ACER3 (alkaline ceramidase 3)

Gene

• Entrez ID: 55331
• Gene name: Alkaline ceramidase 3
• Gene symbol: ACER3
• Synonyms (NCBI Gene): APHC, PHCA, PLDECO
• Chromosome: 11
• Chromosome location: 11q13.5

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs782709009	C>A,T	Pathogenic	Synonymous variant, stop gained, coding sequence variant, genic downstream transcript variant, non coding transcript variant, 3 prime UTR variant
rs1554988032	A>G	Pathogenic	5 prime UTR variant, coding sequence variant, missense variant, non coding transcript variant, genic upstream transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT046140	hsa-miR-30b-5p	CLASH	23622248
MIRT514753	hsa-miR-5692a	HITS-CLIP	21572407
MIRT514751	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT514749	hsa-miR-142-5p	HITS-CLIP	21572407
MIRT514748	hsa-miR-5590-3p	HITS-CLIP	21572407
MIRT514747	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT514745	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT514746	hsa-miR-340-5p	HITS-CLIP	21572407
MIRT514744	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT660945	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT660946	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT660944	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT660943	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT660941	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT660942	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT660940	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT514755	hsa-miR-3133	PAR-CLIP	20371350
MIRT514754	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT514752	hsa-miR-6507-5p	PAR-CLIP	20371350
MIRT514751	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT514749	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT514748	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT514747	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT514745	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT514746	hsa-miR-340-5p	PAR-CLIP	20371350
MIRT514744	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT514755	hsa-miR-3133	PAR-CLIP	21572407
MIRT514754	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT514752	hsa-miR-6507-5p	PAR-CLIP	21572407
MIRT514751	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT514750	hsa-miR-3163	PAR-CLIP	21572407
MIRT514749	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT514748	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT514747	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT514745	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT514746	hsa-miR-340-5p	PAR-CLIP	21572407
MIRT514744	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT514755	hsa-miR-3133	PAR-CLIP	22012620
MIRT514754	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT514752	hsa-miR-6507-5p	PAR-CLIP	22012620
MIRT514751	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT514750	hsa-miR-3163	PAR-CLIP	22012620
MIRT514749	hsa-miR-142-5p	PAR-CLIP	22012620
MIRT514748	hsa-miR-5590-3p	PAR-CLIP	22012620
MIRT514747	hsa-miR-410-3p	PAR-CLIP	22012620
MIRT514745	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT514746	hsa-miR-340-5p	PAR-CLIP	22012620
MIRT514744	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT514755	hsa-miR-3133	PAR-CLIP	23446348
MIRT514754	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT514753	hsa-miR-5692a	PAR-CLIP	23446348
MIRT514752	hsa-miR-6507-5p	PAR-CLIP	23446348
