Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55854
Gene name	Zinc finger CCCH-type containing 15
Gene symbol	ZC3H15
Synonyms (NCBI Gene)	DFRP1HT010LEREPO4MSTP012
Chromosome	2
Chromosome location	2q32.1

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Show/Hide all (123)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021112	hsa-miR-186-5p	Sequencing	20371350
MIRT027880	hsa-miR-96-5p	Sequencing	20371350
MIRT1505779	hsa-miR-1253	CLIP-seq
MIRT1505780	hsa-miR-1262	CLIP-seq
MIRT1505781	hsa-miR-1286	CLIP-seq
MIRT1505782	hsa-miR-1293	CLIP-seq
MIRT1505783	hsa-miR-129-5p	CLIP-seq
MIRT1505784	hsa-miR-1305	CLIP-seq
MIRT1505785	hsa-miR-2276	CLIP-seq
MIRT1505786	hsa-miR-2681	CLIP-seq
MIRT1505787	hsa-miR-3138	CLIP-seq
MIRT1505788	hsa-miR-3160-3p	CLIP-seq
MIRT1505789	hsa-miR-3664-5p	CLIP-seq
MIRT1505790	hsa-miR-4459	CLIP-seq
MIRT1505791	hsa-miR-4483	CLIP-seq
MIRT1505792	hsa-miR-4487	CLIP-seq
MIRT1505793	hsa-miR-450b-5p	CLIP-seq
MIRT1505794	hsa-miR-4520a-3p	CLIP-seq
MIRT1505795	hsa-miR-4528	CLIP-seq
MIRT1505796	hsa-miR-4539	CLIP-seq
MIRT1505797	hsa-miR-4691-5p	CLIP-seq
MIRT1505798	hsa-miR-4701-3p	CLIP-seq
MIRT1505799	hsa-miR-4705	CLIP-seq
MIRT1505800	hsa-miR-4714-5p	CLIP-seq
MIRT1505801	hsa-miR-4722-5p	CLIP-seq
MIRT1505802	hsa-miR-4764-3p	CLIP-seq
MIRT1505803	hsa-miR-4772-3p	CLIP-seq
MIRT1505804	hsa-miR-4775	CLIP-seq
MIRT1505805	hsa-miR-507	CLIP-seq
MIRT1505806	hsa-miR-532-5p	CLIP-seq
MIRT1505807	hsa-miR-544	CLIP-seq
MIRT1505808	hsa-miR-550b	CLIP-seq
MIRT1505809	hsa-miR-557	CLIP-seq
MIRT1505810	hsa-miR-558	CLIP-seq
MIRT1505811	hsa-miR-590-3p	CLIP-seq
MIRT1505812	hsa-miR-591	CLIP-seq
MIRT1505813	hsa-miR-606	CLIP-seq
MIRT1505814	hsa-miR-890	CLIP-seq
MIRT1505815	hsa-miR-935	CLIP-seq
MIRT1555700	hsa-miR-3125	CLIP-seq
MIRT1555701	hsa-miR-3916	CLIP-seq
MIRT1555702	hsa-miR-4797-5p	CLIP-seq
MIRT1505779	hsa-miR-1253	CLIP-seq
MIRT2152264	hsa-miR-1273f	CLIP-seq
MIRT1505784	hsa-miR-1305	CLIP-seq
MIRT2152265	hsa-miR-143	CLIP-seq
MIRT1505786	hsa-miR-2681	CLIP-seq
MIRT1505789	hsa-miR-3664-5p	CLIP-seq
MIRT1505795	hsa-miR-4528	CLIP-seq
MIRT1505796	hsa-miR-4539	CLIP-seq
MIRT2152266	hsa-miR-4662a-5p	CLIP-seq
MIRT2152267	hsa-miR-4708-5p	CLIP-seq
MIRT2152268	hsa-miR-4712-3p	CLIP-seq
MIRT1505800	hsa-miR-4714-5p	CLIP-seq
MIRT2152269	hsa-miR-4770	CLIP-seq
MIRT1505812	hsa-miR-591	CLIP-seq
MIRT1505813	hsa-miR-606	CLIP-seq
MIRT1505779	hsa-miR-1253	CLIP-seq
MIRT1505780	hsa-miR-1262	CLIP-seq
MIRT1505782	hsa-miR-1293	CLIP-seq
MIRT2372683	hsa-miR-2682	CLIP-seq
MIRT1505787	hsa-miR-3138	CLIP-seq
MIRT2372684	hsa-miR-3978	CLIP-seq
MIRT2372685	hsa-miR-4307	CLIP-seq
MIRT2372686	hsa-miR-4423-3p	CLIP-seq
MIRT1505791	hsa-miR-4483	CLIP-seq
MIRT2372687	hsa-miR-449c	CLIP-seq
MIRT1505794	hsa-miR-4520a-3p	CLIP-seq
MIRT1505798	hsa-miR-4701-3p	CLIP-seq
MIRT1505799	hsa-miR-4705	CLIP-seq
MIRT2372688	hsa-miR-4799-5p	CLIP-seq
MIRT1505808	hsa-miR-550b	CLIP-seq
MIRT1505814	hsa-miR-890	CLIP-seq
MIRT1505815	hsa-miR-935	CLIP-seq
MIRT2372689	hsa-miR-940	CLIP-seq
MIRT2372683	hsa-miR-2682	CLIP-seq
MIRT1555700	hsa-miR-3125	CLIP-seq
MIRT2665555	hsa-miR-34b	CLIP-seq
MIRT1555701	hsa-miR-3916	CLIP-seq
MIRT2372685	hsa-miR-4307	CLIP-seq
MIRT2372686	hsa-miR-4423-3p	CLIP-seq
MIRT2372687	hsa-miR-449c	CLIP-seq
MIRT1555702	hsa-miR-4797-5p	CLIP-seq
MIRT2372688	hsa-miR-4799-5p	CLIP-seq
MIRT2665556	hsa-miR-548a-3p	CLIP-seq
MIRT2665557	hsa-miR-548ac	CLIP-seq
MIRT2665558	hsa-miR-548ae	CLIP-seq
MIRT2665559	hsa-miR-548aj	CLIP-seq
MIRT2665560	hsa-miR-548am	CLIP-seq
MIRT2665561	hsa-miR-548d-3p	CLIP-seq
MIRT2665562	hsa-miR-548e	CLIP-seq
MIRT2665563	hsa-miR-548f	CLIP-seq
MIRT2665564	hsa-miR-548g	CLIP-seq
MIRT2665565	hsa-miR-548x	CLIP-seq
MIRT2665566	hsa-miR-548z	CLIP-seq
MIRT2372689	hsa-miR-940	CLIP-seq
MIRT2695514	hsa-miR-105	CLIP-seq
MIRT2372683	hsa-miR-2682	CLIP-seq
MIRT1555700	hsa-miR-3125	CLIP-seq
MIRT2695515	hsa-miR-3179	CLIP-seq
MIRT2665555	hsa-miR-34b	CLIP-seq
MIRT2695516	hsa-miR-3646	CLIP-seq
MIRT1555701	hsa-miR-3916	CLIP-seq
MIRT2372685	hsa-miR-4307	CLIP-seq
MIRT2372686	hsa-miR-4423-3p	CLIP-seq
MIRT2372687	hsa-miR-449c	CLIP-seq
MIRT1555702	hsa-miR-4797-5p	CLIP-seq
MIRT2372688	hsa-miR-4799-5p	CLIP-seq
MIRT2665556	hsa-miR-548a-3p	CLIP-seq
MIRT2665557	hsa-miR-548ac	CLIP-seq
MIRT2665558	hsa-miR-548ae	CLIP-seq
MIRT2665559	hsa-miR-548aj	CLIP-seq
MIRT2665560	hsa-miR-548am	CLIP-seq
MIRT2665561	hsa-miR-548d-3p	CLIP-seq
MIRT2665562	hsa-miR-548e	CLIP-seq
MIRT2665563	hsa-miR-548f	CLIP-seq
MIRT2665564	hsa-miR-548g	CLIP-seq
MIRT2665565	hsa-miR-548x	CLIP-seq
MIRT2665566	hsa-miR-548z	CLIP-seq
MIRT2695517	hsa-miR-592	CLIP-seq
MIRT2695518	hsa-miR-597	CLIP-seq
MIRT2695519	hsa-miR-892a	CLIP-seq
MIRT2372689	hsa-miR-940	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IBA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	19819225, 21516116, 25416956, 28514442, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0008270	Function	Zinc ion binding	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0043547	Process	Positive regulation of GTPase activity	IDA	23711155
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
619704	29528	ENSG00000065548

