Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55761
Gene name	Tetratricopeptide repeat domain 17
Gene symbol	TTC17
Synonyms (NCBI Gene)	-
Chromosome	11
Chromosome location	11p12-p11.2

223

Show/Hide all (223)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023975	hsa-miR-1-3p	Proteomics	18668040
MIRT031893	hsa-miR-16-5p	Proteomics	18668040
MIRT1460867	hsa-miR-1	CLIP-seq
MIRT1460868	hsa-miR-103a	CLIP-seq
MIRT1460869	hsa-miR-107	CLIP-seq
MIRT1460870	hsa-miR-1200	CLIP-seq
MIRT1460871	hsa-miR-1256	CLIP-seq
MIRT1460872	hsa-miR-1264	CLIP-seq
MIRT1460873	hsa-miR-1270	CLIP-seq
MIRT1460874	hsa-miR-127-5p	CLIP-seq
MIRT1460875	hsa-miR-1279	CLIP-seq
MIRT1460876	hsa-miR-128	CLIP-seq
MIRT1460877	hsa-miR-15a	CLIP-seq
MIRT1460878	hsa-miR-15b	CLIP-seq
MIRT1460879	hsa-miR-16	CLIP-seq
MIRT1460880	hsa-miR-186	CLIP-seq
MIRT1460881	hsa-miR-194	CLIP-seq
MIRT1460882	hsa-miR-195	CLIP-seq
MIRT1460883	hsa-miR-19a	CLIP-seq
MIRT1460884	hsa-miR-19b	CLIP-seq
MIRT1460885	hsa-miR-206	CLIP-seq
MIRT1460886	hsa-miR-24	CLIP-seq
MIRT1460887	hsa-miR-28-5p	CLIP-seq
MIRT1460888	hsa-miR-3123	CLIP-seq
MIRT1460889	hsa-miR-3124-3p	CLIP-seq
MIRT1460890	hsa-miR-3127-3p	CLIP-seq
MIRT1460891	hsa-miR-3139	CLIP-seq
MIRT1460892	hsa-miR-3150b-3p	CLIP-seq
MIRT1460893	hsa-miR-331-3p	CLIP-seq
MIRT1460894	hsa-miR-3612	CLIP-seq
MIRT1460895	hsa-miR-3667-3p	CLIP-seq
MIRT1460896	hsa-miR-3673	CLIP-seq
MIRT1460897	hsa-miR-377	CLIP-seq
MIRT1460898	hsa-miR-3910	CLIP-seq
MIRT1460899	hsa-miR-3919	CLIP-seq
MIRT1460900	hsa-miR-3921	CLIP-seq
MIRT1460901	hsa-miR-3935	CLIP-seq
MIRT1460902	hsa-miR-3938	CLIP-seq
MIRT1460903	hsa-miR-3941	CLIP-seq
MIRT1460904	hsa-miR-411	CLIP-seq
MIRT1460905	hsa-miR-424	CLIP-seq
MIRT1460906	hsa-miR-4251	CLIP-seq
MIRT1460907	hsa-miR-4264	CLIP-seq
MIRT1460908	hsa-miR-4284	CLIP-seq
MIRT1460909	hsa-miR-431	CLIP-seq
MIRT1460910	hsa-miR-4324	CLIP-seq
MIRT1460911	hsa-miR-4325	CLIP-seq
MIRT1460912	hsa-miR-4329	CLIP-seq
MIRT1460913	hsa-miR-4419a	CLIP-seq
MIRT1460914	hsa-miR-4426	CLIP-seq
MIRT1460915	hsa-miR-4443	CLIP-seq
MIRT1460916	hsa-miR-4484	CLIP-seq
MIRT1460917	hsa-miR-4509	CLIP-seq
MIRT1460918	hsa-miR-4510	CLIP-seq
MIRT1460919	hsa-miR-4531	CLIP-seq
MIRT1460920	hsa-miR-455-5p	CLIP-seq
MIRT1460921	hsa-miR-4633-3p	CLIP-seq
MIRT1460922	hsa-miR-4635	CLIP-seq
MIRT1460923	hsa-miR-4647	CLIP-seq
MIRT1460924	hsa-miR-4653-5p	CLIP-seq
MIRT1460925	hsa-miR-466	CLIP-seq
MIRT1460926	hsa-miR-4662b	CLIP-seq
MIRT1460927	hsa-miR-4667-3p	CLIP-seq
MIRT1460928	hsa-miR-4672	CLIP-seq
MIRT1460929	hsa-miR-4689	CLIP-seq
MIRT1460930	hsa-miR-4691-5p	CLIP-seq
MIRT1460931	hsa-miR-4693-3p	CLIP-seq
MIRT1460932	hsa-miR-4699-3p	CLIP-seq
MIRT1460933	hsa-miR-4714-3p	CLIP-seq
MIRT1460934	hsa-miR-4731-3p	CLIP-seq
MIRT1460935	hsa-miR-4756-3p	CLIP-seq
MIRT1460936	hsa-miR-4784	CLIP-seq
MIRT1460937	hsa-miR-4793-3p	CLIP-seq
MIRT1460938	hsa-miR-4797-3p	CLIP-seq
