Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55287
Gene name	Transmembrane protein 40
Gene symbol	TMEM40
Synonyms (NCBI Gene)	-
Chromosome	3
Chromosome location	3p25.2

126

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miRTarBase ID	miRNA	Experiments	Reference
MIRT652403	hsa-miR-487b-3p	HITS-CLIP	23824327
MIRT652402	hsa-miR-5693	HITS-CLIP	23824327
MIRT652401	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT652400	hsa-miR-3135b	HITS-CLIP	23824327
MIRT652399	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT652398	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT652397	hsa-miR-3652	HITS-CLIP	23824327
MIRT652396	hsa-miR-4430	HITS-CLIP	23824327
MIRT652395	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT652394	hsa-miR-5698	HITS-CLIP	23824327
MIRT652403	hsa-miR-487b-3p	HITS-CLIP	23824327
MIRT652402	hsa-miR-5693	HITS-CLIP	23824327
MIRT652401	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT652400	hsa-miR-3135b	HITS-CLIP	23824327
MIRT652399	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT652398	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT652397	hsa-miR-3652	HITS-CLIP	23824327
MIRT652396	hsa-miR-4430	HITS-CLIP	23824327
MIRT652395	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT652394	hsa-miR-5698	HITS-CLIP	23824327
MIRT737240	hsa-miR-138-5p	Luciferase reporter assayWestern blottingRNA-seqqRT-PCR	32884956
MIRT652403	hsa-miR-487b-3p	HITS-CLIP	23824327
MIRT652402	hsa-miR-5693	HITS-CLIP	23824327
MIRT652401	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT652400	hsa-miR-3135b	HITS-CLIP	23824327
MIRT652399	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT652398	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT652397	hsa-miR-3652	HITS-CLIP	23824327
MIRT652396	hsa-miR-4430	HITS-CLIP	23824327
MIRT652395	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT652394	hsa-miR-5698	HITS-CLIP	23824327
MIRT652403	hsa-miR-487b-3p	HITS-CLIP	23824327
MIRT652402	hsa-miR-5693	HITS-CLIP	23824327
MIRT652401	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT652400	hsa-miR-3135b	HITS-CLIP	23824327
MIRT652399	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT652398	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT652397	hsa-miR-3652	HITS-CLIP	23824327
MIRT652396	hsa-miR-4430	HITS-CLIP	23824327
MIRT652395	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT652394	hsa-miR-5698	HITS-CLIP	23824327
MIRT1436991	hsa-miR-1273f	CLIP-seq
MIRT1436992	hsa-miR-1343	CLIP-seq
MIRT1436993	hsa-miR-138	CLIP-seq
MIRT1436994	hsa-miR-1910	CLIP-seq
MIRT1436995	hsa-miR-197	CLIP-seq
MIRT1436996	hsa-miR-2278	CLIP-seq
MIRT1436997	hsa-miR-3074-5p	CLIP-seq
MIRT1436998	hsa-miR-3194-3p	CLIP-seq
MIRT1436999	hsa-miR-370	CLIP-seq
MIRT1437000	hsa-miR-378g	CLIP-seq
MIRT1437001	hsa-miR-3909	CLIP-seq
MIRT1437002	hsa-miR-3921	CLIP-seq
MIRT1437003	hsa-miR-4251	CLIP-seq
MIRT1437004	hsa-miR-4274	CLIP-seq
MIRT1437005	hsa-miR-4329	CLIP-seq
MIRT1437006	hsa-miR-4437	CLIP-seq
MIRT1437007	hsa-miR-4519	CLIP-seq
MIRT1437008	hsa-miR-4653-5p	CLIP-seq
MIRT1437009	hsa-miR-4674	CLIP-seq
MIRT1437010	hsa-miR-4711-5p	CLIP-seq
MIRT1437011	hsa-miR-4781-3p	CLIP-seq
MIRT1437012	hsa-miR-626	CLIP-seq
MIRT2131003	hsa-miR-122	CLIP-seq
MIRT2131004	hsa-miR-487b	CLIP-seq
MIRT2352227	hsa-miR-1184	CLIP-seq
MIRT2131003	hsa-miR-122	CLIP-seq
MIRT2352228	hsa-miR-126	CLIP-seq
MIRT1436992	hsa-miR-1343	CLIP-seq
MIRT1437000	hsa-miR-378g	CLIP-seq
