MIOX (myo-inositol oxygenase)

Gene

• Entrez ID: 55586
• Gene name: Myo-inositol oxygenase
• Gene symbol: MIOX
• Synonyms (NCBI Gene): ALDRL6
• Chromosome: 22
• Chromosome location: 22q13.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT674440	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT691634	hsa-miR-411-5p	HITS-CLIP	23313552
MIRT674438	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT674439	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT674436	hsa-miR-4732-3p	HITS-CLIP	23313552
MIRT674437	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT674435	hsa-miR-4635	HITS-CLIP	23313552
MIRT674434	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT674433	hsa-miR-6131	HITS-CLIP	23313552
MIRT674432	hsa-miR-193b-5p	HITS-CLIP	23313552
MIRT691635	hsa-miR-6832-5p	HITS-CLIP	23313552
MIRT691634	hsa-miR-411-5p	HITS-CLIP	23313552
MIRT674431	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT674430	hsa-miR-548s	HITS-CLIP	23313552
MIRT674429	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT674428	hsa-miR-588	HITS-CLIP	23313552
MIRT674427	hsa-miR-4435	HITS-CLIP	23313552
MIRT674426	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT674425	hsa-miR-5096	HITS-CLIP	23313552
MIRT674424	hsa-miR-1303	HITS-CLIP	23313552
MIRT674440	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT674438	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT674439	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT674436	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT674437	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT674435	hsa-miR-4635	HITS-CLIP	23824327
MIRT674434	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT674433	hsa-miR-6131	HITS-CLIP	23824327
MIRT674432	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT674431	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT674430	hsa-miR-548s	HITS-CLIP	23824327
MIRT674429	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT674428	hsa-miR-588	HITS-CLIP	23824327
MIRT674427	hsa-miR-4435	HITS-CLIP	23824327
MIRT674426	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT674425	hsa-miR-5096	HITS-CLIP	23824327
MIRT674424	hsa-miR-1303	HITS-CLIP	23824327
MIRT640621	hsa-miR-8485	HITS-CLIP	23824327
MIRT640620	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT640619	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT640618	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT640617	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT640616	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT640615	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT640614	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT640613	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT640612	hsa-miR-92a-2-5p	HITS-CLIP	23824327
MIRT640611	hsa-miR-6769a-5p	HITS-CLIP	23824327
MIRT640610	hsa-miR-6769b-5p	HITS-CLIP	23824327
MIRT640609	hsa-miR-4648	HITS-CLIP	23824327
MIRT640608	hsa-miR-1302	HITS-CLIP	23824327
MIRT640607	hsa-miR-4298	HITS-CLIP	23824327
MIRT515424	hsa-miR-596	PAR-CLIP	23446348
MIRT515423	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT515422	hsa-miR-20a-3p	PAR-CLIP	23446348
MIRT515421	hsa-miR-6889-3p	PAR-CLIP	23446348
MIRT515420	hsa-miR-4537	PAR-CLIP	23446348
MIRT674440	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT691634	hsa-miR-411-5p	HITS-CLIP	23313552
MIRT674438	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT674439	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT674436	hsa-miR-4732-3p	HITS-CLIP	23313552
MIRT674437	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT674435	hsa-miR-4635	HITS-CLIP	23313552
MIRT674434	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT674433	hsa-miR-6131	HITS-CLIP	23313552
MIRT674432	hsa-miR-193b-5p	HITS-CLIP	23313552
MIRT691635	hsa-miR-6832-5p	HITS-CLIP	23313552
MIRT691634	hsa-miR-411-5p	HITS-CLIP	23313552
MIRT674431	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT674430	hsa-miR-548s	HITS-CLIP	23313552
MIRT674429	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT674428	hsa-miR-588	HITS-CLIP	23313552
MIRT674427	hsa-miR-4435	HITS-CLIP	23313552
MIRT674426	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT674425	hsa-miR-5096	HITS-CLIP	23313552
MIRT674424	hsa-miR-1303	HITS-CLIP	23313552
MIRT674440	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT674438	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT674439	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT674436	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT674437	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT674435	hsa-miR-4635	HITS-CLIP	23824327
MIRT674434	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT674433	hsa-miR-6131	HITS-CLIP	23824327
MIRT674432	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT674431	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT674430	hsa-miR-548s	HITS-CLIP	23824327
MIRT674429	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT674428	hsa-miR-588	HITS-CLIP	23824327
MIRT674427	hsa-miR-4435	HITS-CLIP	23824327
MIRT674426	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT674425	hsa-miR-5096	HITS-CLIP	23824327
MIRT674424	hsa-miR-1303	HITS-CLIP	23824327
MIRT640621	hsa-miR-8485	HITS-CLIP	23824327
MIRT640620	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT640619	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT640618	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT640617	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT640616	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT640615	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT640614	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT640613	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT640612	hsa-miR-92a-2-5p	HITS-CLIP	23824327
MIRT640611	hsa-miR-6769a-5p	HITS-CLIP	23824327
MIRT640610	hsa-miR-6769b-5p	HITS-CLIP	23824327
MIRT640609	hsa-miR-4648	HITS-CLIP	23824327
MIRT640608	hsa-miR-1302	HITS-CLIP	23824327
MIRT640607	hsa-miR-4298	HITS-CLIP	23824327
MIRT515424	hsa-miR-596	PAR-CLIP	23446348
MIRT515423	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT515422	hsa-miR-20a-3p	PAR-CLIP	23446348
MIRT515421	hsa-miR-6889-3p	PAR-CLIP	23446348
MIRT515420	hsa-miR-4537	PAR-CLIP	23446348
MIRT1149375	hsa-miR-15a	CLIP-seq
MIRT1149376	hsa-miR-15b	CLIP-seq
MIRT1149377	hsa-miR-16	CLIP-seq
MIRT1149378	hsa-miR-195	CLIP-seq
MIRT1149379	hsa-miR-3135	CLIP-seq
MIRT1149380	hsa-miR-338-3p	CLIP-seq
MIRT1149381	hsa-miR-424	CLIP-seq
MIRT1149382	hsa-miR-4530	CLIP-seq
MIRT1149383	hsa-miR-4640-5p	CLIP-seq
MIRT1149384	hsa-miR-4650-5p	CLIP-seq
MIRT1149385	hsa-miR-4726-5p	CLIP-seq
MIRT1149386	hsa-miR-497	CLIP-seq
MIRT2042493	hsa-miR-1262	CLIP-seq
MIRT2042494	hsa-miR-4701-3p	CLIP-seq
MIRT2390897	hsa-miR-1228	CLIP-seq
MIRT2390898	hsa-miR-3199	CLIP-seq
MIRT2390899	hsa-miR-329	CLIP-seq
MIRT2390900	hsa-miR-661	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005506	Function	Iron ion binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	TAS
GO:0008106	Function	Alcohol dehydrogenase (NADP+) activity	ISS
GO:0008106	Function	Alcohol dehydrogenase (NADP+) activity	TAS	10944187
GO:0008199	Function	Ferric iron binding	IDA	18364358
GO:0016234	Component	Inclusion body	ISS
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016651	Function	Oxidoreductase activity, acting on NAD(P)H	IEA
GO:0019310	Process	Inositol catabolic process	IBA
GO:0019310	Process	Inositol catabolic process	IDA	18364358
GO:0019310	Process	Inositol catabolic process	IEA
GO:0019310	Process	Inositol catabolic process	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0050113	Function	Inositol oxygenase activity	IBA
GO:0050113	Function	Inositol oxygenase activity	IDA	18364358
GO:0050113	Function	Inositol oxygenase activity	IEA
GO:0050113	Function	Inositol oxygenase activity	ISS

