Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55738
Gene name	ARF GTPase activating protein 1
Gene symbol	ARFGAP1
Synonyms (NCBI Gene)	ARF1GAPHRIHFB2281
Chromosome	20
Chromosome location	20q13.33
Summary	The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required f

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Show/Hide all (154)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047930	hsa-miR-30c-5p	CLASH	23622248
MIRT042628	hsa-miR-423-3p	CLASH	23622248
MIRT038909	hsa-miR-93-3p	CLASH	23622248
MIRT792746	hsa-miR-1343	CLIP-seq
MIRT792747	hsa-miR-1908	CLIP-seq
MIRT792748	hsa-miR-1909	CLIP-seq
MIRT792749	hsa-miR-3135b	CLIP-seq
MIRT792750	hsa-miR-3189-5p	CLIP-seq
MIRT792751	hsa-miR-3622b-5p	CLIP-seq
MIRT792752	hsa-miR-3652	CLIP-seq
MIRT792753	hsa-miR-3944-5p	CLIP-seq
MIRT792754	hsa-miR-4283	CLIP-seq
MIRT792755	hsa-miR-4323	CLIP-seq
MIRT792756	hsa-miR-4430	CLIP-seq
MIRT792757	hsa-miR-4436b-3p	CLIP-seq
MIRT792758	hsa-miR-4489	CLIP-seq
MIRT792759	hsa-miR-4492	CLIP-seq
MIRT792760	hsa-miR-4498	CLIP-seq
MIRT792761	hsa-miR-4633-3p	CLIP-seq
MIRT792762	hsa-miR-4642	CLIP-seq
MIRT792763	hsa-miR-4793-5p	CLIP-seq
MIRT792764	hsa-miR-663	CLIP-seq
MIRT792765	hsa-miR-762	CLIP-seq
MIRT792766	hsa-miR-105	CLIP-seq
MIRT792747	hsa-miR-1908	CLIP-seq
MIRT792748	hsa-miR-1909	CLIP-seq
MIRT792767	hsa-miR-1910	CLIP-seq
MIRT792768	hsa-miR-2114	CLIP-seq
MIRT792769	hsa-miR-214	CLIP-seq
MIRT792770	hsa-miR-296-3p	CLIP-seq
MIRT792771	hsa-miR-3120-3p	CLIP-seq
MIRT792772	hsa-miR-3154	CLIP-seq
MIRT792773	hsa-miR-3158-5p	CLIP-seq
MIRT792774	hsa-miR-3166	CLIP-seq
MIRT792775	hsa-miR-3173-3p	CLIP-seq
MIRT792776	hsa-miR-3179	CLIP-seq
MIRT792750	hsa-miR-3189-5p	CLIP-seq
MIRT792777	hsa-miR-3202	CLIP-seq
MIRT792778	hsa-miR-342-3p	CLIP-seq
MIRT792779	hsa-miR-342-5p	CLIP-seq
MIRT792780	hsa-miR-3619-5p	CLIP-seq
MIRT792751	hsa-miR-3622b-5p	CLIP-seq
MIRT792752	hsa-miR-3652	CLIP-seq
MIRT792781	hsa-miR-3665	CLIP-seq
MIRT792782	hsa-miR-3689d	CLIP-seq
MIRT792783	hsa-miR-377	CLIP-seq
MIRT792784	hsa-miR-3909	CLIP-seq
MIRT792785	hsa-miR-3922-5p	CLIP-seq
MIRT792786	hsa-miR-3926	CLIP-seq
MIRT792753	hsa-miR-3944-5p	CLIP-seq
MIRT792787	hsa-miR-4256	CLIP-seq
MIRT792788	hsa-miR-4270	CLIP-seq
MIRT792755	hsa-miR-4323	CLIP-seq
MIRT792789	hsa-miR-4418	CLIP-seq
MIRT792756	hsa-miR-4430	CLIP-seq
MIRT792757	hsa-miR-4436b-3p	CLIP-seq
MIRT792790	hsa-miR-4438	CLIP-seq
MIRT792791	hsa-miR-4441	CLIP-seq
MIRT792792	hsa-miR-4475	CLIP-seq
MIRT792793	hsa-miR-4520a-3p	CLIP-seq
MIRT792794	hsa-miR-4533	CLIP-seq
MIRT792795	hsa-miR-4638-3p	CLIP-seq
MIRT792762	hsa-miR-4642	CLIP-seq
MIRT792796	hsa-miR-4648	CLIP-seq
MIRT792797	hsa-miR-4651	CLIP-seq
MIRT792798	hsa-miR-4656	CLIP-seq
MIRT792799	hsa-miR-4664-5p	CLIP-seq
MIRT792800	hsa-miR-4694-3p	CLIP-seq
MIRT792801	hsa-miR-4710	CLIP-seq
MIRT792802	hsa-miR-4753-5p	CLIP-seq
MIRT792803	hsa-miR-4765	CLIP-seq
MIRT792804	hsa-miR-4771	CLIP-seq
MIRT792805	hsa-miR-4795-5p	CLIP-seq
MIRT792806	hsa-miR-509-3-5p	CLIP-seq
MIRT792807	hsa-miR-509-5p	CLIP-seq
MIRT792808	hsa-miR-542-5p	CLIP-seq
MIRT792809	hsa-miR-548s	CLIP-seq
MIRT792810	hsa-miR-604	CLIP-seq
