Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55339
Gene name	WD repeat domain 33
Gene symbol	WDR33
Synonyms (NCBI Gene)	NET14WDC146
Chromosome	2
Chromosome location	2q14.3
Summary	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein com

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020148	hsa-miR-130b-3p	Sequencing	20371350
MIRT021125	hsa-miR-186-5p	Sequencing	20371350
MIRT023762	hsa-miR-1-3p	Proteomics	18668040
MIRT027636	hsa-miR-98-5p	Microarray	19088304
MIRT028001	hsa-miR-93-5p	Sequencing	20371350
MIRT031149	hsa-miR-19b-3p	Sequencing	20371350
MIRT032334	hsa-let-7b-5p	Proteomics	18668040
MIRT044276	hsa-miR-106b-5p	CLASH	23622248
MIRT040378	hsa-miR-615-3p	CLASH	23622248
MIRT036873	hsa-miR-877-3p	CLASH	23622248
MIRT035775	hsa-miR-1914-3p	CLASH	23622248
MIRT723506	hsa-miR-146a-3p	HITS-CLIP	19536157
MIRT723505	hsa-miR-4766-5p	HITS-CLIP	19536157
MIRT723504	hsa-miR-378a-3p	HITS-CLIP	19536157
MIRT723503	hsa-miR-378b	HITS-CLIP	19536157
MIRT723502	hsa-miR-378c	HITS-CLIP	19536157
MIRT723501	hsa-miR-378d	HITS-CLIP	19536157
MIRT723500	hsa-miR-378e	HITS-CLIP	19536157
MIRT723499	hsa-miR-378f	HITS-CLIP	19536157
MIRT723498	hsa-miR-378h	HITS-CLIP	19536157
MIRT723497	hsa-miR-378i	HITS-CLIP	19536157
MIRT723495	hsa-miR-422a	HITS-CLIP	19536157
MIRT723496	hsa-miR-570-3p	HITS-CLIP	19536157
MIRT723494	hsa-miR-5009-5p	HITS-CLIP	19536157
MIRT723493	hsa-miR-8058	HITS-CLIP	19536157
MIRT723492	hsa-miR-183-5p	HITS-CLIP	19536157
MIRT723491	hsa-miR-1271-5p	HITS-CLIP	19536157
MIRT723490	hsa-miR-96-5p	HITS-CLIP	19536157
MIRT723489	hsa-miR-4431	HITS-CLIP	19536157
MIRT718532	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT718531	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT718530	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT718529	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT718528	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT718527	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT718526	hsa-miR-1913	HITS-CLIP	19536157
MIRT718525	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT718524	hsa-miR-5699-5p	HITS-CLIP	19536157
MIRT718523	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT718522	hsa-miR-3189-5p	HITS-CLIP	19536157
MIRT718521	hsa-miR-3074-5p	HITS-CLIP	19536157
MIRT718520	hsa-miR-7152-5p	HITS-CLIP	19536157
MIRT723506	hsa-miR-146a-3p	HITS-CLIP	19536157
MIRT723505	hsa-miR-4766-5p	HITS-CLIP	19536157
MIRT723504	hsa-miR-378a-3p	HITS-CLIP	19536157
MIRT723503	hsa-miR-378b	HITS-CLIP	19536157
MIRT723502	hsa-miR-378c	HITS-CLIP	19536157
MIRT723501	hsa-miR-378d	HITS-CLIP	19536157
MIRT723500	hsa-miR-378e	HITS-CLIP	19536157
MIRT723499	hsa-miR-378f	HITS-CLIP	19536157
MIRT723498	hsa-miR-378h	HITS-CLIP	19536157
MIRT723497	hsa-miR-378i	HITS-CLIP	19536157
MIRT723495	hsa-miR-422a	HITS-CLIP	19536157
MIRT723496	hsa-miR-570-3p	HITS-CLIP	19536157
MIRT723494	hsa-miR-5009-5p	HITS-CLIP	19536157
MIRT723493	hsa-miR-8058	HITS-CLIP	19536157
MIRT723492	hsa-miR-183-5p	HITS-CLIP	19536157
MIRT723491	hsa-miR-1271-5p	HITS-CLIP	19536157
MIRT723490	hsa-miR-96-5p	HITS-CLIP	19536157
MIRT723489	hsa-miR-4431	HITS-CLIP	19536157
MIRT718532	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT718531	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT718530	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT718529	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT718528	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT718527	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT718526	hsa-miR-1913	HITS-CLIP	19536157
MIRT718525	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT718524	hsa-miR-5699-5p	HITS-CLIP	19536157
MIRT718523	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT718522	hsa-miR-3189-5p	HITS-CLIP	19536157
MIRT718521	hsa-miR-3074-5p	HITS-CLIP	19536157
MIRT718520	hsa-miR-7152-5p	HITS-CLIP	19536157
MIRT1490068	hsa-miR-188-3p	CLIP-seq
MIRT1490069	hsa-miR-4643	CLIP-seq
MIRT1490070	hsa-miR-4714-3p	CLIP-seq
MIRT1490071	hsa-miR-4717-3p	CLIP-seq
MIRT1490072	hsa-miR-505	CLIP-seq
MIRT1490073	hsa-miR-532-3p	CLIP-seq
MIRT1490074	hsa-miR-1197	CLIP-seq
MIRT1490075	hsa-miR-124	CLIP-seq
