CCDC25 (coiled-coil domain containing 25)

Gene

• Entrez ID: 55246
• Gene name: Coiled-coil domain containing 25
• Gene symbol: CCDC25
• Synonyms (NCBI Gene): -
• Chromosome: 8
• Chromosome location: 8p21.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029529	hsa-miR-26b-5p	Microarray	19088304
MIRT529176	hsa-miR-5003-3p	PAR-CLIP	22012620
MIRT529175	hsa-miR-6501-3p	PAR-CLIP	22012620
MIRT529174	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT529173	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT529172	hsa-miR-4487	PAR-CLIP	22012620
MIRT529171	hsa-miR-6853-3p	PAR-CLIP	22012620
MIRT529170	hsa-miR-5696	PAR-CLIP	22012620
MIRT529169	hsa-miR-579-3p	PAR-CLIP	22012620
MIRT529168	hsa-miR-664b-3p	PAR-CLIP	22012620
MIRT529167	hsa-miR-3942-3p	PAR-CLIP	22012620
MIRT529166	hsa-miR-30a-3p	PAR-CLIP	22012620
MIRT529165	hsa-miR-30d-3p	PAR-CLIP	22012620
MIRT529164	hsa-miR-30e-3p	PAR-CLIP	22012620
MIRT529176	hsa-miR-5003-3p	PAR-CLIP	22012620
MIRT529175	hsa-miR-6501-3p	PAR-CLIP	22012620
MIRT529174	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT529173	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT529172	hsa-miR-4487	PAR-CLIP	22012620
MIRT529171	hsa-miR-6853-3p	PAR-CLIP	22012620
MIRT529170	hsa-miR-5696	PAR-CLIP	22012620
MIRT529169	hsa-miR-579-3p	PAR-CLIP	22012620
MIRT529168	hsa-miR-664b-3p	PAR-CLIP	22012620
MIRT529167	hsa-miR-3942-3p	PAR-CLIP	22012620
MIRT529166	hsa-miR-30a-3p	PAR-CLIP	22012620
MIRT529165	hsa-miR-30d-3p	PAR-CLIP	22012620
MIRT529164	hsa-miR-30e-3p	PAR-CLIP	22012620
MIRT868662	hsa-let-7a	CLIP-seq
MIRT868663	hsa-let-7b	CLIP-seq
MIRT868664	hsa-let-7c	CLIP-seq
MIRT868665	hsa-let-7d	CLIP-seq
MIRT868666	hsa-let-7e	CLIP-seq
MIRT868667	hsa-let-7f	CLIP-seq
MIRT868668	hsa-let-7g	CLIP-seq
MIRT868669	hsa-let-7i	CLIP-seq
MIRT868670	hsa-miR-1	CLIP-seq
MIRT868671	hsa-miR-1207-3p	CLIP-seq
MIRT868672	hsa-miR-1225-3p	CLIP-seq
MIRT868673	hsa-miR-1233	CLIP-seq
MIRT868674	hsa-miR-1265	CLIP-seq
MIRT868675	hsa-miR-1284	CLIP-seq
MIRT868676	hsa-miR-1294	CLIP-seq
MIRT868677	hsa-miR-1298	CLIP-seq
MIRT868678	hsa-miR-1303	CLIP-seq
MIRT868679	hsa-miR-1323	CLIP-seq
MIRT868680	hsa-miR-1324	CLIP-seq
MIRT868681	hsa-miR-181a	CLIP-seq
MIRT868682	hsa-miR-181b	CLIP-seq
MIRT868683	hsa-miR-181c	CLIP-seq
MIRT868684	hsa-miR-181d	CLIP-seq
MIRT868685	hsa-miR-202	CLIP-seq
MIRT868686	hsa-miR-206	CLIP-seq
