LSG1 (large 60S subunit nuclear export GTPase 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 55341 |
| Gene name | Large 60S subunit nuclear export GTPase 1 |
| Gene symbol | LSG1 |
| Synonyms (NCBI Gene) |
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| Chromosome | 3 |
| Chromosome location | 3q29 |
| Summary | This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm.[provided by RefSeq, Feb 2009] |
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miRNA
miRNA information provided by mirtarbase database.
419
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9H089 | ||||||||||
| Protein name | Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-) | ||||||||||
| Protein function | Functions as a GTPase (PubMed:16209721). May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation (PubMed:31148378). {ECO:0000269|PubMed:16209721, ECO:000 | ||||||||||
| PDB | 6LSR | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 658 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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