Gene Gene information from NCBI Gene database.
Entrez ID 55798
Gene name Methyltransferase 2B, tRNA N3-cytidine
Gene symbol METTL2B
Synonyms (NCBI Gene)
METLMETTL2METTL2APSENIP1
Chromosome 7
Chromosome location 7q32.1
Summary This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all va
miRNA miRNA information provided by mirtarbase database.
410
miRTarBase ID miRNA Experiments Reference
MIRT019741 hsa-miR-375 Microarray 20215506
MIRT049548 hsa-miR-92a-3p CLASH 23622248
MIRT041715 hsa-miR-484 CLASH 23622248
MIRT664086 hsa-miR-5197-5p HITS-CLIP 23824327
MIRT664085 hsa-miR-183-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32427860
GO:0005737 Component Cytoplasm IDA 34268557
GO:0005737 Component Cytoplasm IEA
GO:0006399 Process TRNA metabolic process IMP 28655767
GO:0008033 Process TRNA processing IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607846 18272 ENSG00000165055
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6P1Q9
Protein name tRNA N(3)-cytidine methyltransferase METTL2B (EC 2.1.1.-) (Methyltransferase-like protein 2B)
Protein function S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13489 Methyltransf_23 146 344 Domain
Sequence
MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ
RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK
SEVCECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSA
TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL
CDEEKSYPVPKGSLDIIILIFVLSAVVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQ
LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQN
LVDRRLQVNRGKQLTM
YRVWIQCKYCKPLLSSTS
Sequence length 378
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Down Syndrome Down syndrome Pubtator 33633844 Associate
★☆☆☆☆
Found in Text Mining only
Metabolic Syndrome X Metabolic Syndrome BEFREE 30540802
★☆☆☆☆
Found in Text Mining only
Stomach Neoplasms Stomach neoplasms Pubtator 34413861 Associate
★☆☆☆☆
Found in Text Mining only