NXT2 (nuclear transport factor 2 like export factor 2)

Gene

• Entrez ID: 55916
• Gene name: Nuclear transport factor 2 like export factor 2
• Gene symbol: NXT2
• Synonyms (NCBI Gene): P15-2
• Chromosome: X
• Chromosome location: Xq23
• Summary: The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRN

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005043	hsa-let-7b-5p	Microarray	17699775
MIRT019862	hsa-miR-375	Microarray	20215506
MIRT023742	hsa-miR-1-3p	Microarray	18668037
MIRT025786	hsa-miR-7-5p	Microarray	19073608
MIRT044616	hsa-miR-320a	CLASH	23622248
MIRT528462	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT528461	hsa-miR-6835-3p	PAR-CLIP	20371350
MIRT528460	hsa-miR-34b-3p	PAR-CLIP	20371350
MIRT528457	hsa-miR-330-3p	PAR-CLIP	20371350
MIRT528456	hsa-miR-204-3p	PAR-CLIP	20371350
MIRT528455	hsa-miR-4646-5p	PAR-CLIP	20371350
MIRT569290	hsa-miR-3148	PAR-CLIP	20371350
MIRT528454	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT528453	hsa-miR-3153	PAR-CLIP	20371350
MIRT528452	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT528451	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT528450	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT528449	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT528462	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT528461	hsa-miR-6835-3p	PAR-CLIP	22012620
MIRT528460	hsa-miR-34b-3p	PAR-CLIP	22012620
MIRT528459	hsa-miR-101-3p	PAR-CLIP	22012620
MIRT528458	hsa-miR-5002-5p	PAR-CLIP	22012620
MIRT528457	hsa-miR-330-3p	PAR-CLIP	22012620
MIRT528456	hsa-miR-204-3p	PAR-CLIP	22012620
MIRT528455	hsa-miR-4646-5p	PAR-CLIP	22012620
MIRT528454	hsa-miR-4668-5p	PAR-CLIP	22012620
MIRT528453	hsa-miR-3153	PAR-CLIP	22012620
MIRT528452	hsa-miR-6733-5p	PAR-CLIP	22012620
MIRT528451	hsa-miR-6739-5p	PAR-CLIP	22012620
MIRT528450	hsa-miR-520d-5p	PAR-CLIP	22012620
MIRT528449	hsa-miR-524-5p	PAR-CLIP	22012620
MIRT528456	hsa-miR-204-3p	PAR-CLIP	27292025
MIRT528456	hsa-miR-204-3p	PAR-CLIP	27292025
MIRT569290	hsa-miR-3148	PAR-CLIP	27292025
MIRT528453	hsa-miR-3153	PAR-CLIP	27292025
MIRT528453	hsa-miR-3153	PAR-CLIP	27292025
MIRT528457	hsa-miR-330-3p	PAR-CLIP	27292025
MIRT528457	hsa-miR-330-3p	PAR-CLIP	27292025
MIRT528460	hsa-miR-34b-3p	PAR-CLIP	27292025
MIRT528460	hsa-miR-34b-3p	PAR-CLIP	27292025
MIRT528455	hsa-miR-4646-5p	PAR-CLIP	27292025
MIRT528455	hsa-miR-4646-5p	PAR-CLIP	27292025
MIRT528454	hsa-miR-4668-5p	PAR-CLIP	27292025
MIRT528454	hsa-miR-4668-5p	PAR-CLIP	27292025
MIRT528450	hsa-miR-520d-5p	PAR-CLIP	27292025
MIRT528450	hsa-miR-520d-5p	PAR-CLIP	27292025
