-CLIP	23824327
MIRT664969	hsa-miR-4430	HITS-CLIP	23824327
MIRT664968	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT664967	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT664966	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT664965	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT664964	hsa-miR-5698	HITS-CLIP	23824327
MIRT1417103	hsa-miR-1202	CLIP-seq
MIRT1417104	hsa-miR-1252	CLIP-seq
MIRT1417105	hsa-miR-198	CLIP-seq
MIRT1417106	hsa-miR-2114	CLIP-seq
MIRT1417107	hsa-miR-3125	CLIP-seq
MIRT739203	hsa-miR-3138	CLIP-seq
MIRT1417108	hsa-miR-3165	CLIP-seq
MIRT1417109	hsa-miR-3190	CLIP-seq
MIRT1417110	hsa-miR-3202	CLIP-seq
MIRT1417111	hsa-miR-3545-5p	CLIP-seq
MIRT1417112	hsa-miR-3664-5p	CLIP-seq
MIRT1417113	hsa-miR-3916	CLIP-seq
MIRT739205	hsa-miR-3919	CLIP-seq
MIRT1417114	hsa-miR-3924	CLIP-seq
MIRT1417115	hsa-miR-3940-5p	CLIP-seq
MIRT1417116	hsa-miR-3942-3p	CLIP-seq
MIRT1417117	hsa-miR-3972	CLIP-seq
MIRT1417118	hsa-miR-4257	CLIP-seq
MIRT1417119	hsa-miR-4494	CLIP-seq
MIRT1417120	hsa-miR-4507	CLIP-seq
MIRT1417121	hsa-miR-4522	CLIP-seq
MIRT1417122	hsa-miR-4533	CLIP-seq
MIRT1417123	hsa-miR-4742-3p	CLIP-seq
MIRT1417124	hsa-miR-499a-5p	CLIP-seq
MIRT1417125	hsa-miR-502-5p	CLIP-seq
MIRT1417126	hsa-miR-520a-5p	CLIP-seq
MIRT1417127	hsa-miR-525-5p	CLIP-seq
MIRT1417128	hsa-miR-607	CLIP-seq
MIRT1417129	hsa-miR-629	CLIP-seq
MIRT1417130	hsa-miR-630	CLIP-seq
MIRT1417131	hsa-miR-877	CLIP-seq
MIRT739203	hsa-miR-3138	CLIP-seq
MIRT739205	hsa-miR-3919	CLIP-seq
MIRT2125090	hsa-miR-106a	CLIP-seq
MIRT2125091	hsa-miR-106b	CLIP-seq
MIRT2125092	hsa-miR-1208	CLIP-seq
MIRT2125093	hsa-miR-122	CLIP-seq
MIRT2125094	hsa-miR-1268	CLIP-seq
MIRT2125095	hsa-miR-1268b	CLIP-seq
MIRT2125096	hsa-miR-150	CLIP-seq
MIRT2125097	hsa-miR-17	CLIP-seq
MIRT2125098	hsa-miR-20a	CLIP-seq
MIRT2125099	hsa-miR-20b	CLIP-seq
MIRT2125100	hsa-miR-214	CLIP-seq
MIRT2125101	hsa-miR-302a	CLIP-seq
MIRT2125102	hsa-miR-302b	CLIP-seq
MIRT2125103	hsa-miR-302c	CLIP-seq
MIRT2125104	hsa-miR-302d	CLIP-seq
MIRT2125105	hsa-miR-302e	CLIP-seq
MIRT739203	hsa-miR-3138	CLIP-seq
MIRT2125106	hsa-miR-3176	CLIP-seq
MIRT2125107	hsa-miR-3545-3p	CLIP-seq
MIRT2125108	hsa-miR-3619-5p	CLIP-seq
MIRT2125109	hsa-miR-372	CLIP-seq
MIRT2125110	hsa-miR-373	CLIP-seq
MIRT2125111	hsa-miR-3922-3p	CLIP-seq
MIRT2125112	hsa-miR-4486	CLIP-seq