MIRT868687	hsa-miR-218	CLIP-seq
MIRT868688	hsa-miR-2278	CLIP-seq
MIRT868689	hsa-miR-2392	CLIP-seq
MIRT868690	hsa-miR-23a	CLIP-seq
MIRT868691	hsa-miR-23b	CLIP-seq
MIRT868692	hsa-miR-23c	CLIP-seq
MIRT868693	hsa-miR-3125	CLIP-seq
MIRT868694	hsa-miR-3130-5p	CLIP-seq
MIRT868695	hsa-miR-3132	CLIP-seq
MIRT868696	hsa-miR-3148	CLIP-seq
MIRT868697	hsa-miR-3190	CLIP-seq
MIRT868698	hsa-miR-323b-5p	CLIP-seq
MIRT868699	hsa-miR-335	CLIP-seq
MIRT868700	hsa-miR-3620	CLIP-seq
MIRT868701	hsa-miR-3673	CLIP-seq
MIRT868702	hsa-miR-3675-3p	CLIP-seq
MIRT868703	hsa-miR-371-5p	CLIP-seq
MIRT868704	hsa-miR-371b-5p	CLIP-seq
MIRT868705	hsa-miR-3916	CLIP-seq
MIRT868706	hsa-miR-3927	CLIP-seq
MIRT868707	hsa-miR-3978	CLIP-seq
MIRT868708	hsa-miR-4257	CLIP-seq
MIRT868709	hsa-miR-4261	CLIP-seq
MIRT868710	hsa-miR-4262	CLIP-seq
MIRT868711	hsa-miR-4267	CLIP-seq
MIRT868712	hsa-miR-4270	CLIP-seq
MIRT868713	hsa-miR-4282	CLIP-seq
MIRT868714	hsa-miR-4302	CLIP-seq
MIRT868715	hsa-miR-4314	CLIP-seq
MIRT868716	hsa-miR-4316	CLIP-seq
MIRT868717	hsa-miR-4323	CLIP-seq
MIRT868718	hsa-miR-4330	CLIP-seq
MIRT868719	hsa-miR-4427	CLIP-seq
MIRT868720	hsa-miR-4441	CLIP-seq
MIRT868721	hsa-miR-4453	CLIP-seq
MIRT868722	hsa-miR-4458	CLIP-seq
MIRT868723	hsa-miR-4468	CLIP-seq
MIRT868724	hsa-miR-4482	CLIP-seq
MIRT868725	hsa-miR-4488	CLIP-seq
MIRT868726	hsa-miR-4489	CLIP-seq
MIRT868727	hsa-miR-4494	CLIP-seq
MIRT868728	hsa-miR-4499	CLIP-seq
MIRT868729	hsa-miR-4500	CLIP-seq
MIRT868730	hsa-miR-4509	CLIP-seq
MIRT868731	hsa-miR-451b	CLIP-seq
MIRT868732	hsa-miR-4538	CLIP-seq
MIRT868733	hsa-miR-4650-3p	CLIP-seq
MIRT868734	hsa-miR-4684-3p	CLIP-seq
MIRT868735	hsa-miR-4684-5p	CLIP-seq
MIRT868736	hsa-miR-4697-5p	CLIP-seq
MIRT868737	hsa-miR-4698	CLIP-seq
MIRT868738	hsa-miR-4728-3p	CLIP-seq
MIRT868739	hsa-miR-4731-3p	CLIP-seq
MIRT868740	hsa-miR-4744	CLIP-seq
MIRT868741	hsa-miR-4752	CLIP-seq
MIRT868742	hsa-miR-4754	CLIP-seq
MIRT868743	hsa-miR-4766-5p	CLIP-seq
MIRT868744	hsa-miR-4789-3p	CLIP-seq
MIRT868745	hsa-miR-4789-5p	CLIP-seq
MIRT868746	hsa-miR-4795-3p	CLIP-seq
MIRT868747	hsa-miR-4797-5p	CLIP-seq
MIRT868748	hsa-miR-4801	CLIP-seq
MIRT868749	hsa-miR-488	CLIP-seq
MIRT868750	hsa-miR-493	CLIP-seq
MIRT868751	hsa-miR-494	CLIP-seq
MIRT868752	hsa-miR-499a-5p	CLIP-seq
MIRT868753	hsa-miR-5096	CLIP-seq
MIRT868754	hsa-miR-543	CLIP-seq
MIRT868755	hsa-miR-548aa	CLIP-seq
MIRT868756	hsa-miR-548n	CLIP-seq