MIRT1460939	hsa-miR-4801	CLIP-seq
MIRT1460940	hsa-miR-497	CLIP-seq
MIRT1460941	hsa-miR-5096	CLIP-seq
MIRT1460942	hsa-miR-516b	CLIP-seq
MIRT1460943	hsa-miR-539	CLIP-seq
MIRT1460944	hsa-miR-544b	CLIP-seq
MIRT1460945	hsa-miR-548an	CLIP-seq
MIRT1460946	hsa-miR-555	CLIP-seq
MIRT1460947	hsa-miR-610	CLIP-seq
MIRT1460948	hsa-miR-613	CLIP-seq
MIRT1460949	hsa-miR-620	CLIP-seq
MIRT1460950	hsa-miR-633	CLIP-seq
MIRT1460951	hsa-miR-650	CLIP-seq
MIRT1460952	hsa-miR-708	CLIP-seq
MIRT1555236	hsa-miR-181a	CLIP-seq
MIRT1555237	hsa-miR-181b	CLIP-seq
MIRT1555238	hsa-miR-181c	CLIP-seq
MIRT1555239	hsa-miR-181d	CLIP-seq
MIRT1555240	hsa-miR-3160-3p	CLIP-seq
MIRT1555241	hsa-miR-4262	CLIP-seq
MIRT1460872	hsa-miR-1264	CLIP-seq
MIRT1460886	hsa-miR-24	CLIP-seq
MIRT1460894	hsa-miR-3612	CLIP-seq
MIRT1460899	hsa-miR-3919	CLIP-seq
MIRT1460913	hsa-miR-4419a	CLIP-seq
MIRT1460915	hsa-miR-4443	CLIP-seq
MIRT1460918	hsa-miR-4510	CLIP-seq
MIRT1460935	hsa-miR-4756-3p	CLIP-seq
MIRT1460942	hsa-miR-516b	CLIP-seq
MIRT1460951	hsa-miR-650	CLIP-seq
MIRT2359326	hsa-miR-1229	CLIP-seq
MIRT1460872	hsa-miR-1264	CLIP-seq
MIRT2359327	hsa-miR-1470	CLIP-seq
MIRT1555236	hsa-miR-181a	CLIP-seq
MIRT1555237	hsa-miR-181b	CLIP-seq
MIRT1555238	hsa-miR-181c	CLIP-seq
MIRT1555239	hsa-miR-181d	CLIP-seq
MIRT1460890	hsa-miR-3127-3p	CLIP-seq
MIRT2359328	hsa-miR-3679-3p	CLIP-seq
MIRT1460897	hsa-miR-377	CLIP-seq
MIRT2359329	hsa-miR-3943	CLIP-seq
MIRT2359330	hsa-miR-3975	CLIP-seq
MIRT2359331	hsa-miR-3977	CLIP-seq
MIRT1555241	hsa-miR-4262	CLIP-seq
MIRT1460907	hsa-miR-4264	CLIP-seq
MIRT2359332	hsa-miR-4420	CLIP-seq
MIRT2359333	hsa-miR-4469	CLIP-seq
MIRT1460927	hsa-miR-4667-3p	CLIP-seq
MIRT2359334	hsa-miR-4690-3p	CLIP-seq
MIRT1460938	hsa-miR-4797-3p	CLIP-seq
MIRT2359335	hsa-miR-4803	CLIP-seq
MIRT1460941	hsa-miR-5096	CLIP-seq
MIRT2359336	hsa-miR-549	CLIP-seq
MIRT2359337	hsa-miR-587	CLIP-seq
MIRT1460871	hsa-miR-1256	CLIP-seq
MIRT1460873	hsa-miR-1270	CLIP-seq
MIRT1460876	hsa-miR-128	CLIP-seq
MIRT1555236	hsa-miR-181a	CLIP-seq
MIRT1555237	hsa-miR-181b	CLIP-seq
MIRT1555238	hsa-miR-181c	CLIP-seq
MIRT1555239	hsa-miR-181d	CLIP-seq
MIRT1460880	hsa-miR-186	CLIP-seq
MIRT1460883	hsa-miR-19a	CLIP-seq
MIRT1460884	hsa-miR-19b	CLIP-seq
MIRT1460886	hsa-miR-24	CLIP-seq
MIRT1460888	hsa-miR-3123	CLIP-seq
MIRT2652554	hsa-miR-3137	CLIP-seq
MIRT2652555	hsa-miR-3158-3p	CLIP-seq
MIRT2652556	hsa-miR-3619-3p	CLIP-seq
MIRT2652557	hsa-miR-3671	CLIP-seq
MIRT2652558	hsa-miR-376c	CLIP-seq
MIRT1460898	hsa-miR-3910	CLIP-seq
MIRT1460899	hsa-miR-3919	CLIP-seq
MIRT2359330	hsa-miR-3975	CLIP-seq
MIRT2652559	hsa-miR-410	CLIP-seq
MIRT1460906	hsa-miR-4251	CLIP-seq
MIRT1555241	hsa-miR-4262	CLIP-seq
MIRT1460907	hsa-miR-4264	CLIP-seq
MIRT1460908	hsa-miR-4284	CLIP-seq
MIRT1460909	hsa-miR-431	CLIP-seq
MIRT2652560	hsa-miR-4311	CLIP-seq
MIRT1460914	hsa-miR-4426	CLIP-seq
MIRT1460916	hsa-miR-4484	CLIP-seq
MIRT1460917	hsa-miR-4509	CLIP-seq