MIRT792811	hsa-miR-608	CLIP-seq
MIRT792812	hsa-miR-628-5p	CLIP-seq
MIRT792813	hsa-miR-635	CLIP-seq
MIRT792814	hsa-miR-647	CLIP-seq
MIRT792764	hsa-miR-663	CLIP-seq
MIRT792815	hsa-miR-759	CLIP-seq
MIRT792816	hsa-miR-761	CLIP-seq
MIRT792817	hsa-miR-885-3p	CLIP-seq
MIRT1933927	hsa-miR-4455	CLIP-seq
MIRT1933928	hsa-miR-4474-3p	CLIP-seq
MIRT1933929	hsa-miR-644	CLIP-seq
MIRT1933930	hsa-miR-1	CLIP-seq
MIRT1933931	hsa-miR-1321	CLIP-seq
MIRT792767	hsa-miR-1910	CLIP-seq
MIRT1933932	hsa-miR-206	CLIP-seq
MIRT1933933	hsa-miR-296-5p	CLIP-seq
MIRT1933934	hsa-miR-3065-3p	CLIP-seq
MIRT1933935	hsa-miR-323-5p	CLIP-seq
MIRT792752	hsa-miR-3652	CLIP-seq
MIRT1933936	hsa-miR-3673	CLIP-seq
MIRT1933937	hsa-miR-3925-3p	CLIP-seq
MIRT792786	hsa-miR-3926	CLIP-seq
MIRT792788	hsa-miR-4270	CLIP-seq
MIRT792756	hsa-miR-4430	CLIP-seq
MIRT792791	hsa-miR-4441	CLIP-seq
MIRT1933938	hsa-miR-4499	CLIP-seq
MIRT1933939	hsa-miR-4505	CLIP-seq
MIRT1933940	hsa-miR-4739	CLIP-seq
MIRT1933941	hsa-miR-4756-5p	CLIP-seq
MIRT1933942	hsa-miR-508-5p	CLIP-seq
MIRT792809	hsa-miR-548s	CLIP-seq
MIRT792810	hsa-miR-604	CLIP-seq
MIRT1933943	hsa-miR-613	CLIP-seq
MIRT1933944	hsa-miR-626	CLIP-seq
MIRT792814	hsa-miR-647	CLIP-seq
MIRT792815	hsa-miR-759	CLIP-seq
MIRT1933945	hsa-miR-765	CLIP-seq
MIRT792817	hsa-miR-885-3p	CLIP-seq
MIRT1933946	hsa-miR-937	CLIP-seq
MIRT2173778	hsa-miR-125a-3p	CLIP-seq
MIRT2173779	hsa-miR-2277-3p	CLIP-seq
MIRT2173780	hsa-miR-3621	CLIP-seq
MIRT792752	hsa-miR-3652	CLIP-seq
MIRT2173781	hsa-miR-3660	CLIP-seq
MIRT792786	hsa-miR-3926	CLIP-seq
MIRT2173782	hsa-miR-3934	CLIP-seq
MIRT792756	hsa-miR-4430	CLIP-seq
MIRT1933939	hsa-miR-4505	CLIP-seq
MIRT2173783	hsa-miR-4526	CLIP-seq
MIRT792809	hsa-miR-548s	CLIP-seq
MIRT2173784	hsa-miR-764	CLIP-seq
MIRT792768	hsa-miR-2114	CLIP-seq
MIRT2477407	hsa-miR-298	CLIP-seq
MIRT1933934	hsa-miR-3065-3p	CLIP-seq
MIRT792771	hsa-miR-3120-3p	CLIP-seq
MIRT2477408	hsa-miR-3153	CLIP-seq
MIRT792772	hsa-miR-3154	CLIP-seq
MIRT792773	hsa-miR-3158-5p	CLIP-seq
MIRT792774	hsa-miR-3166	CLIP-seq
MIRT792776	hsa-miR-3179	CLIP-seq
MIRT792779	hsa-miR-342-5p	CLIP-seq
MIRT792783	hsa-miR-377	CLIP-seq
MIRT792788	hsa-miR-4270	CLIP-seq
MIRT2477409	hsa-miR-4428	CLIP-seq
MIRT2477410	hsa-miR-4433	CLIP-seq
MIRT792791	hsa-miR-4441	CLIP-seq
MIRT792796	hsa-miR-4648	CLIP-seq
MIRT792797	hsa-miR-4651	CLIP-seq
MIRT792798	hsa-miR-4656	CLIP-seq
MIRT792799	hsa-miR-4664-5p	CLIP-seq
MIRT792802	hsa-miR-4753-5p	CLIP-seq
MIRT792804	hsa-miR-4771	CLIP-seq
MIRT792805	hsa-miR-4795-5p	CLIP-seq
MIRT2477411	hsa-miR-512-3p	CLIP-seq
MIRT792811	hsa-miR-608	CLIP-seq
MIRT2477412	hsa-miR-665	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	22423108
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	22363216, 25416956, 25910212, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0008270	Function	Zinc ion binding	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0030100	Process	Regulation of endocytosis	IBA
GO:0032012	Process	Regulation of ARF protein signal transduction	IBA
GO:0045202	Component	Synapse	IDA	22423108
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
608377	15852	ENSG00000101199