MIRT868757	hsa-miR-548o	CLIP-seq
MIRT868758	hsa-miR-548t	CLIP-seq
MIRT868759	hsa-miR-553	CLIP-seq
MIRT868760	hsa-miR-561	CLIP-seq
MIRT868761	hsa-miR-570	CLIP-seq
MIRT868762	hsa-miR-583	CLIP-seq
MIRT868763	hsa-miR-593	CLIP-seq
MIRT868764	hsa-miR-607	CLIP-seq
MIRT868765	hsa-miR-613	CLIP-seq
MIRT868766	hsa-miR-636	CLIP-seq
MIRT868767	hsa-miR-642b	CLIP-seq
MIRT868768	hsa-miR-646	CLIP-seq
MIRT868769	hsa-miR-659	CLIP-seq
MIRT868770	hsa-miR-664	CLIP-seq
MIRT868771	hsa-miR-7	CLIP-seq
MIRT868772	hsa-miR-720	CLIP-seq
MIRT868773	hsa-miR-767-3p	CLIP-seq
MIRT868774	hsa-miR-98	CLIP-seq
MIRT1920341	hsa-miR-204	CLIP-seq
MIRT1920342	hsa-miR-211	CLIP-seq
MIRT1920343	hsa-miR-3170	CLIP-seq
MIRT1920344	hsa-miR-4446-5p	CLIP-seq
MIRT1920345	hsa-miR-4642	CLIP-seq
MIRT1920346	hsa-miR-4755-5p	CLIP-seq
MIRT1920347	hsa-miR-623	CLIP-seq
MIRT1920341	hsa-miR-204	CLIP-seq
MIRT1920342	hsa-miR-211	CLIP-seq
MIRT1920343	hsa-miR-3170	CLIP-seq
MIRT1920344	hsa-miR-4446-5p	CLIP-seq
MIRT1920345	hsa-miR-4642	CLIP-seq
MIRT1920346	hsa-miR-4755-5p	CLIP-seq
MIRT1920347	hsa-miR-623	CLIP-seq
MIRT1957770	hsa-miR-1302	CLIP-seq
MIRT868680	hsa-miR-1324	CLIP-seq
MIRT868681	hsa-miR-181a	CLIP-seq
MIRT868682	hsa-miR-181b	CLIP-seq
MIRT868683	hsa-miR-181c	CLIP-seq
MIRT868684	hsa-miR-181d	CLIP-seq
MIRT868690	hsa-miR-23a	CLIP-seq
MIRT868691	hsa-miR-23b	CLIP-seq
MIRT868692	hsa-miR-23c	CLIP-seq
MIRT1957771	hsa-miR-3152-5p	CLIP-seq
MIRT1957772	hsa-miR-3688-3p	CLIP-seq
MIRT868703	hsa-miR-371-5p	CLIP-seq
MIRT868704	hsa-miR-371b-5p	CLIP-seq
MIRT1957773	hsa-miR-3940-5p	CLIP-seq
MIRT868709	hsa-miR-4261	CLIP-seq
MIRT868710	hsa-miR-4262	CLIP-seq
MIRT868713	hsa-miR-4282	CLIP-seq
MIRT1957774	hsa-miR-4298	CLIP-seq
MIRT868727	hsa-miR-4494	CLIP-seq
MIRT1957775	hsa-miR-4507	CLIP-seq
MIRT868737	hsa-miR-4698	CLIP-seq
MIRT1957776	hsa-miR-4699-3p	CLIP-seq
MIRT1957777	hsa-miR-4704-5p	CLIP-seq
MIRT1957778	hsa-miR-4715-3p	CLIP-seq
MIRT1957779	hsa-miR-4774-3p	CLIP-seq
MIRT868744	hsa-miR-4789-3p	CLIP-seq
MIRT1957780	hsa-miR-4793-3p	CLIP-seq
MIRT868767	hsa-miR-642b	CLIP-seq
MIRT1957781	hsa-miR-890	CLIP-seq
MIRT2194821	hsa-miR-3189-3p	CLIP-seq
MIRT1957772	hsa-miR-3688-3p	CLIP-seq
MIRT868703	hsa-miR-371-5p	CLIP-seq
MIRT2194822	hsa-miR-3977	CLIP-seq
MIRT868709	hsa-miR-4261	CLIP-seq
MIRT868712	hsa-miR-4270	CLIP-seq
MIRT868720	hsa-miR-4441	CLIP-seq
MIRT868737	hsa-miR-4698	CLIP-seq