MIRT514751	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT514750	hsa-miR-3163	PAR-CLIP	23446348
MIRT514749	hsa-miR-142-5p	PAR-CLIP	23446348
MIRT514748	hsa-miR-5590-3p	PAR-CLIP	23446348
MIRT514747	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT514745	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT514746	hsa-miR-340-5p	PAR-CLIP	23446348
MIRT514744	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT514753	hsa-miR-5692a	HITS-CLIP	21572407
MIRT514751	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT514749	hsa-miR-142-5p	HITS-CLIP	21572407
MIRT514748	hsa-miR-5590-3p	HITS-CLIP	21572407
MIRT514747	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT514745	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT514746	hsa-miR-340-5p	HITS-CLIP	21572407
MIRT514744	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT660945	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT660946	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT660944	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT660943	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT660941	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT660942	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT660940	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT514755	hsa-miR-3133	PAR-CLIP	20371350
MIRT514754	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT514752	hsa-miR-6507-5p	PAR-CLIP	20371350
MIRT514751	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT514749	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT514748	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT514747	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT514745	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT514746	hsa-miR-340-5p	PAR-CLIP	20371350
MIRT514744	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT514755	hsa-miR-3133	PAR-CLIP	21572407
MIRT514754	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT514752	hsa-miR-6507-5p	PAR-CLIP	21572407
MIRT514751	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT514750	hsa-miR-3163	PAR-CLIP	21572407
MIRT514749	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT514748	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT514747	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT514745	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT514746	hsa-miR-340-5p	PAR-CLIP	21572407
MIRT514744	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT514755	hsa-miR-3133	PAR-CLIP	22012620
MIRT514754	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT514752	hsa-miR-6507-5p	PAR-CLIP	22012620
MIRT514751	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT514750	hsa-miR-3163	PAR-CLIP	22012620
MIRT514749	hsa-miR-142-5p	PAR-CLIP	22012620
MIRT514748	hsa-miR-5590-3p	PAR-CLIP	22012620
MIRT514747	hsa-miR-410-3p	PAR-CLIP	22012620
MIRT514745	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT514746	hsa-miR-340-5p	PAR-CLIP	22012620
MIRT514744	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT514755	hsa-miR-3133	PAR-CLIP	23446348
MIRT514754	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT514753	hsa-miR-5692a	PAR-CLIP	23446348
MIRT514752	hsa-miR-6507-5p	PAR-CLIP	23446348
MIRT514751	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT514750	hsa-miR-3163	PAR-CLIP	23446348
MIRT514749	hsa-miR-142-5p	PAR-CLIP	23446348
MIRT514748	hsa-miR-5590-3p	PAR-CLIP	23446348
