Gene Gene information from NCBI Gene database.
Entrez ID 5534
Gene name Protein phosphatase 3 regulatory subunit B, alpha
Gene symbol PPP3R1
Synonyms (NCBI Gene)
CALNB1CNBCNB1
Chromosome 2
Chromosome location 2p14
miRNA miRNA information provided by mirtarbase database.
763
miRTarBase ID miRNA Experiments Reference
MIRT005180 hsa-miR-30a-5p pSILAC 18668040
MIRT025005 hsa-miR-183-5p Sequencing 20371350
MIRT025426 hsa-miR-34a-5p Sequencing 20371350
MIRT005180 hsa-miR-30a-5p Proteomics;Other 18668040
MIRT029303 hsa-miR-26b-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
49
GO ID Ontology Definition Evidence Reference
GO:0001569 Process Branching involved in blood vessel morphogenesis IEA
GO:0001837 Process Epithelial to mesenchymal transition IEA
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004723 Function Calcium-dependent protein serine/threonine phosphatase activity NAS 2558868
GO:0005509 Function Calcium ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601302 9317 ENSG00000221823
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P63098
Protein name Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1)
Protein function Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
PDB 1AUI , 1M63 , 1MF8 , 2P6B , 3LL8 , 4F0Z , 4OR9 , 4ORA , 4ORC , 5SVE , 6NUC , 6NUF , 6NUU , 7U0T , 9B9G , 9CHU , 9CHV , 9CHX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13499 EF-hand_7 20 80 EF-hand domain pair Domain
PF13499 EF-hand_7 89 158 EF-hand domain pair Domain
PF00036 EF-hand_1 132 160 EF hand Domain
Sequence
Sequence length 170
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  MAPK signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Oocyte meiosis
Cellular senescence
Wnt signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
C-type lectin receptor signaling pathway
Natural killer cell mediated cytotoxicity
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
Long-term potentiation
Glutamatergic synapse
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Alzheimer disease
Amyotrophic lateral sclerosis
Prion disease
Pathways of neurodegeneration - multiple diseases
Amphetamine addiction
Tuberculosis
Human cytomegalovirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
PD-L1 expression and PD-1 checkpoint pathway in cancer
Lipid and atherosclerosis
  Activation of BAD and translocation to mitochondria
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMERS DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY, DILATED Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTROPHY, LEFT VENTRICULAR CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LEFT VENTRICULAR HYPERTROPHY Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 23727081, 31745181, 36569892 Associate
★☆☆☆☆
Found in Text Mining only
Amyloidosis Amyloidosis BEFREE 23785163
★☆☆☆☆
Found in Text Mining only
Atrial Fibrillation Atrial fibrillation Pubtator 34198460 Associate
★☆☆☆☆
Found in Text Mining only
Atypical Ductal Breast Hyperplasia Breast Hyperplasia BEFREE 31013355
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 29972239
★☆☆☆☆
Found in Text Mining only
Cardiomyopathy Dilated Dilated cardiomyopathy Pubtator 15012912 Associate
★☆☆☆☆
Found in Text Mining only
Cardiomyopathy Hypertrophic Familial Cardiomyopathy Pubtator 31754133 Associate
★☆☆☆☆
Found in Text Mining only
Cervical lymphadenopathy Cervical lymphadenopathy BEFREE 29188372
★☆☆☆☆
Found in Text Mining only
Colitis Colitis BEFREE 29549257
★☆☆☆☆
Found in Text Mining only
Cornea plana Cornea Plana BEFREE 7601455, 8723718, 8825624, 8929947
★☆☆☆☆
Found in Text Mining only