Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55701
Gene name	Rho guanine nucleotide exchange factor 40
Gene symbol	ARHGEF40
Synonyms (NCBI Gene)	SOLO
Chromosome	14
Chromosome location	14q11.2
Summary	This gene encodes a protein similar to guanosine nucleotide exchange factors for Rho GTPases. The encoded protein contains in its C-terminus a GEF domain involved in exchange activity and a pleckstrin homology domain. Alternatively spliced transcripts tha

219

Show/Hide all (219)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024801	hsa-miR-215-5p	Microarray	19074876
MIRT026863	hsa-miR-192-5p	Microarray	19074876
MIRT795920	hsa-miR-1228	CLIP-seq
MIRT795921	hsa-miR-1273e	CLIP-seq
MIRT795922	hsa-miR-1285	CLIP-seq
MIRT795923	hsa-miR-153	CLIP-seq
MIRT795924	hsa-miR-2861	CLIP-seq
MIRT795925	hsa-miR-3132	CLIP-seq
MIRT795926	hsa-miR-3150b-3p	CLIP-seq
MIRT795927	hsa-miR-3187-5p	CLIP-seq
MIRT795928	hsa-miR-3192	CLIP-seq
MIRT795929	hsa-miR-326	CLIP-seq
MIRT795930	hsa-miR-330-5p	CLIP-seq
MIRT795931	hsa-miR-3689a-3p	CLIP-seq
MIRT795932	hsa-miR-3689c	CLIP-seq
MIRT795933	hsa-miR-378g	CLIP-seq
MIRT795934	hsa-miR-410	CLIP-seq
MIRT795935	hsa-miR-4252	CLIP-seq
MIRT795936	hsa-miR-4300	CLIP-seq
MIRT795937	hsa-miR-4314	CLIP-seq
MIRT795938	hsa-miR-4317	CLIP-seq
MIRT795939	hsa-miR-4318	CLIP-seq
MIRT795940	hsa-miR-4451	CLIP-seq
MIRT795941	hsa-miR-448	CLIP-seq
MIRT795942	hsa-miR-4486	CLIP-seq
MIRT795943	hsa-miR-4646-5p	CLIP-seq
MIRT795944	hsa-miR-4667-3p	CLIP-seq
MIRT795945	hsa-miR-4728-5p	CLIP-seq
MIRT795946	hsa-miR-4784	CLIP-seq
MIRT795947	hsa-miR-612	CLIP-seq
MIRT795948	hsa-miR-661	CLIP-seq
MIRT795949	hsa-miR-758	CLIP-seq
MIRT795950	hsa-miR-765	CLIP-seq
MIRT795951	hsa-miR-889	CLIP-seq
MIRT795952	hsa-miR-920	CLIP-seq
MIRT1545511	hsa-miR-4270	CLIP-seq
MIRT1545512	hsa-miR-4441	CLIP-seq
MIRT1935073	hsa-miR-1226	CLIP-seq
MIRT1935074	hsa-miR-1289	CLIP-seq
MIRT1935075	hsa-miR-145	CLIP-seq
MIRT1935076	hsa-miR-192	CLIP-seq
MIRT1935077	hsa-miR-215	CLIP-seq
MIRT1935078	hsa-miR-3198	CLIP-seq
MIRT1935079	hsa-miR-3661	CLIP-seq
MIRT1935080	hsa-miR-3925-3p	CLIP-seq
MIRT1935081	hsa-miR-4294	CLIP-seq
MIRT1935082	hsa-miR-4309	CLIP-seq
MIRT1935083	hsa-miR-4733-3p	CLIP-seq
MIRT1935084	hsa-miR-4756-3p	CLIP-seq
MIRT1935085	hsa-miR-508-5p	CLIP-seq
MIRT1935086	hsa-miR-631	CLIP-seq
MIRT1935073	hsa-miR-1226	CLIP-seq
MIRT2175015	hsa-miR-1251	CLIP-seq
MIRT1935074	hsa-miR-1289	CLIP-seq
MIRT2175016	hsa-miR-143	CLIP-seq
MIRT1935075	hsa-miR-145	CLIP-seq
MIRT1935076	hsa-miR-192	CLIP-seq
MIRT1935077	hsa-miR-215	CLIP-seq
MIRT795926	hsa-miR-3150b-3p	CLIP-seq
MIRT1935078	hsa-miR-3198	CLIP-seq
MIRT1935079	hsa-miR-3661	CLIP-seq
MIRT1935080	hsa-miR-3925-3p	CLIP-seq
MIRT795935	hsa-miR-4252	CLIP-seq
MIRT1935081	hsa-miR-4294	CLIP-seq
MIRT1935082	hsa-miR-4309	CLIP-seq