MIRT1490076	hsa-miR-125a-3p	CLIP-seq
MIRT1490077	hsa-miR-1266	CLIP-seq
MIRT1490078	hsa-miR-1343	CLIP-seq
MIRT1490079	hsa-miR-181a	CLIP-seq
MIRT1490080	hsa-miR-181b	CLIP-seq
MIRT1490081	hsa-miR-181c	CLIP-seq
MIRT1490082	hsa-miR-181d	CLIP-seq
MIRT1490083	hsa-miR-1910	CLIP-seq
MIRT1490084	hsa-miR-198	CLIP-seq
MIRT1490085	hsa-miR-2115	CLIP-seq
MIRT1490086	hsa-miR-214	CLIP-seq
MIRT1490087	hsa-miR-3122	CLIP-seq
MIRT1490088	hsa-miR-3123	CLIP-seq
MIRT1490089	hsa-miR-3619-5p	CLIP-seq
MIRT1490090	hsa-miR-3660	CLIP-seq
MIRT1490091	hsa-miR-3689a-3p	CLIP-seq
MIRT1490092	hsa-miR-3689c	CLIP-seq
MIRT1490093	hsa-miR-3714	CLIP-seq
MIRT1490094	hsa-miR-376a	CLIP-seq
MIRT1490095	hsa-miR-376b	CLIP-seq
MIRT1490096	hsa-miR-376c	CLIP-seq
MIRT1490097	hsa-miR-3910	CLIP-seq
MIRT1490098	hsa-miR-3913-5p	CLIP-seq
MIRT1490099	hsa-miR-3921	CLIP-seq
MIRT1490100	hsa-miR-3925-5p	CLIP-seq
MIRT1490101	hsa-miR-3934	CLIP-seq
MIRT1490102	hsa-miR-3974	CLIP-seq
MIRT1490103	hsa-miR-3976	CLIP-seq
MIRT1490104	hsa-miR-412	CLIP-seq
MIRT1490105	hsa-miR-4259	CLIP-seq
MIRT1490106	hsa-miR-4260	CLIP-seq
MIRT1490107	hsa-miR-4262	CLIP-seq
MIRT1490108	hsa-miR-4277	CLIP-seq
MIRT1490109	hsa-miR-4495	CLIP-seq
MIRT1490110	hsa-miR-4518	CLIP-seq
MIRT1490111	hsa-miR-4526	CLIP-seq
MIRT1490069	hsa-miR-4643	CLIP-seq
MIRT1490112	hsa-miR-4653-5p	CLIP-seq
MIRT1490113	hsa-miR-466	CLIP-seq
MIRT1490114	hsa-miR-4716-5p	CLIP-seq
MIRT1490115	hsa-miR-4717-5p	CLIP-seq
MIRT1490116	hsa-miR-4719	CLIP-seq
MIRT1490117	hsa-miR-4728-5p	CLIP-seq
MIRT1490118	hsa-miR-4768-5p	CLIP-seq
MIRT1490119	hsa-miR-4789-3p	CLIP-seq
MIRT1490120	hsa-miR-486-3p	CLIP-seq
MIRT1490121	hsa-miR-506	CLIP-seq
MIRT1490122	hsa-miR-510	CLIP-seq
MIRT1490123	hsa-miR-512-5p	CLIP-seq
MIRT1490124	hsa-miR-513b	CLIP-seq
MIRT1490125	hsa-miR-520a-5p	CLIP-seq
MIRT1490126	hsa-miR-525-5p	CLIP-seq
MIRT1490127	hsa-miR-548aa	CLIP-seq
MIRT1490128	hsa-miR-548g	CLIP-seq
MIRT1490129	hsa-miR-548m	CLIP-seq
MIRT1490130	hsa-miR-571	CLIP-seq
MIRT1490131	hsa-miR-589	CLIP-seq
MIRT1490132	hsa-miR-761	CLIP-seq
MIRT1490133	hsa-miR-764	CLIP-seq
MIRT2368151	hsa-miR-106a	CLIP-seq
MIRT2368152	hsa-miR-106b	CLIP-seq
MIRT2368153	hsa-miR-1257	CLIP-seq
MIRT2368154	hsa-miR-1283	CLIP-seq
MIRT2368155	hsa-miR-129-3p	CLIP-seq
MIRT2368156	hsa-miR-17	CLIP-seq
MIRT2368157	hsa-miR-1825	CLIP-seq
MIRT2368158	hsa-miR-199a-5p	CLIP-seq
MIRT2368159	hsa-miR-199b-5p	CLIP-seq
MIRT2368160	hsa-miR-20a	CLIP-seq
MIRT2368161	hsa-miR-20b	CLIP-seq
MIRT2368162	hsa-miR-3185	CLIP-seq
MIRT2368163	hsa-miR-3609	CLIP-seq
MIRT2368164	hsa-miR-4677-3p	CLIP-seq
MIRT2368165	hsa-miR-4796-3p	CLIP-seq
MIRT2368166	hsa-miR-4803	CLIP-seq
MIRT2368167	hsa-miR-519d	CLIP-seq
MIRT2368168	hsa-miR-548ah	CLIP-seq
MIRT2368169	hsa-miR-93	CLIP-seq
MIRT2368170	hsa-miR-938	CLIP-seq
MIRT2463397	hsa-miR-1321	CLIP-seq
MIRT2463398	hsa-miR-3162-5p	CLIP-seq
MIRT2463399	hsa-miR-3929	CLIP-seq
MIRT2463400	hsa-miR-4419b	CLIP-seq
MIRT2463401	hsa-miR-4478	CLIP-seq
MIRT2463402	hsa-miR-4540	CLIP-seq
MIRT2463403	hsa-miR-4633-5p	CLIP-seq
MIRT2463404	hsa-miR-4739	CLIP-seq
MIRT2463405	hsa-miR-4756-5p	CLIP-seq
MIRT2463406	hsa-miR-485-5p	CLIP-seq
MIRT2463407	hsa-miR-532-5p	CLIP-seq
MIRT2661827	hsa-miR-3137	CLIP-seq
MIRT2661828	hsa-miR-3686	CLIP-seq
MIRT2661829	hsa-miR-382	CLIP-seq
MIRT2661830	hsa-miR-4452	CLIP-seq
MIRT2661831	hsa-miR-4652-3p	CLIP-seq
MIRT2661832	hsa-miR-4670-3p	CLIP-seq
MIRT1490075	hsa-miR-124	CLIP-seq
MIRT2368154	hsa-miR-1283	CLIP-seq
MIRT2695202	hsa-miR-3117-5p	CLIP-seq
MIRT2695203	hsa-miR-330-3p	CLIP-seq
MIRT1490093	hsa-miR-3714	CLIP-seq
MIRT1490097	hsa-miR-3910	CLIP-seq
MIRT1490121	hsa-miR-506	CLIP-seq
MIRT2695204	hsa-miR-520d-5p	CLIP-seq
MIRT2695205	hsa-miR-524-5p	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005581	Component	Collagen trimer	IEA
GO:0005634	Component	Nucleus	IDA	11162572
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005847	Component	MRNA cleavage and polyadenylation specificity factor complex	IBA
GO:0006301	Process	Postreplication repair	NAS	11162572
GO:0006397	Process	MRNA processing	IEA
GO:0007283	Process	Spermatogenesis	NAS	11162572
GO:0031124	Process	MRNA 3'-end processing	IEA

