Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55816
Gene name	Docking protein 5
Gene symbol	DOK5
Synonyms (NCBI Gene)	C20orf180IRS-6IRS6
Chromosome	20
Chromosome location	20q13.2
Summary	The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and a

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Show/Hide all (108)

miRTarBase ID	miRNA	Experiments
MIRT943132	hsa-miR-10a	CLIP-seq
MIRT943133	hsa-miR-10b	CLIP-seq
MIRT943134	hsa-miR-198	CLIP-seq
MIRT943135	hsa-miR-30a	CLIP-seq
MIRT943136	hsa-miR-30b	CLIP-seq
MIRT943137	hsa-miR-30c	CLIP-seq
MIRT943138	hsa-miR-30d	CLIP-seq
MIRT943139	hsa-miR-30e	CLIP-seq
MIRT943140	hsa-miR-3607-3p	CLIP-seq
MIRT943141	hsa-miR-4267	CLIP-seq
MIRT943142	hsa-miR-583	CLIP-seq
MIRT2214445	hsa-miR-200b	CLIP-seq
MIRT2214446	hsa-miR-200c	CLIP-seq
MIRT2214447	hsa-miR-3152-3p	CLIP-seq
MIRT2214448	hsa-miR-3202	CLIP-seq
MIRT2214449	hsa-miR-34a	CLIP-seq
MIRT2214450	hsa-miR-34c-5p	CLIP-seq
MIRT2214451	hsa-miR-3614-5p	CLIP-seq
MIRT2214452	hsa-miR-3915	CLIP-seq
MIRT2214453	hsa-miR-3928	CLIP-seq
MIRT2214454	hsa-miR-3936	CLIP-seq
MIRT2214455	hsa-miR-429	CLIP-seq
MIRT2214456	hsa-miR-4457	CLIP-seq
MIRT2214457	hsa-miR-449a	CLIP-seq
MIRT2214458	hsa-miR-449b	CLIP-seq
MIRT2214459	hsa-miR-4533	CLIP-seq
MIRT2214460	hsa-miR-494	CLIP-seq
MIRT2214461	hsa-miR-499-3p	CLIP-seq
MIRT2214462	hsa-miR-499a-3p	CLIP-seq
MIRT2214463	hsa-miR-513b	CLIP-seq
MIRT2214464	hsa-miR-595	CLIP-seq
MIRT2214465	hsa-miR-642b	CLIP-seq
MIRT2214466	hsa-miR-890	CLIP-seq
MIRT2214467	hsa-miR-935	CLIP-seq
MIRT2214468	hsa-miR-943	CLIP-seq
MIRT2448485	hsa-miR-1262	CLIP-seq
MIRT2448486	hsa-miR-3115	CLIP-seq
MIRT2448487	hsa-miR-3185	CLIP-seq
MIRT2448488	hsa-miR-4701-3p	CLIP-seq
MIRT2518698	hsa-miR-1252	CLIP-seq
MIRT2448485	hsa-miR-1262	CLIP-seq
MIRT2518699	hsa-miR-1283	CLIP-seq
MIRT2518700	hsa-miR-130a	CLIP-seq
MIRT2518701	hsa-miR-130b	CLIP-seq
MIRT2518702	hsa-miR-301a	CLIP-seq
MIRT2518703	hsa-miR-301b	CLIP-seq
MIRT2448486	hsa-miR-3115	CLIP-seq
MIRT2214447	hsa-miR-3152-3p	CLIP-seq
MIRT2448487	hsa-miR-3185	CLIP-seq
MIRT2214448	hsa-miR-3202	CLIP-seq
MIRT2518704	hsa-miR-338-5p	CLIP-seq
MIRT2214451	hsa-miR-3614-5p	CLIP-seq
MIRT2518705	hsa-miR-3666	CLIP-seq
MIRT2518706	hsa-miR-3919	CLIP-seq
MIRT2518707	hsa-miR-3973	CLIP-seq
MIRT2518708	hsa-miR-4295	CLIP-seq
MIRT2214456	hsa-miR-4457	CLIP-seq
MIRT2518709	hsa-miR-4475	CLIP-seq
MIRT2214459	hsa-miR-4533	CLIP-seq
MIRT2518710	hsa-miR-454	CLIP-seq
MIRT2448488	hsa-miR-4701-3p	CLIP-seq
MIRT2518711	hsa-miR-4708-3p	CLIP-seq
MIRT2518712	hsa-miR-4756-3p	CLIP-seq
MIRT2214460	hsa-miR-494	CLIP-seq
MIRT2214461	hsa-miR-499-3p	CLIP-seq
MIRT2214462	hsa-miR-499a-3p	CLIP-seq
MIRT2214463	hsa-miR-513b	CLIP-seq
MIRT2518713	hsa-miR-519a	CLIP-seq
MIRT2518714	hsa-miR-519b-3p	CLIP-seq
MIRT2518715	hsa-miR-519c-3p	CLIP-seq
MIRT2518716	hsa-miR-548l	CLIP-seq
MIRT2214464	hsa-miR-595	CLIP-seq
MIRT2214465	hsa-miR-642b	CLIP-seq
MIRT2214466	hsa-miR-890	CLIP-seq
MIRT2518698	hsa-miR-1252	CLIP-seq
MIRT2448485	hsa-miR-1262	CLIP-seq
MIRT2518699	hsa-miR-1283	CLIP-seq
MIRT2518700	hsa-miR-130a	CLIP-seq
MIRT2518701	hsa-miR-130b	CLIP-seq
MIRT2518702	hsa-miR-301a	CLIP-seq
MIRT2518703	hsa-miR-301b	CLIP-seq
MIRT2448486	hsa-miR-3115	CLIP-seq
MIRT2214447	hsa-miR-3152-3p	CLIP-seq
MIRT2448487	hsa-miR-3185	CLIP-seq
MIRT2214448	hsa-miR-3202	CLIP-seq
