RNF121 (ring finger protein 121)

Gene

• Entrez ID: 55298
• Gene name: Ring finger protein 121
• Gene symbol: RNF121
• Synonyms (NCBI Gene): -
• Chromosome: 11
• Chromosome location: 11q13.4
• Summary: The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been n

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017093	hsa-miR-335-5p	Microarray	18185580
MIRT049659	hsa-miR-92a-3p	CLASH	23622248
MIRT610025	hsa-miR-8485	HITS-CLIP	23824327
MIRT610024	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610023	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610022	hsa-miR-603	HITS-CLIP	23824327
MIRT610021	hsa-miR-521	HITS-CLIP	23824327
MIRT610020	hsa-miR-3941	HITS-CLIP	23824327
MIRT610025	hsa-miR-8485	HITS-CLIP	23824327
MIRT610024	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610023	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610022	hsa-miR-603	HITS-CLIP	23824327
MIRT610021	hsa-miR-521	HITS-CLIP	23824327
MIRT610020	hsa-miR-3941	HITS-CLIP	23824327
MIRT610025	hsa-miR-8485	HITS-CLIP	23824327
MIRT610024	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610023	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610022	hsa-miR-603	HITS-CLIP	23824327
MIRT610021	hsa-miR-521	HITS-CLIP	23824327
MIRT610020	hsa-miR-3941	HITS-CLIP	23824327
MIRT469158	hsa-miR-6768-5p	PAR-CLIP	23592263
MIRT469157	hsa-miR-3154	PAR-CLIP	23592263
MIRT469156	hsa-miR-9500	PAR-CLIP	23592263
MIRT469155	hsa-miR-3185	PAR-CLIP	23592263
MIRT469154	hsa-miR-7515	PAR-CLIP	23592263
MIRT469153	hsa-miR-6127	PAR-CLIP	23592263
MIRT469152	hsa-miR-4481	PAR-CLIP	23592263
MIRT469151	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT469150	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT469149	hsa-miR-6745	PAR-CLIP	23592263
MIRT469148	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT469147	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT469146	hsa-miR-1293	PAR-CLIP	23592263
MIRT469144	hsa-miR-4483	PAR-CLIP	23592263
MIRT469145	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT469143	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT469141	hsa-miR-4417	PAR-CLIP	23592263
MIRT469142	hsa-miR-6748-5p	PAR-CLIP	23592263
MIRT610021	hsa-miR-521	HITS-CLIP	27418678
MIRT610025	hsa-miR-8485	HITS-CLIP	23824327
MIRT610024	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610023	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610022	hsa-miR-603	HITS-CLIP	23824327
MIRT610021	hsa-miR-521	HITS-CLIP	23824327
MIRT610020	hsa-miR-3941	HITS-CLIP	23824327
MIRT610025	hsa-miR-8485	HITS-CLIP	23824327
MIRT610024	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610023	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610022	hsa-miR-603	HITS-CLIP	23824327
MIRT610021	hsa-miR-521	HITS-CLIP	23824327
MIRT610020	hsa-miR-3941	HITS-CLIP	23824327
MIRT610025	hsa-miR-8485	HITS-CLIP	23824327
MIRT610024	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610023	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610022	hsa-miR-603	HITS-CLIP	23824327
MIRT610021	hsa-miR-521	HITS-CLIP	23824327
MIRT610020	hsa-miR-3941	HITS-CLIP	23824327
MIRT469158	hsa-miR-6768-5p	PAR-CLIP	23592263
MIRT469157	hsa-miR-3154	PAR-CLIP	23592263
MIRT469156	hsa-miR-9500	PAR-CLIP	23592263
MIRT469155	hsa-miR-3185	PAR-CLIP	23592263
MIRT469154	hsa-miR-7515	PAR-CLIP	23592263
MIRT469153	hsa-miR-6127	PAR-CLIP	23592263
MIRT469152	hsa-miR-4481	PAR-CLIP	23592263
MIRT469151	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT469150	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT469149	hsa-miR-6745	PAR-CLIP	23592263
MIRT469148	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT469147	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT469146	hsa-miR-1293	PAR-CLIP	23592263
MIRT469144	hsa-miR-4483	PAR-CLIP	23592263
MIRT469145	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT469143	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT469141	hsa-miR-4417	PAR-CLIP	23592263
MIRT469142	hsa-miR-6748-5p	PAR-CLIP	23592263
MIRT1309682	hsa-miR-1245b-5p	CLIP-seq
MIRT1309683	hsa-miR-1253	CLIP-seq
MIRT1309684	hsa-miR-1284	CLIP-seq
MIRT1309685	hsa-miR-1307	CLIP-seq
MIRT1309686	hsa-miR-143	CLIP-seq
MIRT1309687	hsa-miR-1587	CLIP-seq
MIRT1309688	hsa-miR-2117	CLIP-seq
MIRT1309689	hsa-miR-302a	CLIP-seq
MIRT1309690	hsa-miR-302b	CLIP-seq
MIRT1309691	hsa-miR-302c	CLIP-seq
MIRT1309692	hsa-miR-302d	CLIP-seq
MIRT1309693	hsa-miR-302e	CLIP-seq
MIRT1309694	hsa-miR-3142	CLIP-seq
MIRT1309695	hsa-miR-3192	CLIP-seq
MIRT1309696	hsa-miR-329	CLIP-seq