MIM	HGNC	e!Ensembl
618082	25651	ENSG00000136709

Q9C0J8

Protein name

pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa)

Protein function

Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.

PDB

6BLY , 6BM0 , 6DNH , 6F9N , 6FUW , 6URG , 6URO , 8E3I , 8E3Q , 8R8R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	192 → 230	WD domain, G-beta repeat	Repeat
PF00400	WD40	234 → 268	WD domain, G-beta repeat	Repeat
PF00400	WD40	278 → 316	WD domain, G-beta repeat	Repeat
PF00400	WD40	321 → 360	WD domain, G-beta repeat	Repeat
PF00400	WD40	367 → 403	WD domain, G-beta repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Most highly expressed in testis. {ECO:0000269|PubMed:11162572}.

Sequence

MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYN
PSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKC
PVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTAD
HGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERIL
RGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNG
NWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWH
VGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLL
PGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESNEIEMTIPGLDWGMEE
VMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAE
IEQEMATLQYTNPQLLEQLKIERLAQKQVEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQG
FQQPHPSQQMPMNMAQMGPPGPQGQFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPQG
PPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGPQ
GPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLN
PRGMQGPPGPRENQGPAPQGMIMGHPPQEMRGPHPPGGLLGHGPQEMRGPQEIRGMQGPP
PQGSMLGPPQELRGPPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPI
PFQQQKTPLLGDGPRAPFNQEGQSTGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDSR
GPPNHHMGPMSERRHEQSGGPEHGPERGPFRGGQDCRGPPDRRGPHPDFPDDFSRPDDFH
PDKRFGHRLREFEGRGGPLPQEEKWRRGGPGPPFPPDHREFSEGDGRGAARGPPGAWEGR
RPGDERFPRDPEDPRFRGRREESFRRGAPPRHEGRAPPRGRDGFPGPEDFGPEENFDASE
EAARGRDLRGRGRGTPRGGRKGLLPTPDEFPRFEGGRKPDSWDGNREPGPGHEHFRDTPR
PDHPPHDGHSPASRERSSSLQGMDMASLPPRKRPWHDGPGTSEHREMEAPGGPSEDRGGK
GRGGPGPAQRVPKSGRSSSLDGEHHDGYHRDEPFGGPPGSGTPSRGGRSGSNWGRGSNMN
SGPPRRGASRGGGRGR

Sequence length

1336

Interactions

View interactions

	KEGG		Reactome
	mRNA surveillance pathway		Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	37354922	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	30991224	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

WDR33 (WD repeat domain 33)