MIRT514747	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT514745	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT514746	hsa-miR-340-5p	PAR-CLIP	23446348
MIRT514744	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT762549	hsa-miR-105	CLIP-seq
MIRT762550	hsa-miR-1245b-3p	CLIP-seq
MIRT762551	hsa-miR-125a-5p	CLIP-seq
MIRT762552	hsa-miR-125b	CLIP-seq
MIRT762553	hsa-miR-1261	CLIP-seq
MIRT762554	hsa-miR-1271	CLIP-seq
MIRT762555	hsa-miR-1297	CLIP-seq
MIRT762556	hsa-miR-1305	CLIP-seq
MIRT762557	hsa-miR-1343	CLIP-seq
MIRT762558	hsa-miR-149	CLIP-seq
MIRT762559	hsa-miR-181a	CLIP-seq
MIRT762560	hsa-miR-181b	CLIP-seq
MIRT762561	hsa-miR-181c	CLIP-seq
MIRT762562	hsa-miR-181d	CLIP-seq
MIRT762563	hsa-miR-182	CLIP-seq
MIRT762564	hsa-miR-188-3p	CLIP-seq
MIRT762565	hsa-miR-190	CLIP-seq
MIRT762566	hsa-miR-190b	CLIP-seq
MIRT762567	hsa-miR-205	CLIP-seq
MIRT762568	hsa-miR-2052	CLIP-seq
MIRT762569	hsa-miR-2053	CLIP-seq
MIRT762570	hsa-miR-214	CLIP-seq
MIRT762571	hsa-miR-22	CLIP-seq
MIRT762572	hsa-miR-23a	CLIP-seq
MIRT762573	hsa-miR-23b	CLIP-seq
MIRT762574	hsa-miR-23c	CLIP-seq
MIRT762575	hsa-miR-24	CLIP-seq
MIRT762576	hsa-miR-26a	CLIP-seq
MIRT762577	hsa-miR-26b	CLIP-seq
MIRT762578	hsa-miR-27a	CLIP-seq
MIRT762579	hsa-miR-27b	CLIP-seq
MIRT762580	hsa-miR-3074-5p	CLIP-seq
MIRT762581	hsa-miR-31	CLIP-seq
MIRT762582	hsa-miR-3126-3p	CLIP-seq
MIRT762583	hsa-miR-3170	CLIP-seq
MIRT762584	hsa-miR-3185	CLIP-seq
MIRT762585	hsa-miR-3189-3p	CLIP-seq
MIRT762586	hsa-miR-3201	CLIP-seq
MIRT762587	hsa-miR-335	CLIP-seq
MIRT762588	hsa-miR-34b	CLIP-seq
MIRT762589	hsa-miR-34c-3p	CLIP-seq
MIRT762590	hsa-miR-3545-3p	CLIP-seq
MIRT762591	hsa-miR-3606	CLIP-seq
MIRT762592	hsa-miR-3612	CLIP-seq
MIRT762593	hsa-miR-3619-5p	CLIP-seq
MIRT762594	hsa-miR-362-5p	CLIP-seq
MIRT762595	hsa-miR-3647-3p	CLIP-seq
MIRT762596	hsa-miR-3663-3p	CLIP-seq
MIRT762597	hsa-miR-3671	CLIP-seq
MIRT762598	hsa-miR-3675-5p	CLIP-seq
MIRT762599	hsa-miR-3689a-5p	CLIP-seq
MIRT762600	hsa-miR-3689b	CLIP-seq
MIRT762601	hsa-miR-3689d	CLIP-seq
MIRT762602	hsa-miR-3689e	CLIP-seq
MIRT762603	hsa-miR-3689f	CLIP-seq
MIRT762604	hsa-miR-3690	CLIP-seq
MIRT762605	hsa-miR-3913-3p	CLIP-seq
MIRT762606	hsa-miR-3938	CLIP-seq
MIRT762607	hsa-miR-3973	CLIP-seq
MIRT762608	hsa-miR-4254	CLIP-seq
MIRT762609	hsa-miR-4260	CLIP-seq
MIRT762610	hsa-miR-4261	CLIP-seq
MIRT762611	hsa-miR-4262	CLIP-seq
MIRT762612	hsa-miR-4284	CLIP-seq
MIRT762613	hsa-miR-4291	CLIP-seq
MIRT762614	hsa-miR-4303	CLIP-seq
MIRT762615	hsa-miR-4307	CLIP-seq
MIRT762616	hsa-miR-4308	CLIP-seq
MIRT762617	hsa-miR-4319	CLIP-seq
MIRT762618	hsa-miR-4443	CLIP-seq
MIRT762619	hsa-miR-4465	CLIP-seq
MIRT762620	hsa-miR-4488	CLIP-seq
MIRT762621	hsa-miR-4496	CLIP-seq
MIRT762622	hsa-miR-4511	CLIP-seq
MIRT762623	hsa-miR-4659a-3p	CLIP-seq
MIRT762624	hsa-miR-4659b-3p	CLIP-seq
MIRT762625	hsa-miR-4661-5p	CLIP-seq
MIRT762626	hsa-miR-4672	CLIP-seq
MIRT762627	hsa-miR-4676-5p	CLIP-seq
MIRT762628	hsa-miR-4694-3p	CLIP-seq
MIRT762629	hsa-miR-4697-5p	CLIP-seq
MIRT762630	hsa-miR-4718	CLIP-seq
MIRT762631	hsa-miR-4719	CLIP-seq
MIRT762632	hsa-miR-4732-3p	CLIP-seq
MIRT762633	hsa-miR-4732-5p	CLIP-seq
MIRT762634	hsa-miR-4736	CLIP-seq
MIRT762635	hsa-miR-4753-3p	CLIP-seq
MIRT762636	hsa-miR-4782-5p	CLIP-seq
MIRT762637	hsa-miR-4789-5p	CLIP-seq
MIRT762638	hsa-miR-4791	CLIP-seq
MIRT762639	hsa-miR-4802-5p	CLIP-seq
MIRT762640	hsa-miR-486-3p	CLIP-seq
MIRT762641	hsa-miR-489	CLIP-seq
MIRT762642	hsa-miR-498	CLIP-seq
MIRT762643	hsa-miR-499a-5p	CLIP-seq
MIRT762644	hsa-miR-500b	CLIP-seq
