Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55288
Gene name	Ras homolog family member T1
Gene symbol	RHOT1
Synonyms (NCBI Gene)	ARHT1MIRO-1MIRO1
Chromosome	17
Chromosome location	17q11.2

222

Show/Hide all (222)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000900	hsa-miR-15a-5p	Microarray	18362358
MIRT000899	hsa-miR-16-5p	Microarray	18362358
MIRT018247	hsa-miR-335-5p	Microarray	18185580
MIRT036811	hsa-miR-877-3p	CLASH	23622248
MIRT438490	hsa-miR-139-5p	Luciferase reporter assay	24158791
MIRT438490	hsa-miR-139-5p	Luciferase reporter assay	24158791
MIRT1306041	hsa-miR-200b	CLIP-seq
MIRT1306042	hsa-miR-200c	CLIP-seq
MIRT1306043	hsa-miR-217	CLIP-seq
MIRT1306044	hsa-miR-3146	CLIP-seq
MIRT1306045	hsa-miR-323b-3p	CLIP-seq
MIRT1306046	hsa-miR-34b	CLIP-seq
MIRT1306047	hsa-miR-3614-5p	CLIP-seq
MIRT1306048	hsa-miR-376c	CLIP-seq
MIRT1306049	hsa-miR-429	CLIP-seq
MIRT1306050	hsa-miR-4418	CLIP-seq
MIRT1306051	hsa-miR-450b-3p	CLIP-seq
MIRT1306052	hsa-miR-4662a-5p	CLIP-seq
MIRT1306053	hsa-miR-509-3-5p	CLIP-seq
MIRT1306054	hsa-miR-509-5p	CLIP-seq
MIRT1306055	hsa-miR-577	CLIP-seq
MIRT1306056	hsa-miR-614	CLIP-seq
MIRT1306057	hsa-miR-621	CLIP-seq
MIRT1306058	hsa-miR-769-3p	CLIP-seq
MIRT1306059	hsa-miR-3140-5p	CLIP-seq
MIRT1306046	hsa-miR-34b	CLIP-seq
MIRT1306048	hsa-miR-376c	CLIP-seq
MIRT1306060	hsa-miR-4427	CLIP-seq
MIRT1306061	hsa-miR-4699-3p	CLIP-seq
MIRT1306055	hsa-miR-577	CLIP-seq
MIRT1306056	hsa-miR-614	CLIP-seq
MIRT1306059	hsa-miR-3140-5p	CLIP-seq
MIRT1306062	hsa-miR-320e	CLIP-seq
MIRT1306046	hsa-miR-34b	CLIP-seq
MIRT1306048	hsa-miR-376c	CLIP-seq
MIRT1306060	hsa-miR-4427	CLIP-seq
MIRT1306063	hsa-miR-4781-3p	CLIP-seq
MIRT1306064	hsa-miR-4786-5p	CLIP-seq
MIRT1306055	hsa-miR-577	CLIP-seq
MIRT1306056	hsa-miR-614	CLIP-seq
MIRT2315345	hsa-miR-199a-3p	CLIP-seq
MIRT2315346	hsa-miR-199b-3p	CLIP-seq
MIRT2315347	hsa-miR-297	CLIP-seq
MIRT2315348	hsa-miR-3117-5p	CLIP-seq
MIRT2315349	hsa-miR-3129-5p	CLIP-seq
MIRT2315350	hsa-miR-3149	CLIP-seq
MIRT1306047	hsa-miR-3614-5p	CLIP-seq
MIRT2315351	hsa-miR-421	CLIP-seq
MIRT2315352	hsa-miR-4272	CLIP-seq
MIRT2315353	hsa-miR-4307	CLIP-seq
MIRT2315354	hsa-miR-4480	CLIP-seq
MIRT1306051	hsa-miR-450b-3p	CLIP-seq
MIRT2315355	hsa-miR-4709-5p	CLIP-seq
MIRT2315356	hsa-miR-494	CLIP-seq
MIRT2315357	hsa-miR-548c-3p	CLIP-seq
MIRT2315358	hsa-miR-567	CLIP-seq
MIRT2315359	hsa-miR-643	CLIP-seq
MIRT1306058	hsa-miR-769-3p	CLIP-seq
MIRT1306044	hsa-miR-3146	CLIP-seq
MIRT2315360	hsa-miR-3163	CLIP-seq
MIRT2315361	hsa-miR-4282	CLIP-seq
MIRT2315362	hsa-miR-664	CLIP-seq
MIRT2393735	hsa-miR-185	CLIP-seq
MIRT2315347	hsa-miR-297	CLIP-seq
MIRT2315350	hsa-miR-3149	CLIP-seq
MIRT2393736	hsa-miR-4306	CLIP-seq
MIRT2315353	hsa-miR-4307	CLIP-seq
MIRT2393737	hsa-miR-4470	CLIP-seq
MIRT2393738	hsa-miR-4644	CLIP-seq
MIRT2393739	hsa-miR-4694-3p	CLIP-seq
MIRT2315357	hsa-miR-548c-3p	CLIP-seq
MIRT2315358	hsa-miR-567	CLIP-seq
MIRT2315359	hsa-miR-643	CLIP-seq
MIRT2611631	hsa-miR-106a	CLIP-seq
MIRT2611632	hsa-miR-106b	CLIP-seq
MIRT2611633	hsa-miR-1245	CLIP-seq
MIRT2611634	hsa-miR-135a	CLIP-seq
MIRT2611635	hsa-miR-135b	CLIP-seq
MIRT2611636	hsa-miR-142-5p	CLIP-seq
MIRT2611637	hsa-miR-151-3p	CLIP-seq
MIRT2611638	hsa-miR-17	CLIP-seq
