Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55320
Gene name	MIS18 binding protein 1
Gene symbol	MIS18BP1
Synonyms (NCBI Gene)	C14orf106HSA242977KNL2M18BP1
Chromosome	14
Chromosome location	14q21.2

Show/Hide all (98)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016110	hsa-miR-421	Sequencing	20371350
MIRT024369	hsa-miR-215-5p	Microarray	19074876
MIRT026637	hsa-miR-192-5p	Microarray	19074876
MIRT027045	hsa-miR-103a-3p	Sequencing	20371350
MIRT030640	hsa-miR-22-3p	Sequencing	20371350
MIRT544930	hsa-miR-320e	HITS-CLIP	21572407
MIRT544929	hsa-miR-3908	HITS-CLIP	21572407
MIRT070074	hsa-miR-1184	HITS-CLIP	21572407
MIRT544928	hsa-miR-1185-5p	HITS-CLIP	21572407
MIRT544927	hsa-miR-3679-5p	HITS-CLIP	21572407
MIRT544926	hsa-miR-3605-5p	HITS-CLIP	21572407
MIRT544925	hsa-miR-3145-3p	HITS-CLIP	21572407
MIRT027045	hsa-miR-103a-3p	HITS-CLIP	21572407
MIRT544924	hsa-miR-107	HITS-CLIP	21572407
MIRT544930	hsa-miR-320e	PAR-CLIP	21572407
MIRT544929	hsa-miR-3908	PAR-CLIP	21572407
MIRT070074	hsa-miR-1184	PAR-CLIP	21572407
MIRT544928	hsa-miR-1185-5p	PAR-CLIP	21572407
MIRT544927	hsa-miR-3679-5p	PAR-CLIP	21572407
MIRT544926	hsa-miR-3605-5p	PAR-CLIP	21572407
MIRT544925	hsa-miR-3145-3p	PAR-CLIP	21572407
MIRT027045	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT544924	hsa-miR-107	PAR-CLIP	21572407
MIRT544930	hsa-miR-320e	HITS-CLIP	21572407
MIRT544929	hsa-miR-3908	HITS-CLIP	21572407
MIRT070074	hsa-miR-1184	HITS-CLIP	21572407
MIRT544928	hsa-miR-1185-5p	HITS-CLIP	21572407
MIRT544927	hsa-miR-3679-5p	HITS-CLIP	21572407
MIRT544926	hsa-miR-3605-5p	HITS-CLIP	21572407
MIRT544925	hsa-miR-3145-3p	HITS-CLIP	21572407
MIRT027045	hsa-miR-103a-3p	HITS-CLIP	21572407
MIRT544924	hsa-miR-107	HITS-CLIP	21572407
MIRT544930	hsa-miR-320e	PAR-CLIP	21572407
MIRT544929	hsa-miR-3908	PAR-CLIP	21572407
MIRT070074	hsa-miR-1184	PAR-CLIP	21572407
MIRT544928	hsa-miR-1185-5p	PAR-CLIP	21572407
MIRT544927	hsa-miR-3679-5p	PAR-CLIP	21572407
MIRT544926	hsa-miR-3605-5p	PAR-CLIP	21572407
MIRT544925	hsa-miR-3145-3p	PAR-CLIP	21572407
MIRT027045	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT544924	hsa-miR-107	PAR-CLIP	21572407
MIRT1149536	hsa-miR-103a	CLIP-seq
MIRT1149537	hsa-miR-1185	CLIP-seq
MIRT1149538	hsa-miR-141	CLIP-seq
MIRT1149539	hsa-miR-145	CLIP-seq
MIRT1149540	hsa-miR-1915	CLIP-seq
MIRT1149541	hsa-miR-200a	CLIP-seq
MIRT1149542	hsa-miR-3145-5p	CLIP-seq
MIRT1149543	hsa-miR-3165	CLIP-seq
MIRT1149544	hsa-miR-3647-3p	CLIP-seq
MIRT1149545	hsa-miR-3925-3p	CLIP-seq
MIRT1149546	hsa-miR-452	CLIP-seq
MIRT1149547	hsa-miR-4668-3p	CLIP-seq
MIRT1149548	hsa-miR-4676-3p	CLIP-seq
MIRT1149549	hsa-miR-4726-3p	CLIP-seq
MIRT1149550	hsa-miR-508-5p	CLIP-seq
MIRT1149551	hsa-miR-548c-3p	CLIP-seq
MIRT1149552	hsa-miR-548p	CLIP-seq
MIRT1149553	hsa-miR-584	CLIP-seq
MIRT1149554	hsa-miR-605	CLIP-seq
MIRT2042522	hsa-miR-1305	CLIP-seq
MIRT1149539	hsa-miR-145	CLIP-seq
MIRT2042523	hsa-miR-3065-5p	CLIP-seq
MIRT1149542	hsa-miR-3145-5p	CLIP-seq
MIRT1149544	hsa-miR-3647-3p	CLIP-seq
MIRT1149545	hsa-miR-3925-3p	CLIP-seq
MIRT2042524	hsa-miR-4517	CLIP-seq
MIRT2042525	hsa-miR-4666-5p	CLIP-seq
MIRT2042526	hsa-miR-4775	CLIP-seq
MIRT1149550	hsa-miR-508-5p	CLIP-seq
MIRT2042527	hsa-miR-889	CLIP-seq
MIRT1149536	hsa-miR-103a	CLIP-seq
MIRT1149537	hsa-miR-1185	CLIP-seq
MIRT1149539	hsa-miR-145	CLIP-seq
MIRT1149542	hsa-miR-3145-5p	CLIP-seq
MIRT1149544	hsa-miR-3647-3p	CLIP-seq
MIRT1149545	hsa-miR-3925-3p	CLIP-seq
MIRT2042525	hsa-miR-4666-5p	CLIP-seq
MIRT1149550	hsa-miR-508-5p	CLIP-seq
MIRT2390904	hsa-miR-185	CLIP-seq
MIRT2390905	hsa-miR-376a	CLIP-seq
MIRT2390906	hsa-miR-376b	CLIP-seq
MIRT2390907	hsa-miR-4306	CLIP-seq
MIRT2390908	hsa-miR-4433	CLIP-seq
MIRT2390909	hsa-miR-4459	CLIP-seq
MIRT2390910	hsa-miR-4633-5p	CLIP-seq
MIRT2390911	hsa-miR-4644	CLIP-seq
MIRT2390912	hsa-miR-4768-3p	CLIP-seq
MIRT2390913	hsa-miR-520d-5p	CLIP-seq
MIRT2390914	hsa-miR-524-5p	CLIP-seq
MIRT2390915	hsa-miR-532-5p	CLIP-seq
MIRT2390916	hsa-miR-548ac	CLIP-seq
MIRT2390917	hsa-miR-548ae	CLIP-seq
MIRT2390918	hsa-miR-548aj	CLIP-seq
MIRT2390919	hsa-miR-548am	CLIP-seq
MIRT2390920	hsa-miR-548d-3p	CLIP-seq
MIRT2390921	hsa-miR-548x	CLIP-seq
MIRT2390922	hsa-miR-548z	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IBA
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000775	Component	Chromosome, centromeric region	NAS	38951710
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	17199038, 28514442, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0034080	Process	CENP-A containing chromatin assembly	NAS	38951710
GO:0051301	Process	Cell division	IEA
GO:0098654	Component	CENP-A recruiting complex	IPI	38951710
GO:0140462	Process	Pericentric heterochromatin organization	NAS	38951710

