Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55813
Gene name	UTP6 small subunit processome component
Gene symbol	UTP6
Synonyms (NCBI Gene)	C17orf40HCA66
Chromosome	17
Chromosome location	17q11.2

116

Show/Hide all (116)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028657	hsa-miR-30a-5p	Proteomics	18668040
MIRT032485	hsa-let-7b-5p	Proteomics	18668040
MIRT051727	hsa-let-7d-5p	CLASH	23622248
MIRT651797	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT651786	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT651796	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT651795	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT651794	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT651793	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT651792	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT651791	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT651790	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT651789	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT651787	hsa-miR-8086	HITS-CLIP	23824327
MIRT651788	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT651785	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT651786	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT651783	hsa-miR-4474-5p	HITS-CLIP	23824327
MIRT651784	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT651782	hsa-miR-548s	HITS-CLIP	23824327
MIRT651781	hsa-miR-588	HITS-CLIP	23824327
MIRT651780	hsa-miR-4435	HITS-CLIP	23824327
MIRT651779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT651777	hsa-miR-5096	HITS-CLIP	23824327
MIRT651778	hsa-miR-1303	HITS-CLIP	23824327
MIRT651776	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT637874	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT637873	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT637872	hsa-miR-1253	HITS-CLIP	23824327
MIRT637871	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT637869	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT637872	hsa-miR-1253	HITS-CLIP	23824327
MIRT637871	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT637870	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT637869	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT540763	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT540762	hsa-miR-1273g-3p	PAR-CLIP	21572407
MIRT540761	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT540760	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT540759	hsa-miR-4793-3p	PAR-CLIP	21572407
MIRT540758	hsa-miR-1273f	PAR-CLIP	21572407
MIRT540756	hsa-miR-4534	PAR-CLIP	21572407
MIRT540757	hsa-miR-8082	PAR-CLIP	21572407
MIRT540755	hsa-miR-4252	PAR-CLIP	21572407
MIRT540754	hsa-miR-1254	PAR-CLIP	21572407
MIRT540753	hsa-miR-3116	PAR-CLIP	21572407
MIRT540752	hsa-miR-505-5p	PAR-CLIP	21572407
MIRT540751	hsa-miR-6744-5p	PAR-CLIP	21572407
MIRT540750	hsa-miR-1255a	PAR-CLIP	21572407
MIRT540749	hsa-miR-1255b-5p	PAR-CLIP	21572407
MIRT540748	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT540746	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT540747	hsa-miR-7703	PAR-CLIP	21572407
MIRT651797	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT651786	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT651796	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT651795	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT651794	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT651793	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT651792	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT651791	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT651790	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT651789	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT651787	hsa-miR-8086	HITS-CLIP	23824327
MIRT651788	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT651785	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT651786	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT651783	hsa-miR-4474-5p	HITS-CLIP	23824327
MIRT651784	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT651782	hsa-miR-548s	HITS-CLIP	23824327
MIRT651781	hsa-miR-588	HITS-CLIP	23824327
MIRT651780	hsa-miR-4435	HITS-CLIP	23824327
MIRT651779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT651777	hsa-miR-5096	HITS-CLIP	23824327
MIRT651778	hsa-miR-1303	HITS-CLIP	23824327
MIRT651776	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT637874	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT637873	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT637872	hsa-miR-1253	HITS-CLIP	23824327
MIRT637871	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT637869	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT637872	hsa-miR-1253	HITS-CLIP	23824327
MIRT637871	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT637870	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT637869	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT540763	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT540762	hsa-miR-1273g-3p	PAR-CLIP	21572407
MIRT540761	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT540760	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT540759	hsa-miR-4793-3p	PAR-CLIP	21572407
MIRT540758	hsa-miR-1273f	PAR-CLIP	21572407
MIRT540756	hsa-miR-4534	PAR-CLIP	21572407
MIRT540757	hsa-miR-8082	PAR-CLIP	21572407
MIRT540755	hsa-miR-4252	PAR-CLIP	21572407
MIRT540754	hsa-miR-1254	PAR-CLIP	21572407
MIRT540753	hsa-miR-3116	PAR-CLIP	21572407
MIRT540752	hsa-miR-505-5p	PAR-CLIP	21572407
MIRT540751	hsa-miR-6744-5p	PAR-CLIP	21572407
MIRT540750	hsa-miR-1255a	PAR-CLIP	21572407
MIRT540749	hsa-miR-1255b-5p	PAR-CLIP	21572407
MIRT540748	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT540746	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT540747	hsa-miR-7703	PAR-CLIP	21572407
MIRT1481321	hsa-miR-320a	CLIP-seq
MIRT1481322	hsa-miR-320b	CLIP-seq
MIRT1481323	hsa-miR-320c	CLIP-seq
MIRT1481324	hsa-miR-320d	CLIP-seq
MIRT1481325	hsa-miR-4429	CLIP-seq
MIRT1481326	hsa-miR-4719	CLIP-seq
MIRT1481327	hsa-miR-513b	CLIP-seq
MIRT1481328	hsa-miR-943	CLIP-seq
MIRT2144823	hsa-miR-1323	CLIP-seq
MIRT2144824	hsa-miR-1324	CLIP-seq
MIRT2144825	hsa-miR-371-5p	CLIP-seq
MIRT2144826	hsa-miR-548aa	CLIP-seq
MIRT2144827	hsa-miR-548o	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000462	Process	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000462	Process	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0006396	Process	RNA processing	IEA
GO:0030515	Function	SnoRNA binding	IBA
GO:0030515	Function	SnoRNA binding	IEA
GO:0032040	Component	Small-subunit processome	IBA
GO:0032040	Component	Small-subunit processome	IDA	34516797
GO:0034388	Component	Pwp2p-containing subcomplex of 90S preribosome	IBA
GO:0042274	Process	Ribosomal small subunit biogenesis	IDA	34516797