Other IDs

• MIM: 606774
• HGNC: 14522
• e!Ensembl: ENSG00000100253

Protein

• UniProt ID: Q9UGB7
• Protein name: Inositol oxygenase (EC 1.13.99.1) (Aldehyde reductase-like 6) (Kidney-specific protein 32) (Myo-inositol oxygenase) (MI oxygenase) (Renal-specific oxidoreductase)
• PDB: 2IBN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05153	MIOX	37 → 285	Myo-inositol oxygenase	Family

• Tissue specificity: TISSUE SPECIFICITY: Kidney specific.
• Sequence:

  MKVTVGPDPSLVYRPDVDPEVAKDKASFRNYTSGPLLDRVFTTYKLMHTHQTVDFVRSKH
  AQFGGFSYKKMTVMEAVDLLDGLVDESDPDVDFPNSFHAFQTAEGIRKAHPDKDWFHLVG
  LLHDLGKVLALFGEPQWAVVGDTFPVGCRPQASVVFCDSTFQDNPDLQDPRYSTELGMYQ
  PHCGLDRVLMSWGHDEYMYQVMKFNKFSLPPEAFYMIRFHSFYPWHTGRDYQQLCSQQDL
  AMLPWVREFNKFDLYTKCPDLPDVDKLRPYYQGLIDKYCPGILSW

• Sequence length: 285

Pathways

KEGG:

Ascorbate and aldarate metabolism
Inositol phosphate metabolism
Metabolic pathways
Biosynthesis of nucleotide sugars

Reactome:

Synthesis of IP2, IP, and Ins in the cytosol

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
HEARING LOSS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY DISEASES	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	37977044	Inhibit	★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	26578517		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	26578517		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	30504713	Stimulate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	19896870		★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	30504713	Associate	★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	28931523, 30504713		★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	28107998		★☆☆☆☆ Found in Text Mining only
Kidney Failure, Acute	Kidney Failure	BEFREE	10966922, 24486646, 30581335, 31437128		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	26578517		★☆☆☆☆ Found in Text Mining only
Polycystic Kidney Diseases	Polycystic kidney disease	Pubtator	34469896	Associate	★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	BEFREE	29187000		★☆☆☆☆ Found in Text Mining only