STAP2 (signal transducing adaptor family member 2)

Gene

• Entrez ID: 55620
• Gene name: Signal transducing adaptor family member 2
• Gene symbol: STAP2
• Synonyms (NCBI Gene): BKS
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019827	hsa-miR-375	Microarray	20215506
MIRT1395041	hsa-miR-1343	CLIP-seq
MIRT1395042	hsa-miR-146b-3p	CLIP-seq
MIRT1395043	hsa-miR-186	CLIP-seq
MIRT1395044	hsa-miR-3126-3p	CLIP-seq
MIRT1395045	hsa-miR-3148	CLIP-seq
MIRT1395046	hsa-miR-3153	CLIP-seq
MIRT1395047	hsa-miR-3173-5p	CLIP-seq
MIRT1395048	hsa-miR-3176	CLIP-seq
MIRT1395049	hsa-miR-3199	CLIP-seq
MIRT1395050	hsa-miR-3922-3p	CLIP-seq
MIRT1395051	hsa-miR-3940-3p	CLIP-seq
MIRT1395052	hsa-miR-4281	CLIP-seq
MIRT1395053	hsa-miR-4292	CLIP-seq
MIRT1395054	hsa-miR-4640-5p	CLIP-seq
MIRT1395055	hsa-miR-4646-5p	CLIP-seq
MIRT1395056	hsa-miR-4668-5p	CLIP-seq
MIRT1395057	hsa-miR-4726-5p	CLIP-seq
MIRT1395058	hsa-miR-500a	CLIP-seq
MIRT1395059	hsa-miR-874	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16365431, 28514442, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0035591	Function	Signaling adaptor activity	IEA

Other IDs

• MIM: 607881
• HGNC: 30430
• e!Ensembl: ENSG00000178078

Protein

• UniProt ID: Q9UGK3
• Protein name: Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate)
• Protein function: Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.
• PDB: 2EL8
• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10980601, ECO:0000269|PubMed:12540842}.
• Sequence:

  MASALRPPRVPKPKGVLPSHYYESFLEKKGPCDRDYKKFWAGLQGLTIYFYNSNRDFQHV
  EKLNLGAFEKLTDEIPWGSSRDPGTHFSLILRDQEIKFKVETLECREMWKGFILTVVELR
  VPTDLTLLPGHLYMMSEVLAKEEARRALETPSCFLKVSRLEAQLLLERYPECGNLLLRPS
  GDGADGVSVTTRQMHNGTHVVRHYKVKREGPKYVIDVEQPFSCTSLDAVVNYFVSHTKKA
  LVPFLLDEDYEKVLGYVEADKENGENVWVAPSAPGPGPAPCTGGPKPLSPASSQDKLPPL
  PPLPNQEENYVTPIGDGPAVDYENQDVASSSWPVILKPKKLPKPPAKLPKPPVGPKPEPK
  VFNGGLGRKLPVSSAQPLFPTAGLADMTAELQKKLEKRRALEH

• Sequence length: 403

Pathways

Reactome:

PTK6 Activates STAT3

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Gastric cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEPHROLITHIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	22231445		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	21205088		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	20929863, 21205088	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	29377150		★☆☆☆☆ Found in Text Mining only
Cardiomyopathy, Familial Idiopathic	Cardiomyopathy	BEFREE	28272348		★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	31394992		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	21412687, 30353243		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	21412687, 30353243		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	28365567		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	28272348, 29143802, 29377150, 29959129, 30257976, 30696927, 30974944, 31394992		★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	29959129		★☆☆☆☆ Found in Text Mining only
Diabetic Neuropathies	Diabetic Nephropathy	BEFREE	30082375		★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic Retinopathy	BEFREE	30696927		★☆☆☆☆ Found in Text Mining only
Dyslipidemias	Dyslipidemias	BEFREE	30641913, 30974944		★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	BEFREE	30974944		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21205088		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	28986450		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28430604		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	12810085		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	28986450		★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	28381495		★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	22231445		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	29143802		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	28986450		★☆☆☆☆ Found in Text Mining only