Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55781
Gene name	RIO kinase 2
Gene symbol	RIOK2
Synonyms (NCBI Gene)	RIO2
Chromosome	5
Chromosome location	5q15

135

Show/Hide all (135)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020827	hsa-miR-155-5p	Proteomics	18668040
MIRT027348	hsa-miR-101-3p	Sequencing	20371350
MIRT032368	hsa-let-7b-5p	Proteomics	18668040
MIRT048452	hsa-miR-100-5p	CLASH	23622248
MIRT047511	hsa-miR-10a-5p	CLASH	23622248
MIRT042078	hsa-miR-484	CLASH	23622248
MIRT1307451	hsa-miR-124	CLIP-seq
MIRT1307452	hsa-miR-1297	CLIP-seq
MIRT1307453	hsa-miR-1915	CLIP-seq
MIRT1307454	hsa-miR-217	CLIP-seq
MIRT1307455	hsa-miR-26a	CLIP-seq
MIRT1307456	hsa-miR-26b	CLIP-seq
MIRT1307457	hsa-miR-3149	CLIP-seq
MIRT1307458	hsa-miR-3714	CLIP-seq
MIRT1307459	hsa-miR-3910	CLIP-seq
MIRT1307460	hsa-miR-4328	CLIP-seq
MIRT1307461	hsa-miR-4418	CLIP-seq
MIRT1307462	hsa-miR-4465	CLIP-seq
MIRT1307463	hsa-miR-4477b	CLIP-seq
MIRT1307464	hsa-miR-4726-3p	CLIP-seq
MIRT1307465	hsa-miR-4772-3p	CLIP-seq
MIRT1307466	hsa-miR-506	CLIP-seq
MIRT1307467	hsa-miR-509-3-5p	CLIP-seq
MIRT1307468	hsa-miR-509-5p	CLIP-seq
MIRT1307469	hsa-miR-9	CLIP-seq
MIRT1307470	hsa-miR-101	CLIP-seq
MIRT1307471	hsa-miR-125a-3p	CLIP-seq
MIRT1307452	hsa-miR-1297	CLIP-seq
MIRT1307472	hsa-miR-144	CLIP-seq
MIRT1307473	hsa-miR-146a	CLIP-seq
MIRT1307474	hsa-miR-146b-5p	CLIP-seq
MIRT1307475	hsa-miR-2053	CLIP-seq
MIRT1307455	hsa-miR-26a	CLIP-seq
MIRT1307456	hsa-miR-26b	CLIP-seq
MIRT1307476	hsa-miR-3074-5p	CLIP-seq
MIRT1307477	hsa-miR-3124-3p	CLIP-seq
MIRT1307478	hsa-miR-331-5p	CLIP-seq
MIRT1307479	hsa-miR-3687	CLIP-seq
MIRT1307480	hsa-miR-3924	CLIP-seq
MIRT1307481	hsa-miR-3934	CLIP-seq
MIRT1307482	hsa-miR-4442	CLIP-seq
MIRT1307462	hsa-miR-4465	CLIP-seq
MIRT1307483	hsa-miR-4503	CLIP-seq
MIRT1307484	hsa-miR-4678	CLIP-seq
MIRT1307485	hsa-miR-4709-3p	CLIP-seq
MIRT1307486	hsa-miR-513c	CLIP-seq
MIRT1307487	hsa-miR-514b-5p	CLIP-seq
MIRT1307488	hsa-miR-582-5p	CLIP-seq
MIRT1307489	hsa-miR-587	CLIP-seq
MIRT1307490	hsa-miR-589	CLIP-seq
MIRT1307491	hsa-miR-764	CLIP-seq
MIRT2091117	hsa-miR-1207-5p	CLIP-seq
MIRT2091118	hsa-miR-1271	CLIP-seq
MIRT2091119	hsa-miR-182	CLIP-seq
MIRT2091120	hsa-miR-340	CLIP-seq
MIRT2091121	hsa-miR-371b-5p	CLIP-seq
MIRT1307480	hsa-miR-3924	CLIP-seq
MIRT2091122	hsa-miR-3935	CLIP-seq
MIRT2091123	hsa-miR-411	CLIP-seq
MIRT2091124	hsa-miR-4282	CLIP-seq
MIRT2091125	hsa-miR-4729	CLIP-seq
MIRT2091126	hsa-miR-4736	CLIP-seq
MIRT2091127	hsa-miR-4763-3p	CLIP-seq
MIRT2091128	hsa-miR-579	CLIP-seq
MIRT2091129	hsa-miR-591	CLIP-seq
MIRT2091130	hsa-miR-888	CLIP-seq
MIRT2091131	hsa-miR-944	CLIP-seq
MIRT2091132	hsa-miR-96	CLIP-seq
MIRT2315870	hsa-miR-122	CLIP-seq
MIRT1307453	hsa-miR-1915	CLIP-seq
MIRT1307454	hsa-miR-217	CLIP-seq
MIRT2315871	hsa-miR-3135b	CLIP-seq
MIRT2315872	hsa-miR-3652	CLIP-seq
MIRT1307461	hsa-miR-4418	CLIP-seq
MIRT2315873	hsa-miR-4430	CLIP-seq
MIRT1307464	hsa-miR-4726-3p	CLIP-seq
MIRT1307465	hsa-miR-4772-3p	CLIP-seq
MIRT1307467	hsa-miR-509-3-5p	CLIP-seq
MIRT1307468	hsa-miR-509-5p	CLIP-seq
MIRT2315870	hsa-miR-122	CLIP-seq
MIRT1307452	hsa-miR-1297	CLIP-seq
MIRT1307453	hsa-miR-1915	CLIP-seq
MIRT2393769	hsa-miR-1976	CLIP-seq
MIRT1307454	hsa-miR-217	CLIP-seq
MIRT1307455	hsa-miR-26a	CLIP-seq
MIRT1307456	hsa-miR-26b	CLIP-seq
MIRT2315871	hsa-miR-3135b	CLIP-seq
MIRT2315872	hsa-miR-3652	CLIP-seq
MIRT2393770	hsa-miR-4264	CLIP-seq
MIRT2393771	hsa-miR-4279	CLIP-seq
MIRT1307461	hsa-miR-4418	CLIP-seq
MIRT2315873	hsa-miR-4430	CLIP-seq
MIRT1307462	hsa-miR-4465	CLIP-seq
MIRT2393772	hsa-miR-4722-3p	CLIP-seq
MIRT1307464	hsa-miR-4726-3p	CLIP-seq
MIRT1307465	hsa-miR-4772-3p	CLIP-seq
MIRT1307467	hsa-miR-509-3-5p	CLIP-seq
MIRT1307468	hsa-miR-509-5p	CLIP-seq
MIRT2393773	hsa-miR-622	CLIP-seq
MIRT2439915	hsa-miR-22	CLIP-seq
MIRT2439916	hsa-miR-3607-3p	CLIP-seq
MIRT2439915	hsa-miR-22	CLIP-seq
MIRT2439916	hsa-miR-3607-3p	CLIP-seq
MIRT1307452	hsa-miR-1297	CLIP-seq
MIRT1307453	hsa-miR-1915	CLIP-seq
MIRT2393769	hsa-miR-1976	CLIP-seq
MIRT1307455	hsa-miR-26a	CLIP-seq
MIRT1307456	hsa-miR-26b	CLIP-seq
MIRT2393770	hsa-miR-4264	CLIP-seq
MIRT2393771	hsa-miR-4279	CLIP-seq
MIRT1307462	hsa-miR-4465	CLIP-seq
MIRT2393772	hsa-miR-4722-3p	CLIP-seq
MIRT1307464	hsa-miR-4726-3p	CLIP-seq
MIRT1307452	hsa-miR-1297	CLIP-seq
MIRT1307453	hsa-miR-1915	CLIP-seq
MIRT2393769	hsa-miR-1976	CLIP-seq
MIRT1307455	hsa-miR-26a	CLIP-seq
MIRT1307456	hsa-miR-26b	CLIP-seq
MIRT2393770	hsa-miR-4264	CLIP-seq
MIRT2393771	hsa-miR-4279	CLIP-seq
MIRT1307462	hsa-miR-4465	CLIP-seq
MIRT2393772	hsa-miR-4722-3p	CLIP-seq
MIRT1307464	hsa-miR-4726-3p	CLIP-seq
MIRT2393773	hsa-miR-622	CLIP-seq
MIRT1307452	hsa-miR-1297	CLIP-seq
MIRT1307453	hsa-miR-1915	CLIP-seq
MIRT2393769	hsa-miR-1976	CLIP-seq
MIRT1307455	hsa-miR-26a	CLIP-seq
MIRT1307456	hsa-miR-26b	CLIP-seq
MIRT2393770	hsa-miR-4264	CLIP-seq
MIRT2393771	hsa-miR-4279	CLIP-seq
MIRT1307462	hsa-miR-4465	CLIP-seq
MIRT2393772	hsa-miR-4722-3p	CLIP-seq
MIRT1307464	hsa-miR-4726-3p	CLIP-seq
MIRT2393773	hsa-miR-622	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004672	Function	Protein kinase activity	IBA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	21880710
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	IMP	19564402
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030071	Process	Regulation of mitotic metaphase/anaphase transition	IMP	21880710
GO:0030490	Process	Maturation of SSU-rRNA	IBA
GO:0030490	Process	Maturation of SSU-rRNA	IMP	19564402
GO:0030688	Component	Preribosome, small subunit precursor	IBA
GO:0030688	Component	Preribosome, small subunit precursor	IDA	19564402
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042274	Process	Ribosomal small subunit biogenesis	IMP	19564402
GO:0046777	Process	Protein autophosphorylation	IMP	21880710
GO:0046872	Function	Metal ion binding	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:2000208	Process	Positive regulation of ribosomal small subunit export from nucleus	IMP	19564402
GO:2000234	Process	Positive regulation of rRNA processing	IDA	19564402