MIRT795939	hsa-miR-4318	CLIP-seq
MIRT2175017	hsa-miR-4448	CLIP-seq
MIRT1935083	hsa-miR-4733-3p	CLIP-seq
MIRT1935084	hsa-miR-4756-3p	CLIP-seq
MIRT2175018	hsa-miR-4770	CLIP-seq
MIRT795946	hsa-miR-4784	CLIP-seq
MIRT1935085	hsa-miR-508-5p	CLIP-seq
MIRT1935086	hsa-miR-631	CLIP-seq
MIRT795950	hsa-miR-765	CLIP-seq
MIRT2175019	hsa-miR-877	CLIP-seq
MIRT1935073	hsa-miR-1226	CLIP-seq
MIRT1935074	hsa-miR-1289	CLIP-seq
MIRT1935075	hsa-miR-145	CLIP-seq
MIRT1935078	hsa-miR-3198	CLIP-seq
MIRT1935080	hsa-miR-3925-3p	CLIP-seq
MIRT1935081	hsa-miR-4294	CLIP-seq
MIRT1935082	hsa-miR-4309	CLIP-seq
MIRT1935083	hsa-miR-4733-3p	CLIP-seq
MIRT1935085	hsa-miR-508-5p	CLIP-seq
MIRT2478214	hsa-miR-1205	CLIP-seq
MIRT2478215	hsa-miR-1207-5p	CLIP-seq
MIRT1935073	hsa-miR-1226	CLIP-seq
MIRT2478216	hsa-miR-124	CLIP-seq
MIRT2478217	hsa-miR-1266	CLIP-seq
MIRT2478218	hsa-miR-1286	CLIP-seq
MIRT1935074	hsa-miR-1289	CLIP-seq
MIRT2478219	hsa-miR-1321	CLIP-seq
MIRT2478220	hsa-miR-140-5p	CLIP-seq
MIRT2175016	hsa-miR-143	CLIP-seq
MIRT1935075	hsa-miR-145	CLIP-seq
MIRT2478221	hsa-miR-1587	CLIP-seq
MIRT1935076	hsa-miR-192	CLIP-seq
MIRT2478222	hsa-miR-1976	CLIP-seq
MIRT2478223	hsa-miR-198	CLIP-seq
MIRT1935077	hsa-miR-215	CLIP-seq
MIRT2478224	hsa-miR-2467-3p	CLIP-seq
MIRT795926	hsa-miR-3150b-3p	CLIP-seq
MIRT2478225	hsa-miR-3153	CLIP-seq
MIRT2478226	hsa-miR-3162-5p	CLIP-seq
MIRT1935078	hsa-miR-3198	CLIP-seq
MIRT2478227	hsa-miR-3545-5p	CLIP-seq
MIRT2478228	hsa-miR-3657	CLIP-seq
MIRT1935079	hsa-miR-3661	CLIP-seq
MIRT2478229	hsa-miR-3663-5p	CLIP-seq
MIRT2478230	hsa-miR-3664-3p	CLIP-seq
MIRT2478231	hsa-miR-3664-5p	CLIP-seq
MIRT2478232	hsa-miR-3684	CLIP-seq
MIRT1935080	hsa-miR-3925-3p	CLIP-seq
MIRT1545511	hsa-miR-4270	CLIP-seq
MIRT1935081	hsa-miR-4294	CLIP-seq
MIRT1935082	hsa-miR-4309	CLIP-seq
MIRT2478233	hsa-miR-4434	CLIP-seq
MIRT1545512	hsa-miR-4441	CLIP-seq
MIRT2478234	hsa-miR-4460	CLIP-seq
MIRT2478235	hsa-miR-4492	CLIP-seq
MIRT2478236	hsa-miR-4498	CLIP-seq
MIRT2478237	hsa-miR-4516	CLIP-seq
MIRT2478238	hsa-miR-4518	CLIP-seq
MIRT2478239	hsa-miR-4656	CLIP-seq
MIRT2478240	hsa-miR-4659a-3p	CLIP-seq
MIRT2478241	hsa-miR-4659b-3p	CLIP-seq
MIRT2478242	hsa-miR-4669	CLIP-seq
MIRT2478243	hsa-miR-4675	CLIP-seq
MIRT2478244	hsa-miR-4714-5p	CLIP-seq
MIRT2478245	hsa-miR-4722-5p	CLIP-seq
MIRT1935083	hsa-miR-4733-3p	CLIP-seq
MIRT2478246	hsa-miR-4736	CLIP-seq
MIRT2478247	hsa-miR-4739	CLIP-seq
MIRT2478248	hsa-miR-4741	CLIP-seq
MIRT1935084	hsa-miR-4756-3p	CLIP-seq
MIRT2478249	hsa-miR-4756-5p	CLIP-seq
MIRT2478250	hsa-miR-4763-3p	CLIP-seq
MIRT2478251	hsa-miR-4768-3p	CLIP-seq
MIRT2175018	hsa-miR-4770	CLIP-seq
MIRT795946	hsa-miR-4784	CLIP-seq
MIRT2478252	hsa-miR-506	CLIP-seq
MIRT1935085	hsa-miR-508-5p	CLIP-seq
MIRT2478253	hsa-miR-539	CLIP-seq
MIRT2478254	hsa-miR-583	CLIP-seq
MIRT1935086	hsa-miR-631	CLIP-seq
