Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55355
Gene name	Holliday junction recognition protein
Gene symbol	HJURP
Synonyms (NCBI Gene)	FAKTSURLC9hFLEG1
Chromosome	2
Chromosome location	2q37.1

144

Show/Hide all (144)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024443	hsa-miR-215-5p	Microarray	19074876
MIRT026468	hsa-miR-192-5p	Microarray	19074876
MIRT039300	hsa-miR-671-5p	CLASH	23622248
MIRT691145	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT691144	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT691143	hsa-miR-3929	HITS-CLIP	23313552
MIRT691142	hsa-miR-4419b	HITS-CLIP	23313552
MIRT691141	hsa-miR-4478	HITS-CLIP	23313552
MIRT691140	hsa-miR-5690	HITS-CLIP	23313552
MIRT691139	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT691138	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT691137	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT691136	hsa-miR-1827	HITS-CLIP	23313552
MIRT691135	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT691134	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT691133	hsa-miR-298	HITS-CLIP	23313552
MIRT691132	hsa-miR-6720-3p	HITS-CLIP	23313552
MIRT691131	hsa-miR-4783-5p	HITS-CLIP	23313552
MIRT691130	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT691129	hsa-miR-4634	HITS-CLIP	23313552
MIRT691128	hsa-miR-7977	HITS-CLIP	23313552
MIRT691127	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT691126	hsa-miR-665	HITS-CLIP	23313552
MIRT440500	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440500	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT691145	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT691144	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT691143	hsa-miR-3929	HITS-CLIP	23313552
MIRT691142	hsa-miR-4419b	HITS-CLIP	23313552
MIRT691141	hsa-miR-4478	HITS-CLIP	23313552
MIRT691140	hsa-miR-5690	HITS-CLIP	23313552
MIRT691139	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT691138	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT691137	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT691136	hsa-miR-1827	HITS-CLIP	23313552
MIRT691135	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT691134	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT691133	hsa-miR-298	HITS-CLIP	23313552
MIRT691132	hsa-miR-6720-3p	HITS-CLIP	23313552
MIRT691131	hsa-miR-4783-5p	HITS-CLIP	23313552
MIRT691130	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT691129	hsa-miR-4634	HITS-CLIP	23313552
MIRT691128	hsa-miR-7977	HITS-CLIP	23313552
MIRT691127	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT691126	hsa-miR-665	HITS-CLIP	23313552
MIRT1048020	hsa-miR-1227	CLIP-seq
MIRT1048021	hsa-miR-3134	CLIP-seq
MIRT1048022	hsa-miR-3675-3p	CLIP-seq
MIRT1048023	hsa-miR-3921	CLIP-seq
MIRT1048024	hsa-miR-3976	CLIP-seq
MIRT1048025	hsa-miR-4486	CLIP-seq
MIRT1048026	hsa-miR-4502	CLIP-seq
MIRT1048027	hsa-miR-4534	CLIP-seq
MIRT1048028	hsa-miR-4649-5p	CLIP-seq
MIRT1048029	hsa-miR-4653-5p	CLIP-seq
MIRT1048030	hsa-miR-4684-5p	CLIP-seq
MIRT1048031	hsa-miR-508-5p	CLIP-seq
MIRT1048032	hsa-miR-661	CLIP-seq
MIRT1048033	hsa-miR-766	CLIP-seq
MIRT2010894	hsa-miR-3122	CLIP-seq
MIRT2010895	hsa-miR-3689a-3p	CLIP-seq
MIRT2010896	hsa-miR-3689c	CLIP-seq
MIRT2010897	hsa-miR-3913-5p	CLIP-seq
MIRT2010898	hsa-miR-4728-5p	CLIP-seq
MIRT1048020	hsa-miR-1227	CLIP-seq
MIRT2010894	hsa-miR-3122	CLIP-seq
MIRT1048021	hsa-miR-3134	CLIP-seq
MIRT2010895	hsa-miR-3689a-3p	CLIP-seq
MIRT2010896	hsa-miR-3689c	CLIP-seq
MIRT2010897	hsa-miR-3913-5p	CLIP-seq
MIRT1048025	hsa-miR-4486	CLIP-seq
MIRT1048028	hsa-miR-4649-5p	CLIP-seq
MIRT2243126	hsa-miR-4699-3p	CLIP-seq