MIM	HGNC	e!Ensembl
618139	20190	ENSG00000129534

Q6P0N0

Protein name

Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243)

Protein function

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

PDB

1WGX , 8S31

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09133	SANTA	383 → 470	SANTA (SANT Associated)	Domain
PF00249	Myb_DNA-binding	877 → 925	Myb-like DNA-binding domain	Domain

Sequence

MIATPLKHSRIYLPPEASSQRRNLPMDAIFFDSIPSGTLTPVKDLVKYQNSSLKLNDHKK
NQFLKMTTFNNKNIFQSTMLTEATTSNSSLDISAIKPNKDGLKNKANYESPGKIFLRMKE
KVLRDKQEQPSRNSSLLEPQKSGNNETFTPNRVEKKKLQHTYLCEEKENNKSFQSDDSSL
RASVQGVPLESSNNDIFLPVKQKIQCQQEKKAPLHNLTYELPTLNQEQENFLAVEARNKT
LTRAQLAKQIFHSKESIVATTKSKKDTFVLESVDSADEQFQNTNAETLSTNCIPIKNGSL
LMVSDSERTTEGTSQQKVKEGNGKTVPGETGLPGSMKDTCKIVLATPRLHITIPRRSKRN
ISKLSPPRIFQTVTNGLKKNQVVQLQEWMIKSINNNTAICVEGKLIDVTNIYWHSNVIIE
RIEHNKLRTISGNVYILKGMIDQISMKEAGYPNYLIRKFMFGFPENWKEHIDNFLEQLRA
GEKNREKTKQKQKTGRSVRDIRKSMKNDARENQTDTAQRATTTYDFDCDNLELKSNKHSE
SPGATELNMCHSNCQNKPTLRFPDDQVNNTIQNGGGDDLSNQELIGKKEYKMSSKKLKIG
ERTNERIIKSQKQETTEELDVSIDILTSREQFFSDEERKYMAINQKKAYILVTPLKSRKV
IEQRCMRYNLSAGTIKAVTDFVIPECQKKSPISKSMGTLENTFEGHKSKNKEDCDERDLL
TVNRKIKISNLEKEQMLTSDFKKNTRLLPKLKKIENQVAMSFYKHQSSPDLSSEESETEK
EIKRKAEVKKTKAGNTKEAVVHLRKSTRNTSNIPVILEPETEESENEFYIKQKKARPSVK
ETLQKSGVRKEFPITEAVGSDKTNRHPLECLPGLIQDKEWNEKELQKLHCAFASLPKHKP
GFWSEVAAAVGSRSPEECQRKYMENPRGKGSQKHVTKKKPANSKGQNGKRGDADQKQTIK
ITAKVGTLKRKQQMREFLEQLPKDDHDDFFSTTPLQHQRILLPSFQDSEDDDDILPNMDK
NPTTPSSVIFPLVKTPQCQHVSPGMLGSINRNDCDKYVFRMQKYHKSNGGIVWGNIKKKL
VETDFSTPTPRRKTPFNTDLGENSGIGKLFTNAVESLDEEEKDYYFSNSDSA

Sequence length

1132

Interactions

View interactions

	Reactome
			Deposition of new CENPA-containing nucleosomes at the centromere

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Familial cancer of breast	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autism Spectrum Disorder	Autism	Pubtator	35205231	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MIS18BP1 (MIS18 binding protein 1)