Gene Gene information from NCBI Gene database.
Entrez ID 5578
Gene name Protein kinase C alpha
Gene symbol PRKCA
Synonyms (NCBI Gene)
AAG6PKC-alphaPKCAPKCI+/-PKCalphaPRKACA
Chromosome 17
Chromosome location 17q24.2
Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved
SNPs SNP information provided by dbSNP.
1
SNP ID Visualize variation Clinical significance Consequence
rs16960228 G>A Drug-response Intron variant, genic downstream transcript variant
miRNA miRNA information provided by mirtarbase database.
995
miRTarBase ID miRNA Experiments Reference
MIRT006882 mmu-miR-24-2-5p Luciferase reporter assayqRT-PCRWestern blot 22911661
MIRT020045 hsa-miR-375 Microarray 20215506
MIRT050756 hsa-miR-17-3p CLASH 23622248
MIRT049636 hsa-miR-92a-3p CLASH 23622248
MIRT041382 hsa-miR-193b-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
RARA Activation 11525643
TFAP2A Activation 12269829
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
109
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000302 Process Response to reactive oxygen species IEA
GO:0001525 Process Angiogenesis IEA
GO:0001938 Process Positive regulation of endothelial cell proliferation IMP 11909826
GO:0002159 Process Desmosome assembly IMP 18474624
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
176960 9393 ENSG00000154229
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P17252
Protein name Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Protein function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, ca
PDB 2ELI , 3IW4 , 4DNL , 4RA4 , 8U37 , 8UAK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00130 C1_1 37 89 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00130 C1_1 102 154 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00168 C2 171 277 C2 domain Domain
PF00069 Pkinase 339 597 Protein kinase domain Domain
PF00433 Pkinase_C 623 658 Protein kinase C terminal domain Family
Sequence
Sequence length 672
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Axon guidance
VEGF signaling pathway
Focal adhesion
Gap junction
Neutrophil extracellular trap formation
Natural killer cell mediated cytotoxicity
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone synthesis and secretion
Relaxin signaling pathway
Parathyroid hormone synthesis, secretion and action
GnRH secretion
AGE-RAGE signaling pathway in diabetic complications
Growth hormone synthesis, secretion and action
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Spinocerebellar ataxia
Pathways of neurodegeneration - multiple diseases
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
African trypanosomiasis
Amoebiasis
Hepatitis B
Human cytomegalovirus infection
Influenza A
Human immunodeficiency virus 1 infection
Coronavirus disease - COVID-19
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Chemical carcinogenesis - receptor activation
Glioma
Non-small cell lung cancer
Hepatocellular carcinoma
Choline metabolism in cancer
Diabetic cardiomyopathy
Lipid and atherosclerosis
  Calmodulin induced events
Disinhibition of SNARE formation
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Syndecan interactions
Acetylcholine regulates insulin secretion
Trafficking of GluR2-containing AMPA receptors
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
RHO GTPases Activate NADPH Oxidases
Response to elevated platelet cytosolic Ca2+
RET signaling
ROBO receptors bind AKAP5
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
27
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANDROGENETIC ALOPECIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA, OCCUPATIONAL CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BRUGADA SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acne Acne HPO_DG
★☆☆☆☆
Found in Text Mining only
Acquired Nephrogenic Diabetes Insipidus Diabetes Insipidus CTD_human_DG 25006961
★☆☆☆☆
Found in Text Mining only
Acth-Independent Macronodular Adrenal Hyperplasia Cushing`s Syndrome BEFREE 31276155
★☆☆☆☆
Found in Text Mining only
ACTH-Secreting Pituitary Adenoma Pituitary adenoma BEFREE 26701869
★☆☆☆☆
Found in Text Mining only
Actinic keratosis Actinic keratosis BEFREE 30944245
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 24990612
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 20200558
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of large intestine Colorectal Cancer UNIPROT_DG
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 23604119, 28751441, 31420605, 31612005
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 30904392
★☆☆☆☆
Found in Text Mining only