Q8N6T3

Protein name

ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)

Protein function

GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golg

PDB

3DWD , 3O47

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01412	ArfGap	7 → 120	Putative GTPase activating protein for Arf	Domain

Sequence

MASPRTRKVLKEVRVQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVR
SVTMDKWKDIELEKMKAGGNAKFREFLESQEDYDPCWSLQEKYNSRAAALFRDKVVALAE
GREWSLESSPAQNWTPPQPRTLPSMVHRVSGQPQSVTASSDKAFEDWLNDDLGSYQGAQG
NRYVGFGNTPPPQKKEDDFLNNAMSSLYSGWSSFTTGASRFASAAKEGATKFGSQASQKA
SELGHSLNENVLKPAQEKVKEGKIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEG
PLDSPSEGHSYQNSGLDHFQNSNIDQSFWETFGSAEPTKTRKSPSSDSWTCADTSTERRS
SDSWEVWGSASTNRNSNSDGGEGGEGTKKAVPPAVPTDDGWDNQNW

Sequence length

406

Interactions

View interactions

	KEGG		Reactome
	Endocytosis		XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DEVELOPMENTAL DISABILITIES	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NERVOUS SYSTEM DISEASES	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NERVOUS SYSTEM DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Child Development Deviations	Development Disorder	CTD_human_DG	20805988		★★★★★ ★☆☆☆☆ Found in Text Mining only
Child Development Disorders, Specific	Development Disorder	CTD_human_DG	20805988		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	23752192		★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Development Disorder	CTD_human_DG	20805988		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neoplasms	Neoplasms	BEFREE	23752192		★★★★★ ★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	CTD_human_DG	20805988		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	BEFREE	22363216		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	22363216, 36593912	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Venous Thromboembolism	Venous thromboembolism	Pubtator	28011674	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ARFGAP1 (ARF GTPase activating protein 1)