MIRT762645	hsa-miR-5096	CLIP-seq
MIRT762646	hsa-miR-512-3p	CLIP-seq
MIRT762647	hsa-miR-513a-5p	CLIP-seq
MIRT762648	hsa-miR-548ac	CLIP-seq
MIRT762649	hsa-miR-548ae	CLIP-seq
MIRT762650	hsa-miR-548aj	CLIP-seq
MIRT762651	hsa-miR-548am	CLIP-seq
MIRT762652	hsa-miR-548d-3p	CLIP-seq
MIRT762653	hsa-miR-548l	CLIP-seq
MIRT762654	hsa-miR-548x	CLIP-seq
MIRT762655	hsa-miR-548z	CLIP-seq
MIRT762656	hsa-miR-549	CLIP-seq
MIRT762657	hsa-miR-569	CLIP-seq
MIRT762658	hsa-miR-575	CLIP-seq
MIRT762659	hsa-miR-607	CLIP-seq
MIRT762660	hsa-miR-635	CLIP-seq
MIRT762661	hsa-miR-637	CLIP-seq
MIRT762662	hsa-miR-650	CLIP-seq
MIRT762663	hsa-miR-670	CLIP-seq
MIRT762664	hsa-miR-759	CLIP-seq
MIRT762665	hsa-miR-761	CLIP-seq
MIRT762666	hsa-miR-890	CLIP-seq
MIRT762667	hsa-miR-922	CLIP-seq
MIRT762668	hsa-miR-944	CLIP-seq
MIRT762669	hsa-miR-96	CLIP-seq
MIRT762550	hsa-miR-1245b-3p	CLIP-seq
MIRT762558	hsa-miR-149	CLIP-seq
MIRT762563	hsa-miR-182	CLIP-seq
MIRT1924800	hsa-miR-203	CLIP-seq
MIRT1924801	hsa-miR-217	CLIP-seq
MIRT1924802	hsa-miR-2278	CLIP-seq
MIRT762572	hsa-miR-23a	CLIP-seq
MIRT762573	hsa-miR-23b	CLIP-seq
MIRT762574	hsa-miR-23c	CLIP-seq
MIRT762575	hsa-miR-24	CLIP-seq
MIRT1924803	hsa-miR-2467-3p	CLIP-seq
MIRT762578	hsa-miR-27a	CLIP-seq
MIRT762579	hsa-miR-27b	CLIP-seq
MIRT1924804	hsa-miR-3064-5p	CLIP-seq
MIRT762582	hsa-miR-3126-3p	CLIP-seq
MIRT1924805	hsa-miR-3167	CLIP-seq
MIRT762583	hsa-miR-3170	CLIP-seq
MIRT762584	hsa-miR-3185	CLIP-seq
MIRT1924806	hsa-miR-3187-3p	CLIP-seq
MIRT762586	hsa-miR-3201	CLIP-seq
MIRT1924807	hsa-miR-338-5p	CLIP-seq
MIRT762590	hsa-miR-3545-3p	CLIP-seq
MIRT762591	hsa-miR-3606	CLIP-seq
MIRT1924808	hsa-miR-3660	CLIP-seq
MIRT762597	hsa-miR-3671	CLIP-seq
MIRT1924809	hsa-miR-3674	CLIP-seq
MIRT762598	hsa-miR-3675-5p	CLIP-seq
MIRT1924810	hsa-miR-383	CLIP-seq
MIRT1924811	hsa-miR-3935	CLIP-seq
MIRT762612	hsa-miR-4284	CLIP-seq
MIRT762614	hsa-miR-4303	CLIP-seq
MIRT762615	hsa-miR-4307	CLIP-seq
MIRT762616	hsa-miR-4308	CLIP-seq
MIRT1924812	hsa-miR-4328	CLIP-seq
MIRT1924813	hsa-miR-4468	CLIP-seq
MIRT1924814	hsa-miR-4477b	CLIP-seq
MIRT1924815	hsa-miR-4487	CLIP-seq
MIRT762620	hsa-miR-4488	CLIP-seq
MIRT1924816	hsa-miR-4526	CLIP-seq
MIRT1924817	hsa-miR-4529-5p	CLIP-seq
MIRT762629	hsa-miR-4697-5p	CLIP-seq
MIRT762630	hsa-miR-4718	CLIP-seq
MIRT1924818	hsa-miR-4727-5p	CLIP-seq
MIRT762633	hsa-miR-4732-5p	CLIP-seq
MIRT762634	hsa-miR-4736	CLIP-seq
MIRT762635	hsa-miR-4753-3p	CLIP-seq
MIRT1924819	hsa-miR-4762-5p	CLIP-seq
MIRT1924820	hsa-miR-4769-3p	CLIP-seq
MIRT1924821	hsa-miR-4778-5p	CLIP-seq
MIRT762636	hsa-miR-4782-5p	CLIP-seq
MIRT762638	hsa-miR-4791	CLIP-seq
MIRT762640	hsa-miR-486-3p	CLIP-seq
MIRT1924822	hsa-miR-494	CLIP-seq
MIRT1924823	hsa-miR-510	CLIP-seq
MIRT762646	hsa-miR-512-3p	CLIP-seq
MIRT1924824	hsa-miR-512-5p	CLIP-seq
MIRT762647	hsa-miR-513a-5p	CLIP-seq
MIRT1924825	hsa-miR-518a-5p	CLIP-seq
MIRT1924826	hsa-miR-527	CLIP-seq
MIRT1924827	hsa-miR-590-3p	CLIP-seq
MIRT762661	hsa-miR-637	CLIP-seq
MIRT1924828	hsa-miR-642b	CLIP-seq
MIRT1924829	hsa-miR-663b	CLIP-seq
MIRT1924830	hsa-miR-760	CLIP-seq
MIRT1924831	hsa-miR-876-5p	CLIP-seq
MIRT762553	hsa-miR-1261	CLIP-seq
MIRT2166000	hsa-miR-1265	CLIP-seq
MIRT2166001	hsa-miR-1278	CLIP-seq
MIRT762555	hsa-miR-1297	CLIP-seq
MIRT2166002	hsa-miR-135a	CLIP-seq
MIRT2166003	hsa-miR-135b	CLIP-seq
MIRT762558	hsa-miR-149	CLIP-seq
MIRT2166004	hsa-miR-154	CLIP-seq
MIRT762570	hsa-miR-214	CLIP-seq
MIRT1924801	hsa-miR-217	CLIP-seq
MIRT2166005	hsa-miR-2277-3p	CLIP-seq