MIRT1309697	hsa-miR-372	CLIP-seq
MIRT1309698	hsa-miR-373	CLIP-seq
MIRT1309699	hsa-miR-4255	CLIP-seq
MIRT1309700	hsa-miR-4273	CLIP-seq
MIRT1309701	hsa-miR-4300	CLIP-seq
MIRT1309702	hsa-miR-4448	CLIP-seq
MIRT1309703	hsa-miR-4492	CLIP-seq
MIRT1309704	hsa-miR-4498	CLIP-seq
MIRT1309705	hsa-miR-4519	CLIP-seq
MIRT1309706	hsa-miR-4530	CLIP-seq
MIRT1309707	hsa-miR-4638-5p	CLIP-seq
MIRT1309708	hsa-miR-4649-3p	CLIP-seq
MIRT1309709	hsa-miR-4656	CLIP-seq
MIRT1309710	hsa-miR-4675	CLIP-seq
MIRT1309711	hsa-miR-4733-3p	CLIP-seq
MIRT1309712	hsa-miR-4741	CLIP-seq
MIRT1309713	hsa-miR-4756-3p	CLIP-seq
MIRT1309714	hsa-miR-4770	CLIP-seq
MIRT1309715	hsa-miR-519a	CLIP-seq
MIRT1309716	hsa-miR-519b-3p	CLIP-seq
MIRT1309717	hsa-miR-519c-3p	CLIP-seq
MIRT1309718	hsa-miR-520a-3p	CLIP-seq
MIRT1309719	hsa-miR-520b	CLIP-seq
MIRT1309720	hsa-miR-520c-3p	CLIP-seq
MIRT1309721	hsa-miR-520d-3p	CLIP-seq
MIRT1309722	hsa-miR-520e	CLIP-seq
MIRT1309723	hsa-miR-541	CLIP-seq
MIRT1309724	hsa-miR-619	CLIP-seq
MIRT1309725	hsa-miR-762	CLIP-seq
MIRT1309726	hsa-miR-767-5p	CLIP-seq
MIRT1309727	hsa-miR-920	CLIP-seq
MIRT2091973	hsa-miR-1275	CLIP-seq
MIRT2091974	hsa-miR-1279	CLIP-seq
MIRT2091975	hsa-miR-1321	CLIP-seq
MIRT2091976	hsa-miR-1324	CLIP-seq
MIRT2091977	hsa-miR-3182	CLIP-seq
MIRT1309695	hsa-miR-3192	CLIP-seq
MIRT1309696	hsa-miR-329	CLIP-seq
MIRT2091978	hsa-miR-370	CLIP-seq
MIRT2091979	hsa-miR-3913-3p	CLIP-seq
MIRT2091980	hsa-miR-4267	CLIP-seq
MIRT1309701	hsa-miR-4300	CLIP-seq
MIRT2091981	hsa-miR-4419a	CLIP-seq
MIRT2091982	hsa-miR-4434	CLIP-seq
MIRT2091983	hsa-miR-4447	CLIP-seq
MIRT2091984	hsa-miR-4472	CLIP-seq
MIRT2091985	hsa-miR-4504	CLIP-seq
MIRT2091986	hsa-miR-4510	CLIP-seq
MIRT2091987	hsa-miR-4516	CLIP-seq
MIRT2091988	hsa-miR-4525	CLIP-seq
MIRT2091989	hsa-miR-4659a-3p	CLIP-seq
MIRT2091990	hsa-miR-4659b-3p	CLIP-seq
MIRT2091991	hsa-miR-4665-5p	CLIP-seq
MIRT2091992	hsa-miR-4723-5p	CLIP-seq
MIRT2091993	hsa-miR-4727-5p	CLIP-seq
MIRT2091994	hsa-miR-4728-5p	CLIP-seq
MIRT2091995	hsa-miR-4739	CLIP-seq
MIRT2091996	hsa-miR-4756-5p	CLIP-seq
MIRT2091997	hsa-miR-4793-5p	CLIP-seq
MIRT2091998	hsa-miR-483-5p	CLIP-seq
MIRT2091999	hsa-miR-489	CLIP-seq
MIRT2092000	hsa-miR-549	CLIP-seq
MIRT2092001	hsa-miR-564	CLIP-seq
MIRT2092002	hsa-miR-597	CLIP-seq
MIRT1309724	hsa-miR-619	CLIP-seq
MIRT2092003	hsa-miR-625	CLIP-seq
MIRT1309727	hsa-miR-920	CLIP-seq
MIRT2091974	hsa-miR-1279	CLIP-seq
MIRT2316459	hsa-miR-3064-5p	CLIP-seq
MIRT1309696	hsa-miR-329	CLIP-seq
MIRT2316460	hsa-miR-3660	CLIP-seq
MIRT2091979	hsa-miR-3913-3p	CLIP-seq
MIRT2316461	hsa-miR-4270	CLIP-seq
MIRT2316462	hsa-miR-4313	CLIP-seq
MIRT2091982	hsa-miR-4434	CLIP-seq
MIRT2316463	hsa-miR-4441	CLIP-seq
MIRT2091987	hsa-miR-4516	CLIP-seq
MIRT2316464	hsa-miR-4526	CLIP-seq
MIRT2316465	hsa-miR-4758-3p	CLIP-seq
MIRT2091999	hsa-miR-489	CLIP-seq
MIRT2316466	hsa-miR-642b	CLIP-seq
MIRT2316467	hsa-miR-892b	CLIP-seq
MIRT2393796	hsa-miR-4457	CLIP-seq
MIRT2393797	hsa-miR-4704-3p	CLIP-seq
MIRT2612535	hsa-miR-1197	CLIP-seq
MIRT2091973	hsa-miR-1275	CLIP-seq
MIRT2091975	hsa-miR-1321	CLIP-seq
MIRT2091976	hsa-miR-1324	CLIP-seq
MIRT2612536	hsa-miR-1914	CLIP-seq
MIRT2612537	hsa-miR-3152-5p	CLIP-seq
MIRT2612538	hsa-miR-3161	CLIP-seq
MIRT2612539	hsa-miR-3175	CLIP-seq
MIRT2612540	hsa-miR-3657	CLIP-seq
MIRT2612541	hsa-miR-432	CLIP-seq
MIRT2091981	hsa-miR-4419a	CLIP-seq
MIRT2612542	hsa-miR-4436b-5p	CLIP-seq
MIRT2091983	hsa-miR-4447	CLIP-seq
MIRT2091984	hsa-miR-4472	CLIP-seq
MIRT2091986	hsa-miR-4510	CLIP-seq
MIRT2612543	hsa-miR-4520a-3p	CLIP-seq
MIRT2612544	hsa-miR-4520b-3p	CLIP-seq
MIRT2091988	hsa-miR-4525	CLIP-seq
MIRT2091991	hsa-miR-4665-5p	CLIP-seq
MIRT2612545	hsa-miR-4669	CLIP-seq
MIRT2612546	hsa-miR-4716-3p	CLIP-seq
MIRT2091992	hsa-miR-4723-5p	CLIP-seq
MIRT2091994	hsa-miR-4728-5p	CLIP-seq
MIRT2091995	hsa-miR-4739	CLIP-seq
MIRT2091996	hsa-miR-4756-5p	CLIP-seq
MIRT2612547	hsa-miR-4797-5p	CLIP-seq
MIRT2092003	hsa-miR-625	CLIP-seq
MIRT2612536	hsa-miR-1914	CLIP-seq
MIRT2612537	hsa-miR-3152-5p	CLIP-seq
MIRT2612538	hsa-miR-3161	CLIP-seq
MIRT2612539	hsa-miR-3175	CLIP-seq
MIRT2612540	hsa-miR-3657	CLIP-seq
MIRT2612541	hsa-miR-432	CLIP-seq
MIRT2612542	hsa-miR-4436b-5p	CLIP-seq
MIRT2612543	hsa-miR-4520a-3p	CLIP-seq
MIRT2612544	hsa-miR-4520b-3p	CLIP-seq
MIRT2612545	hsa-miR-4669	CLIP-seq
MIRT2612546	hsa-miR-4716-3p	CLIP-seq
MIRT2091992	hsa-miR-4723-5p	CLIP-seq
MIRT2612547	hsa-miR-4797-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0036503	Process	ERAD pathway	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA

Other IDs

• MIM: 620529
• HGNC: 21070
• e!Ensembl: ENSG00000137522

Protein

• UniProt ID: Q9H920
• Protein name: E3 ubiquitin ligase RNF121 (EC 2.3.2.27) (RING finger protein 121)
• Protein function: E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates thereby promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of m
• Sequence:

  MAAVVEVEVGGGAAGERELDEVDMSDLSPEEQWRVEHARMHAKHRGHEAMHAEMVLILIA
  TLVVAQLLLVQWKQRHPRSYNMVTLFQMWVVPLYFTVKLHWWRFLVIWILFSAVTAFVTF
  RATRKPLVQTTPRLVYKWFLLIYKISYATGIVGYMAVMFTLFGLNLLFKIKPEDAMDFGI
  SLLFYGLYYGVLERDFAEMCADYMASTIGFYSESGMPTKHLSDSVCAVCGQQIFVDVSEE
  GIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLL
  DWLRYLVAWQPVIIGVVQGINYILGLE

• Sequence length: 327

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Barrett Esophagus	Barrett esophagus	BEFREE	25228972		★☆☆☆☆ Found in Text Mining only
Barrett Esophagus	Barrett esophagus	Pubtator	25228972	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29955133	Associate	★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30149063		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	25228972	Associate	★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30149063		★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30149063		★☆☆☆☆ Found in Text Mining only