MIRT1957777	hsa-miR-4704-5p	CLIP-seq
MIRT2194823	hsa-miR-4778-5p	CLIP-seq
MIRT1957780	hsa-miR-4793-3p	CLIP-seq
MIRT868751	hsa-miR-494	CLIP-seq
MIRT868754	hsa-miR-543	CLIP-seq
MIRT2446420	hsa-miR-324-5p	CLIP-seq
MIRT2194822	hsa-miR-3977	CLIP-seq
MIRT2498110	hsa-miR-1273d	CLIP-seq
MIRT2498111	hsa-miR-1305	CLIP-seq
MIRT868679	hsa-miR-1323	CLIP-seq
MIRT2498112	hsa-miR-216b	CLIP-seq
MIRT2498113	hsa-miR-22	CLIP-seq
MIRT2498114	hsa-miR-3064-3p	CLIP-seq
MIRT2498115	hsa-miR-3160-3p	CLIP-seq
MIRT2498116	hsa-miR-3182	CLIP-seq
MIRT2498117	hsa-miR-320a	CLIP-seq
MIRT2498118	hsa-miR-320b	CLIP-seq
MIRT2498119	hsa-miR-320c	CLIP-seq
MIRT2498120	hsa-miR-320d	CLIP-seq
MIRT2498121	hsa-miR-330-3p	CLIP-seq
MIRT2498122	hsa-miR-3591-3p	CLIP-seq
MIRT2498123	hsa-miR-3612	CLIP-seq
MIRT868701	hsa-miR-3673	CLIP-seq
MIRT868709	hsa-miR-4261	CLIP-seq
MIRT2498124	hsa-miR-4263	CLIP-seq
MIRT868712	hsa-miR-4270	CLIP-seq
MIRT2498125	hsa-miR-4289	CLIP-seq
MIRT2498126	hsa-miR-4303	CLIP-seq
MIRT2498127	hsa-miR-4420	CLIP-seq
MIRT2498128	hsa-miR-4426	CLIP-seq
MIRT2498129	hsa-miR-4429	CLIP-seq
MIRT868720	hsa-miR-4441	CLIP-seq
MIRT2498130	hsa-miR-4443	CLIP-seq
MIRT868721	hsa-miR-4453	CLIP-seq
MIRT2498131	hsa-miR-4534	CLIP-seq
MIRT868732	hsa-miR-4538	CLIP-seq
MIRT2498132	hsa-miR-4647	CLIP-seq
MIRT2498133	hsa-miR-4653-3p	CLIP-seq
MIRT2498134	hsa-miR-4662b	CLIP-seq
MIRT1957777	hsa-miR-4704-5p	CLIP-seq
MIRT1957778	hsa-miR-4715-3p	CLIP-seq
MIRT2498135	hsa-miR-4735-5p	CLIP-seq
MIRT2498136	hsa-miR-4753-3p	CLIP-seq
MIRT2498137	hsa-miR-4757-5p	CLIP-seq
MIRT868743	hsa-miR-4766-5p	CLIP-seq
MIRT2498138	hsa-miR-4775	CLIP-seq
MIRT2498139	hsa-miR-4781-3p	CLIP-seq
MIRT1957780	hsa-miR-4793-3p	CLIP-seq
MIRT2498140	hsa-miR-4802-5p	CLIP-seq
MIRT868751	hsa-miR-494	CLIP-seq
MIRT2498141	hsa-miR-539	CLIP-seq
MIRT868754	hsa-miR-543	CLIP-seq
MIRT2498142	hsa-miR-548c-3p	CLIP-seq
MIRT868757	hsa-miR-548o	CLIP-seq
MIRT2498143	hsa-miR-558	CLIP-seq
MIRT2498144	hsa-miR-576-5p	CLIP-seq
MIRT2498145	hsa-miR-590-3p	CLIP-seq
MIRT868764	hsa-miR-607	CLIP-seq
MIRT2498146	hsa-miR-650	CLIP-seq
MIRT868773	hsa-miR-767-3p	CLIP-seq
MIRT868678	hsa-miR-1303	CLIP-seq
MIRT868679	hsa-miR-1323	CLIP-seq
MIRT2498113	hsa-miR-22	CLIP-seq
MIRT868688	hsa-miR-2278	CLIP-seq
MIRT2498114	hsa-miR-3064-3p	CLIP-seq
MIRT868693	hsa-miR-3125	CLIP-seq
MIRT2498115	hsa-miR-3160-3p	CLIP-seq