MIRT762572	hsa-miR-23a	CLIP-seq
MIRT762573	hsa-miR-23b	CLIP-seq
MIRT762574	hsa-miR-23c	CLIP-seq
MIRT762575	hsa-miR-24	CLIP-seq
MIRT762576	hsa-miR-26a	CLIP-seq
MIRT762577	hsa-miR-26b	CLIP-seq
MIRT762582	hsa-miR-3126-3p	CLIP-seq
MIRT2166006	hsa-miR-3159	CLIP-seq
MIRT762583	hsa-miR-3170	CLIP-seq
MIRT2166007	hsa-miR-3174	CLIP-seq
MIRT2166008	hsa-miR-3182	CLIP-seq
MIRT762585	hsa-miR-3189-3p	CLIP-seq
MIRT2166009	hsa-miR-3194-3p	CLIP-seq
MIRT762586	hsa-miR-3201	CLIP-seq
MIRT762590	hsa-miR-3545-3p	CLIP-seq
MIRT762593	hsa-miR-3619-5p	CLIP-seq
MIRT2166010	hsa-miR-3622b-5p	CLIP-seq
MIRT762594	hsa-miR-362-5p	CLIP-seq
MIRT762598	hsa-miR-3675-5p	CLIP-seq
MIRT2166011	hsa-miR-3682-5p	CLIP-seq
MIRT2166012	hsa-miR-3909	CLIP-seq
MIRT762605	hsa-miR-3913-3p	CLIP-seq
MIRT2166013	hsa-miR-3915	CLIP-seq
MIRT2166014	hsa-miR-3928	CLIP-seq
MIRT2166015	hsa-miR-4272	CLIP-seq
MIRT762612	hsa-miR-4284	CLIP-seq
MIRT2166016	hsa-miR-4294	CLIP-seq
MIRT762614	hsa-miR-4303	CLIP-seq
MIRT2166017	hsa-miR-4320	CLIP-seq
MIRT2166018	hsa-miR-4426	CLIP-seq
MIRT762619	hsa-miR-4465	CLIP-seq
MIRT1924813	hsa-miR-4468	CLIP-seq
MIRT2166019	hsa-miR-4475	CLIP-seq
MIRT762620	hsa-miR-4488	CLIP-seq
MIRT2166020	hsa-miR-4533	CLIP-seq
MIRT2166021	hsa-miR-4539	CLIP-seq
MIRT2166022	hsa-miR-4633-3p	CLIP-seq
MIRT2166023	hsa-miR-4639-5p	CLIP-seq
MIRT2166024	hsa-miR-4642	CLIP-seq
MIRT2166025	hsa-miR-4647	CLIP-seq
MIRT2166026	hsa-miR-4662b	CLIP-seq
MIRT762629	hsa-miR-4697-5p	CLIP-seq
MIRT2166027	hsa-miR-4699-3p	CLIP-seq
MIRT2166028	hsa-miR-4715-3p	CLIP-seq
MIRT2166029	hsa-miR-4717-3p	CLIP-seq
MIRT2166030	hsa-miR-4724-5p	CLIP-seq
MIRT1924818	hsa-miR-4727-5p	CLIP-seq
MIRT2166031	hsa-miR-4728-5p	CLIP-seq
MIRT762634	hsa-miR-4736	CLIP-seq
MIRT2166032	hsa-miR-4747-5p	CLIP-seq
MIRT2166033	hsa-miR-4760-3p	CLIP-seq
MIRT2166034	hsa-miR-4762-3p	CLIP-seq
MIRT1924820	hsa-miR-4769-3p	CLIP-seq
MIRT2166035	hsa-miR-4775	CLIP-seq
MIRT762636	hsa-miR-4782-5p	CLIP-seq
MIRT762638	hsa-miR-4791	CLIP-seq
MIRT762640	hsa-miR-486-3p	CLIP-seq
MIRT762641	hsa-miR-489	CLIP-seq
MIRT2166036	hsa-miR-490-5p	CLIP-seq
MIRT762644	hsa-miR-500b	CLIP-seq
MIRT762645	hsa-miR-5096	CLIP-seq
MIRT762646	hsa-miR-512-3p	CLIP-seq
MIRT2166037	hsa-miR-562	CLIP-seq
MIRT2166038	hsa-miR-587	CLIP-seq
MIRT1924827	hsa-miR-590-3p	CLIP-seq
MIRT2166039	hsa-miR-622	CLIP-seq
MIRT762661	hsa-miR-637	CLIP-seq
MIRT1924828	hsa-miR-642b	CLIP-seq
MIRT2166040	hsa-miR-720	CLIP-seq
MIRT1924830	hsa-miR-760	CLIP-seq
MIRT762665	hsa-miR-761	CLIP-seq
MIRT2166041	hsa-miR-921	CLIP-seq
MIRT762575	hsa-miR-24	CLIP-seq
MIRT2383816	hsa-miR-3934	CLIP-seq
MIRT762612	hsa-miR-4284	CLIP-seq
MIRT2383817	hsa-miR-605	CLIP-seq
MIRT2166009	hsa-miR-3194-3p	CLIP-seq
MIRT2166028	hsa-miR-4715-3p	CLIP-seq
MIRT1924818	hsa-miR-4727-5p	CLIP-seq
MIRT1924820	hsa-miR-4769-3p	CLIP-seq
MIRT2166001	hsa-miR-1278	CLIP-seq
MIRT2468536	hsa-miR-129-3p	CLIP-seq
MIRT2468537	hsa-miR-1294	CLIP-seq
MIRT762555	hsa-miR-1297	CLIP-seq
MIRT762557	hsa-miR-1343	CLIP-seq
MIRT2468538	hsa-miR-2276	CLIP-seq
MIRT2166005	hsa-miR-2277-3p	CLIP-seq
MIRT1924802	hsa-miR-2278	CLIP-seq
MIRT762576	hsa-miR-26a	CLIP-seq
MIRT762577	hsa-miR-26b	CLIP-seq
MIRT2468539	hsa-miR-3115	CLIP-seq
MIRT2468540	hsa-miR-3132	CLIP-seq
MIRT2468541	hsa-miR-3150b-3p	CLIP-seq
MIRT2468542	hsa-miR-3156-5p	CLIP-seq
MIRT2166007	hsa-miR-3174	CLIP-seq
MIRT762590	hsa-miR-3545-3p	CLIP-seq
MIRT2468543	hsa-miR-3605-5p	CLIP-seq
MIRT762591	hsa-miR-3606	CLIP-seq
MIRT2468544	hsa-miR-3607-3p	CLIP-seq
