TMCO6 (transmembrane and coiled-coil domains 6)

Gene

• Entrez ID: 55374
• Gene name: Transmembrane and coiled-coil domains 6
• Gene symbol: TMCO6
• Synonyms (NCBI Gene): PRO1580
• Chromosome: 5
• Chromosome location: 5q31.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044768	hsa-miR-320a	CLASH	23622248
MIRT439451	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439451	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1428491	hsa-miR-1243	CLIP-seq
MIRT1428492	hsa-miR-3654	CLIP-seq
MIRT1428493	hsa-miR-3919	CLIP-seq
MIRT1428494	hsa-miR-3925-5p	CLIP-seq
MIRT1428495	hsa-miR-4300	CLIP-seq
MIRT1428496	hsa-miR-4468	CLIP-seq
MIRT1428497	hsa-miR-4528	CLIP-seq
MIRT1428498	hsa-miR-4638-3p	CLIP-seq
MIRT1428499	hsa-miR-4786-5p	CLIP-seq
MIRT1428500	hsa-miR-515-5p	CLIP-seq
MIRT1428501	hsa-miR-584	CLIP-seq
MIRT1428502	hsa-miR-634	CLIP-seq
MIRT1428503	hsa-miR-769-5p	CLIP-seq
MIRT1428504	hsa-miR-920	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 32296183, 33961781
GO:0006606	Process	Protein import into nucleus	IEA
GO:0016020	Component	Membrane	IEA
GO:0061608	Function	Nuclear import signal receptor activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q96DC7
• Protein name: Transmembrane and coiled-coil domain-containing protein 6
• Sequence:

  MWSRRQGRLRPTVCGVEELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAA
  ILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSN
  QALLQLEAARCLHELSHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVES
  EAVRRQLLPQGIVPALAACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQH
  MLQMLQPGPKLNPGVAVEFAWCLHYIICSQVSNPLLIGHGALSTLGLLLLDLAGAVQKTE
  DAGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAALFILLQFFFQKQPSLLPEG
  LWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNVVSVMVLTVLCNVAEKGPAYCQRLW
  PGPLLPALLHTLAFSDTEVVGQSLELLHLLFLYQPEAVQVFLQQSGLQALERHQEEAQLQ
  DRVYALQQTALQG

• Sequence length: 493

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Colon adenocarcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITOCHONDRIAL COMPLEX I DEFICIENCY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 13	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Chronic Periodontitis	Periodontitis	Pubtator	30760334	Associate	★☆☆☆☆ Found in Text Mining only