MIRT2498122	hsa-miR-3591-3p	CLIP-seq
MIRT2498123	hsa-miR-3612	CLIP-seq
MIRT868700	hsa-miR-3620	CLIP-seq
MIRT868704	hsa-miR-371b-5p	CLIP-seq
MIRT868705	hsa-miR-3916	CLIP-seq
MIRT868708	hsa-miR-4257	CLIP-seq
MIRT2498126	hsa-miR-4303	CLIP-seq
MIRT2498127	hsa-miR-4420	CLIP-seq
MIRT2498128	hsa-miR-4426	CLIP-seq
MIRT2498130	hsa-miR-4443	CLIP-seq
MIRT868731	hsa-miR-451b	CLIP-seq
MIRT2498131	hsa-miR-4534	CLIP-seq
MIRT2498132	hsa-miR-4647	CLIP-seq
MIRT2498134	hsa-miR-4662b	CLIP-seq
MIRT1957777	hsa-miR-4704-5p	CLIP-seq
MIRT1957778	hsa-miR-4715-3p	CLIP-seq
MIRT2498137	hsa-miR-4757-5p	CLIP-seq
MIRT2498139	hsa-miR-4781-3p	CLIP-seq
MIRT1957780	hsa-miR-4793-3p	CLIP-seq
MIRT2498140	hsa-miR-4802-5p	CLIP-seq
MIRT868757	hsa-miR-548o	CLIP-seq
MIRT2498143	hsa-miR-558	CLIP-seq
MIRT2498146	hsa-miR-650	CLIP-seq
MIRT868773	hsa-miR-767-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IDA	32528174
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005886	Component	Plasma membrane	IDA	32528174
GO:0005886	Component	Plasma membrane	IEA
GO:0012505	Component	Endomembrane system	IDA	32528174
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:2000147	Process	Positive regulation of cell motility	IDA	32528174

Other IDs

• MIM: 619100
• HGNC: 25591
• e!Ensembl: ENSG00000147419

Protein

• UniProt ID: Q86WR0
• Protein name: Coiled-coil domain-containing protein 25
• Protein function: Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens duri
• PDB: 7EOE, 7EOF, 8WOH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05670	NFACT-R_1	1 → 113	NFACT protein RNA binding domain	Domain

• Sequence:

  MVFYFTSSSVNSSAYTIYMGKDKYENEDLIKHGWPEDIWFHVDKLSSAHVYLRLHKGENI
  EDIPKEVLMDCAHLVKANSIQGCKMNNVNVVYTPWSNLKKTADMDVGQIGFHRQKDVKIV
  TVEKKVNEILNRLEKTKVERFPDLAAEKECRDREERNEKKAQIQEMKKREKEEMKKKREM
  DELRSYSSLMKVENMSSNQDGNDSDEFM

• Sequence length: 208

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	28789463		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	34067437	Associate	★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	36593058	Stimulate	★☆☆☆☆ Found in Text Mining only
Congenital contractural arachnodactyly	Congenital Contractural Arachnodactyly	BEFREE	28789463		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	34067437	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	26851141		★☆☆☆☆ Found in Text Mining only