Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55892
Gene name	Myoneurin
Gene symbol	MYNN
Synonyms (NCBI Gene)	OSZFSBBIZ1ZBTB31ZNF902
Chromosome	3
Chromosome location	3q26.2
Summary	This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome

121

Show/Hide all (121)

miRTarBase ID	miRNA	Experiments	Reference
MIRT442893	hsa-miR-1179	PAR-CLIP	22100165
MIRT442892	hsa-miR-1253	PAR-CLIP	22100165
MIRT442893	hsa-miR-1179	PAR-CLIP	22100165
MIRT442892	hsa-miR-1253	PAR-CLIP	22100165
MIRT1169045	hsa-miR-1254	CLIP-seq
MIRT1169046	hsa-miR-1827	CLIP-seq
MIRT1169047	hsa-miR-2467-3p	CLIP-seq
MIRT1169048	hsa-miR-2861	CLIP-seq
MIRT1169049	hsa-miR-3116	CLIP-seq
MIRT1169050	hsa-miR-3120-5p	CLIP-seq
MIRT1169051	hsa-miR-3201	CLIP-seq
MIRT1169052	hsa-miR-342-5p	CLIP-seq
MIRT1169053	hsa-miR-3612	CLIP-seq
MIRT1169054	hsa-miR-3920	CLIP-seq
MIRT1169055	hsa-miR-4257	CLIP-seq
MIRT1169056	hsa-miR-4459	CLIP-seq
MIRT1169057	hsa-miR-4651	CLIP-seq
MIRT1169058	hsa-miR-4664-5p	CLIP-seq
MIRT1169059	hsa-miR-4695-5p	CLIP-seq
MIRT1169060	hsa-miR-4791	CLIP-seq
MIRT1169061	hsa-miR-541	CLIP-seq
MIRT1169062	hsa-miR-608	CLIP-seq
MIRT1169063	hsa-miR-650	CLIP-seq
MIRT1169064	hsa-miR-654-5p	CLIP-seq
MIRT1169065	hsa-miR-665	CLIP-seq
MIRT1169066	hsa-miR-125a-3p	CLIP-seq
MIRT1169067	hsa-miR-1271	CLIP-seq
MIRT1169068	hsa-miR-1273d	CLIP-seq
MIRT1169069	hsa-miR-1273e	CLIP-seq
MIRT1169070	hsa-miR-153	CLIP-seq
MIRT1169071	hsa-miR-181a	CLIP-seq
MIRT1169072	hsa-miR-181b	CLIP-seq
MIRT1169073	hsa-miR-181c	CLIP-seq
MIRT1169074	hsa-miR-181d	CLIP-seq
MIRT1169075	hsa-miR-182	CLIP-seq
MIRT1169046	hsa-miR-1827	CLIP-seq
MIRT1169076	hsa-miR-1912	CLIP-seq
MIRT1169077	hsa-miR-23a	CLIP-seq
MIRT1169078	hsa-miR-23b	CLIP-seq
MIRT1169079	hsa-miR-23c	CLIP-seq
MIRT1169047	hsa-miR-2467-3p	CLIP-seq
MIRT1169080	hsa-miR-2964a-3p	CLIP-seq
MIRT1169081	hsa-miR-302f	CLIP-seq
MIRT1169082	hsa-miR-3151	CLIP-seq
MIRT1169083	hsa-miR-3157-3p	CLIP-seq
MIRT1169084	hsa-miR-3163	CLIP-seq
MIRT1169085	hsa-miR-3188	CLIP-seq
MIRT1169086	hsa-miR-323b-3p	CLIP-seq
MIRT1169087	hsa-miR-331-5p	CLIP-seq
MIRT1169088	hsa-miR-337-3p	CLIP-seq
MIRT1169053	hsa-miR-3612	CLIP-seq
MIRT1169089	hsa-miR-3664-3p	CLIP-seq
MIRT1169090	hsa-miR-3929	CLIP-seq
MIRT1169091	hsa-miR-3934	CLIP-seq
MIRT1169055	hsa-miR-4257	CLIP-seq
MIRT1169092	hsa-miR-4262	CLIP-seq