MIRT2478255	hsa-miR-665	CLIP-seq
MIRT2478256	hsa-miR-762	CLIP-seq
MIRT2478257	hsa-miR-942	CLIP-seq
MIRT2478214	hsa-miR-1205	CLIP-seq
MIRT2478215	hsa-miR-1207-5p	CLIP-seq
MIRT1935073	hsa-miR-1226	CLIP-seq
MIRT2478216	hsa-miR-124	CLIP-seq
MIRT2478217	hsa-miR-1266	CLIP-seq
MIRT2478218	hsa-miR-1286	CLIP-seq
MIRT1935074	hsa-miR-1289	CLIP-seq
MIRT2478219	hsa-miR-1321	CLIP-seq
MIRT2478220	hsa-miR-140-5p	CLIP-seq
MIRT2175016	hsa-miR-143	CLIP-seq
MIRT1935075	hsa-miR-145	CLIP-seq
MIRT2478221	hsa-miR-1587	CLIP-seq
MIRT1935076	hsa-miR-192	CLIP-seq
MIRT2478222	hsa-miR-1976	CLIP-seq
MIRT2478223	hsa-miR-198	CLIP-seq
MIRT1935077	hsa-miR-215	CLIP-seq
MIRT2478224	hsa-miR-2467-3p	CLIP-seq
MIRT795926	hsa-miR-3150b-3p	CLIP-seq
MIRT2478225	hsa-miR-3153	CLIP-seq
MIRT2478226	hsa-miR-3162-5p	CLIP-seq
MIRT1935078	hsa-miR-3198	CLIP-seq
MIRT2478227	hsa-miR-3545-5p	CLIP-seq
MIRT2675331	hsa-miR-3622b-5p	CLIP-seq
MIRT2478228	hsa-miR-3657	CLIP-seq
MIRT1935079	hsa-miR-3661	CLIP-seq
MIRT2478229	hsa-miR-3663-5p	CLIP-seq
MIRT2478230	hsa-miR-3664-3p	CLIP-seq
MIRT2478231	hsa-miR-3664-5p	CLIP-seq
MIRT2478232	hsa-miR-3684	CLIP-seq
MIRT1935080	hsa-miR-3925-3p	CLIP-seq
MIRT1545511	hsa-miR-4270	CLIP-seq
MIRT1935081	hsa-miR-4294	CLIP-seq
MIRT1935082	hsa-miR-4309	CLIP-seq
MIRT2478233	hsa-miR-4434	CLIP-seq
MIRT1545512	hsa-miR-4441	CLIP-seq
MIRT2675332	hsa-miR-4446-3p	CLIP-seq
MIRT2478234	hsa-miR-4460	CLIP-seq
MIRT2478235	hsa-miR-4492	CLIP-seq
MIRT2478236	hsa-miR-4498	CLIP-seq
MIRT2478237	hsa-miR-4516	CLIP-seq
MIRT2478238	hsa-miR-4518	CLIP-seq
MIRT2478239	hsa-miR-4656	CLIP-seq
MIRT2478240	hsa-miR-4659a-3p	CLIP-seq
MIRT2478241	hsa-miR-4659b-3p	CLIP-seq
MIRT2478242	hsa-miR-4669	CLIP-seq
MIRT2478243	hsa-miR-4675	CLIP-seq
MIRT2478244	hsa-miR-4714-5p	CLIP-seq
MIRT2675333	hsa-miR-4720-5p	CLIP-seq
MIRT2675334	hsa-miR-4721	CLIP-seq
MIRT2478245	hsa-miR-4722-5p	CLIP-seq
MIRT795945	hsa-miR-4728-5p	CLIP-seq
MIRT1935083	hsa-miR-4733-3p	CLIP-seq
MIRT2478246	hsa-miR-4736	CLIP-seq
MIRT2478247	hsa-miR-4739	CLIP-seq
MIRT2478248	hsa-miR-4741	CLIP-seq
MIRT2675335	hsa-miR-4755-3p	CLIP-seq
MIRT1935084	hsa-miR-4756-3p	CLIP-seq
MIRT2478249	hsa-miR-4756-5p	CLIP-seq
MIRT2478250	hsa-miR-4763-3p	CLIP-seq
MIRT2478251	hsa-miR-4768-3p	CLIP-seq
MIRT2175018	hsa-miR-4770	CLIP-seq
MIRT795946	hsa-miR-4784	CLIP-seq
MIRT2675336	hsa-miR-4799-3p	CLIP-seq
MIRT2478252	hsa-miR-506	CLIP-seq
MIRT1935085	hsa-miR-508-5p	CLIP-seq
MIRT2478253	hsa-miR-539	CLIP-seq
MIRT2478254	hsa-miR-583	CLIP-seq
MIRT1935086	hsa-miR-631	CLIP-seq
MIRT2478255	hsa-miR-665	CLIP-seq
MIRT2478256	hsa-miR-762	CLIP-seq
MIRT2478257	hsa-miR-942	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0007411	Process	Axon guidance	IBA
GO:0019898	Component	Extrinsic component of membrane	IBA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

