Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55421
Gene name	Nuclear cap binding subunit 3
Gene symbol	NCBP3
Synonyms (NCBI Gene)	C17orf85ELGHSA277841
Chromosome	17
Chromosome location	17p13.2

Show/Hide all (94)

miRTarBase ID	miRNA	Experiments	Reference
MIRT675913	hsa-miR-4714-5p	HITS-CLIP	23824327
MIRT675912	hsa-miR-514a-5p	HITS-CLIP	23824327
MIRT675911	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT675910	hsa-miR-5690	HITS-CLIP	23824327
MIRT675909	hsa-miR-518c-5p	HITS-CLIP	23824327
MIRT675908	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT675907	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT675906	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT675905	hsa-miR-3612	HITS-CLIP	23824327
MIRT675904	hsa-miR-650	HITS-CLIP	23824327
MIRT675903	hsa-miR-7977	HITS-CLIP	23824327
MIRT675902	hsa-miR-516b-5p	HITS-CLIP	23824327
MIRT675901	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT675900	hsa-miR-4443	HITS-CLIP	23824327
MIRT675899	hsa-miR-665	HITS-CLIP	23824327
MIRT669300	hsa-miR-6854-5p	HITS-CLIP	23824327
MIRT669299	hsa-miR-7705	HITS-CLIP	23824327
MIRT669298	hsa-miR-5693	HITS-CLIP	23824327
MIRT669297	hsa-miR-103b	HITS-CLIP	23824327
MIRT669296	hsa-miR-93-3p	HITS-CLIP	23824327
MIRT669295	hsa-miR-3692-5p	HITS-CLIP	23824327
MIRT540977	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT669294	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT669293	hsa-miR-3135b	HITS-CLIP	23824327
MIRT669292	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT669291	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT669290	hsa-miR-3652	HITS-CLIP	23824327
MIRT669289	hsa-miR-4430	HITS-CLIP	23824327
MIRT669288	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT669287	hsa-miR-6071	HITS-CLIP	23824327
MIRT669286	hsa-miR-5698	HITS-CLIP	23824327
MIRT540981	hsa-miR-194-3p	PAR-CLIP	21572407
MIRT540980	hsa-miR-6134	PAR-CLIP	21572407
MIRT540979	hsa-miR-377-5p	PAR-CLIP	21572407
MIRT540978	hsa-miR-6086	PAR-CLIP	21572407
MIRT540977	hsa-miR-6499-3p	PAR-CLIP	21572407
MIRT540976	hsa-miR-3689d	PAR-CLIP	21572407
MIRT540975	hsa-miR-6851-5p	PAR-CLIP	21572407
MIRT540974	hsa-miR-6877-5p	PAR-CLIP	21572407
MIRT540973	hsa-miR-6781-5p	PAR-CLIP	21572407
MIRT540972	hsa-miR-6880-5p	PAR-CLIP	21572407
MIRT540971	hsa-miR-7847-3p	PAR-CLIP	21572407
MIRT540970	hsa-miR-455-3p	PAR-CLIP	21572407
MIRT540969	hsa-miR-6516-5p	PAR-CLIP	21572407
MIRT540981	hsa-miR-194-3p	PAR-CLIP	21572407
MIRT540980	hsa-miR-6134	PAR-CLIP	21572407
MIRT540979	hsa-miR-377-5p	PAR-CLIP	21572407
MIRT540978	hsa-miR-6086	PAR-CLIP	21572407
MIRT540977	hsa-miR-6499-3p	PAR-CLIP	21572407
MIRT540976	hsa-miR-3689d	PAR-CLIP	21572407
MIRT540975	hsa-miR-6851-5p	PAR-CLIP	21572407
MIRT540974	hsa-miR-6877-5p	PAR-CLIP	21572407
MIRT540973	hsa-miR-6781-5p	PAR-CLIP	21572407
MIRT540972	hsa-miR-6880-5p	PAR-CLIP	21572407
MIRT540971	hsa-miR-7847-3p	PAR-CLIP	21572407
MIRT540970	hsa-miR-455-3p	PAR-CLIP	21572407
MIRT540969	hsa-miR-6516-5p	PAR-CLIP	21572407
MIRT496093	hsa-miR-3121-3p	PAR-CLIP	22291592
MIRT196899	hsa-miR-4789-3p	PAR-CLIP	22291592
MIRT496092	hsa-miR-4676-5p	PAR-CLIP	22291592
MIRT496091	hsa-miR-575	PAR-CLIP	22291592
MIRT496089	hsa-miR-4719	PAR-CLIP	22291592
MIRT496090	hsa-miR-4704-3p	PAR-CLIP	22291592
MIRT496088	hsa-miR-4786-3p	PAR-CLIP	22291592
MIRT496087	hsa-miR-642a-3p	PAR-CLIP	22291592
MIRT496086	hsa-miR-642b-3p	PAR-CLIP	22291592
MIRT496093	hsa-miR-3121-3p	PAR-CLIP	22291592
MIRT196899	hsa-miR-4789-3p	PAR-CLIP	22291592
MIRT496092	hsa-miR-4676-5p	PAR-CLIP	22291592
MIRT496091	hsa-miR-575	PAR-CLIP	22291592
MIRT496089	hsa-miR-4719	PAR-CLIP	22291592
MIRT496090	hsa-miR-4704-3p	PAR-CLIP	22291592
MIRT496088	hsa-miR-4786-3p	PAR-CLIP	22291592
MIRT496087	hsa-miR-642a-3p	PAR-CLIP	22291592
MIRT496086	hsa-miR-642b-3p	PAR-CLIP	22291592
MIRT491714	hsa-miR-6165	PAR-CLIP	23592263
MIRT491713	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT480433	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT480431	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT480432	hsa-miR-766-3p	PAR-CLIP	23592263
MIRT480429	hsa-miR-3925-3p	PAR-CLIP	23592263
MIRT480430	hsa-miR-4693-3p	PAR-CLIP	23592263
MIRT480428	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT480427	hsa-miR-4784	PAR-CLIP	23592263
MIRT480426	hsa-miR-4481	PAR-CLIP	23592263
MIRT480425	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT480424	hsa-miR-4261	PAR-CLIP	23592263
MIRT480423	hsa-miR-5192	PAR-CLIP	23592263
MIRT480422	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT480421	hsa-miR-3153	PAR-CLIP	23592263
MIRT480420	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT480418	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT480419	hsa-miR-520a-5p	PAR-CLIP	23592263
MIRT480417	hsa-miR-525-5p	PAR-CLIP	23592263