MIRT1437004	hsa-miR-4274	CLIP-seq
MIRT2352229	hsa-miR-4418	CLIP-seq
MIRT1437006	hsa-miR-4437	CLIP-seq
MIRT2352230	hsa-miR-4539	CLIP-seq
MIRT1437009	hsa-miR-4674	CLIP-seq
MIRT2352231	hsa-miR-4680-5p	CLIP-seq
MIRT2131004	hsa-miR-487b	CLIP-seq
MIRT2352232	hsa-miR-509-3-5p	CLIP-seq
MIRT2352233	hsa-miR-509-5p	CLIP-seq
MIRT2396013	hsa-miR-1224-3p	CLIP-seq
MIRT2396014	hsa-miR-619	CLIP-seq
MIRT2646032	hsa-miR-1266	CLIP-seq
MIRT2646033	hsa-miR-1913	CLIP-seq
MIRT2646034	hsa-miR-24	CLIP-seq
MIRT1436998	hsa-miR-3194-3p	CLIP-seq
MIRT2646035	hsa-miR-324-3p	CLIP-seq
MIRT2646036	hsa-miR-4265	CLIP-seq
MIRT2646037	hsa-miR-4293	CLIP-seq
MIRT2646038	hsa-miR-4296	CLIP-seq
MIRT2646039	hsa-miR-4322	CLIP-seq
MIRT2646040	hsa-miR-4417	CLIP-seq
MIRT1437006	hsa-miR-4437	CLIP-seq
MIRT2646041	hsa-miR-4518	CLIP-seq
MIRT1437009	hsa-miR-4674	CLIP-seq
MIRT2646042	hsa-miR-539	CLIP-seq
MIRT2646043	hsa-miR-548aa	CLIP-seq
MIRT2646044	hsa-miR-548ac	CLIP-seq
MIRT2646045	hsa-miR-548d-3p	CLIP-seq
MIRT2646046	hsa-miR-548z	CLIP-seq
MIRT2646047	hsa-miR-580	CLIP-seq
MIRT2646048	hsa-miR-596	CLIP-seq
MIRT2646049	hsa-miR-661	CLIP-seq
MIRT2646050	hsa-miR-938	CLIP-seq
MIRT2131003	hsa-miR-122	CLIP-seq
MIRT2646032	hsa-miR-1266	CLIP-seq
MIRT2646033	hsa-miR-1913	CLIP-seq
MIRT2646034	hsa-miR-24	CLIP-seq
MIRT1436998	hsa-miR-3194-3p	CLIP-seq
MIRT2646035	hsa-miR-324-3p	CLIP-seq
MIRT2646036	hsa-miR-4265	CLIP-seq
MIRT2646037	hsa-miR-4293	CLIP-seq
MIRT2646038	hsa-miR-4296	CLIP-seq
MIRT2646039	hsa-miR-4322	CLIP-seq
MIRT2646040	hsa-miR-4417	CLIP-seq
MIRT1437006	hsa-miR-4437	CLIP-seq
MIRT2646041	hsa-miR-4518	CLIP-seq
MIRT1437009	hsa-miR-4674	CLIP-seq
MIRT2646042	hsa-miR-539	CLIP-seq
MIRT2646043	hsa-miR-548aa	CLIP-seq
MIRT2646044	hsa-miR-548ac	CLIP-seq
MIRT2646045	hsa-miR-548d-3p	CLIP-seq
MIRT2646046	hsa-miR-548z	CLIP-seq
MIRT2646047	hsa-miR-580	CLIP-seq
MIRT2646048	hsa-miR-596	CLIP-seq
MIRT2646049	hsa-miR-661	CLIP-seq
MIRT2646050	hsa-miR-938	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	26618866, 35156780
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q8WWA1

Protein name

Transmembrane protein 40

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15817	TMEM40	113 → 232	Transmembrane protein 40 family	Family

Sequence

METSASSSQPQDNSQVHRETEDVDYGETDFHKQDGKAGLFSQEQYERNKSSSSSSSSSSS
SSSSSSSSSSESNDEDQQPRATGKHRRSLGAGYPHGNGSPGPGHGEPDVLKDELQLYGDA
PGEVVPSGESGLRRRGSDPASGEVEASQLRRLNIKKDDEFFHFVLLCFAIGALLVCYHYY
ADWFMSLGVGLLTFASLETVGIYFGLVYRIHSVLQGFIPLFQKFRLTGFRKTD

Sequence length

233

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITRAL VALVE PROLAPSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Bladder Neoplasm	Bladder Neoplasm	BEFREE	29351801		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	29351801		★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontotemporal Lobar Degeneration	Frontotemporal dementia	BEFREE	23419701		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	29351801		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29351801		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	30320346	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of tongue	Tongue carcinoma	BEFREE	30320346		★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Diseases	Urinary bladder diseases	Pubtator	29351801	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	29351801	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

TMEM40 (transmembrane protein 40)