Gene Gene information from NCBI Gene database.
Entrez ID 55845
Gene name BRICK1 subunit of SCAR/WAVE actin nucleating complex
Gene symbol BRK1
Synonyms (NCBI Gene)
C3orf10HSPC300MDS027hHBrk1
Chromosome 3
Chromosome location 3p25.3
miRNA miRNA information provided by mirtarbase database.
457
miRTarBase ID miRNA Experiments Reference
MIRT824924 hsa-miR-1224-5p CLIP-seq
MIRT824925 hsa-miR-1260 CLIP-seq
MIRT824926 hsa-miR-1260b CLIP-seq
MIRT824927 hsa-miR-130a CLIP-seq
MIRT824928 hsa-miR-130b CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0001701 Process In utero embryonic development IEA
GO:0005515 Function Protein binding IPI 18560548, 24439377, 25416956, 31413325, 32296183, 32814053, 33961781
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol TAS
GO:0005856 Component Cytoskeleton IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611183 23057 ENSG00000254999
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WUW1
Protein name Protein BRICK1 (BRK1)
Protein function Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By simil
PDB 3P8C , 4N78 , 7USC , 7USD , 7USE
Family and domains
Sequence
MAGQEDPVQREIHQDWANREYIEIITSSIKKIADFLNSFDMSCRSRLATLNEKLTALERR
IEYIEARVTKGETLT
Sequence length 75
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Regulation of actin cytoskeleton
Pathogenic Escherichia coli infection
Salmonella infection
  Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
FCGR3A-mediated phagocytosis
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
KIDNEY CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
KIDNEY NEOPLASM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MALIGNANT URINARY SYSTEM NEOPLASM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
URINARY BLADDER CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Angioma Angioma BEFREE 19280651
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 40489916 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 19576655
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 22761941 Associate
★☆☆☆☆
Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma Renal Carcinoma BEFREE 14695531, 17311301, 19764026
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of lung Lung Cancer BEFREE 19576655
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 17311301, 19576655, 20861187
★☆☆☆☆
Found in Text Mining only
Neuroblastoma Neuroblastoma BEFREE 23939472
★☆☆☆☆
Found in Text Mining only
Non-Small Cell Lung Carcinoma Lung carcinoma BEFREE 24680773
★☆☆☆☆
Found in Text Mining only
Renal Cell Carcinoma Renal Carcinoma BEFREE 14695531, 17311301, 19280651, 19764026
★☆☆☆☆
Found in Text Mining only