MIRT2468545	hsa-miR-3664-5p	CLIP-seq
MIRT762597	hsa-miR-3671	CLIP-seq
MIRT2468546	hsa-miR-3686	CLIP-seq
MIRT1924810	hsa-miR-383	CLIP-seq
MIRT2166013	hsa-miR-3915	CLIP-seq
MIRT2166014	hsa-miR-3928	CLIP-seq
MIRT2166015	hsa-miR-4272	CLIP-seq
MIRT762614	hsa-miR-4303	CLIP-seq
MIRT762616	hsa-miR-4308	CLIP-seq
MIRT2468547	hsa-miR-4316	CLIP-seq
MIRT762619	hsa-miR-4465	CLIP-seq
MIRT1924813	hsa-miR-4468	CLIP-seq
MIRT1924815	hsa-miR-4487	CLIP-seq
MIRT762620	hsa-miR-4488	CLIP-seq
MIRT2468548	hsa-miR-4501	CLIP-seq
MIRT2166021	hsa-miR-4539	CLIP-seq
MIRT2468549	hsa-miR-4687-5p	CLIP-seq
MIRT2468550	hsa-miR-4689	CLIP-seq
MIRT762629	hsa-miR-4697-5p	CLIP-seq
MIRT2166030	hsa-miR-4724-5p	CLIP-seq
MIRT2166031	hsa-miR-4728-5p	CLIP-seq
MIRT762634	hsa-miR-4736	CLIP-seq
MIRT2468551	hsa-miR-4764-5p	CLIP-seq
MIRT2468552	hsa-miR-4772-3p	CLIP-seq
MIRT2468553	hsa-miR-4784	CLIP-seq
MIRT762640	hsa-miR-486-3p	CLIP-seq
MIRT1924825	hsa-miR-518a-5p	CLIP-seq
MIRT1924826	hsa-miR-527	CLIP-seq
MIRT762656	hsa-miR-549	CLIP-seq
MIRT2383817	hsa-miR-605	CLIP-seq
MIRT762659	hsa-miR-607	CLIP-seq
MIRT762661	hsa-miR-637	CLIP-seq
MIRT2166041	hsa-miR-921	CLIP-seq
MIRT2674222	hsa-miR-103a	CLIP-seq
MIRT2674223	hsa-miR-107	CLIP-seq
MIRT2674224	hsa-miR-1179	CLIP-seq
MIRT2674225	hsa-miR-1183	CLIP-seq
MIRT2674226	hsa-miR-1200	CLIP-seq
MIRT2166001	hsa-miR-1278	CLIP-seq
MIRT2674227	hsa-miR-1279	CLIP-seq
MIRT2674228	hsa-miR-1284	CLIP-seq
MIRT2468536	hsa-miR-129-3p	CLIP-seq
MIRT2468537	hsa-miR-1294	CLIP-seq
MIRT762555	hsa-miR-1297	CLIP-seq
MIRT762557	hsa-miR-1343	CLIP-seq
MIRT762558	hsa-miR-149	CLIP-seq
MIRT2674229	hsa-miR-18a	CLIP-seq
MIRT2674230	hsa-miR-18b	CLIP-seq
MIRT2468538	hsa-miR-2276	CLIP-seq
MIRT2166005	hsa-miR-2277-3p	CLIP-seq
MIRT1924802	hsa-miR-2278	CLIP-seq
MIRT762575	hsa-miR-24	CLIP-seq
MIRT1924803	hsa-miR-2467-3p	CLIP-seq
MIRT762576	hsa-miR-26a	CLIP-seq
MIRT762577	hsa-miR-26b	CLIP-seq
MIRT1924804	hsa-miR-3064-5p	CLIP-seq
MIRT2674231	hsa-miR-30a	CLIP-seq
MIRT2674232	hsa-miR-30b	CLIP-seq
MIRT2674233	hsa-miR-30c	CLIP-seq
MIRT2674234	hsa-miR-30d	CLIP-seq
MIRT2674235	hsa-miR-30e	CLIP-seq
MIRT2468539	hsa-miR-3115	CLIP-seq
MIRT762582	hsa-miR-3126-3p	CLIP-seq
MIRT2468540	hsa-miR-3132	CLIP-seq
MIRT2674236	hsa-miR-3137	CLIP-seq
MIRT2674237	hsa-miR-3148	CLIP-seq
MIRT2468541	hsa-miR-3150b-3p	CLIP-seq
MIRT2468542	hsa-miR-3156-5p	CLIP-seq
MIRT2674238	hsa-miR-3165	CLIP-seq
MIRT762583	hsa-miR-3170	CLIP-seq
MIRT2166007	hsa-miR-3174	CLIP-seq
MIRT762586	hsa-miR-3201	CLIP-seq
MIRT762590	hsa-miR-3545-3p	CLIP-seq
MIRT2468543	hsa-miR-3605-5p	CLIP-seq
MIRT2674239	hsa-miR-3607-5p	CLIP-seq
MIRT2674240	hsa-miR-3646	CLIP-seq
MIRT2674241	hsa-miR-3664-3p	CLIP-seq
MIRT762597	hsa-miR-3671	CLIP-seq
MIRT762598	hsa-miR-3675-5p	CLIP-seq
MIRT1924810	hsa-miR-383	CLIP-seq
MIRT2166013	hsa-miR-3915	CLIP-seq
MIRT2166014	hsa-miR-3928	CLIP-seq
MIRT2674242	hsa-miR-3944-5p	CLIP-seq
MIRT2166015	hsa-miR-4272	CLIP-seq
MIRT762612	hsa-miR-4284	CLIP-seq
MIRT762614	hsa-miR-4303	CLIP-seq
MIRT2674243	hsa-miR-4305	CLIP-seq
MIRT762616	hsa-miR-4308	CLIP-seq
MIRT2674244	hsa-miR-4310	CLIP-seq
MIRT2468547	hsa-miR-4316	CLIP-seq
MIRT2674245	hsa-miR-4324	CLIP-seq
MIRT762619	hsa-miR-4465	CLIP-seq
MIRT1924813	hsa-miR-4468	CLIP-seq
MIRT1924815	hsa-miR-4487	CLIP-seq
MIRT762620	hsa-miR-4488	CLIP-seq
MIRT2468548	hsa-miR-4501	CLIP-seq
MIRT2674246	hsa-miR-4536	CLIP-seq
MIRT2166021	hsa-miR-4539	CLIP-seq
MIRT2468549	hsa-miR-4687-5p	CLIP-seq
MIRT2468550	hsa-miR-4689	CLIP-seq