MIRT1169093	hsa-miR-4265	CLIP-seq
MIRT1169094	hsa-miR-4296	CLIP-seq
MIRT1169095	hsa-miR-4312	CLIP-seq
MIRT1169096	hsa-miR-4322	CLIP-seq
MIRT1169097	hsa-miR-4419b	CLIP-seq
MIRT1169098	hsa-miR-4433	CLIP-seq
MIRT1169099	hsa-miR-4447	CLIP-seq
MIRT1169056	hsa-miR-4459	CLIP-seq
MIRT1169100	hsa-miR-4472	CLIP-seq
MIRT1169101	hsa-miR-4478	CLIP-seq
MIRT1169102	hsa-miR-4634	CLIP-seq
MIRT1169103	hsa-miR-4643	CLIP-seq
MIRT1169104	hsa-miR-4649-3p	CLIP-seq
MIRT1169105	hsa-miR-466	CLIP-seq
MIRT1169059	hsa-miR-4695-5p	CLIP-seq
MIRT1169106	hsa-miR-4724-5p	CLIP-seq
MIRT1169107	hsa-miR-4743	CLIP-seq
MIRT1169108	hsa-miR-4768-3p	CLIP-seq
MIRT1169109	hsa-miR-4789-3p	CLIP-seq
MIRT1169110	hsa-miR-485-5p	CLIP-seq
MIRT1169111	hsa-miR-491-5p	CLIP-seq
MIRT1169112	hsa-miR-510	CLIP-seq
MIRT1169113	hsa-miR-512-5p	CLIP-seq
MIRT1169114	hsa-miR-577	CLIP-seq
MIRT1169063	hsa-miR-650	CLIP-seq
MIRT1169065	hsa-miR-665	CLIP-seq
MIRT1169115	hsa-miR-764	CLIP-seq
MIRT1169116	hsa-miR-874	CLIP-seq
MIRT1169117	hsa-miR-938	CLIP-seq
MIRT1169118	hsa-miR-96	CLIP-seq
MIRT1551521	hsa-miR-607	CLIP-seq
MIRT1169066	hsa-miR-125a-3p	CLIP-seq
MIRT1169091	hsa-miR-3934	CLIP-seq
MIRT1169056	hsa-miR-4459	CLIP-seq
MIRT1169059	hsa-miR-4695-5p	CLIP-seq
MIRT1169107	hsa-miR-4743	CLIP-seq
MIRT2048622	hsa-miR-4803	CLIP-seq
MIRT2048623	hsa-miR-515-5p	CLIP-seq
MIRT1169115	hsa-miR-764	CLIP-seq
MIRT2048624	hsa-miR-766	CLIP-seq
MIRT2576337	hsa-miR-3646	CLIP-seq
MIRT2576338	hsa-miR-501-3p	CLIP-seq
MIRT2576339	hsa-miR-502-3p	CLIP-seq
MIRT2576337	hsa-miR-3646	CLIP-seq
MIRT2576337	hsa-miR-3646	CLIP-seq
MIRT2576338	hsa-miR-501-3p	CLIP-seq
MIRT2576339	hsa-miR-502-3p	CLIP-seq
MIRT2685657	hsa-miR-105	CLIP-seq
MIRT2576337	hsa-miR-3646	CLIP-seq
MIRT2685658	hsa-miR-3908	CLIP-seq
MIRT2685659	hsa-miR-3925-3p	CLIP-seq
MIRT2685660	hsa-miR-3942-5p	CLIP-seq
MIRT2685661	hsa-miR-4517	CLIP-seq
MIRT2685662	hsa-miR-4703-5p	CLIP-seq
MIRT2685663	hsa-miR-4756-3p	CLIP-seq
MIRT2685664	hsa-miR-4766-3p	CLIP-seq
MIRT2685665	hsa-miR-4790-3p	CLIP-seq
MIRT2576338	hsa-miR-501-3p	CLIP-seq
MIRT2576339	hsa-miR-502-3p	CLIP-seq
MIRT2048623	hsa-miR-515-5p	CLIP-seq
MIRT2685666	hsa-miR-587	CLIP-seq
MIRT2685667	hsa-miR-591	CLIP-seq
MIRT2048624	hsa-miR-766	CLIP-seq
MIRT2685668	hsa-miR-888	CLIP-seq
MIRT2685669	hsa-miR-889	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA

MIM	HGNC	e!Ensembl
606042	14955	ENSG00000085274

Q9NPC7

Protein name

Myoneurin (Zinc finger and BTB domain-containing protein 31)

PDB

2VPK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00651	BTB	14 → 118	BTB/POZ domain	Domain
PF00096	zf-C2H2	303 → 324	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	330 → 352	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	387 → 409	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	415 → 437	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	443 → 465	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	471 → 493	Zinc finger, C2H2 type	Domain
PF13912	zf-C2H2_6	499 → 524		Domain

Tissue specificity

TISSUE SPECIFICITY: Mainly expressed in the neuromuscular system. Located in and around synaptic myonuclei in adult muscle. Expression is dysregulated after nerve injury. Also found in the testis, ovary and placenta. {ECO:0000269|PubMed:10873615, ECO:0000

Sequence

MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENN
VFLDQSQVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAF
IANPSSTEISSITGNIELNQQTCLLTLRDYNNREKSEVSTDLIQANPKQGALAKKSSQTK
KKKKAFNSPKTGQNKTVQYPSDILENASVELFLDANKLPTPVVEQVAQINDNSELELTSV
VENTFPAQDIVHTVTVKRKRGKSQPNCALKEHSMSNIASVKSPYEAENSGEELDQRYSKA
KPMCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGEKPYKC
ELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRC
GQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEKPYICGICGKSF
ISSGELNKHFRSHTGERPFICELCGNSYTDIKNLKKHKTKVHSGADKTLDSSAEDHTLSE
QDSIQKSPLSETMDVKPSDMTLPLALPLGTEDHHMLLPVTDTQSPTSDTLLRSTVNGYSE
PQLIFLQQLY

Sequence length

610

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (20)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CELIAC DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC LYMPHOCYTIC LEUKEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic osteomyelitis	association	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
CLEAR CELL RENAL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CUTANEOUS MELANOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEUKEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LYMPHOID LEUKEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE MYELOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYELOPROLIFERATIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PULMONARY FIBROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESPIRATORY SYSTEM DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
URINARY BLADDER CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (41)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of large intestine	Colorectal Cancer	GWASCAT_DG	20972440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	32309439	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	32486379	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	30120764		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	24163127	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	GWASCAT_DG	24163127		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	30120764		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	32312758	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Celiac Disease	Celiac disease	GWASCAT_DG	20190752		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Celiac Disease	Celiac disease	GWASDB_DG	20190752		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cerebral Infarction	Ischemic stroke	Pubtator	28057933	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Small Vessel Diseases	Cerebral microangiopathy	Pubtator	30769869	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	GWASDB_DG	24292274		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	GWASCAT_DG	24292274		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic osteomyelitis	Osteomyelitis	CLINVAR_DG			★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Colorectal Carcinoma	Colorectal Cancer	GWASDB_DG	20972440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	GWASCAT_DG	20972440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	GWASCAT_DG	20972440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	20972440, 21708826, 22999960, 24875374, 24978480, 30518759	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Disease	Coronary artery disease	Pubtator	24904205	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	32296102	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	40474102	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Heart Failure	Heart failure	Pubtator	33763035	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic neoplasm	Pubtator	23955597	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukocyte Disorders	Leukocyte disorders	Pubtator	31388112	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases, Interstitial	Lung Diseases	GWASDB_DG	23583980		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	28108556	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of large intestine	Colorectal Neoplasms	GWASCAT_DG	20972440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	GWASDB_DG	24163127		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	30120764		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	GWASCAT_DG	20972440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	Pubtator	30796745	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	GWASDB_DG	23955597		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multiple Myeloma	Multiple myeloma	GWASCAT_DG	23955597		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multiple Myeloma	Multiple myeloma	Pubtator	23955597, 24449210, 32433745	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multiple Sclerosis	Multiple Sclerosis	GWASDB_DG	21833088		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multiple Sclerosis	Multiple Sclerosis	GWASCAT_DG	21833088		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	Pubtator	24455749	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	20386695	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Small Lymphocytic Lymphoma	Lymphocytic Leukemia	GWASCAT_DG	24292274		★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	24163127, 30120764	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MYNN (myoneurin)