MIRT1460919	hsa-miR-4531	CLIP-seq
MIRT1460923	hsa-miR-4647	CLIP-seq
MIRT1460926	hsa-miR-4662b	CLIP-seq
MIRT1460930	hsa-miR-4691-5p	CLIP-seq
MIRT2652561	hsa-miR-4721	CLIP-seq
MIRT2652562	hsa-miR-4732-5p	CLIP-seq
MIRT2652563	hsa-miR-4776-5p	CLIP-seq
MIRT2652564	hsa-miR-4793-5p	CLIP-seq
MIRT2652565	hsa-miR-513b	CLIP-seq
MIRT1460943	hsa-miR-539	CLIP-seq
MIRT1460945	hsa-miR-548an	CLIP-seq
MIRT2359336	hsa-miR-549	CLIP-seq
MIRT1460946	hsa-miR-555	CLIP-seq
MIRT2359337	hsa-miR-587	CLIP-seq
MIRT2652566	hsa-miR-607	CLIP-seq
MIRT1460949	hsa-miR-620	CLIP-seq
MIRT2652567	hsa-miR-622	CLIP-seq
MIRT1460871	hsa-miR-1256	CLIP-seq
MIRT1460873	hsa-miR-1270	CLIP-seq
MIRT1460876	hsa-miR-128	CLIP-seq
MIRT1555236	hsa-miR-181a	CLIP-seq
MIRT1555237	hsa-miR-181b	CLIP-seq
MIRT1555238	hsa-miR-181c	CLIP-seq
MIRT1555239	hsa-miR-181d	CLIP-seq
MIRT1460880	hsa-miR-186	CLIP-seq
MIRT1460883	hsa-miR-19a	CLIP-seq
MIRT1460884	hsa-miR-19b	CLIP-seq
MIRT1460886	hsa-miR-24	CLIP-seq
MIRT1460888	hsa-miR-3123	CLIP-seq
MIRT2652554	hsa-miR-3137	CLIP-seq
MIRT2652555	hsa-miR-3158-3p	CLIP-seq
MIRT2652556	hsa-miR-3619-3p	CLIP-seq
MIRT2652557	hsa-miR-3671	CLIP-seq
MIRT2652558	hsa-miR-376c	CLIP-seq
MIRT1460898	hsa-miR-3910	CLIP-seq
MIRT1460899	hsa-miR-3919	CLIP-seq
MIRT2359330	hsa-miR-3975	CLIP-seq
MIRT1460906	hsa-miR-4251	CLIP-seq
MIRT1555241	hsa-miR-4262	CLIP-seq
MIRT1460907	hsa-miR-4264	CLIP-seq
MIRT1460908	hsa-miR-4284	CLIP-seq
MIRT1460909	hsa-miR-431	CLIP-seq
MIRT2652560	hsa-miR-4311	CLIP-seq
MIRT1460914	hsa-miR-4426	CLIP-seq
MIRT1460916	hsa-miR-4484	CLIP-seq
MIRT1460917	hsa-miR-4509	CLIP-seq
MIRT1460919	hsa-miR-4531	CLIP-seq
MIRT1460923	hsa-miR-4647	CLIP-seq
MIRT1460926	hsa-miR-4662b	CLIP-seq
MIRT1460930	hsa-miR-4691-5p	CLIP-seq
MIRT2652561	hsa-miR-4721	CLIP-seq
MIRT2652562	hsa-miR-4732-5p	CLIP-seq
MIRT2652563	hsa-miR-4776-5p	CLIP-seq
MIRT2652564	hsa-miR-4793-5p	CLIP-seq
MIRT2694368	hsa-miR-509-3p	CLIP-seq
MIRT2652565	hsa-miR-513b	CLIP-seq
MIRT1460943	hsa-miR-539	CLIP-seq
MIRT1460945	hsa-miR-548an	CLIP-seq
MIRT2359336	hsa-miR-549	CLIP-seq
MIRT1460946	hsa-miR-555	CLIP-seq
MIRT2359337	hsa-miR-587	CLIP-seq
MIRT2652566	hsa-miR-607	CLIP-seq
MIRT1460949	hsa-miR-620	CLIP-seq
MIRT2652567	hsa-miR-622	CLIP-seq
MIRT2694369	hsa-miR-649	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	24475127
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	24475127
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA	24475127
GO:0005886	Component	Plasma membrane	IEA
GO:0015629	Component	Actin cytoskeleton	IBA
GO:0015629	Component	Actin cytoskeleton	IDA	24475127
GO:0016020	Component	Membrane	IEA
GO:0030030	Process	Cell projection organization	IEA
GO:0030041	Process	Actin filament polymerization	IBA
GO:0030041	Process	Actin filament polymerization	IMP	24475127
GO:0044782	Process	Cilium organization	IBA
GO:0044782	Process	Cilium organization	IMP	24475127