MIRT2125113	hsa-miR-4680-5p	CLIP-seq
MIRT2125114	hsa-miR-4722-5p	CLIP-seq
MIRT2125115	hsa-miR-4731-5p	CLIP-seq
MIRT2125116	hsa-miR-4752	CLIP-seq
MIRT2125117	hsa-miR-4768-3p	CLIP-seq
MIRT2125118	hsa-miR-4800-5p	CLIP-seq
MIRT2125119	hsa-miR-487a	CLIP-seq
MIRT2125120	hsa-miR-512-3p	CLIP-seq
MIRT2125121	hsa-miR-519d	CLIP-seq
MIRT2125122	hsa-miR-520a-3p	CLIP-seq
MIRT2125123	hsa-miR-520b	CLIP-seq
MIRT2125124	hsa-miR-520c-3p	CLIP-seq
MIRT2125125	hsa-miR-520d-3p	CLIP-seq
MIRT2125126	hsa-miR-520e	CLIP-seq
MIRT2125127	hsa-miR-520g	CLIP-seq
MIRT2125128	hsa-miR-520h	CLIP-seq
MIRT2125129	hsa-miR-585	CLIP-seq
MIRT2125130	hsa-miR-761	CLIP-seq
MIRT2125131	hsa-miR-93	CLIP-seq
MIRT2125090	hsa-miR-106a	CLIP-seq
MIRT2125091	hsa-miR-106b	CLIP-seq
MIRT2125092	hsa-miR-1208	CLIP-seq
MIRT2125093	hsa-miR-122	CLIP-seq
MIRT2347518	hsa-miR-1224-3p	CLIP-seq
MIRT2347519	hsa-miR-1260	CLIP-seq
MIRT2347520	hsa-miR-1260b	CLIP-seq
MIRT2125094	hsa-miR-1268	CLIP-seq
MIRT2125095	hsa-miR-1268b	CLIP-seq
MIRT2347521	hsa-miR-1280	CLIP-seq
MIRT2125096	hsa-miR-150	CLIP-seq
MIRT2125097	hsa-miR-17	CLIP-seq
MIRT2125098	hsa-miR-20a	CLIP-seq
MIRT2125099	hsa-miR-20b	CLIP-seq
MIRT2125101	hsa-miR-302a	CLIP-seq
MIRT2125102	hsa-miR-302b	CLIP-seq
MIRT2125103	hsa-miR-302c	CLIP-seq
MIRT2125104	hsa-miR-302d	CLIP-seq
MIRT2125105	hsa-miR-302e	CLIP-seq
MIRT739203	hsa-miR-3138	CLIP-seq
MIRT2125106	hsa-miR-3176	CLIP-seq
MIRT2125107	hsa-miR-3545-3p	CLIP-seq
MIRT2125109	hsa-miR-372	CLIP-seq
MIRT2125110	hsa-miR-373	CLIP-seq
MIRT2125111	hsa-miR-3922-3p	CLIP-seq
MIRT2125112	hsa-miR-4486	CLIP-seq
MIRT2125113	hsa-miR-4680-5p	CLIP-seq
MIRT2347522	hsa-miR-4713-3p	CLIP-seq
MIRT2125115	hsa-miR-4731-5p	CLIP-seq
MIRT2347523	hsa-miR-4757-5p	CLIP-seq
MIRT2125119	hsa-miR-487a	CLIP-seq
MIRT2125120	hsa-miR-512-3p	CLIP-seq
MIRT2125121	hsa-miR-519d	CLIP-seq
MIRT2125122	hsa-miR-520a-3p	CLIP-seq
MIRT2125123	hsa-miR-520b	CLIP-seq
MIRT2125124	hsa-miR-520c-3p	CLIP-seq
MIRT2125125	hsa-miR-520d-3p	CLIP-seq
MIRT2125126	hsa-miR-520e	CLIP-seq
MIRT2125127	hsa-miR-520g	CLIP-seq
MIRT2125128	hsa-miR-520h	CLIP-seq
MIRT2347524	hsa-miR-532-3p	CLIP-seq
MIRT2125129	hsa-miR-585	CLIP-seq
MIRT2125131	hsa-miR-93	CLIP-seq
MIRT2125092	hsa-miR-1208	CLIP-seq
MIRT2125119	hsa-miR-487a	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
ERG	Activation	23319146
ERG	Repression	23555854

