PLXNA3 (plexin A3)

Gene

• Entrez ID: 55558
• Gene name: Plexin A3
• Gene symbol: PLXNA3
• Synonyms (NCBI Gene): 6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6
• Chromosome: X
• Chromosome location: Xq28
• Summary: This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs202070666	G>A	Likely-pathogenic	Upstream transcript variant, genic upstream transcript variant, intron variant, non coding transcript variant, coding sequence variant, missense variant
rs782515431	G>C	Likely-pathogenic	Coding sequence variant, non coding transcript variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018079	hsa-miR-335-5p	Microarray	18185580
MIRT687218	hsa-miR-6512-5p	HITS-CLIP	23313552
MIRT687217	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT687216	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT687215	hsa-miR-5694	HITS-CLIP	23313552
MIRT687214	hsa-miR-154-3p	HITS-CLIP	23313552
MIRT687213	hsa-miR-487a-3p	HITS-CLIP	23313552
MIRT687212	hsa-miR-25-3p	HITS-CLIP	23313552
MIRT687211	hsa-miR-32-5p	HITS-CLIP	23313552
MIRT687210	hsa-miR-363-3p	HITS-CLIP	23313552
MIRT687209	hsa-miR-367-3p	HITS-CLIP	23313552
MIRT687208	hsa-miR-92a-3p	HITS-CLIP	23313552
MIRT687207	hsa-miR-92b-3p	HITS-CLIP	23313552
MIRT687206	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT687205	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT687204	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT687203	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT687202	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT687201	hsa-miR-612	HITS-CLIP	23313552
MIRT687200	hsa-miR-6860	HITS-CLIP	23313552
MIRT687199	hsa-miR-4738-3p	HITS-CLIP	23313552
MIRT687198	hsa-miR-661	HITS-CLIP	23313552
MIRT687197	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT687196	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT687195	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT687194	hsa-miR-7703	HITS-CLIP	23313552
MIRT687193	hsa-miR-4325	HITS-CLIP	23313552
MIRT645933	hsa-miR-425-5p	HITS-CLIP	23824327
MIRT645932	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT645931	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT645930	hsa-miR-3183	HITS-CLIP	23824327
MIRT645929	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT645928	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT645927	hsa-miR-4469	HITS-CLIP	23824327
MIRT645926	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT645925	hsa-miR-4287	HITS-CLIP	23824327
MIRT645924	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT645923	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT645922	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT645921	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT645920	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT645919	hsa-miR-3117-5p	HITS-CLIP	23824327
MIRT645918	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT645917	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT645916	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT645915	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT645914	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT645913	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT645912	hsa-miR-5691	HITS-CLIP	23824327
MIRT645911	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT645910	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT645909	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT645908	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT645907	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT645906	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT619213	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT619212	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT625925	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT619211	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT619213	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT619212	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT619211	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT619210	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT687217	hsa-miR-508-5p	HITS-CLIP	27418678
MIRT687196	hsa-miR-6512-3p	HITS-CLIP	27418678
MIRT687198	hsa-miR-661	HITS-CLIP	27418678
MIRT687195	hsa-miR-6720-5p	HITS-CLIP	27418678
MIRT687205	hsa-miR-766-3p	HITS-CLIP	27418678
MIRT687194	hsa-miR-7703	HITS-CLIP	27418678
MIRT687206	hsa-miR-939-3p	HITS-CLIP	27418678
MIRT687218	hsa-miR-6512-5p	HITS-CLIP	23313552
MIRT687217	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT687216	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT687215	hsa-miR-5694	HITS-CLIP	23313552
MIRT687214	hsa-miR-154-3p	HITS-CLIP	23313552
MIRT687213	hsa-miR-487a-3p	HITS-CLIP	23313552
MIRT687212	hsa-miR-25-3p	HITS-CLIP	23313552
MIRT687211	hsa-miR-32-5p	HITS-CLIP	23313552
MIRT687210	hsa-miR-363-3p	HITS-CLIP	23313552
MIRT687209	hsa-miR-367-3p	HITS-CLIP	23313552
MIRT687208	hsa-miR-92a-3p	HITS-CLIP	23313552
MIRT687207	hsa-miR-92b-3p	HITS-CLIP	23313552
MIRT687206	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT687205	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT687204	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT687203	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT687202	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT687201	hsa-miR-612	HITS-CLIP	23313552
MIRT687200	hsa-miR-6860	HITS-CLIP	23313552
MIRT687199	hsa-miR-4738-3p	HITS-CLIP	23313552
MIRT687198	hsa-miR-661	HITS-CLIP	23313552
MIRT687197	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT687196	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT687195	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT687194	hsa-miR-7703	HITS-CLIP	23313552
MIRT687193	hsa-miR-4325	HITS-CLIP	23313552
MIRT645933	hsa-miR-425-5p	HITS-CLIP	23824327
MIRT645932	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT645931	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT645930	hsa-miR-3183	HITS-CLIP	23824327
MIRT645929	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT645928	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT645927	hsa-miR-4469	HITS-CLIP	23824327
MIRT645926	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT645925	hsa-miR-4287	HITS-CLIP	23824327
MIRT645924	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT645923	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT645922	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT645921	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT645920	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT645919	hsa-miR-3117-5p	HITS-CLIP	23824327
MIRT645918	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT645917	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT645916	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT645915	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT645914	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT645913	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT645912	hsa-miR-5691	HITS-CLIP	23824327
MIRT645911	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT645910	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT645909	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT645908	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT645907	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT645906	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT619213	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT619212	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT625925	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT619211	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT619213	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT619212	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT619211	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT619210	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT1243676	hsa-miR-1252	CLIP-seq
MIRT1243677	hsa-miR-125a-3p	CLIP-seq
MIRT1243678	hsa-miR-1273	CLIP-seq
MIRT1243679	hsa-miR-1321	CLIP-seq
MIRT1243680	hsa-miR-184	CLIP-seq
MIRT1243681	hsa-miR-3166	CLIP-seq
MIRT1243682	hsa-miR-3180	CLIP-seq
MIRT1243683	hsa-miR-3180-3p	CLIP-seq
MIRT1243684	hsa-miR-3196	CLIP-seq
MIRT1243685	hsa-miR-3199	CLIP-seq
MIRT1243686	hsa-miR-3654	CLIP-seq
MIRT1243687	hsa-miR-3665	CLIP-seq
MIRT1243688	hsa-miR-3675-5p	CLIP-seq
MIRT1243689	hsa-miR-3683	CLIP-seq
MIRT1243690	hsa-miR-4270	CLIP-seq
MIRT1243691	hsa-miR-4441	CLIP-seq
MIRT1243692	hsa-miR-4447	CLIP-seq
MIRT1243693	hsa-miR-4472	CLIP-seq
MIRT1243694	hsa-miR-4534	CLIP-seq
MIRT1243695	hsa-miR-4648	CLIP-seq
MIRT1243696	hsa-miR-4690-5p	CLIP-seq
MIRT1243697	hsa-miR-4699-3p	CLIP-seq
MIRT1243698	hsa-miR-4728-5p	CLIP-seq
MIRT1243699	hsa-miR-4736	CLIP-seq
MIRT1243700	hsa-miR-4739	CLIP-seq
MIRT1243701	hsa-miR-4756-5p	CLIP-seq
MIRT1243702	hsa-miR-4765	CLIP-seq
MIRT1243703	hsa-miR-4767	CLIP-seq
MIRT1243704	hsa-miR-4771	CLIP-seq
MIRT1243705	hsa-miR-4785	CLIP-seq
MIRT1243706	hsa-miR-4789-3p	CLIP-seq
MIRT1243707	hsa-miR-4790-3p	CLIP-seq
MIRT1243708	hsa-miR-4804-5p	CLIP-seq
MIRT1243709	hsa-miR-642b	CLIP-seq
MIRT1243710	hsa-miR-764	CLIP-seq
MIRT2072017	hsa-miR-124	CLIP-seq
MIRT2072018	hsa-miR-298	CLIP-seq
MIRT2072019	hsa-miR-3177-3p	CLIP-seq
MIRT2072020	hsa-miR-328	CLIP-seq
MIRT2072021	hsa-miR-3612	CLIP-seq
MIRT2072022	hsa-miR-3622a-5p	CLIP-seq
MIRT2072023	hsa-miR-3714	CLIP-seq
MIRT2072024	hsa-miR-3910	CLIP-seq
MIRT2072025	hsa-miR-4257	CLIP-seq
MIRT1243694	hsa-miR-4534	CLIP-seq
MIRT2072026	hsa-miR-4640-5p	CLIP-seq
MIRT2072027	hsa-miR-4695-5p	CLIP-seq
MIRT2072028	hsa-miR-4726-5p	CLIP-seq
MIRT2072029	hsa-miR-4797-5p	CLIP-seq
MIRT2072030	hsa-miR-506	CLIP-seq
MIRT2072031	hsa-miR-564	CLIP-seq
MIRT2072032	hsa-miR-650	CLIP-seq
MIRT2299063	hsa-miR-122	CLIP-seq
MIRT2299064	hsa-miR-1224-5p	CLIP-seq
MIRT1243676	hsa-miR-1252	CLIP-seq
MIRT2299065	hsa-miR-1271	CLIP-seq
MIRT2299066	hsa-miR-141	CLIP-seq
MIRT2299067	hsa-miR-182	CLIP-seq
MIRT2299068	hsa-miR-200a	CLIP-seq
MIRT2299069	hsa-miR-3136-3p	CLIP-seq
MIRT1243681	hsa-miR-3166	CLIP-seq
MIRT1243682	hsa-miR-3180	CLIP-seq
MIRT1243683	hsa-miR-3180-3p	CLIP-seq
MIRT1243684	hsa-miR-3196	CLIP-seq
MIRT2299070	hsa-miR-34a	CLIP-seq
MIRT2299071	hsa-miR-34c-5p	CLIP-seq
MIRT2299072	hsa-miR-3659	CLIP-seq
MIRT1243687	hsa-miR-3665	CLIP-seq
MIRT1243688	hsa-miR-3675-5p	CLIP-seq
MIRT2299073	hsa-miR-3918	CLIP-seq
MIRT2299074	hsa-miR-449a	CLIP-seq
MIRT2299075	hsa-miR-449b	CLIP-seq
MIRT1243694	hsa-miR-4534	CLIP-seq
MIRT2299076	hsa-miR-4691-3p	CLIP-seq
MIRT1243697	hsa-miR-4699-3p	CLIP-seq
MIRT2299077	hsa-miR-4751	CLIP-seq
MIRT1243704	hsa-miR-4771	CLIP-seq
MIRT1243705	hsa-miR-4785	CLIP-seq
MIRT1243707	hsa-miR-4790-3p	CLIP-seq
MIRT1243710	hsa-miR-764	CLIP-seq
MIRT2299078	hsa-miR-96	CLIP-seq
MIRT2392721	hsa-miR-24	CLIP-seq
MIRT2392722	hsa-miR-3121-3p	CLIP-seq
MIRT2595951	hsa-miR-3123	CLIP-seq
MIRT2595952	hsa-miR-3148	CLIP-seq
MIRT2595953	hsa-miR-3907	CLIP-seq
MIRT2595954	hsa-miR-3919	CLIP-seq
MIRT2595955	hsa-miR-4290	CLIP-seq
MIRT2595956	hsa-miR-4293	CLIP-seq
MIRT2595957	hsa-miR-4687-5p	CLIP-seq
MIRT2595958	hsa-miR-4756-3p	CLIP-seq
MIRT2595959	hsa-miR-543	CLIP-seq
MIRT1243710	hsa-miR-764	CLIP-seq
MIRT2595960	hsa-miR-873	CLIP-seq
MIRT2595952	hsa-miR-3148	CLIP-seq
MIRT2595953	hsa-miR-3907	CLIP-seq
MIRT2595955	hsa-miR-4290	CLIP-seq
MIRT2595956	hsa-miR-4293	CLIP-seq
MIRT2595957	hsa-miR-4687-5p	CLIP-seq
MIRT2595959	hsa-miR-543	CLIP-seq
MIRT1243710	hsa-miR-764	CLIP-seq
MIRT2595960	hsa-miR-873	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002116	Component	Semaphorin receptor complex	IBA
GO:0002116	Component	Semaphorin receptor complex	TAS	19909241
GO:0005515	Function	Protein binding	IPI	20138877
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007411	Process	Axon guidance	IEA
GO:0007411	Process	Axon guidance	ISS
GO:0007416	Process	Synapse assembly	IBA
GO:0008045	Process	Motor neuron axon guidance	IBA
GO:0016020	Component	Membrane	IEA
GO:0017154	Function	Semaphorin receptor activity	IBA
GO:0017154	Function	Semaphorin receptor activity	IEA
GO:0017154	Function	Semaphorin receptor activity	ISS
GO:0021537	Process	Telencephalon development	IEA
GO:0021612	Process	Facial nerve structural organization	IEA
GO:0021612	Process	Facial nerve structural organization	ISS
GO:0021628	Process	Olfactory nerve formation	IEA
GO:0021637	Process	Trigeminal nerve structural organization	IEA
GO:0021637	Process	Trigeminal nerve structural organization	ISS
GO:0021766	Process	Hippocampus development	IEA
GO:0021766	Process	Hippocampus development	ISS
GO:0021785	Process	Branchiomotor neuron axon guidance	IEA
GO:0021785	Process	Branchiomotor neuron axon guidance	ISS
GO:0021828	Process	Gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IEA
GO:0021860	Process	Pyramidal neuron development	IEA
GO:0021860	Process	Pyramidal neuron development	ISS
GO:0030334	Process	Regulation of cell migration	IBA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0048675	Process	Axon extension	IEA
GO:0048841	Process	Regulation of axon extension involved in axon guidance	IEA
GO:0048843	Process	Negative regulation of axon extension involved in axon guidance	IEA
GO:0048846	Process	Axon extension involved in axon guidance	IEA
GO:0050770	Process	Regulation of axonogenesis	IEA
GO:0050919	Process	Negative chemotaxis	IEA
GO:0050919	Process	Negative chemotaxis	IEA
GO:0050920	Process	Regulation of chemotaxis	IEA
GO:0051495	Process	Positive regulation of cytoskeleton organization	IEA
GO:0051495	Process	Positive regulation of cytoskeleton organization	ISS
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	ISS
GO:0071526	Process	Semaphorin-plexin signaling pathway	NAS	19909241
GO:0097485	Process	Neuron projection guidance	IEA
GO:0097485	Process	Neuron projection guidance	ISS
GO:1990138	Process	Neuron projection extension	IEA

Other IDs

• MIM: 300022
• HGNC: 9101
• e!Ensembl: ENSG00000130827

Protein

• UniProt ID: P51805
• Protein name: Plexin-A3 (Plexin-4) (Semaphorin receptor SEX)
• Protein function: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but n
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01403	Sema	35 → 469	Sema domain	Family
  PF01437	PSI	490 → 540	Plexin repeat	Family
  PF17960	TIG_plexin	545 → 636	TIG domain	Domain
  PF01437	PSI	637 → 685	Plexin repeat	Family
  PF18020	TIG_2	690 → 784	TIG domain found in plexin	Domain
  PF01833	TIG	840 → 932	IPT/TIG domain	Domain
  PF01833	TIG	935 → 1019	IPT/TIG domain	Domain
  PF01833	TIG	1023 → 1121	IPT/TIG domain	Domain
  PF01833	TIG	1126 → 1209	IPT/TIG domain	Domain
  PF08337	Plexin_cytopl	1293 → 1841	Plexin cytoplasmic RasGAP domain	Family

• Sequence:

  MPSVCLLLLLFLAVGGALGNRPFRAFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLAPNL
  TELRAHVTGPVEDNARCYPPPSMRVCAHRLAPVDNINKLLLIDYAARRLVACGSIWQGIC
  QFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGQGPSKLFVGTAVDGKSEYFPT
  LSSRKLISDEDSADMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLT
  LQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKP
  GLLLAQALGVPADEDVLFTIFSQGQKNRASPPRQTILCLFTLSNINAHIRRRIQSCYRGE
  GTLALPWLLNKELPCINTPMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAY
  TYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPILRDLLFSPDHRHIYLLSE
  KQVSQLPVETCEQYQSCAACLGSGDPHCGWCVLRHRCCREGACLGASAPHGFAEELSKCV
  QVRVRPNNVSVTSPGVQLTVTLHNVPDLSAGVSCAFEAAAENEAVLLPSGELLCPSPSLQ
  ELRALTRGHGATRTVRLQLLSKETGVRFAGADFVFYNCSVLQSCMSCVGSPYPCHWCKYR
  HTCTSRPHECSFQEGRVHSPEGCPEILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYE
  CVVRVQGRQQRVPAVRFNSSSVQCQNASYSYEGDEHGDTELDFSVVWDGDFPIDKPPSFR
  ALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRTHCPAPKTNWMHLSQKGTRCSHP
  RITQIHPLVGPKEGGTRVTIVGDNLGLLSREVGLRVAGVRCNSIPAEYISAERIVCEMEE
  SLVPSPPPGPVELCVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTRLTISGSSL
  DAGSRVTVTVRDSECQFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLIYTYT
  QDPTVTRLEPTWSIINGSTAITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLCK
  APGIFLGRPQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLDVKP
  GSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCSLTVSDTQLLCDSPSQTGRQPVMVLVGG
  LEFWLGTLHISAERALTLPAMMGLAAGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQM
  DNLESRVALECKEAFAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAHPVLKEL
  DTPPNVEKALRLFGQLLHSRAFVLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYAT
  GLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLY
  CAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPENEGSAQVPVKVLNC
  DSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMTRIILQDEDVTTKIECDWKRLN
  SLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRTASSPDSLRSRAPMITP
  DQETGTKLWHLVKNHDHADHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTA
  HRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHK
  NSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMAS
  ISDQDMDAYLVEQSRLHASDFSVLSALNELYFYVTKYRQEILTALDRDASCRKHKLRQKL
  EQIISLVSSDS

• Sequence length: 1871

Pathways

KEGG:

Axon guidance

Reactome:

Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Adrenocortical carcinoma, hereditary	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autism	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Uncertain significance; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Childhood-onset schizophrenia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL SMALL EARS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Disorder of sexual differentiation	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypogonadotropic hypogonadism	Conflicting classifications of pathogenicity; Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Lung cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Microtia	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Uncertain significance; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PLXNA3-associated seizure disorder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PLXNA3-related disorder	Uncertain significance; Benign; Likely benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Short stature	Conflicting classifications of pathogenicity; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer disease, familial, type 3	Alzheimer disease	BEFREE	31158389		★☆☆☆☆ Found in Text Mining only
Attention Deficit Disorder with Hyperactivity	Attention deficit hyperactivity disorder	Pubtator	34740135	Associate	★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	34740135	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Carcinoma	Breast Carcinoma	BEFREE	21925246		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	21658281		★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	BEFREE	28571893, 30733210		★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	BEFREE	29742360		★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	30551341		★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	34740135	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	29742360		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	29742360		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	29855077		★☆☆☆☆ Found in Text Mining only
Dyssomnias	Dyssomnia	BEFREE	26149676		★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	21933904		★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	CTD_human_DG	21933904		★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial Neoplasms	CTD_human_DG	21933904		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	21933904	Inhibit	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Focal glomerulosclerosis	Glomerulosclerosis	BEFREE	29636065		★☆☆☆☆ Found in Text Mining only
Growth Disorders	Growth disorder	Pubtator	30809043	Associate	★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	8011962		★☆☆☆☆ Found in Text Mining only
Idiopathic Hypogonadotropic Hypogonadism	Hypogonadotropic hypogonadism	Pubtator	33495532	Associate	★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	34740135	Associate	★☆☆☆☆ Found in Text Mining only
Li-Fraumeni Syndrome	Li-Fraumeni Syndrome	BEFREE	9399838		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	23411869		★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	31158389		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21925246		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	31322260		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26141947, 9399838		★☆☆☆☆ Found in Text Mining only
Meniere Disease	Meniere Disease	BEFREE	23484733		★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	30551341		★☆☆☆☆ Found in Text Mining only
Mood Disorders	Mood Disorder	BEFREE	6846043		★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	28536997		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15800706, 9399838		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	28763833		★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	29623499		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	20124444	Inhibit	★☆☆☆☆ Found in Text Mining only
Seizures	Seizures	Pubtator	34740135	Associate	★☆☆☆☆ Found in Text Mining only
Sleep Disorders	Sleep Disorders	BEFREE	26149676		★☆☆☆☆ Found in Text Mining only
Toxic Epidermal Necrolysis	Stevens-Johnson Syndrome	BEFREE	21480948		★☆☆☆☆ Found in Text Mining only
Tremor	Tremor	Pubtator	34740135	Associate	★☆☆☆☆ Found in Text Mining only