TMEM176A (transmembrane protein 176A)

Gene

• Entrez ID: 55365
• Gene name: Transmembrane protein 176A
• Gene symbol: TMEM176A
• Synonyms (NCBI Gene): GS188, HCA112, MS4B1
• Chromosome: 7
• Chromosome location: 7q36.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1432820	hsa-miR-338-3p	CLIP-seq
MIRT1432821	hsa-miR-3664-3p	CLIP-seq
MIRT1432822	hsa-miR-4274	CLIP-seq
MIRT1432823	hsa-miR-4433	CLIP-seq
MIRT1432824	hsa-miR-4459	CLIP-seq
MIRT1432825	hsa-miR-4530	CLIP-seq
MIRT1432826	hsa-miR-4659a-3p	CLIP-seq
MIRT1432827	hsa-miR-4659b-3p	CLIP-seq
MIRT1432828	hsa-miR-4768-3p	CLIP-seq
MIRT1432829	hsa-miR-4778-3p	CLIP-seq
MIRT1432830	hsa-miR-4779	CLIP-seq
MIRT1432831	hsa-miR-510	CLIP-seq
MIRT1432832	hsa-miR-512-5p	CLIP-seq
MIRT1432833	hsa-miR-622	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0016020	Component	Membrane	IEA
GO:2001199	Process	Negative regulation of dendritic cell differentiation	IEA

Other IDs

• MIM: 610334
• HGNC: 24930
• e!Ensembl: ENSG00000002933

Protein

• UniProt ID: Q96HP8
• Protein name: Transmembrane protein 176A (Hepatocellular carcinoma-associated antigen 112)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04103	CD20	56 → 214	CD20-like family	Family

• Sequence:

  MGTADSDEMAPEAPQHTHIDVHIHQESALAKLLLTCCSALRPRATQARGSSRLLVASWVM
  QIVLGILSAVLGGFFYIRDYTLLVTSGAAIWTGAVAVLAGAAAFIYEKRGGTYWALLRTL
  LTLAAFSTAIAALKLWNEDFRYGYSYYNSACRISSSSDWNTPAPTQSPEEVRRLHLCTSF
  MDMLKALFRTLQAMLLGVWILLLLASLTPLWLYCWRMFPTKGKRDQKEMLEVSGI

• Sequence length: 235

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
OSTEOARTHRITIS, KNEE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Behcet Syndrome	Behcet disease	Pubtator	36226612	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	22244448	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	22244448		★☆☆☆☆ Found in Text Mining only
Carotid Stenosis	Carotid artery stenosis	Pubtator	36304068	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	28678648		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	35712898	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	29050260		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	29050260		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	30464524		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	30464524		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30400968		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	22244448	Stimulate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	33593482	Stimulate	★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	22244448		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	22244448	Stimulate	★☆☆☆☆ Found in Text Mining only
Macular Degeneration	Macular degeneration	Pubtator	27374485	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	29050260		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	22244448		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22244448, 29050260		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28678648, 29050260, 30464524		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	33593482	Associate	★☆☆☆☆ Found in Text Mining only
Proteinuria	Proteinuria	Pubtator	22244448	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	28902459		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	28902459	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	29050260		★☆☆☆☆ Found in Text Mining only