MIRT2393735	hsa-miR-185	CLIP-seq
MIRT2315345	hsa-miR-199a-3p	CLIP-seq
MIRT2315346	hsa-miR-199b-3p	CLIP-seq
MIRT2611639	hsa-miR-204	CLIP-seq
MIRT2611640	hsa-miR-20a	CLIP-seq
MIRT2611641	hsa-miR-20b	CLIP-seq
MIRT2611642	hsa-miR-211	CLIP-seq
MIRT2315347	hsa-miR-297	CLIP-seq
MIRT2611643	hsa-miR-302f	CLIP-seq
MIRT2315348	hsa-miR-3117-5p	CLIP-seq
MIRT2315349	hsa-miR-3129-5p	CLIP-seq
MIRT2611644	hsa-miR-3140-3p	CLIP-seq
MIRT1306059	hsa-miR-3140-5p	CLIP-seq
MIRT2315350	hsa-miR-3149	CLIP-seq
MIRT2611645	hsa-miR-3160-3p	CLIP-seq
MIRT1306062	hsa-miR-320e	CLIP-seq
MIRT1306046	hsa-miR-34b	CLIP-seq
MIRT2611646	hsa-miR-3609	CLIP-seq
MIRT1306047	hsa-miR-3614-5p	CLIP-seq
MIRT2611647	hsa-miR-3620	CLIP-seq
MIRT2611648	hsa-miR-3689a-3p	CLIP-seq
MIRT2611649	hsa-miR-3689c	CLIP-seq
MIRT1306048	hsa-miR-376c	CLIP-seq
MIRT2611650	hsa-miR-3922-5p	CLIP-seq
MIRT2611651	hsa-miR-3938	CLIP-seq
MIRT2611652	hsa-miR-412	CLIP-seq
MIRT2315351	hsa-miR-421	CLIP-seq
MIRT2315352	hsa-miR-4272	CLIP-seq
MIRT2611653	hsa-miR-4303	CLIP-seq
MIRT2611654	hsa-miR-4305	CLIP-seq
MIRT2393736	hsa-miR-4306	CLIP-seq
MIRT2315353	hsa-miR-4307	CLIP-seq
MIRT1306060	hsa-miR-4427	CLIP-seq
MIRT2611655	hsa-miR-4453	CLIP-seq
MIRT2611656	hsa-miR-4463	CLIP-seq
MIRT2393737	hsa-miR-4470	CLIP-seq
MIRT2611657	hsa-miR-4487	CLIP-seq
MIRT2611658	hsa-miR-4499	CLIP-seq
MIRT1306051	hsa-miR-450b-3p	CLIP-seq
MIRT2611659	hsa-miR-4522	CLIP-seq
MIRT2611660	hsa-miR-4538	CLIP-seq
MIRT2393738	hsa-miR-4644	CLIP-seq
MIRT2611661	hsa-miR-4682	CLIP-seq
MIRT2393739	hsa-miR-4694-3p	CLIP-seq
MIRT1306061	hsa-miR-4699-3p	CLIP-seq
MIRT2315355	hsa-miR-4709-5p	CLIP-seq
MIRT2611662	hsa-miR-4731-3p	CLIP-seq
MIRT2611663	hsa-miR-4755-5p	CLIP-seq
MIRT2611664	hsa-miR-4777-5p	CLIP-seq
MIRT1306063	hsa-miR-4781-3p	CLIP-seq
MIRT1306064	hsa-miR-4786-5p	CLIP-seq
MIRT2611665	hsa-miR-4792	CLIP-seq
MIRT2611666	hsa-miR-4796-3p	CLIP-seq
MIRT2611667	hsa-miR-4801	CLIP-seq
MIRT2611668	hsa-miR-4803	CLIP-seq
MIRT2315356	hsa-miR-494	CLIP-seq
MIRT2611669	hsa-miR-512-5p	CLIP-seq
MIRT2611670	hsa-miR-518d-5p	CLIP-seq
MIRT2611671	hsa-miR-519b-5p	CLIP-seq
MIRT2611672	hsa-miR-519c-5p	CLIP-seq
MIRT2611673	hsa-miR-519d	CLIP-seq
MIRT2611674	hsa-miR-520c-5p	CLIP-seq
MIRT2611675	hsa-miR-520d-5p	CLIP-seq
MIRT2611676	hsa-miR-524-5p	CLIP-seq
MIRT2611677	hsa-miR-526a	CLIP-seq
MIRT2611678	hsa-miR-548ah	CLIP-seq
MIRT2315357	hsa-miR-548c-3p	CLIP-seq
MIRT2611679	hsa-miR-548m	CLIP-seq
MIRT2611680	hsa-miR-558	CLIP-seq
MIRT2315358	hsa-miR-567	CLIP-seq
MIRT1306055	hsa-miR-577	CLIP-seq
MIRT1306056	hsa-miR-614	CLIP-seq
MIRT2611681	hsa-miR-623	CLIP-seq
MIRT2611682	hsa-miR-640	CLIP-seq
MIRT2315359	hsa-miR-643	CLIP-seq
MIRT1306058	hsa-miR-769-3p	CLIP-seq
MIRT2611683	hsa-miR-93	CLIP-seq
MIRT2611631	hsa-miR-106a	CLIP-seq
MIRT2611632	hsa-miR-106b	CLIP-seq
MIRT2611633	hsa-miR-1245	CLIP-seq
MIRT2611636	hsa-miR-142-5p	CLIP-seq
MIRT2611638	hsa-miR-17	CLIP-seq
MIRT2393735	hsa-miR-185	CLIP-seq
MIRT2315345	hsa-miR-199a-3p	CLIP-seq
MIRT2315346	hsa-miR-199b-3p	CLIP-seq
MIRT2611640	hsa-miR-20a	CLIP-seq
MIRT2611641	hsa-miR-20b	CLIP-seq
MIRT2315347	hsa-miR-297	CLIP-seq
MIRT2611643	hsa-miR-302f	CLIP-seq
MIRT2315348	hsa-miR-3117-5p	CLIP-seq
MIRT2315349	hsa-miR-3129-5p	CLIP-seq
