Gene Gene information from NCBI Gene database.
Entrez ID 55884
Gene name WD repeat and SOCS box containing 2
Gene symbol WSB2
Synonyms (NCBI Gene)
SBA2
Chromosome 12
Chromosome location 12q24.23
Summary This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquit
miRNA miRNA information provided by mirtarbase database.
517
miRTarBase ID miRNA Experiments Reference
MIRT020364 hsa-miR-29c-3p Sequencing 20371350
MIRT039837 hsa-miR-615-3p CLASH 23622248
MIRT530234 hsa-miR-577 PAR-CLIP 22012620
MIRT530233 hsa-miR-218-2-3p PAR-CLIP 22012620
MIRT530232 hsa-miR-758-5p PAR-CLIP 22012620
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination IBA
GO:0005515 Function Protein binding IPI 25036637, 33961781
GO:0005829 Component Cytosol TAS
GO:0016567 Process Protein ubiquitination IEA
GO:0035556 Process Intracellular signal transduction IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NYS7
Protein name WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein)
Protein function May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00400 WD40 143 182 WD domain, G-beta repeat Repeat
PF00400 WD40 187 225 WD domain, G-beta repeat Repeat
PF00400 WD40 229 267 WD domain, G-beta repeat Repeat
PF00400 WD40 284 320 WD domain, G-beta repeat Repeat
PF00400 WD40 331 361 WD domain, G-beta repeat Repeat
PF07525 SOCS_box 367 401 SOCS box Domain
Sequence
MEAGEEPLLLAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCIVKLIPWPLEEQ
FIPKGFEAKSRSSKNETKGRGSPKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPD
VSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRI
WD
LNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQS
SVVSCDFSPDSALLVTASYDTNVIMWD
PYTGERLRSLHHTQVDPAMDDSDVHISSLRSVC
FSPEGLYLATVADDRLLRIW
ALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW
T
APRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRTF
Sequence length 404
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neddylation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CHRONIC RHINOSINUSITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COMPLEX NEURODEVELOPMENTAL DISORDER GenCC
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Neoplasms Breast neoplasm Pubtator 32945370 Associate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 38177295 Stimulate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 38177295 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 11819827
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal Neoplasms LHGDN 11819827
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 11819827 Associate
★☆☆☆☆
Found in Text Mining only
leukemia Leukemia BEFREE 17001306
★☆☆☆☆
Found in Text Mining only
melanoma Melanoma BEFREE 31103822
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 31103822
★☆☆☆☆
Found in Text Mining only