MIRT528449	hsa-miR-524-5p	PAR-CLIP	27292025
MIRT528449	hsa-miR-524-5p	PAR-CLIP	27292025
MIRT528462	hsa-miR-548c-3p	PAR-CLIP	27292025
MIRT528462	hsa-miR-548c-3p	PAR-CLIP	27292025
MIRT528452	hsa-miR-6733-5p	PAR-CLIP	27292025
MIRT528452	hsa-miR-6733-5p	PAR-CLIP	27292025
MIRT528451	hsa-miR-6739-5p	PAR-CLIP	27292025
MIRT528451	hsa-miR-6739-5p	PAR-CLIP	27292025
MIRT528461	hsa-miR-6835-3p	PAR-CLIP	27292025
MIRT528461	hsa-miR-6835-3p	PAR-CLIP	27292025
MIRT528462	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT528461	hsa-miR-6835-3p	PAR-CLIP	20371350
MIRT528460	hsa-miR-34b-3p	PAR-CLIP	20371350
MIRT528457	hsa-miR-330-3p	PAR-CLIP	20371350
MIRT528456	hsa-miR-204-3p	PAR-CLIP	20371350
MIRT528455	hsa-miR-4646-5p	PAR-CLIP	20371350
MIRT569290	hsa-miR-3148	PAR-CLIP	20371350
MIRT528454	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT528453	hsa-miR-3153	PAR-CLIP	20371350
MIRT528452	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT528451	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT528450	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT528449	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT528462	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT528461	hsa-miR-6835-3p	PAR-CLIP	22012620
MIRT528460	hsa-miR-34b-3p	PAR-CLIP	22012620
MIRT528459	hsa-miR-101-3p	PAR-CLIP	22012620
MIRT528458	hsa-miR-5002-5p	PAR-CLIP	22012620
MIRT528457	hsa-miR-330-3p	PAR-CLIP	22012620
MIRT528456	hsa-miR-204-3p	PAR-CLIP	22012620
MIRT528455	hsa-miR-4646-5p	PAR-CLIP	22012620
MIRT528454	hsa-miR-4668-5p	PAR-CLIP	22012620
MIRT528453	hsa-miR-3153	PAR-CLIP	22012620
MIRT528452	hsa-miR-6733-5p	PAR-CLIP	22012620
MIRT528451	hsa-miR-6739-5p	PAR-CLIP	22012620
MIRT528450	hsa-miR-520d-5p	PAR-CLIP	22012620
MIRT528449	hsa-miR-524-5p	PAR-CLIP	22012620
MIRT1200763	hsa-miR-3613-3p	CLIP-seq
MIRT1200764	hsa-miR-3659	CLIP-seq
MIRT1200765	hsa-miR-4436b-5p	CLIP-seq
MIRT1200766	hsa-miR-4778-3p	CLIP-seq
MIRT1200767	hsa-miR-548ae	CLIP-seq
MIRT1200768	hsa-miR-548aj	CLIP-seq
MIRT1200769	hsa-miR-548am	CLIP-seq
MIRT1200770	hsa-miR-548x	CLIP-seq
MIRT1200771	hsa-miR-759	CLIP-seq
MIRT1200772	hsa-miR-1264	CLIP-seq
MIRT1200773	hsa-miR-1270	CLIP-seq
MIRT1200774	hsa-miR-1273g	CLIP-seq
MIRT1200775	hsa-miR-127-5p	CLIP-seq
MIRT1200776	hsa-miR-1301	CLIP-seq
MIRT1200777	hsa-miR-137	CLIP-seq
MIRT1200778	hsa-miR-2116	CLIP-seq
MIRT1200779	hsa-miR-219-5p	CLIP-seq
MIRT1200780	hsa-miR-300	CLIP-seq
MIRT1200781	hsa-miR-381	CLIP-seq
MIRT1200782	hsa-miR-4273	CLIP-seq
MIRT1200783	hsa-miR-4445	CLIP-seq
MIRT1200784	hsa-miR-4659a-3p	CLIP-seq
MIRT1200785	hsa-miR-4659b-3p	CLIP-seq
MIRT1200786	hsa-miR-4660	CLIP-seq