MIRT2611644	hsa-miR-3140-3p	CLIP-seq
MIRT1306059	hsa-miR-3140-5p	CLIP-seq
MIRT2315350	hsa-miR-3149	CLIP-seq
MIRT2611645	hsa-miR-3160-3p	CLIP-seq
MIRT1306046	hsa-miR-34b	CLIP-seq
MIRT2611646	hsa-miR-3609	CLIP-seq
MIRT1306047	hsa-miR-3614-5p	CLIP-seq
MIRT2611647	hsa-miR-3620	CLIP-seq
MIRT2611648	hsa-miR-3689a-3p	CLIP-seq
MIRT2611649	hsa-miR-3689c	CLIP-seq
MIRT1306048	hsa-miR-376c	CLIP-seq
MIRT2611652	hsa-miR-412	CLIP-seq
MIRT2315351	hsa-miR-421	CLIP-seq
MIRT2315352	hsa-miR-4272	CLIP-seq
MIRT2611653	hsa-miR-4303	CLIP-seq
MIRT2393736	hsa-miR-4306	CLIP-seq
MIRT2315353	hsa-miR-4307	CLIP-seq
MIRT1306060	hsa-miR-4427	CLIP-seq
MIRT2611655	hsa-miR-4453	CLIP-seq
MIRT2393737	hsa-miR-4470	CLIP-seq
MIRT2611657	hsa-miR-4487	CLIP-seq
MIRT1306051	hsa-miR-450b-3p	CLIP-seq
MIRT2611660	hsa-miR-4538	CLIP-seq
MIRT2393738	hsa-miR-4644	CLIP-seq
MIRT2611661	hsa-miR-4682	CLIP-seq
MIRT2393739	hsa-miR-4694-3p	CLIP-seq
MIRT2315355	hsa-miR-4709-5p	CLIP-seq
MIRT2611664	hsa-miR-4777-5p	CLIP-seq
MIRT1306064	hsa-miR-4786-5p	CLIP-seq
MIRT2611665	hsa-miR-4792	CLIP-seq
MIRT2611666	hsa-miR-4796-3p	CLIP-seq
MIRT2611668	hsa-miR-4803	CLIP-seq
MIRT2315356	hsa-miR-494	CLIP-seq
MIRT2611669	hsa-miR-512-5p	CLIP-seq
MIRT2611670	hsa-miR-518d-5p	CLIP-seq
MIRT2611671	hsa-miR-519b-5p	CLIP-seq
MIRT2611672	hsa-miR-519c-5p	CLIP-seq
MIRT2611673	hsa-miR-519d	CLIP-seq
MIRT2611674	hsa-miR-520c-5p	CLIP-seq
MIRT2611677	hsa-miR-526a	CLIP-seq
MIRT2611678	hsa-miR-548ah	CLIP-seq
MIRT2315357	hsa-miR-548c-3p	CLIP-seq
MIRT2611679	hsa-miR-548m	CLIP-seq
MIRT2611680	hsa-miR-558	CLIP-seq
MIRT2315358	hsa-miR-567	CLIP-seq
MIRT1306055	hsa-miR-577	CLIP-seq
MIRT1306056	hsa-miR-614	CLIP-seq
MIRT2315359	hsa-miR-643	CLIP-seq
MIRT1306058	hsa-miR-769-3p	CLIP-seq
MIRT2611683	hsa-miR-93	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	27605430, 33132189
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IDA	30513825
GO:0003924	Function	GTPase activity	IEA
GO:0005509	Function	Calcium ion binding	IDA	27605430
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	16630562, 19135897, 19528298, 22078885, 24995978, 33961781
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IDA	33132189
GO:0005525	Function	GTP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	NAS	22078885
GO:0005741	Component	Mitochondrial outer membrane	IBA
GO:0005741	Component	Mitochondrial outer membrane	IDA	12482879, 19528298
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0007005	Process	Mitochondrion organization	IBA
GO:0007005	Process	Mitochondrion organization	IEA
GO:0010821	Process	Regulation of mitochondrion organization	IMP	27716788
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IDA	30513825
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0019003	Function	GDP binding	IDA	27605430
GO:0019725	Process	Cellular homeostasis	IMP	12482879
GO:0046872	Function	Metal ion binding	IEA
GO:0047497	Process	Mitochondrion transport along microtubule	IBA
GO:0047497	Process	Mitochondrion transport along microtubule	IEA
GO:0047497	Process	Mitochondrion transport along microtubule	IMP	16630562
GO:0097345	Process	Mitochondrial outer membrane permeabilization	IEA
GO:0097345	Process	Mitochondrial outer membrane permeabilization	IMP	12482879

