Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	56154
Gene name	Testis expressed 15, meiosis and synapsis associated
Gene symbol	TEX15
Synonyms (NCBI Gene)	CT42SPGF25
Chromosome	8
Chromosome location	8p12
Summary	This gene encodes a protein that is required for DNA double-strand break repair, chromosome synapsis, and meiotic recombination in spermatocytes. Male mice with a knockout of the orthologous gene are viable but sterile. Loss-of-function mutations in the o

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021099	hsa-miR-186-5p	Sequencing	20371350
MIRT031507	hsa-miR-16-5p	Sequencing	20371350
MIRT1419190	hsa-miR-1276	CLIP-seq
MIRT1419191	hsa-miR-1343	CLIP-seq
MIRT1419192	hsa-miR-137	CLIP-seq
MIRT1419193	hsa-miR-142-5p	CLIP-seq
MIRT1419194	hsa-miR-23a	CLIP-seq
MIRT1419195	hsa-miR-23b	CLIP-seq
MIRT1419196	hsa-miR-23c	CLIP-seq
MIRT1419197	hsa-miR-3157-5p	CLIP-seq
MIRT1419198	hsa-miR-3188	CLIP-seq
MIRT1419199	hsa-miR-340	CLIP-seq
MIRT1419200	hsa-miR-3655	CLIP-seq
MIRT1419201	hsa-miR-4311	CLIP-seq
MIRT1419202	hsa-miR-4450	CLIP-seq
MIRT1419203	hsa-miR-4667-5p	CLIP-seq
MIRT1419204	hsa-miR-4691-3p	CLIP-seq
MIRT1419205	hsa-miR-4700-5p	CLIP-seq
MIRT1419206	hsa-miR-4720-3p	CLIP-seq
MIRT1419207	hsa-miR-4753-3p	CLIP-seq
MIRT1419208	hsa-miR-4804-3p	CLIP-seq
MIRT1419209	hsa-miR-583	CLIP-seq
MIRT2125866	hsa-miR-1305	CLIP-seq
MIRT2125867	hsa-miR-216b	CLIP-seq
MIRT2125868	hsa-miR-298	CLIP-seq
MIRT2125869	hsa-miR-3671	CLIP-seq
MIRT2125870	hsa-miR-3678-3p	CLIP-seq
MIRT2125871	hsa-miR-3682-5p	CLIP-seq
MIRT2125872	hsa-miR-4433	CLIP-seq
MIRT2125873	hsa-miR-4459	CLIP-seq
MIRT2125874	hsa-miR-450b-5p	CLIP-seq
MIRT2125875	hsa-miR-4762-5p	CLIP-seq
MIRT2125876	hsa-miR-4768-3p	CLIP-seq
MIRT2125877	hsa-miR-507	CLIP-seq
MIRT2125878	hsa-miR-550b	CLIP-seq
MIRT2125879	hsa-miR-557	CLIP-seq
MIRT2125880	hsa-miR-607	CLIP-seq
MIRT2433803	hsa-miR-1227	CLIP-seq
MIRT2125866	hsa-miR-1305	CLIP-seq
MIRT2433804	hsa-miR-1914	CLIP-seq
MIRT2125880	hsa-miR-607	CLIP-seq

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GO ID	Ontology	Definition	Evidence
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0006281	Process	DNA repair	IEA
GO:0006346	Process	DNA methylation-dependent constitutive heterochromatin formation	ISS
GO:0006974	Process	DNA damage response	IEA
GO:0007129	Process	Homologous chromosome pairing at meiosis	IEA
GO:0007130	Process	Synaptonemal complex assembly	IBA
GO:0007140	Process	Male meiotic nuclear division	IBA
GO:0007140	Process	Male meiotic nuclear division	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0010526	Process	Transposable element silencing	ISS
GO:0010569	Process	Regulation of double-strand break repair via homologous recombination	IBA
GO:0010569	Process	Regulation of double-strand break repair via homologous recombination	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0031047	Process	Regulatory ncRNA-mediated gene silencing	IEA
GO:0034587	Process	PiRNA processing	ISS
GO:0051321	Process	Meiotic cell cycle	IEA

MIM	HGNC	e!Ensembl
605795	11738	ENSG00000133863

Q9BXT5

Protein name

Testis-expressed protein 15 (Cancer/testis antigen 42) (CT42)