MIRT2243127	hsa-miR-4715-3p	CLIP-seq
MIRT2010898	hsa-miR-4728-5p	CLIP-seq
MIRT1048031	hsa-miR-508-5p	CLIP-seq
MIRT1048032	hsa-miR-661	CLIP-seq
MIRT1048033	hsa-miR-766	CLIP-seq
MIRT2451211	hsa-miR-1283	CLIP-seq
MIRT2451212	hsa-miR-3613-3p	CLIP-seq
MIRT2451213	hsa-miR-371-5p	CLIP-seq
MIRT2451214	hsa-miR-371b-5p	CLIP-seq
MIRT1048030	hsa-miR-4684-5p	CLIP-seq
MIRT2451215	hsa-miR-495	CLIP-seq
MIRT2451216	hsa-miR-548a-3p	CLIP-seq
MIRT2451217	hsa-miR-548e	CLIP-seq
MIRT2451218	hsa-miR-548f	CLIP-seq
MIRT2451211	hsa-miR-1283	CLIP-seq
MIRT2451212	hsa-miR-3613-3p	CLIP-seq
MIRT2451213	hsa-miR-371-5p	CLIP-seq
MIRT2451214	hsa-miR-371b-5p	CLIP-seq
MIRT1048030	hsa-miR-4684-5p	CLIP-seq
MIRT2451215	hsa-miR-495	CLIP-seq
MIRT2451216	hsa-miR-548a-3p	CLIP-seq
MIRT2451217	hsa-miR-548e	CLIP-seq
MIRT2451218	hsa-miR-548f	CLIP-seq
MIRT1048020	hsa-miR-1227	CLIP-seq
MIRT2451211	hsa-miR-1283	CLIP-seq
MIRT2010894	hsa-miR-3122	CLIP-seq
MIRT2451212	hsa-miR-3613-3p	CLIP-seq
MIRT2010895	hsa-miR-3689a-3p	CLIP-seq
MIRT2010896	hsa-miR-3689c	CLIP-seq
MIRT2451213	hsa-miR-371-5p	CLIP-seq
MIRT2451214	hsa-miR-371b-5p	CLIP-seq
MIRT2010897	hsa-miR-3913-5p	CLIP-seq
MIRT1048025	hsa-miR-4486	CLIP-seq
MIRT2546342	hsa-miR-4662a-5p	CLIP-seq
MIRT2546343	hsa-miR-4676-5p	CLIP-seq
MIRT1048030	hsa-miR-4684-5p	CLIP-seq
MIRT2243127	hsa-miR-4715-3p	CLIP-seq
MIRT2010898	hsa-miR-4728-5p	CLIP-seq
MIRT2546344	hsa-miR-4755-3p	CLIP-seq
MIRT2451215	hsa-miR-495	CLIP-seq
MIRT1048031	hsa-miR-508-5p	CLIP-seq
MIRT2451216	hsa-miR-548a-3p	CLIP-seq
MIRT2451217	hsa-miR-548e	CLIP-seq
MIRT2451218	hsa-miR-548f	CLIP-seq
MIRT2546345	hsa-miR-575	CLIP-seq
MIRT1048032	hsa-miR-661	CLIP-seq
MIRT1048033	hsa-miR-766	CLIP-seq
MIRT1048020	hsa-miR-1227	CLIP-seq
MIRT2451211	hsa-miR-1283	CLIP-seq
MIRT2010894	hsa-miR-3122	CLIP-seq
MIRT2451212	hsa-miR-3613-3p	CLIP-seq
MIRT2010895	hsa-miR-3689a-3p	CLIP-seq
MIRT2010896	hsa-miR-3689c	CLIP-seq
MIRT2451213	hsa-miR-371-5p	CLIP-seq
MIRT2451214	hsa-miR-371b-5p	CLIP-seq
MIRT2010897	hsa-miR-3913-5p	CLIP-seq
MIRT1048025	hsa-miR-4486	CLIP-seq
MIRT2546342	hsa-miR-4662a-5p	CLIP-seq
MIRT2546343	hsa-miR-4676-5p	CLIP-seq
MIRT1048030	hsa-miR-4684-5p	CLIP-seq
MIRT2243127	hsa-miR-4715-3p	CLIP-seq
MIRT2010898	hsa-miR-4728-5p	CLIP-seq
MIRT2546344	hsa-miR-4755-3p	CLIP-seq
MIRT2451215	hsa-miR-495	CLIP-seq
MIRT1048031	hsa-miR-508-5p	CLIP-seq
MIRT2451216	hsa-miR-548a-3p	CLIP-seq
MIRT2451217	hsa-miR-548e	CLIP-seq
MIRT2451218	hsa-miR-548f	CLIP-seq
MIRT2546345	hsa-miR-575	CLIP-seq
MIRT1048032	hsa-miR-661	CLIP-seq
MIRT1048033	hsa-miR-766	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IBA
GO:0000775	Component	Chromosome, centromeric region	IDA	19410544
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IDA	19410545
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	19410544, 19410545, 20080577, 21478274, 26496610, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005730	Component	Nucleolus	IDA	19410545
GO:0005730	Component	Nucleolus	IEA
GO:0005829	Component	Cytosol	IDA
GO:0007059	Process	Chromosome segregation	IMP	19410544, 19410545
GO:0034080	Process	CENP-A containing chromatin assembly	IBA
GO:0034080	Process	CENP-A containing chromatin assembly	IMP	19410544, 19410545
GO:0042393	Function	Histone binding	IBA
GO:0042393	Function	Histone binding	IDA	21478274
GO:0042393	Function	Histone binding	IEA
GO:0042393	Function	Histone binding	IPI	19410544, 19410545
GO:0042802	Function	Identical protein binding	IPI	23771058
GO:0043254	Process	Regulation of protein-containing complex assembly	IDA	21478274
GO:0051101	Process	Regulation of DNA binding	IDA	21478274