MIRT1200787	hsa-miR-4666-3p	CLIP-seq
MIRT1200788	hsa-miR-4677-5p	CLIP-seq
MIRT1200789	hsa-miR-4683	CLIP-seq
MIRT1200790	hsa-miR-4694-3p	CLIP-seq
MIRT1200791	hsa-miR-4699-3p	CLIP-seq
MIRT1200792	hsa-miR-4703-3p	CLIP-seq
MIRT1200793	hsa-miR-4724-3p	CLIP-seq
MIRT1200794	hsa-miR-4782-3p	CLIP-seq
MIRT1200795	hsa-miR-5047	CLIP-seq
MIRT1200796	hsa-miR-508-3p	CLIP-seq
MIRT1200797	hsa-miR-522	CLIP-seq
MIRT1200798	hsa-miR-620	CLIP-seq
MIRT1200799	hsa-miR-942	CLIP-seq
MIRT1200800	hsa-miR-124	CLIP-seq
MIRT1200801	hsa-miR-23a	CLIP-seq
MIRT1200802	hsa-miR-23b	CLIP-seq
MIRT1200803	hsa-miR-23c	CLIP-seq
MIRT1200804	hsa-miR-2861	CLIP-seq
MIRT1200805	hsa-miR-3117-5p	CLIP-seq
MIRT1200806	hsa-miR-320b	CLIP-seq
MIRT1200807	hsa-miR-320c	CLIP-seq
MIRT1200808	hsa-miR-320d	CLIP-seq
MIRT1200809	hsa-miR-3614-5p	CLIP-seq
MIRT1200810	hsa-miR-3616-3p	CLIP-seq
MIRT1200811	hsa-miR-3662	CLIP-seq
MIRT1200812	hsa-miR-3714	CLIP-seq
MIRT1200813	hsa-miR-3910	CLIP-seq
MIRT1200814	hsa-miR-425	CLIP-seq
MIRT1200815	hsa-miR-433	CLIP-seq
MIRT1200816	hsa-miR-4429	CLIP-seq
MIRT1200817	hsa-miR-4495	CLIP-seq
MIRT1200791	hsa-miR-4699-3p	CLIP-seq
MIRT1200818	hsa-miR-4717-3p	CLIP-seq
MIRT1200793	hsa-miR-4724-3p	CLIP-seq
MIRT1200819	hsa-miR-4802-3p	CLIP-seq
MIRT1200820	hsa-miR-506	CLIP-seq
MIRT1200821	hsa-miR-561	CLIP-seq
MIRT1200822	hsa-miR-7	CLIP-seq
MIRT1200823	hsa-miR-877	CLIP-seq
MIRT1200824	hsa-miR-885-3p	CLIP-seq
MIRT2058049	hsa-miR-128	CLIP-seq
MIRT2058050	hsa-miR-27a	CLIP-seq
MIRT2058051	hsa-miR-27b	CLIP-seq
MIRT2058052	hsa-miR-31	CLIP-seq
MIRT2058053	hsa-miR-3174	CLIP-seq
MIRT2058054	hsa-miR-3646	CLIP-seq
MIRT2058055	hsa-miR-3913-3p	CLIP-seq
MIRT2058056	hsa-miR-3929	CLIP-seq
MIRT2058057	hsa-miR-4419b	CLIP-seq
MIRT2058058	hsa-miR-4478	CLIP-seq
MIRT2058059	hsa-miR-450b-5p	CLIP-seq
MIRT2058060	hsa-miR-4781-5p	CLIP-seq
MIRT2058061	hsa-miR-489	CLIP-seq
MIRT2058062	hsa-miR-496	CLIP-seq
MIRT2058063	hsa-miR-507	CLIP-seq
MIRT2058064	hsa-miR-513a-5p	CLIP-seq
MIRT2058065	hsa-miR-557	CLIP-seq
MIRT2058066	hsa-miR-656	CLIP-seq
MIRT1200822	hsa-miR-7	CLIP-seq
MIRT2286470	hsa-let-7a	CLIP-seq
MIRT2286471	hsa-let-7b	CLIP-seq
MIRT2286472	hsa-let-7c	CLIP-seq
MIRT2286473	hsa-let-7d	CLIP-seq
MIRT2286474	hsa-let-7e	CLIP-seq
MIRT2286475	hsa-let-7f	CLIP-seq
MIRT2286476	hsa-let-7g	CLIP-seq
MIRT2286477	hsa-let-7i	CLIP-seq
MIRT1200806	hsa-miR-320b	CLIP-seq
MIRT1200807	hsa-miR-320c	CLIP-seq
MIRT1200808	hsa-miR-320d	CLIP-seq
MIRT2286478	hsa-miR-3927	CLIP-seq
MIRT1200816	hsa-miR-4429	CLIP-seq
MIRT2286479	hsa-miR-4458	CLIP-seq
MIRT2286480	hsa-miR-4500	CLIP-seq