Protein function

Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair (By sim

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15326	TEX15	1535 → 1770		Family
PF15326	TEX15	1901 → 2115		Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in testis, predominantly in germ cells (PubMed:11279525, PubMed:26199321). Low expression, if any, in ovary (PubMed:11279525, PubMed:26199321). Also expressed in several cancers (PubMed:12704671). {ECO:0000269|PubMed:11279525

Sequence

MPSDAKDSVNGDLLLNWTSLKNILSGLNASFPLHNNTGSSTVTTSKSIKDPRLMRREESM
GEQSSTAGLNEVLQFEKSSDNVNSEIKSTPSNSASSSEVVPGDCAVLTNGLDTPCFKTSV
NDSQSWAHNMGSEDYDCIPPNKVTMAGQCKDQGNFSFPISVSNVVSEVENQNHSEEKAQR
AQQESGNAYTKEYSSHIFQDSQSSDLKTIYQTGCQTSTVFPLKKKVSIDEYLQNTGKMKN
FADLEDSSKHEEKQTSWKEIDNDFTNETKISPIDNYIVLHQEYKESESHNSFGKSCDKIL
ITQELEITKSSTSTIKDKDELDHLALEWQITPSFESLSQKHPQHSVEYEGNIHTSLAIAQ
KLMELKLGKINQNYASIITEAFPKPKDIPQAKEMFIDTVISSYNIETAHDSSNCSITREH
ICVHRKNENEPVSLENIQRDYKETAYVEDRGQDHNLFCNSQLSNDIWLNVNFKKQTDREN
QNEAKENSASCVENNIENIYGDKKQDSHTNENFSNIDEKEDKNYHNIEILSSEEFSTKFN
LICREDNAVSAATALLESEEDTISAVKQKDTENTGRSVEHLASTTFPKTASSSVCVASNA
AIQIASATMPALSLNNDDHQIYQFKETCSSESPDFGLLVKHRVSDCEIDTDKNKSQESFH
QSINENLVLQSIELESEIEIELEDCDDAFIFQQDTHSHENMLCEEFVTSYKALKSRISWE
GLLALDNGEMEVLESTTGRENSDQHYSKESNYFYSSTQNNETELTSPILLPDLQIKITNI
FRPGFSPTADSLALKDSFCTHVTEATKPEINKEDGEILGFDIYSQPFGENADYPCEDKVD
NIRQESGPVSNSEISLSFDLSRNTDVNHTSENQNSESLFTEPSNVTTIDDGSRCFFTKSK
TDYNDTKNKKEVESRISKRKLHISSRDQNIPHKDLRRHKIYGRKRRLTSQDSSECFSSLS
QGRIKTFSQSEKHIKSVLNILSDEASLCKSKCLSRKLDKAVVHLKKAHRRVHTSLQLITK
VGEERKGPLPKSYAIICNNFWESCDLQGYSSVSQRKYYSTKHFSSKRKYDKRRKKRAPKA
DISKSLTHVSKHKSYKTSGEKKCLSRKSMASSVSKSHPTTSHMGEFCNQEHPESQLPVSS
TSQSTSQSVYYNSSVSNPSLSEEHQPFSGKTAYLFSPDHSDEKLIEKENQIDTAFLSSTS
KYEKLEKHSANHNVKDATKENSCDANEVINESNSVSLSCIKENINSSTGNDCDATCIGHT
KAKTDVLISVLDSNVKHFLNDLYQQGNLILSDCKRNLEVKWTDPIERPKQNIITGNFLMG
PLNLTLIASKKYSIPQLSAAAVTDSEGESSKSYLDKQRILTVDSFAASSTVPHCEQSCRE
KELLKTEQCSSGNCLHTDGNETNVTENYELDVASGTEEDKSYGENIVELSSSDSSLLLKD
NVKGSSSETCIVKKDTEDRITWKVKQAEKAKDSVYKRSMTEGSTVNTEYKNQKNQISEES
CLNEKIITTNLIDSHLSTKNTTTESVPLKNTVSNPLNKREKKGEIKVSKDSQSDLTLHSE
IAYISKPGILGVNHTPILPAHSETCKVPTLLKKPASYVSDFKEKHCSANHTALIANLSQI
LQRADEASSLQILQEETKVCLNILPLFVEAFERKQECSVEQILISRELLVDQNLWNNCKH
TLKPCAVDTLVELQMMMETIQFIENKKRHLEGEPTLRSLLWYDETLYAELLGKPRGFQQQ
SNFYPGFQGRLKYNAFCELQTYHDQLVELLEETKREKNSYYVFLKYKRQVNECEAIMEHC
SDCFDFSLSVPFTCGVNFGDSLEDLEILRKSTLKLINVCGDSPKVHSYPGKQDHLWIIIE
MISSKVNFIKNNEAVRVKISLYGLEHIFFDAAKNLVWKERTQSFSKKYSQKKDEERLLRV
NKCAFSKLQKIYDTLSKDLNNEPISPIGLEEDTIIASRKSDHPINEATISIENSKFNSNL
LAHPDICCISEILDQAEFADLKKLQDLTLRCTDHLEILKKYFQMLQDNNMDNIFITEENV
LDVVINHSHEAIILKPEAIEMYIEIVMVSETIHFLKNSIAKKLDKQRFRGMLWFDLSLLP
ELVQCQEKMASFSFLKDNSTDVCLWKVIETAVSELKKDLDIICKYNEAVNCSYAIHLLSR
ELQELSEIKKLLKKSKYFISTYIDFVPYIASINYGSTVTELEYNYNQFSTLLKNVMSAPR
KDLGKMAHIRKVMKTIEHMKMICTKNAELTISFFLCQMLYNRRKILQLKRKEKMNIHIVK
PGENNNKFSISTMLPPVSECINKNISNSSKKRPSTVDKCEDSQEQQQDTTVSSCKKLKVD
MKDVTKINREKATFKHPRTTGSHPKSENKIVPSSCDSLKRNHLTPKKVEMQRSLPGSLLP
LENPKDTCASKSESKIDLTVSSDHFSGQQENLNSMKKRNVNFSAAETKSDKKDCAAFAIC
DQKSVHGTFSPDHGTLLQKFLKNSPDPTQKSCLSDINPETDVSLVPDASVLSKPIFCFVK
DVHPDLEMNDTVFELQDNDIVNSSIKNSSCMTSPEPICIQNKIPTLQINKLQPTETESED
KYMKDTLNPNTVHTFGASGHITLNVNQGAEYSLSEQQNDKNSKVLMQNAATYWNELPQSA
CNPTYNSSEHLFGTSYPYSAWCVYQYSNSNGNAITQTYQGITSYEVQPSPSGLLTTVAST
AQGTHSNLLYSQYFTYFAGEPQANGFVPVNGYFQSQIPASNFRQPIFSQYASHQPLPQAT
YPYLPNRFVPPEVPWVYAPWHQESFHPGH

