Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55846
Gene name	Integrin alpha FG-GAP repeat containing 2
Gene symbol	ITFG2
Synonyms (NCBI Gene)	FGGAP1KICS3MDS028
Chromosome	12
Chromosome location	12p13.33

Show/Hide all (67)

miRTarBase ID	miRNA	Experiments	Reference
MIRT532425	hsa-miR-3169	PAR-CLIP	22012620
MIRT532424	hsa-miR-3190-5p	PAR-CLIP	22012620
MIRT532423	hsa-miR-5580-5p	PAR-CLIP	22012620
MIRT532422	hsa-miR-1288-3p	PAR-CLIP	22012620
MIRT532421	hsa-miR-4529-5p	PAR-CLIP	22012620
MIRT532419	hsa-miR-3187-3p	PAR-CLIP	22012620
MIRT532425	hsa-miR-3169	PAR-CLIP	22012620
MIRT532424	hsa-miR-3190-5p	PAR-CLIP	22012620
MIRT532423	hsa-miR-5580-5p	PAR-CLIP	22012620
MIRT532422	hsa-miR-1288-3p	PAR-CLIP	22012620
MIRT532421	hsa-miR-4529-5p	PAR-CLIP	22012620
MIRT532419	hsa-miR-3187-3p	PAR-CLIP	22012620
MIRT1073324	hsa-miR-1323	CLIP-seq
MIRT1073325	hsa-miR-205	CLIP-seq
MIRT1073326	hsa-miR-23a	CLIP-seq
MIRT1073327	hsa-miR-23b	CLIP-seq
MIRT1073328	hsa-miR-23c	CLIP-seq
MIRT1073329	hsa-miR-3158-3p	CLIP-seq
MIRT1073330	hsa-miR-3620	CLIP-seq
MIRT1073331	hsa-miR-4446-3p	CLIP-seq
MIRT1073332	hsa-miR-4769-3p	CLIP-seq
MIRT1073333	hsa-miR-548o	CLIP-seq
MIRT2018050	hsa-miR-3115	CLIP-seq
MIRT1073329	hsa-miR-3158-3p	CLIP-seq
MIRT2249920	hsa-miR-4481	CLIP-seq
MIRT2249921	hsa-miR-4745-5p	CLIP-seq
MIRT2553387	hsa-miR-1233	CLIP-seq
MIRT2553388	hsa-miR-129-3p	CLIP-seq
MIRT2553389	hsa-miR-2861	CLIP-seq
MIRT2553390	hsa-miR-331-3p	CLIP-seq
MIRT2553391	hsa-miR-342-5p	CLIP-seq
MIRT2553392	hsa-miR-4292	CLIP-seq
MIRT2553393	hsa-miR-4426	CLIP-seq
MIRT2553394	hsa-miR-4647	CLIP-seq
MIRT2553395	hsa-miR-4651	CLIP-seq
MIRT2553396	hsa-miR-4662b	CLIP-seq
MIRT2553397	hsa-miR-4664-5p	CLIP-seq
MIRT2553398	hsa-miR-4720-3p	CLIP-seq
MIRT2553399	hsa-miR-4777-3p	CLIP-seq
MIRT2553400	hsa-miR-608	CLIP-seq
MIRT2553401	hsa-miR-7	CLIP-seq
MIRT2553402	hsa-miR-938	CLIP-seq
MIRT2682948	hsa-miR-1183	CLIP-seq
MIRT2553387	hsa-miR-1233	CLIP-seq
MIRT2682949	hsa-miR-1266	CLIP-seq
MIRT2553388	hsa-miR-129-3p	CLIP-seq
MIRT2682950	hsa-miR-296-3p	CLIP-seq
MIRT2553391	hsa-miR-342-5p	CLIP-seq
MIRT2682951	hsa-miR-3664-3p	CLIP-seq
MIRT2682952	hsa-miR-3667-5p	CLIP-seq
MIRT2682953	hsa-miR-3914	CLIP-seq
MIRT2553393	hsa-miR-4426	CLIP-seq
MIRT2682954	hsa-miR-4494	CLIP-seq
MIRT2682955	hsa-miR-4518	CLIP-seq
MIRT2553394	hsa-miR-4647	CLIP-seq
MIRT2553395	hsa-miR-4651	CLIP-seq
MIRT2553396	hsa-miR-4662b	CLIP-seq
MIRT2553397	hsa-miR-4664-5p	CLIP-seq
MIRT2682956	hsa-miR-4694-3p	CLIP-seq
MIRT2553398	hsa-miR-4720-3p	CLIP-seq
MIRT2682957	hsa-miR-522	CLIP-seq
MIRT2682958	hsa-miR-555	CLIP-seq
MIRT2553400	hsa-miR-608	CLIP-seq
MIRT2553401	hsa-miR-7	CLIP-seq
MIRT2682959	hsa-miR-9	CLIP-seq
MIRT2553402	hsa-miR-938	CLIP-seq
MIRT2682960	hsa-miR-941	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002314	Process	Germinal center B cell differentiation	IEA
GO:0005515	Function	Protein binding	IPI	33961781, 38288086
GO:0005654	Component	Nucleoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	28199306
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	NAS	28199306
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IEA
GO:0016020	Component	Membrane	IEA
GO:0032006	Process	Regulation of TOR signaling	IBA
GO:0034198	Process	Cellular response to amino acid starvation	IMP	28199306
GO:0042149	Process	Cellular response to glucose starvation	IMP	28199306
GO:0140007	Component	KICSTOR complex	IBA
GO:0140007	Component	KICSTOR complex	IDA	28199306
GO:0140007	Component	KICSTOR complex	NAS	28199306
GO:1904262	Process	Negative regulation of TORC1 signaling	IMP	28199306

MIM	HGNC	e!Ensembl
617421	30879	ENSG00000111203

Q969R8

Protein name

KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2)

Protein function

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15907	Itfg2	49 → 386	Integrin-alpha FG-GAP repeat-containing protein 2	Family

Sequence

MRSVSYVQRVALEFSGSLFPHAICLGDVDNDTLNELVVGDTSGKVSVYKNDDSRPWLTCS
CQGMLTCVGVGDVCNKGKNLLVAVSAEGWFHLFDLTPAKVLDASGHHETLIGEEQRPVFK
QHIPANTKVMLISDIDGDGCRELVVGYTDRVVRAFRWEELGEGPEHLTGQLVSLKKWMLE
GQVDSLSVTLGPLGLPELMVSQPGCAYAILLCTWKKDTGSPPASEGPTDGSRETPAARDV
VLHQTSGRIHNKNVSTHLIGNIKQGHGTESSGSGLFALCTLDGTLKLMEEMEEADKLLWS
VQVDHQLFALEKLDVTGNGHEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGLYAC
KEGRNSPCLVYVTFNQKIYVYWEVQLERMESTNLVKLLETKPEYHSLLQELGVDPDDLPV
TRALLHQTLYHPDQPPQCAPSSLQDPT

Sequence length

447

Interactions

View interactions

	Reactome
			Amino acids regulate mTORC1

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ITFG2 (integrin alpha FG-GAP repeat containing 2)