MIM	HGNC	e!Ensembl
612667	25444	ENSG00000123485

Q8NCD3

Protein name

Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9)

Protein function

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules

PDB

3R45

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10384	Scm3	18 → 75	Centromere protein Scm3	Family
PF12346	HJURP_mid	271 → 385	Holliday junction recognition protein-associated repeat	Domain
PF12347	HJURP_C	409 → 470	Holliday junction regulator protein family C-terminal repeat	Domain
PF12347	HJURP_C	554 → 613	Holliday junction regulator protein family C-terminal repeat	Domain

Tissue specificity

TISSUE SPECIFICITY: According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower lev

Sequence

MLGTLRAMEGEDVEDDQLLQKLRASRRRFQRRMQRLIEKYNQPFEDTPVVQMATLTYETP
QGLRIWGGRLIKERNEGEIQDSSMKPADRTDGSVQAAAWGPELPSHRTVLGADSKSGEVD
ATSDQEESVAWALAPAVPQSPLKNELRRKYLTQVDILLQGAEYFECAGNRAGRDVRVTPL
PSLASPAVPAPGYCSRISRKSPGDPAKPASSPREWDPLHPSSTDMALVPRNDSLSLQETS
SSSFLSSQPFEDDDICNVTISDLYAGMLHSMSRLLSTKPSSIISTKTFIMQNWNSRRRHR
YKSRMNKTYCKGARRSQRSSKENFIPCSEPVKGTGALRDCKNVLDVSCRKTGLKLEKAFL
EVNRPQIHKLDPSWKERKVTPSKYSSLIYFDSSATYNLDEENRFRTLKWLISPVKIVSRP
TIRQGHGENRQREIEIRFDQLHREYCLSPRNQPRRMCLPDSWAMNMYRGGPASPGGLQGL
ETRRLSLPSSKAKAKSLSEAFENLGKRSLEAGRCLPKSDSSSSLPKTNPTHSATRPQQTS
DLHVQGNSSGIFRKSVSPSKTLSVPDKEVPGHGRNRYDEIKEEFDKLHQKYCLKSPGQMT
VPLCIGVSTDKASMEVRYQTEGFLGKLNPDPHFQGFQKLPSSPLGCRKSLLGSTAIEAPS
STCVARAITRDGTRDHQFPAKRPRLSEPQGSGRQGNSLGASDGVDNTVRPGDQGSSSQPN
SEERGENTSYRMEEKSDFMLEKLETKSV

Sequence length

748

Interactions

View interactions

	Reactome
			Deposition of new CENPA-containing nucleosomes at the centromere

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARCINOMA, HEPATOCELLULAR	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (41)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anophthalmia with pulmonary hypoplasia	Anophthalmia	Pubtator	32439850	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	23638004	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	28819432		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Tumor, Primary	Brain Neoplasms	BEFREE	31138900		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	20211017, 20497617		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	20211017, 20497617, 25497280, 28351365	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	20334636	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	26863619, 31223275, 35783358, 39596041	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	28819432		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	28410204		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	31746384, 38179741	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	29871630		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	33114545	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30988807		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	30655845		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	23638004	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	31138900		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	31138900		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	23638004, 24039914	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	28284560		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	28553125, 30111352, 31223275		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	28410204	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	29743473	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	20211017, 20497617, 21980305		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	30655845		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	28410204		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31814851		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	28819432		★★★★★ ★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Migraine	GWASCAT_DG	27322543		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	34893510	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	20211017, 28356341, 31814851		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28410204		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	29743473, 35173547	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	33235818	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	32439850, 38124367	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	31814851		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	34099634	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	34617858	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	35459269	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	36543245	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	33235818	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HJURP (Holliday junction recognition protein)