Gene Gene information from NCBI Gene database.
Entrez ID 55966
Gene name Adherens junctions associated protein 1
Gene symbol AJAP1
Synonyms (NCBI Gene)
MOT8SHREW-1SHREW1
Chromosome 1
Chromosome location 1p36.32
miRNA miRNA information provided by mirtarbase database.
254
miRTarBase ID miRNA Experiments Reference
MIRT722005 hsa-miR-6889-3p HITS-CLIP 19536157
MIRT709670 hsa-miR-4641 HITS-CLIP 19536157
MIRT709669 hsa-miR-6778-3p HITS-CLIP 19536157
MIRT709668 hsa-miR-6791-3p HITS-CLIP 19536157
MIRT709667 hsa-miR-6829-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24
GO ID Ontology Definition Evidence Reference
GO:0001953 Process Negative regulation of cell-matrix adhesion IDA 16410724
GO:0005515 Function Protein binding IPI 17267690
GO:0005886 Component Plasma membrane IDA 14595118
GO:0005886 Component Plasma membrane IEA
GO:0005912 Component Adherens junction IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610972 30801 ENSG00000196581
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UKB5
Protein name Adherens junction-associated protein 1 (Membrane protein shrew-1)
Protein function Plays a role in cell adhesion and cell migration.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15298 AJAP1_PANP_C 181 388 AJAP1/PANP C-terminus Family
Tissue specificity TISSUE SPECIFICITY: Expressed in uterus and pancreas (at protein level). {ECO:0000269|PubMed:14595118}.
Sequence
MWIQQLLGLSSMSIRWPGRPLGSHAWILIAMFQLAVDLPACEALGPGPEFWLLPRSPPRP
PRLWSFRSGQPARVPAPVWSPRPPRVERIHGQMQMPRARRAHRPRDQAAALVPKAGLAKP
PAAAKSSPSLASSSSSSSSAVAGGAPEQQALLRRGKRHLQGDGLSSFDSRGSRPTTETEF
IAWGPTGDEEALESNTFPGVYGPTTVSILQTRKTTVAATTTTTTTATPMTLQTKGFTESL
DPRRRIPGGVSTTEPSTSPSNNGEVTQPPRILGEASGLAVHQIITITVSLIMVIAALITT
LVLKNCCAQSGNTRRNSHQRKTNQQEESCQNLTDFPSARVPSSLDIFTAYNETLQCSHEC
VRASVPVYTDETLHSTTGEYKSTFNGNR
PSSSDRHLIPVAFVSEKWFEISC
Sequence length 411
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DEMENTIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DENTAL CARIES GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DEVELOPMENTAL DYSPLASIA OF THE HIP GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Carcinoma Breast Carcinoma BEFREE 31171012
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 19515834 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 28514750 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 37247081 Associate
★☆☆☆☆
Found in Text Mining only
Conduction disorder of the heart Conduction Disorder Of The Heart BEFREE 29213071
★☆☆☆☆
Found in Text Mining only
Dental Caries Dental caries Pubtator 23064961, 24556642 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Glioblastoma Glioblastoma BEFREE 19861460, 21439246, 22241217, 24481586
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma Pubtator 21439246 Associate
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma Pubtator 22241217 Inhibit
★☆☆☆☆
Found in Text Mining only
Glioblastoma Multiforme Glioblastoma BEFREE 19861460, 21439246, 22241217, 24481586, 24483339, 29115565
★☆☆☆☆
Found in Text Mining only