MIM	HGNC	e!Ensembl
620948	18279	ENSG00000108651

Q9NYH9

Protein name

U3 small nucleolar RNA-associated protein 6 homolog (Hepatocellular carcinoma-associated antigen 66) (Multiple hat domains protein)

Protein function

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associat

PDB

7MQ8 , 7MQ9 , 7MQA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08640	U3_assoc_6	9 → 91	U3 small nucleolar RNA-associated protein 6	Family

Sequence

MAEIIQERIEDRLPELEQLERIGLFSHAEIKAIIKKASDLEYKIQRRTLFKEDFINYVQY
EINLLELIQRRRTRIGYSFKKDEIENSIVHRVQGVFQRASAKWKDDVQLWLSYVAFCKKW
ATKTRLSKVFSAMLAIHSNKPALWIMAAKWEMEDRLSSESARQLFLRALRFHPECPKLYK
EYFRMELMHAEKLRKEKEEFEKASMDVENPDYSEEILKGELAWIIYKNSVSIIKGAEFHV
SLLSIAQLFDFAKDLQKEIYDDLQALHTDDPLTWDYVARRELEIESQTEEQPTTKQAKAV
EVGRKEERCCAVYEEAVKTLPTEAMWKCYITFCLERFTKKSNSGFLRGKRLERTMTVFRK
AHELKLLSECQYKQLSVSLLCYNFLREALEVAVAGTELFRDSGTMWQLKLQVLIESKSPD
IAMLFEEAFVHLKPQVCLPLWISWAEWSEGAKSQEDTEAVFKKALLAVIGADSVTLKNKY
LDWAYRSGGYKKARAVFKSLQESRPFSVDFFRKMIQFEKEQESCNMANIREYYERALREF
GSADSDLWMDYMKEELNHPLGRPENCGQIYWRAMKMLQGESAEAFVAKHAMHQTGHL

Sequence length

597

Interactions

View interactions

	KEGG		Reactome
	Ribosome biogenesis in eukaryotes		Major pathway of rRNA processing in the nucleolus and cytosol

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POST-TRAUMATIC STRESS DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Intellectual Disability	Intellectual developmental disorder	Pubtator	11468690	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	17380155		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurofibromatosis 1	Neurofibromatosis	BEFREE	17380155, 31703719		★★★★★ ★☆☆☆☆ Found in Text Mining only
NF1 Microdeletion Syndrome	NF1 Microdeletion Syndrome	BEFREE	17380155		★★★★★ ★☆☆☆☆ Found in Text Mining only

UTP6 (UTP6 small subunit processome component)