MIRT2214451	hsa-miR-3614-5p	CLIP-seq
MIRT2518705	hsa-miR-3666	CLIP-seq
MIRT2518706	hsa-miR-3919	CLIP-seq
MIRT2518707	hsa-miR-3973	CLIP-seq
MIRT2518708	hsa-miR-4295	CLIP-seq
MIRT2214456	hsa-miR-4457	CLIP-seq
MIRT2518709	hsa-miR-4475	CLIP-seq
MIRT2214459	hsa-miR-4533	CLIP-seq
MIRT2518710	hsa-miR-454	CLIP-seq
MIRT2448488	hsa-miR-4701-3p	CLIP-seq
MIRT2518711	hsa-miR-4708-3p	CLIP-seq
MIRT2518712	hsa-miR-4756-3p	CLIP-seq
MIRT2214460	hsa-miR-494	CLIP-seq
MIRT2214461	hsa-miR-499-3p	CLIP-seq
MIRT2214462	hsa-miR-499a-3p	CLIP-seq
MIRT2214463	hsa-miR-513b	CLIP-seq
MIRT2518713	hsa-miR-519a	CLIP-seq
MIRT2518714	hsa-miR-519b-3p	CLIP-seq
MIRT2518715	hsa-miR-519c-3p	CLIP-seq
MIRT2518716	hsa-miR-548l	CLIP-seq
MIRT2214464	hsa-miR-595	CLIP-seq
MIRT2214465	hsa-miR-642b	CLIP-seq
MIRT2214466	hsa-miR-890	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA
GO:0030182	Process	Neuron differentiation	IEA
GO:0043410	Process	Positive regulation of MAPK cascade	IEA
GO:0051386	Process	Regulation of neurotrophin TRK receptor signaling pathway	IMP	23954828

MIM	HGNC	e!Ensembl
608334	16173	ENSG00000101134

Q9P104

Protein name

Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6)

Protein function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activatio

PDB

1J0W

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02174	IRS	135 → 232	PTB domain (IRS-1 type)	Domain

Tissue specificity

TISSUE SPECIFICITY: Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. {ECO:0000269|PubMed:12595900, ECO:0000269|PubMed:12730241}.

Sequence

MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVT
ELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDIS
LGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWP
LSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQS
VKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFP
AYRSEH

Sequence length

306

Interactions

View interactions

	Reactome
			RET signaling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CELIAC DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VASCULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (16)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Bipolar Disorder	Bipolar Disorder	BEFREE	20215924		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	20215924		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar disorder	Pubtator	20215924	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Carcinoma	Breast Carcinoma	BEFREE	30858725		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32148377	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	28540987	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	20187968, 22152676	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	20187968, 22152676		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	BEFREE	30515784		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30858725		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	20187968		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	20187968	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pheochromocytoma	Pheochromocytoma	Pubtator	20534969	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	35036444	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	24551065		★★★★★ ★☆☆☆☆ Found in Text Mining only

DOK5 (docking protein 5)