DBNDD2 (dysbindin domain containing 2)

Gene

• Entrez ID: 55861
• Gene name: Dysbindin domain containing 2
• Gene symbol: DBNDD2
• Synonyms (NCBI Gene): C20orf35, CK1BP, HSMNP1
• Chromosome: 20
• Chromosome location: 20q13.12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052207	hsa-let-7b-5p	CLASH	23622248
MIRT573854	hsa-miR-4785	PAR-CLIP	20371350
MIRT573853	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT573851	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT573852	hsa-miR-765	PAR-CLIP	20371350
MIRT573850	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT573849	hsa-miR-6880-5p	PAR-CLIP	20371350
MIRT573848	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT573854	hsa-miR-4785	PAR-CLIP	20371350
MIRT573853	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT573851	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT573852	hsa-miR-765	PAR-CLIP	20371350
MIRT573850	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT573849	hsa-miR-6880-5p	PAR-CLIP	20371350
MIRT573848	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT924011	hsa-miR-3144-3p	CLIP-seq
MIRT924012	hsa-miR-3194-3p	CLIP-seq
MIRT924013	hsa-miR-4795-3p	CLIP-seq
MIRT924014	hsa-miR-103a	CLIP-seq
MIRT924015	hsa-miR-107	CLIP-seq
MIRT924016	hsa-miR-1266	CLIP-seq
MIRT924017	hsa-miR-1301	CLIP-seq
MIRT924018	hsa-miR-214	CLIP-seq
MIRT924019	hsa-miR-296-3p	CLIP-seq
MIRT924020	hsa-miR-3148	CLIP-seq
MIRT924021	hsa-miR-3619-5p	CLIP-seq
MIRT924022	hsa-miR-3664-3p	CLIP-seq
MIRT924023	hsa-miR-3689a-3p	CLIP-seq
MIRT924024	hsa-miR-3689c	CLIP-seq
MIRT924025	hsa-miR-4274	CLIP-seq
MIRT924026	hsa-miR-4422	CLIP-seq
MIRT924027	hsa-miR-4433	CLIP-seq
MIRT924028	hsa-miR-4456	CLIP-seq
MIRT924029	hsa-miR-4459	CLIP-seq
MIRT924030	hsa-miR-450b-5p	CLIP-seq
MIRT924031	hsa-miR-4518	CLIP-seq
MIRT924032	hsa-miR-4519	CLIP-seq
MIRT924033	hsa-miR-4524	CLIP-seq
MIRT924034	hsa-miR-4722-5p	CLIP-seq
MIRT924035	hsa-miR-4728-5p	CLIP-seq
MIRT924036	hsa-miR-4768-3p	CLIP-seq
MIRT924037	hsa-miR-5047	CLIP-seq
MIRT924038	hsa-miR-518a-5p	CLIP-seq
MIRT924039	hsa-miR-527	CLIP-seq
MIRT924040	hsa-miR-541	CLIP-seq
MIRT924041	hsa-miR-548a-3p	CLIP-seq
MIRT924042	hsa-miR-548ae	CLIP-seq
MIRT924043	hsa-miR-548aj	CLIP-seq
MIRT924044	hsa-miR-548am	CLIP-seq
MIRT924045	hsa-miR-548e	CLIP-seq
MIRT924046	hsa-miR-548f	CLIP-seq
MIRT924047	hsa-miR-548x	CLIP-seq
MIRT924048	hsa-miR-582-3p	CLIP-seq
MIRT924049	hsa-miR-654-5p	CLIP-seq
MIRT924050	hsa-miR-761	CLIP-seq
MIRT1973684	hsa-miR-299-5p	CLIP-seq
MIRT1973685	hsa-miR-1207-5p	CLIP-seq
MIRT1973686	hsa-miR-1909	CLIP-seq
MIRT1973687	hsa-miR-2682	CLIP-seq
MIRT1973688	hsa-miR-3137	CLIP-seq
MIRT1973689	hsa-miR-449c	CLIP-seq
MIRT1973690	hsa-miR-4676-5p	CLIP-seq
MIRT1973691	hsa-miR-4763-3p	CLIP-seq
MIRT1973692	hsa-miR-575	CLIP-seq
MIRT1973693	hsa-miR-622	CLIP-seq
MIRT1973694	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16618118
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0006469	Process	Negative regulation of protein kinase activity	IDA	16618118
GO:0006915	Process	Apoptotic process	IEA
GO:0009966	Process	Regulation of signal transduction	IBA
GO:0022008	Process	Neurogenesis	IEA
GO:0031175	Process	Neuron projection development	IEA
GO:0050801	Process	Monoatomic ion homeostasis	IEA
GO:0051117	Function	ATPase binding	IEA
GO:0070371	Process	ERK1 and ERK2 cascade	IEA

Other IDs

• MIM: 611453
• HGNC: 15881
• e!Ensembl: ENSG00000244274

Protein

• UniProt ID: Q9BQY9
• Protein name: Dysbindin domain-containing protein 2 (Casein kinase-1 binding protein) (CK1BP) (HSMNP1)
• Protein function: May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04440	Dysbindin	101 → 241	Dysbindin (Dystrobrevin binding protein 1)	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in brain. {ECO:0000269|PubMed:16618118}.
• Sequence:

  MGAGNFLTALEVPVAALAGAASDRRASCERVSPPPPLPHFRLPPLPRSRLPGPVSRPEPG
  APLLGCWLQWGAPSPGPLCLLFRLCSCTCFAPLPAGADMDPNPRAALERQQLRLRERQKF
  FEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVDTLEQVELIDLGDPDAADVFLPC
  EDPPPTPQSSGMDNHLEELSLPVPTSDRTTSRTSSSSSSDSSTNLHSPNPSDDGADTPLA
  QSDEEEERGDGGAEPGACS

• Sequence length: 259

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations