DNAJA4 (DnaJ heat shock protein family (Hsp40) member A4)

Gene

• Entrez ID: 55466
• Gene name: DnaJ heat shock protein family (Hsp40) member A4
• Gene symbol: DNAJA4
• Synonyms (NCBI Gene): MST104, MSTP104, PRO1472
• Chromosome: 15
• Chromosome location: 15q25.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028423	hsa-miR-30a-5p	Proteomics	18668040
MIRT031496	hsa-miR-16-5p	Proteomics	18668040
MIRT053555	hsa-miR-1908-5p	ELISA, Luciferase reporter assay, Microarray	23142051
MIRT053556	hsa-miR-199a-3p	ELISA, Luciferase reporter assay, Microarray	23142051
MIRT053557	hsa-miR-199a-5p	ELISA, Luciferase reporter assay, Microarray	23142051
MIRT640624	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT640623	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT640622	hsa-miR-6083	HITS-CLIP	23824327
MIRT440805	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440804	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT440805	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440804	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT640624	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT640623	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT640622	hsa-miR-6083	HITS-CLIP	23824327
MIRT939767	hsa-let-7a	CLIP-seq
MIRT939768	hsa-let-7b	CLIP-seq
MIRT939769	hsa-let-7c	CLIP-seq
MIRT939770	hsa-let-7d	CLIP-seq
MIRT939771	hsa-let-7e	CLIP-seq
MIRT939772	hsa-let-7f	CLIP-seq
MIRT939773	hsa-let-7g	CLIP-seq
MIRT939774	hsa-let-7i	CLIP-seq
MIRT939775	hsa-miR-125a-5p	CLIP-seq
MIRT939776	hsa-miR-125b	CLIP-seq
MIRT939777	hsa-miR-1266	CLIP-seq
MIRT939778	hsa-miR-1306	CLIP-seq
MIRT939779	hsa-miR-15a	CLIP-seq
MIRT939780	hsa-miR-15b	CLIP-seq
MIRT939781	hsa-miR-16	CLIP-seq
MIRT939782	hsa-miR-195	CLIP-seq
MIRT939783	hsa-miR-202	CLIP-seq
MIRT939784	hsa-miR-2110	CLIP-seq
MIRT939785	hsa-miR-219-2-3p	CLIP-seq
MIRT939786	hsa-miR-3121-3p	CLIP-seq
MIRT939787	hsa-miR-3150a-3p	CLIP-seq
MIRT939788	hsa-miR-3153	CLIP-seq
MIRT939789	hsa-miR-3163	CLIP-seq
MIRT939790	hsa-miR-3614-5p	CLIP-seq
MIRT939791	hsa-miR-3663-5p	CLIP-seq
MIRT939792	hsa-miR-3664-3p	CLIP-seq
MIRT939793	hsa-miR-424	CLIP-seq
MIRT939794	hsa-miR-4271	CLIP-seq
MIRT939795	hsa-miR-4290	CLIP-seq
MIRT939796	hsa-miR-4292	CLIP-seq
MIRT939797	hsa-miR-4308	CLIP-seq
MIRT939798	hsa-miR-4319	CLIP-seq
MIRT939799	hsa-miR-4324	CLIP-seq
MIRT939800	hsa-miR-4422	CLIP-seq
MIRT939801	hsa-miR-4458	CLIP-seq
MIRT939802	hsa-miR-4468	CLIP-seq
MIRT939803	hsa-miR-4496	CLIP-seq
MIRT939804	hsa-miR-4499	CLIP-seq
MIRT939805	hsa-miR-4500	CLIP-seq
MIRT939806	hsa-miR-4518	CLIP-seq
MIRT939807	hsa-miR-4524	CLIP-seq
MIRT939808	hsa-miR-4527	CLIP-seq
MIRT939809	hsa-miR-4668-5p	CLIP-seq
MIRT939810	hsa-miR-4682	CLIP-seq
MIRT939811	hsa-miR-4725-3p	CLIP-seq
MIRT939812	hsa-miR-4738-3p	CLIP-seq
MIRT939813	hsa-miR-4744	CLIP-seq
MIRT939814	hsa-miR-4765	CLIP-seq
MIRT939815	hsa-miR-497	CLIP-seq
MIRT939816	hsa-miR-499-3p	CLIP-seq
MIRT939817	hsa-miR-499a-3p	CLIP-seq
MIRT939818	hsa-miR-503	CLIP-seq
MIRT939819	hsa-miR-5096	CLIP-seq
MIRT939820	hsa-miR-541	CLIP-seq
MIRT939821	hsa-miR-548u	CLIP-seq
MIRT939822	hsa-miR-618	CLIP-seq
MIRT939823	hsa-miR-645	CLIP-seq
MIRT939824	hsa-miR-646	CLIP-seq
MIRT939825	hsa-miR-654-5p	CLIP-seq
MIRT939826	hsa-miR-9	CLIP-seq
MIRT939827	hsa-miR-98	CLIP-seq
MIRT1977969	hsa-miR-1244	CLIP-seq
MIRT1977970	hsa-miR-199b-3p	CLIP-seq
MIRT1977971	hsa-miR-3129-5p	CLIP-seq
MIRT1977972	hsa-miR-590-3p	CLIP-seq
MIRT2213378	hsa-miR-1227	CLIP-seq
MIRT1977969	hsa-miR-1244	CLIP-seq
MIRT939775	hsa-miR-125a-5p	CLIP-seq
MIRT939776	hsa-miR-125b	CLIP-seq
MIRT2213379	hsa-miR-1291	CLIP-seq
MIRT939778	hsa-miR-1306	CLIP-seq
MIRT2213380	hsa-miR-1324	CLIP-seq
MIRT2213381	hsa-miR-143	CLIP-seq
MIRT2213382	hsa-miR-146b-3p	CLIP-seq
MIRT939779	hsa-miR-15a	CLIP-seq
MIRT939780	hsa-miR-15b	CLIP-seq
MIRT939781	hsa-miR-16	CLIP-seq
MIRT2213383	hsa-miR-181a	CLIP-seq
MIRT2213384	hsa-miR-181b	CLIP-seq
MIRT2213385	hsa-miR-181c	CLIP-seq
MIRT2213386	hsa-miR-181d	CLIP-seq
MIRT939782	hsa-miR-195	CLIP-seq
MIRT1977970	hsa-miR-199b-3p	CLIP-seq
MIRT2213387	hsa-miR-2116	CLIP-seq
MIRT2213388	hsa-miR-218	CLIP-seq
MIRT2213389	hsa-miR-224	CLIP-seq
MIRT2213390	hsa-miR-28-5p	CLIP-seq
MIRT939786	hsa-miR-3121-3p	CLIP-seq
MIRT1977971	hsa-miR-3129-5p	CLIP-seq
MIRT2213391	hsa-miR-3139	CLIP-seq
MIRT2213392	hsa-miR-3140-3p	CLIP-seq
MIRT2213393	hsa-miR-3151	CLIP-seq
MIRT2213394	hsa-miR-3160-3p	CLIP-seq
MIRT939789	hsa-miR-3163	CLIP-seq
MIRT2213395	hsa-miR-3166	CLIP-seq
MIRT2213396	hsa-miR-3168	CLIP-seq
MIRT2213397	hsa-miR-3179	CLIP-seq
MIRT2213398	hsa-miR-3185	CLIP-seq
MIRT2213399	hsa-miR-3202	CLIP-seq
MIRT2213400	hsa-miR-320e	CLIP-seq
MIRT2213401	hsa-miR-328	CLIP-seq
MIRT2213402	hsa-miR-3607-5p	CLIP-seq
MIRT939790	hsa-miR-3614-5p	CLIP-seq
MIRT2213403	hsa-miR-3646	CLIP-seq
MIRT2213404	hsa-miR-380	CLIP-seq
MIRT2213405	hsa-miR-382	CLIP-seq
MIRT2213406	hsa-miR-383	CLIP-seq
MIRT2213407	hsa-miR-3908	CLIP-seq
MIRT2213408	hsa-miR-3922-5p	CLIP-seq
MIRT2213409	hsa-miR-3942-5p	CLIP-seq
MIRT2213410	hsa-miR-3973	CLIP-seq
MIRT939793	hsa-miR-424	CLIP-seq
MIRT2213411	hsa-miR-425	CLIP-seq
MIRT2213412	hsa-miR-4262	CLIP-seq
MIRT2213413	hsa-miR-4269	CLIP-seq
MIRT2213414	hsa-miR-4282	CLIP-seq
MIRT939798	hsa-miR-4319	CLIP-seq
MIRT939799	hsa-miR-4324	CLIP-seq
MIRT2213415	hsa-miR-4453	CLIP-seq
MIRT2213416	hsa-miR-4457	CLIP-seq
MIRT939802	hsa-miR-4468	CLIP-seq
MIRT2213417	hsa-miR-4470	CLIP-seq
MIRT2213418	hsa-miR-4476	CLIP-seq
MIRT939803	hsa-miR-4496	CLIP-seq
MIRT2213419	hsa-miR-4503	CLIP-seq
MIRT939807	hsa-miR-4524	CLIP-seq
MIRT2213420	hsa-miR-4530	CLIP-seq
MIRT2213421	hsa-miR-4533	CLIP-seq
MIRT2213422	hsa-miR-4538	CLIP-seq
MIRT2213423	hsa-miR-4687-3p	CLIP-seq
MIRT2213424	hsa-miR-4690-5p	CLIP-seq
MIRT2213425	hsa-miR-4703-5p	CLIP-seq
MIRT2213426	hsa-miR-4715-5p	CLIP-seq
MIRT2213427	hsa-miR-4729	CLIP-seq
MIRT2213428	hsa-miR-4731-3p	CLIP-seq
MIRT2213429	hsa-miR-4733-5p	CLIP-seq
MIRT2213430	hsa-miR-4753-5p	CLIP-seq
MIRT2213431	hsa-miR-4764-5p	CLIP-seq
MIRT2213432	hsa-miR-4766-3p	CLIP-seq
MIRT2213433	hsa-miR-4770	CLIP-seq
MIRT2213434	hsa-miR-4771	CLIP-seq
MIRT2213435	hsa-miR-4772-5p	CLIP-seq
MIRT2213436	hsa-miR-4773	CLIP-seq
MIRT2213437	hsa-miR-4775	CLIP-seq
MIRT2213438	hsa-miR-4796-3p	CLIP-seq
MIRT2213439	hsa-miR-4798-3p	CLIP-seq
MIRT2213440	hsa-miR-4801	CLIP-seq
MIRT939815	hsa-miR-497	CLIP-seq
MIRT939816	hsa-miR-499-3p	CLIP-seq
MIRT939817	hsa-miR-499a-3p	CLIP-seq
MIRT939818	hsa-miR-503	CLIP-seq
MIRT939819	hsa-miR-5096	CLIP-seq
MIRT2213441	hsa-miR-518a-3p	CLIP-seq
MIRT2213442	hsa-miR-518b	CLIP-seq
MIRT2213443	hsa-miR-518c	CLIP-seq
MIRT2213444	hsa-miR-518d-3p	CLIP-seq
MIRT2213445	hsa-miR-518f	CLIP-seq
MIRT2213446	hsa-miR-520g	CLIP-seq
MIRT2213447	hsa-miR-520h	CLIP-seq
MIRT2213448	hsa-miR-548ad	CLIP-seq
MIRT2213449	hsa-miR-552	CLIP-seq
MIRT2213450	hsa-miR-554	CLIP-seq
MIRT2213451	hsa-miR-587	CLIP-seq
MIRT1977972	hsa-miR-590-3p	CLIP-seq
MIRT2213452	hsa-miR-616	CLIP-seq
MIRT2213453	hsa-miR-636	CLIP-seq
MIRT939823	hsa-miR-645	CLIP-seq
MIRT939824	hsa-miR-646	CLIP-seq
MIRT2213454	hsa-miR-7	CLIP-seq
MIRT2213455	hsa-miR-708	CLIP-seq
MIRT2213456	hsa-miR-885-5p	CLIP-seq
MIRT2386947	hsa-miR-4436a	CLIP-seq
MIRT2213417	hsa-miR-4470	CLIP-seq
MIRT2213429	hsa-miR-4733-5p	CLIP-seq
MIRT2517203	hsa-miR-125a-3p	CLIP-seq
MIRT939777	hsa-miR-1266	CLIP-seq
MIRT2517204	hsa-miR-3132	CLIP-seq
MIRT939792	hsa-miR-3664-3p	CLIP-seq
MIRT2517205	hsa-miR-3934	CLIP-seq
MIRT939806	hsa-miR-4518	CLIP-seq
MIRT2517206	hsa-miR-4659a-5p	CLIP-seq
MIRT2517207	hsa-miR-4659b-5p	CLIP-seq
MIRT939812	hsa-miR-4738-3p	CLIP-seq
MIRT2517208	hsa-miR-764	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25036637, 25416956, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	21231916
GO:0005829	Component	Cytosol	TAS
GO:0006457	Process	Protein folding	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009408	Process	Response to heat	IEA
GO:0010596	Process	Negative regulation of endothelial cell migration	IMP	23142051
GO:0010628	Process	Positive regulation of gene expression	IMP	23142051
GO:0016020	Component	Membrane	IDA	21231916
GO:0016020	Component	Membrane	IEA
GO:0030544	Function	Hsp70 protein binding	IEA
GO:0031072	Function	Heat shock protein binding	IEA
GO:0042026	Process	Protein refolding	IBA
GO:0042026	Process	Protein refolding	IDA	21231916
GO:0046872	Function	Metal ion binding	IEA
GO:0051082	Function	Unfolded protein binding	IDA	21231916
GO:0051082	Function	Unfolded protein binding	IEA
GO:0051087	Function	Protein-folding chaperone binding	IBA
GO:0051087	Function	Protein-folding chaperone binding	IEA
GO:0051087	Function	Protein-folding chaperone binding	IPI	21231916
GO:0090084	Process	Negative regulation of inclusion body assembly	IDA	21231916

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8WW22
• Protein name: DnaJ homolog subfamily A member 4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00226	DnaJ	6 → 65	DnaJ domain	Domain
  PF01556	DnaJ_C	108 → 330	DnaJ C terminal domain	Domain
  PF00684	DnaJ_CXXCXGXG	135 → 201	DnaJ central domain	Domain

• Sequence:

  MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGEKFKLISQAYEVLSDPKK
  RDVYDQGGEQAIKEGGSGSPSFSSPMDIFDMFFGGGGRMARERRGKNVVHQLSVTLEDLY
  NGVTKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGMQIHIQQIGPGMVQQIQTVCIE
  CKGQGERINPKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEPGDV
  IIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDNRILVITSKAGEVIKHGD
  LRCVRDEGMPIYKAPLEKGILIIQFLVIFPEKHWLSLEKLPQLEALLPPRQKVRITDDMD
  QVELKEFCPNEQNWRQHREAYEEDEDGPQAGVQCQTA

• Sequence length: 397

Pathways

Reactome:

HSP90 chaperone cycle for steroid hormone receptors (SHR)

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BRAIN ANEURYSM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VASCULAR DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Atrial Fibrillation	Atrial fibrillation	Pubtator	34737791	Associate	★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	37875476	Inhibit	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	37875476	Stimulate	★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	37875476	Associate	★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma	Rhabdomyosarcoma	Pubtator	22419069	Associate	★☆☆☆☆ Found in Text Mining only
Sarcoma Ewing	Sarcoma	Pubtator	24005033	Associate	★☆☆☆☆ Found in Text Mining only