Sequence length

2789

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Non-obstructive azoospermia	Pathogenic	rs1351772557	RCV001648512	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Oligosynaptic infertility	Pathogenic	rs864309485	RCV000202575	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Spermatogenic failure 25	Likely pathogenic; Pathogenic	rs62000447, rs864309485, rs754041709, rs1244093431, rs752501149, rs141978088, rs2486836794, rs1224137237, rs1554492164, rs1554491783, rs763654373	RCV005399036 RCV000626476 RCV003149068 RCV003149070 RCV003149072 View all (6 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATROPHIC MACULAR DEGENERATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION	—	Disgenet, Orphanet Disgenet, Orphanet Disgenet, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myoepithelial tumor	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TESTICULAR AZOOSPERMIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TEX15-related disorder	Likely benign; Benign; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (15)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Azoospermia	Azoospermia	Pubtator	29932616	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Azoospermia	Azoospermia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Azoospermia, Nonobstructive	Azoospermia	BEFREE	28355598		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Cancer, Familial	Breast Cancer	BEFREE	28386063		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28386063		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28386063	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Male infertility with azoospermia or oligozoospermia due to single gene mutation	Male infertility	Orphanet			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast	Breast Cancer	BEFREE	28386063		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	28730685		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28386063		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-obstructive azoospermia	Non-obstructive azoospermia	HPO_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Obstructive azoospermia	Obstructive azoospermia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	28730685		★★★★★ ★☆☆☆☆ Found in Text Mining only
Riddle Syndrome	Riddle syndrome	Pubtator	28386063	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
SPERMATOGENIC FAILURE 25	Spermatogenic Failure	CLINVAR_DG			★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

TEX15 (testis expressed 15, meiosis and synapsis associated)