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000339	Function	RNA cap binding	IBA
GO:0000339	Function	RNA cap binding	IEA
GO:0000340	Function	RNA 7-methylguanosine cap binding	IEA
GO:0000340	Function	RNA 7-methylguanosine cap binding	IMP	26382858
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0003729	Function	MRNA binding	IDA	26382858
GO:0003729	Function	MRNA binding	IEA
GO:0005515	Function	Protein binding	IPI	22365833, 26382858, 32296183, 32960270, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	26382858
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	26382858
GO:0005737	Component	Cytoplasm	IEA
GO:0005846	Component	Nuclear cap binding complex	IPI	26382858
GO:0006370	Process	7-methylguanosine mRNA capping	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0006406	Process	MRNA export from nucleus	IMP	26382858
GO:0006408	Process	SnRNA export from nucleus	IMP	26382858
GO:0016607	Component	Nuclear speck	IDA
GO:0034518	Component	RNA cap binding complex	TAS	26382858
GO:0035194	Process	Regulatory ncRNA-mediated post-transcriptional gene silencing	NAS	26382858
GO:0042789	Process	MRNA transcription by RNA polymerase II	NAS	26382858
GO:0051028	Process	MRNA transport	IEA
GO:0051607	Process	Defense response to virus	IEA
GO:0051607	Process	Defense response to virus	IMP	26382858

MIM	HGNC	e!Ensembl
616624	24612	ENSG00000074356

Q53F19

Protein name

Nuclear cap-binding protein subunit 3 (Protein ELG)

Protein function

Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCB

PDB

8BY6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10309	NCBP3	123 → 177	Nuclear cap-binding protein subunit 3	Family

Sequence

MAAVRGLRVSVKAEAPAGPALGLPSPEAESGVDRGEPEPMEVEEGELEIVPVRRSLKELI
PDTSRRYENKAGSFITGIDVTSKEAIEKKEQRAKRFHFRSEVNLAQRNVALDRDMMKKAI
PKVRLETIYICGVDEMSTQDVFSYFKEYPPAHIEWLDDTSCNVVWLDEMTATRALINMSS
LPAQDKIRSRDASEDKSAEKRKKDKQEDSSDDDEAEEGEVEDENSSDVELDTLSQVEEES
LLRNDLRPANKLAKGNRLFMRFATKDDKKELGAARRSQYYMKYGNPNYGGMKGILSNSWK
RRYHSRRIQRDVIKKRALIGDDVGLTSYKHRHSGLVNVPEEPIEEEEEEEEEEEEEEEED
QDMDADDRVVVEYHEELPALKQPRERSASRRSSASSSDSDEMDYDLELKMISTPSPKKSM
KMTMYADEVESQLKNIRNSMRADSVSSSNIKNRIGNKLPPEKFADVRHLLDEKRQHSRPR
PPVSSTKSDIRQRLGKRPHSPEKAFSSNPVVRREPSSDVHSRLGVPRQDSKGLYADTREK
KSGNLWTRLGSAPKTKEKNTKKVDHRAPGAEEDDSELQRAWGALIKEKEQSRQKKSRLDN
LPSLQIEVSRESSSGSEAES

Sequence length

620

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	36335189	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	32618493	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	36473947	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NCBP3 (nuclear cap binding subunit 3)