MIM	HGNC	e!Ensembl
610018	25516	ENSG00000165801

Q8TER5

Protein name

Rho guanine nucleotide exchange factor 40 (Protein SOLO)

Protein function

May act as a guanine nucleotide exchange factor (GEF).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00621	RhoGEF	1089 → 1248	RhoGEF domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at higher level in the central nervous system and skeletal muscle and greater abundance in fetal than adult brain (at protein level). {ECO:0000269|PubMed:16143467}.

Sequence

MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA
KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA
LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE
LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG
EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ
DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG
GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP
SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL
CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG
GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL
PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW
ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ
KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ
EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE
ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGRE
AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA
SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG
PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERK
RSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTH
FLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYL
PRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVR
GCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFK
TADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKE
LRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPG
ACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGI
LGLSRQSHARALSDPTTPL

Sequence length

1519

Interactions

View interactions

	Reactome
			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myoepithelial tumor	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROBLASTOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDER	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	32276436	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis, Atopic	Dermatitis	BEFREE	31109652, 31179791		★★★★★ ★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	31109652, 31179791		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endocarditis	Endocarditis	BEFREE	30114715		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma Open Angle	Open angle glaucoma	Pubtator	34427245	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	29803590, 30880441, 31268917		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	18443953		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	32276436	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neuroblastoma	Neuroblastoma	Pubtator	32599975	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ARHGEF40 (Rho guanine nucleotide exchange factor 40)