MIM	HGNC	e!Ensembl
613888	21168	ENSG00000126858

Q8IXI2

Protein name

Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1)

Protein function

Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their

PDB

5KSO , 5KSP , 5KSY , 5KSZ , 5KTY , 5KU1 , 6D71

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00071	Ras	6 → 168	Ras family	Domain
PF08356	EF_assoc_2	219 → 305	EF hand associated	Family
PF08355	EF_assoc_1	341 → 413	EF hand associated	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. {ECO:0000269|PubMed:12482879}.

Sequence

MKKDVRILLVGEPRVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSE
AEQSDEQLHQEISQANVICIVYAVNNKHSIDKVTSRWIPLINERTDKDSRLPLILVGNKS
DLVEYSSMETILPIMNQYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYCPEEKE
MKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVKNVVRKHISDG
VADSGLTLKGFLFLHTLFIQRGRHETTWTVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTE
LNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFKVFPYIPWGPDVNNTVCTNERGWITYQ
GFLSQWTLTTYLDVQRCLEYLGYLGYSILTEQESQASAVTVTRDKKIDLQKKQTQRNVFR
CNVIGVKNCGKSGVLQALLGRNLMRQKKIREDHKSYYAINTVYVYGQEKYLLLHDISESE
FLTEAEIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEYSI
SPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPHVTQADLKSSTFWLRASFGA
TVFAVLGFAMYKALLKQR

Sequence length

618

Interactions

View interactions

	KEGG		Reactome
	Mitophagy - animal		Rho GTPase cycle Ub-specific processing proteases

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CATARACT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NASOPHARYNGEAL NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POST-TRAUMATIC STRESS DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (20)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	22258555, 28973175		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33374314	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	29562677		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37587156	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	29207597		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	29207597		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	29207597		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	29365285		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	BEFREE	29207597		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung diseases	Lung Diseases	BEFREE	31593750		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	31593750	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	22860091	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	31593750	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	24671417		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	37003181, 37364399	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	22860091, 32697386	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	24671417, 28598236, 29372317, 31564441		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	28598233, 28598236, 31303019, 32280985, 32948353, 37003181, 37364399, 38060381	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
PARKINSON DISEASE, LATE-ONSET	Parkinson disease	BEFREE	24671417		★★★★★ ★☆☆☆☆ Found in Text Mining only
Status Epilepticus	Status Epilepticus	BEFREE	29365285		★★★★★ ★☆☆☆☆ Found in Text Mining only

RHOT1 (ras homolog family member T1)