MIM	HGNC	e!Ensembl
619388	25596	ENSG00000052841

Q96AE7

Protein name

Tetratricopeptide repeat protein 17 (TPR repeat protein 17)

Protein function

Plays a role in primary ciliogenesis by modulating actin polymerization.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13181	TPR_8	295 → 328	Tetratricopeptide repeat	Repeat
PF13181	TPR_8	691 → 722	Tetratricopeptide repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Expressed in germ cells as well as in somatic cells of the testis (at protein level). {ECO:0000269|PubMed:24475127}.

Sequence

MAAAVGVRGRYELPPCSGPGWLLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNL
KHPHDLVILMRQEATVNYLKELEKQLVAQKIHIEENEDRDTGLEQRHNKEDPDCIKAKVP
LGDLDLYDGTYITLESKDISPEDYIDTESPVPPDPEQPDCTKILELPYSIHAFQHLRGVQ
ERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHEGLQKNTSSWVLYNMASFYWRIKN
EPYQVVECAMRALHFSSRHNKDIALVNLANVLHRAHFSADAAVVVHAALDDSDFFTSYYT
LGNIYAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLN
ELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLVNQQHS
LHCQWDQPVRYHRGDIFENVDYVQFGEDSSTSSMMSVNFDVQSNQSDINDSVKSSPVAHS
ILWIWGRDSDAYRDKQHILWPKRADCTESYPRVPVGGELPTYFLPPENKGLRIHELSSDD
YSTEEEAQTPDCSITDFRKSHTLSYLVKELEVRMDLKAKMPDDHARKILLSRINNYTIPE
EEIGSFLFHAINKPNAPIWLILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQDVPLVN
LANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALKLTT
KCPECENSLKLIRCMQFYPFLYNITSSVCSGTVVEESNGSDEMENSDETKMSEEILALVD
EFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGVARSSCYGDCRSEDDEATEWITF
QVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVASPGPQGKKRDYQRLGWP
SPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTL
DHLHGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSM
AALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWNDAVIVATMAVEI
APHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRS
P

Sequence length

1141

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	30519852	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	30519852		★★★★★ ★☆☆☆☆ Found in Text Mining only

TTC17 (tetratricopeptide repeat domain 17)