MIRT762629	hsa-miR-4697-5p	CLIP-seq
MIRT2166030	hsa-miR-4724-5p	CLIP-seq
MIRT2166031	hsa-miR-4728-5p	CLIP-seq
MIRT2674247	hsa-miR-4735-3p	CLIP-seq
MIRT762634	hsa-miR-4736	CLIP-seq
MIRT2674248	hsa-miR-4738-3p	CLIP-seq
MIRT1924819	hsa-miR-4762-5p	CLIP-seq
MIRT2468551	hsa-miR-4764-5p	CLIP-seq
MIRT2468552	hsa-miR-4772-3p	CLIP-seq
MIRT762636	hsa-miR-4782-5p	CLIP-seq
MIRT2468553	hsa-miR-4784	CLIP-seq
MIRT762638	hsa-miR-4791	CLIP-seq
MIRT762640	hsa-miR-486-3p	CLIP-seq
MIRT2674249	hsa-miR-493	CLIP-seq
MIRT1924822	hsa-miR-494	CLIP-seq
MIRT2674250	hsa-miR-500a	CLIP-seq
MIRT762646	hsa-miR-512-3p	CLIP-seq
MIRT1924825	hsa-miR-518a-5p	CLIP-seq
MIRT1924826	hsa-miR-527	CLIP-seq
MIRT2674251	hsa-miR-544b	CLIP-seq
MIRT2674252	hsa-miR-548a-3p	CLIP-seq
MIRT762648	hsa-miR-548ac	CLIP-seq
MIRT762649	hsa-miR-548ae	CLIP-seq
MIRT762650	hsa-miR-548aj	CLIP-seq
MIRT762651	hsa-miR-548am	CLIP-seq
MIRT2674253	hsa-miR-548c-3p	CLIP-seq
MIRT762652	hsa-miR-548d-3p	CLIP-seq
MIRT2674254	hsa-miR-548e	CLIP-seq
MIRT2674255	hsa-miR-548f	CLIP-seq
MIRT2674256	hsa-miR-548g	CLIP-seq
MIRT762653	hsa-miR-548l	CLIP-seq
MIRT2674257	hsa-miR-548n	CLIP-seq
MIRT762654	hsa-miR-548x	CLIP-seq
MIRT762655	hsa-miR-548z	CLIP-seq
MIRT762656	hsa-miR-549	CLIP-seq
MIRT2674258	hsa-miR-570	CLIP-seq
MIRT2674259	hsa-miR-598	CLIP-seq
MIRT2383817	hsa-miR-605	CLIP-seq
MIRT762659	hsa-miR-607	CLIP-seq
MIRT762661	hsa-miR-637	CLIP-seq
MIRT1924828	hsa-miR-642b	CLIP-seq
MIRT1924830	hsa-miR-760	CLIP-seq
MIRT2166041	hsa-miR-921	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	11356846
GO:0000139	Component	Golgi membrane	IEA
GO:0005509	Function	Calcium ion binding	IDA	30575723
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	11356846
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006665	Process	Sphingolipid metabolic process	IEA
GO:0006672	Process	Ceramide metabolic process	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0008270	Function	Zinc ion binding	IDA	30575723
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	20068046
GO:0016020	Component	Membrane	IDA	30575723
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016811	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA
GO:0017040	Function	N-acylsphingosine amidohydrolase activity	IBA
GO:0017040	Function	N-acylsphingosine amidohydrolase activity	IDA	11356846, 20068046, 30575723
GO:0017040	Function	N-acylsphingosine amidohydrolase activity	IEA
GO:0017040	Function	N-acylsphingosine amidohydrolase activity	IMP	20207939, 26792856
GO:0042552	Process	Myelination	IMP	26792856
GO:0043067	Process	Regulation of programmed cell death	IDA	20068046
GO:0046512	Process	Sphingosine biosynthetic process	IDA	20068046
GO:0046512	Process	Sphingosine biosynthetic process	IEA
GO:0046512	Process	Sphingosine biosynthetic process	IMP	20207939, 26792856
GO:0046514	Process	Ceramide catabolic process	IDA	30575723
GO:0046514	Process	Ceramide catabolic process	IEA
GO:0046514	Process	Ceramide catabolic process	IMP	20207939, 26792856
GO:0046872	Function	Metal ion binding	IEA
GO:0071602	Process	Phytosphingosine biosynthetic process	IBA
GO:0071602	Process	Phytosphingosine biosynthetic process	IDA	11356846, 20068046

Other IDs

• MIM: 617036
• HGNC: 16066
• e!Ensembl: ENSG00000078124

Protein

• UniProt ID: Q9NUN7
• Protein name: Alkaline ceramidase 3 (AlkCDase 3) (Alkaline CDase 3) (EC 3.5.1.-) (EC 3.5.1.23) (Alkaline dihydroceramidase SB89) (Alkaline phytoceramidase) (aPHC)