Q8WU90

Protein name

Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4)

Protein function

Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18044	zf-CCCH_4	103 → 124	CCCH-type zinc finger	Domain
PF16543	DFRP_C	229 → 330	DRG Family Regulatory Proteins, Tma46	Domain

Sequence

MPPKKQAQAGGSKKAEQKKKEKIIEDKTFGLKNKKGAKQQKFIKAVTHQVKFGQQNPRQV
AQSEAEKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCK
FSHDLTLERKCEKRSVYIDARDEELEKDTMDNWDEKKLEEVVNKKHGEAEKKKPKTQIVC
KHFLEAIENNKYGWFWVCPGGGDICMYRHALPPGFVLKKDKKKEEKEDEISLEDLIERER
SALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADFKAGKALVISGREVFEFRPE
LVNDDDEEADDTRYTQGTGGDEVDDSVSVNDIDLSLYIPRDVDETGITVASLERFSTYTS
DKDENKLSEASGGRAENGERSDLEEDNEREGTENGAIDAVPVDENLFTGEDLDELEEELN
TLDLEE

Sequence length

426

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	23624947		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	35027542	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35027542	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	35027542	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	35027542	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid	Myeloid leukemia	Pubtator	35027542	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	23624947		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	27191988		★★★★★ ★☆☆☆☆ Found in Text Mining only

ZC3H15 (zinc finger CCCH-type containing 15)