MIRT2286481	hsa-miR-4650-3p	CLIP-seq
MIRT2286482	hsa-miR-513a-3p	CLIP-seq
MIRT2286483	hsa-miR-570	CLIP-seq
MIRT2286484	hsa-miR-98	CLIP-seq
MIRT2584407	hsa-miR-129-5p	CLIP-seq
MIRT2584408	hsa-miR-182	CLIP-seq
MIRT2584409	hsa-miR-186	CLIP-seq
MIRT2058052	hsa-miR-31	CLIP-seq
MIRT2584410	hsa-miR-3133	CLIP-seq
MIRT2584411	hsa-miR-3163	CLIP-seq
MIRT2584412	hsa-miR-340	CLIP-seq
MIRT1200809	hsa-miR-3614-5p	CLIP-seq
MIRT2058059	hsa-miR-450b-5p	CLIP-seq
MIRT1200791	hsa-miR-4699-3p	CLIP-seq
MIRT2058063	hsa-miR-507	CLIP-seq
MIRT2058065	hsa-miR-557	CLIP-seq
MIRT2686729	hsa-miR-1245	CLIP-seq
MIRT2584407	hsa-miR-129-5p	CLIP-seq
MIRT2584408	hsa-miR-182	CLIP-seq
MIRT2058052	hsa-miR-31	CLIP-seq
MIRT1200805	hsa-miR-3117-5p	CLIP-seq
MIRT2584411	hsa-miR-3163	CLIP-seq
MIRT2584412	hsa-miR-340	CLIP-seq
MIRT2686730	hsa-miR-3606	CLIP-seq
MIRT1200809	hsa-miR-3614-5p	CLIP-seq
MIRT1200815	hsa-miR-433	CLIP-seq
MIRT2058059	hsa-miR-450b-5p	CLIP-seq
MIRT1200791	hsa-miR-4699-3p	CLIP-seq
MIRT2058063	hsa-miR-507	CLIP-seq
MIRT2058065	hsa-miR-557	CLIP-seq
MIRT2686731	hsa-miR-605	CLIP-seq
MIRT2686732	hsa-miR-921	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 21516116, 25416956, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006406	Process	MRNA export from nucleus	ISS
GO:0006913	Process	Nucleocytoplasmic transport	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016973	Process	Poly(A)+ mRNA export from nucleus	IBA
GO:0042272	Component	Nuclear RNA export factor complex	IEA
GO:0042272	Component	Nuclear RNA export factor complex	IPI	25416956, 32296183
GO:0042272	Component	Nuclear RNA export factor complex	ISS
GO:0044613	Component	Nuclear pore central transport channel	IBA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	ISS
GO:0051028	Process	MRNA transport	IEA

Other IDs

• MIM: 300320
• HGNC: 18151
• e!Ensembl: ENSG00000101888

Protein

• UniProt ID: Q9NPJ8
• Protein name: NTF2-related export protein 2 (Protein p15-2)
• Protein function: Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02136	NTF2	17 → 136	Nuclear transport factor 2 (NTF2) domain	Domain

• Sequence:

  MATSLDFKTYVDQACRAAEEFVNIYYETMDKRRRALTRLYLDKATLIWNGNAVSGLDALN
  NFFDTLPSSEFQVNMLDCQPVHEQATQSQTTVLVVTSGTVKFDGNKQHFFNQNFLLTAQS
  TPNNTVWKIASDCFRFQDWSSS

• Sequence length: 142

Pathways

KEGG:

Ribosome biogenesis in eukaryotes
Nucleocytoplasmic transport
mRNA surveillance pathway
Amyotrophic lateral sclerosis
Influenza A

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Male infertility	Likely pathogenic	rs2520538578	RCV004588562	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)