• Protein function: Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH
• PDB: 6G7O, 6YXH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05875	Ceramidase	9 → 263	Ceramidase	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed. Highly expressed in placenta (PubMed:11356846). Expressed in erythrocytes (PubMed:20207939). {ECO:0000269|PubMed:11356846, ECO:0000269|PubMed:20207939}.
• Sequence:

  MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLE
  KRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYH
  LLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLG
  IFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRT
  LYLRYRPKVKFLFGIWPVILFEPLRKH

• Sequence length: 267

Pathways

KEGG:

Sphingolipid metabolism
Metabolic pathways

Reactome:

Sphingolipid de novo biosynthesis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
ACER3-related disorder	Pathogenic	rs1440353274	RCV003410543	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Alkaline ceramidase 3 deficiency	Pathogenic; Likely pathogenic	rs782673196, rs782709009, rs782329790, rs1949342923	RCV003388177 RCV000662224 RCV001193350 RCV001291525	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Familial cancer of breast	Pathogenic	rs1440353274	RCV005932792	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Germ cell tumor of testis	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROMUSCULAR DISEASES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alkaline ceramidase 3 deficiency	Alkaline Ceramidase Deficiency	Orphanet			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Asthma	Asthma	Pubtator	38297226	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35034572	Associate	★☆☆☆☆ Found in Text Mining only
Cerebral atrophy	Cerebral Atrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Developmental regression	Developmental regression	HPO_DG			★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Dystonia	Dystonia	Pubtator	34281620	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	34817752	Associate	★☆☆☆☆ Found in Text Mining only
Hypoplasia of corpus callosum	Hypoplasia Of Corpus Callosum	HPO_DG			★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	27470583		★☆☆☆☆ Found in Text Mining only
Leukodystrophy	Leukodystrophy	BEFREE	26792856		★☆☆☆☆ Found in Text Mining only
Leukodystrophy	Leukodystrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Leukodystrophy Metachromatic	Metachromatic leukodystrophy	Pubtator	26792856, 34281620	Associate	★☆☆☆☆ Found in Text Mining only
LEUKODYSTROPHY, PROGRESSIVE, EARLY CHILDHOOD-ONSET	PROGRESSIVE LEUKODYSTROPHY	UNIPROT_DG	26792856, 30575723		★☆☆☆☆ Found in Text Mining only
LEUKODYSTROPHY, PROGRESSIVE, EARLY CHILDHOOD-ONSET	PROGRESSIVE LEUKODYSTROPHY	ORPHANET_DG	26792856		★☆☆☆☆ Found in Text Mining only
LEUKODYSTROPHY, PROGRESSIVE, EARLY CHILDHOOD-ONSET	PROGRESSIVE LEUKODYSTROPHY	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30097213		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	CTD_human_DG	22535842		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mouth Neoplasms	Mouth neoplasm	Pubtator	34092610	Stimulate	★☆☆☆☆ Found in Text Mining only
Neurogenic Urinary Bladder	Neurogenic Urinary Bladder	HPO_DG			★☆☆☆☆ Found in Text Mining only
Peripheral Nervous System Diseases	Nervous System Diseases	HPO_DG			★☆☆☆☆ Found in Text Mining only
Relative macrocephaly	Macrocephaly	HPO_DG			★☆☆☆☆ Found in Text Mining only