WSB2 (WD repeat and SOCS box containing 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 55884 |
| Gene name | WD repeat and SOCS box containing 2 |
| Gene symbol | WSB2 |
| Synonyms (NCBI Gene) |
SBA2
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| Chromosome | 12 |
| Chromosome location | 12q24.23 |
| Summary | This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquit |
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miRNA
miRNA information provided by mirtarbase database.
517
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9NYS7 | |||||||||||||||||||||||||||||||||||
| Protein name | WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein) | |||||||||||||||||||||||||||||||||||
| Protein function | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | |||||||||||||||||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 404 | |||||||||||||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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