Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55683
Gene name	KAT8 regulatory NSL complex subunit 3
Gene symbol	KANSL3
Synonyms (NCBI Gene)	KIAA1310NSL3Rcd1
Chromosome	2
Chromosome location	2q11.2

Show/Hide all (36)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030314	hsa-miR-26b-5p	Microarray	19088304
MIRT051184	hsa-miR-16-5p	CLASH	23622248
MIRT049440	hsa-miR-92a-3p	CLASH	23622248
MIRT041753	hsa-miR-484	CLASH	23622248
MIRT038818	hsa-miR-93-3p	CLASH	23622248
MIRT036963	hsa-miR-877-3p	CLASH	23622248
MIRT712977	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT712976	hsa-miR-221-5p	HITS-CLIP	19536157
MIRT712975	hsa-miR-8073	HITS-CLIP	19536157
MIRT712974	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT712973	hsa-miR-3128	HITS-CLIP	19536157
MIRT712972	hsa-miR-7106-3p	HITS-CLIP	19536157
MIRT712971	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT643614	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT643612	hsa-miR-4705	HITS-CLIP	23824327
MIRT643613	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT643611	hsa-miR-4301	HITS-CLIP	23824327
MIRT643610	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT643609	hsa-miR-1260a	HITS-CLIP	23824327
MIRT643608	hsa-miR-1260b	HITS-CLIP	23824327
MIRT643607	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT712977	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT712976	hsa-miR-221-5p	HITS-CLIP	19536157
MIRT712975	hsa-miR-8073	HITS-CLIP	19536157
MIRT712974	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT712973	hsa-miR-3128	HITS-CLIP	19536157
MIRT712972	hsa-miR-7106-3p	HITS-CLIP	19536157
MIRT712971	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT643614	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT643612	hsa-miR-4705	HITS-CLIP	23824327
MIRT643613	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT643611	hsa-miR-4301	HITS-CLIP	23824327
MIRT643610	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT643609	hsa-miR-1260a	HITS-CLIP	23824327
MIRT643608	hsa-miR-1260b	HITS-CLIP	23824327
MIRT643607	hsa-miR-3156-3p	HITS-CLIP	23824327

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000123	Component	Histone acetyltransferase complex	IDA	20018852
GO:0000922	Component	Spindle pole	IEA
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA	27768893
GO:0005739	Component	Mitochondrion	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0044545	Component	NSL complex	IBA
GO:0044545	Component	NSL complex	IDA	20018852, 27768893
GO:0044545	Component	NSL complex	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	NAS	24842875
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:1903108	Process	Regulation of mitochondrial transcription	IDA	27768893

MIM	HGNC	e!Ensembl
617742	25473	ENSG00000114982

Q9P2N6

Protein name

KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD)

Protein function

Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (Pub

Family and domains

Sequence

MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRML
FVTPRRQHESTIESDVPIDVETVTSTPMPLYDNQKARSVMNECERHVIFARTDADAPPPP
EDWEEHVNRTGWTMAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQ
ALASVSWDTKLIQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAA
GAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIASSGPSSSVFPTSRRHRFWQSQLS
CLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRSKVLEIHSHFPHKPIILIGWNTGALVA
CHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFR
EKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHMG
SEPRDQDAEKKKKPRDVARRDLAFEVPERGSRPASPAAKLPASPSGSEDLSSVSSSPTSS
PKTKVTTVTSAQKSSQIGSSQLLKRHVQRTEAVLTHKQAQAQFAAFLKQNMLVRKALPPG
TSSCLFVPISSEPPEEGEKEDLRVQLKRHHPSSPLPGSKTSKRPKIKVSLISQGDTAGGP
CAPSQGSAPEAAGGKPITMTLGQASAGAKELTGLLTTAKSSSSEGGVSASPVPSVVSSST
APSALHTLQSRLVATSPGSSLPGATSASSLLQGLSFSLQDISSKTSGLPANPSPGPAPQA
TSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGGLAKLAS
SLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGAAPSEESSSQVLPSSSQRL
PPAP

Sequence length

904

Interactions

View interactions

	Reactome
			HATs acetylate histones

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
HYPOTHYROIDISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SARCOIDOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	31881804	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	8104536		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	35973998	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

KANSL3 (KAT8 regulatory NSL complex subunit 3)