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0007281	Process	Germ cell development	IEA
GO:0007281	Process	Germ cell development	ISS
GO:0007283	Process	Spermatogenesis	IBA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0008270	Function	Zinc ion binding	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030719	Process	P granule organization	IBA
GO:0031047	Process	Regulatory ncRNA-mediated gene silencing	IEA
GO:0033391	Component	Chromatoid body	IEA
GO:0034587	Process	PiRNA processing	IBA
GO:0034587	Process	PiRNA processing	IEA
GO:0034587	Process	PiRNA processing	ISS
GO:0043186	Component	P granule	IBA
GO:0043186	Component	P granule	IEA
GO:0043186	Component	P granule	ISS
GO:0045202	Component	Synapse	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0071546	Component	Pi-body	IEA
GO:0071546	Component	Pi-body	ISS
GO:0141196	Process	Transposable element silencing by piRNA-mediated DNA methylation	IEA
GO:0141196	Process	Transposable element silencing by piRNA-mediated DNA methylation	ISS
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
605796	11712	ENSG00000095627

Q9BXT4

Protein name

Tudor domain-containing protein 1 (Cancer/testis antigen 41.1) (CT41.1)

Protein function

Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repre

PDB

5M9N

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01753	zf-MYND	170 → 206	MYND finger	Domain
PF00567	TUDOR	260 → 383	Tudor domain	Domain
PF00567	TUDOR	490 → 611	Tudor domain	Domain
PF00567	TUDOR	710 → 832	Tudor domain	Domain
PF00567	TUDOR	936 → 1059	Tudor domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Testis and ovary specific. Also expressed in several cancers. {ECO:0000269|PubMed:12704671}.

Sequence

MSVKSPFNVMSRNNLEAPPCKMTEPFNFEKNENKLPPHESLRSPGTLPNHPNFRLKSSEN
GNKKNNFLLCEQTKQYLASQEDNSVSSNPNGINGEVVGSKGDRKKLPAGNSVSPPSAESN
SPPKEVNIKPGNNVRPAKSKKLNKLVENSLSISNPGLFTSLGPPLRSTTCHRCGLFGSLR
CSQCKQTYYCSTACQRRDWSAHSIVCRPVQPNFHKLENKSSIETKDVEVNNKSDCPLGVT
KEIAIWAERIMFSDLRSLQLKKTMEIKGTVTEFKHPGDFYVQLYSSEVLEYMNQLSASLK
ETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLN
RIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCIKATKPLLMEQYCSIKIVDILEEEV
VTFAVEVELPNSGKLLDHVLIEMGYGLKPSGQDSKKENADQSDPEDVGKMTTENNIVVDK
SDLIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPPRSDF
YPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLEL
PMQAIKCVLAGVKPSLGIWTPEAICLMKKLVQNKIITVKVVDKLENSSLVELIDKSETPH
VSVSKVLLDAGFAVGEQSMVTDKPSDVKETSVPLGVEGKVNPLEWTWVELGVDQTVDVVV
CVIYSPGEFYCHVLKEDALKKLNDLNKSLAEHCQQKLPNGFKAEIGQPCCAFFAGDGSWY
RALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHW
SEEAITRFQMCVAGIKLQARVVEVTENGIGVELTDLSTCYPRIISDVLIDEHLVLKSASP
HKDLPNDRLVNKHELQVHVQGLQATSSAEQWKTIELPVDKTIQANVLEIISPNLFYALPK
GMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTDV
EVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEGLMELNGSSSQLIIMLLKNFML
NQNVMLSVKGITKNVHTVSVEKCSENGTVDVADKLVTFGLAKNITPQRQSALNTEKMYRM
NCCCTELQKQVEKHEHILLFLLNNSTNQNKFIEMKKLLKS

Sequence length

1180

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Male infertility	Likely pathogenic	rs745783399	RCV004573396	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (16)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of prostate	Prostate adenocarcinoma	BEFREE	30195637		★★★★★ ★☆☆☆☆ Found in Text Mining only
Azoospermia Nonobstructive	Nonobstructive azoospermia	Pubtator	27233649	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Benign Prostatic Hyperplasia	Benign Prostatic Hyperplasia	BEFREE	24938434		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	37045473	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Infertility Male	Male infertility	Pubtator	23112866	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	23319146, 23555854, 24938434, 26857646, 27272765, 30712320		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of testis	Malignant Neoplasm Of Testis	BEFREE	21515969		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26857646		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	23319146, 23555854, 24938434, 26857646, 27272765, 30712320		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Hyperplasia	Prostatic hyperplasia	Pubtator	24938434	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	23135352, 23555854, 24938434, 36497036	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	23555854, 27272765		★★★★★ ★☆☆☆☆ Found in Text Mining only
Seminoma	Seminoma	Pubtator	24247010	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Testicular Germ Cell Tumor	Testicular Germ Cell Tumor	BEFREE	24247010		★★★★★ ★☆☆☆☆ Found in Text Mining only
Testicular Germ Cell Tumor	Testicular germ cell tumor	Pubtator	24247010	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Testicular Neoplasms	Testicular neoplasm	Pubtator	24247010	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only

TDRD1 (tudor domain containing 1)