Gene Gene information from NCBI Gene database.
Entrez ID 55300
Gene name Phosphatidylinositol 4-kinase type 2 beta
Gene symbol PI4K2B
Synonyms (NCBI Gene)
PI4KIIBPIK42B
Chromosome 4
Chromosome location 4p15.2
Summary This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [p
miRNA miRNA information provided by mirtarbase database.
415
miRTarBase ID miRNA Experiments Reference
MIRT022232 hsa-miR-124-3p Microarray 18668037
MIRT031512 hsa-miR-16-5p Sequencing 20371350
MIRT685544 hsa-miR-548l HITS-CLIP 23313552
MIRT685543 hsa-miR-3973 HITS-CLIP 23313552
MIRT685542 hsa-miR-186-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 11923287, 12324459
GO:0000139 Component Golgi membrane IEA
GO:0000166 Function Nucleotide binding IEA
GO:0004430 Function 1-phosphatidylinositol 4-kinase activity IBA
GO:0004430 Function 1-phosphatidylinositol 4-kinase activity IDA 11923287, 12324459
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612101 18215 ENSG00000038210
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TCG2
Protein name Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA)
Protein function Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459). This contribution may be especially significant in plasma membrane, endosomal and G
PDB 4WTV , 8A5X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00454 PI3_PI4_kinase 129 429 Phosphatidylinositol 3- and 4-kinase Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11923287}.
Sequence
Sequence length 481
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
  Synthesis of PIPs at the ER membrane
Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the early endosome membrane
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Abnormality of neuronal migration Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Autism Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Attention deficit hyperactivity disorder Attention Deficit Hyperactivity Disorder GWASCAT_DG 30563984
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Bipolar Disorder Bipolar Disorder BEFREE 19539307
★☆☆☆☆
Found in Text Mining only
Graft vs Host Disease Graft-versus-host disease Pubtator 18316730 Associate
★☆☆☆☆
Found in Text Mining only
leukemia Leukemia BEFREE 18316730
★☆☆☆☆
Found in Text Mining only
Mental disorders Mental Disorders BEFREE 19539307
★☆☆☆☆
Found in Text Mining only
Myeloid Leukemia, Chronic Myeloid Leukemia BEFREE 18316730
★☆☆☆☆
Found in Text Mining only
Schizophrenia Schizophrenia BEFREE 19539307
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Schizophrenia Schizophrenia PSYGENET_DG 19539307
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Small Cell Lung Carcinoma Small cell lung carcinoma Pubtator 37189142 Associate
★☆☆☆☆
Found in Text Mining only