MIM	HGNC	e!Ensembl
617754	18999	ENSG00000058729

Q9BVS4

Protein name

Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2)

Protein function

Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required

PDB

5DHF , 6FDM , 6FDN , 6FDO , 6G18 , 6G51 , 6HK6 , 7VBT , 7WU0 , 9F81

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09202	Rio2_N	9 → 91	Rio2, N-terminal	Domain
PF01163	RIO1	108 → 284		Family

Sequence

MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVKHK
LIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQF
ALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPID
YNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESD
HITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEV
SASGYTKEMQADDELLHPLGPDDKNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLE
ESEGCYCRSSGDPEQIKEDSLSEESADARSFEMTEFNQALEEIKGQVVENNSVTEFSEEK
NRTENYNRQDGQRVQGGVPAGSDEYEDECPHLIALSSLNREFRPFRDEENVGAMNQYRTR
TLSITSSGSAVSCSTIPPELVKQKVKRQLTKQQKSAVRRRLQKGEANIFTKQRRENMQNI
KSSLEAASFWGE

Sequence length

552

Interactions

View interactions

	KEGG		Reactome
	Ribosome biogenesis in eukaryotes		Major pathway of rRNA processing in the nucleolus and cytosol

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Amyotrophic lateral sclerosis 1	Amyotrophic lateral sclerosis	Pubtator	37838312	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	23459592		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	23459592		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	32125767	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	27346559	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	29749434		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	36661680	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RIOK2 (RIO kinase 2)